| DONOR ADVISED CHARITABLE GIVING | $11,676,597,614 | T30 | published | violence: community | Lone Tree, CO | 2024 |
| CORNELL UNIVERSITY | $7,482,422,861 | B43 | published | space: outer | Ithaca, NY | 2024 |
| UNIVERSITY OF MIAMI | $7,039,401,641 | B43 | published | space: outer | Coral Gables, FL | 2024 |
| GS DONOR ADVISED PHILANTHROPY FUND FOR WEALTH MANAGEMENT INC | $6,592,899,306 | T30 | published | girls boys: boys | New York, NY | 2024 |
| CEDARS-SINAI MEDICAL CENTER | $5,868,996,069 | E22 | published | space: outer | W Hollywood, CA | 2024 |
| UNIVERSITY OF CHICAGO | $5,617,072,703 | B43 | published | space: outer | Chicago, IL | 2024 |
| HENRY FORD HEALTH SYSTEM | $5,284,200,687 | E21 | published | space: outer | Detroit, MI | 2024 |
| TEXAS CHILDRENS HOSPITAL | $4,436,955,658 | E24 | published | space: for women | Bellaire, TX | 2024 |
| SENTARA HOSPITALS | $4,425,929,465 | E20 | published | space: for women | Virginia Bch, VA | 2024 |
| KAISER FOUNDATION HEALTH PLAN OF WASHINGTON | $4,366,355,550 | E20 | published | violence: gun | Renton, WA | 2024 |
| MICHAEL & SUSAN DELL FOUNDATION | $4,273,133,138 | T20 | published | space: outer | Austin, TX | 2024 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $3,531,221,000 | B43 | published | space: outer | Pasadena, CA | 2024 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $3,438,681,237 | E22 | published | launch: space | Charlestown, MA | 2024 |
| GORDON E AND BETTY I MOORE FOUNDATION | $2,663,649,577 | T20 | published | launch: space | Palo Alto, CA | 2024 |
| THE CHICAGO COMMUNITY TRUST | $2,143,553,763 | T31 | published | survivor: suicide | Chicago, IL | 2024 |
| HOWARD HUGHES MEDICAL INSTITUTE | $2,004,784,057 | H92 | published | space: outer | Chevy Chase, MD | 2024 |
| SMITHSONIAN INSTITUTE | $1,911,142,906 | A50 | published | space: outer | Washington, DC | 2024 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUC | $1,787,499,000 | B43 | published | space: outer | Philadelphia, PA | 2024 |
| UNIVERSITY OF DELAWARE | $1,689,371,610 | B43 | inferred 0.90 | space: outer | Newark, DE | 2024 |
| HACKENSACK MERIDIAN HEALTH INC | $1,677,250,220 | E22 | published | survivor: cancer | Iselin, NJ | 2017 |
| WILLIAM MARSH RICE UNIVERSITY | $1,635,701,788 | B43 | published | space: outer | Houston, TX | 2024 |
| AEROSPACE CORPORATION | $1,623,067,000 | U30 | published | launch: space | Chantilly, VA | 2024 |
| DREXEL UNIVERSITY | $1,465,915,989 | B43 | published | space: outer | Philadelphia, PA | 2024 |
| MOODY FOUNDATION | $1,432,337,894 | T22 | published | survivor: suicide | Galveston, TX | 2024 |
| INTERNATIONAL RESCUE COMMITTEE INC | $1,314,041,795 | Q71 | published | space: for women | New York, NY | 2024 |
| CAPITAL HEALTH SYSTEM INC | $1,285,510,632 | E20 | published | space: for women | Trenton, NJ | 2024 |
| TEXAS CHRISTIAN UNIVERSITY | $1,250,018,653 | B43 | published | space: outer | Fort Worth, TX | 2024 |
| WALTON FAMILY FOUNDATION INC | $1,146,415,772 | T20 | published | launch: aviation | Bentonville, AR | 2024 |
| FREEDOM TOGETHER FOUNDATION | $1,132,105,563 | T21 | published | domestic: workers | New York, NY | 2024 |
| CONSORTIUM MANAGEMENT GROUP INC | $1,065,202,053 | W19 | published | space: outer | Bedminster, NJ | 2024 |
| ANDREW W MELLON FOUNDATION | $1,059,396,782 | B82 | published | violence: sexual | New York, NY | 2024 |
| SOUTHWEST RESEARCH INSTITUTE | $978,595,721 | U99 | published | space: outer | San Antonio, TX | 2024 |
| RAYMOND JAMES CHARITABLE ENDOWMENT FUND | $955,087,502 | T30 | published | launch: aviation | St Petersburg, FL | 2024 |
| SAVANNAH COLLEGE OF ART AND DESIGN INC | $952,827,667 | B43 | published | space: outer | Savannah, GA | 2024 |
| CHARLES STARK DRAPER LABORATORY INC | $949,348,102 | U40 | published | launch: space | Cambridge, MA | 2024 |
| SHERWOOD FOUNDATION | $943,412,098 | T20 | published | violence: gun | Omaha, NE | 2025 |
| GENERAL ELECTRIC COMPANY INSURANCE PLAN TRUST CO V A DIAMANTE | $913,945,910 | Y43 | inferred 0.90 | space: outer | Norwalk, CT | 2024 |
| JOHN D & CATHERINE T MACARTHUR FOUNDATION | $890,851,721 | T20 | published | space: for women | Chicago, IL | 2024 |
| EMBRY-RIDDLE AERONAUTICAL | $864,220,449 | B43 | published | space: outer | Daytona Beach, FL | 2024 |
| ROBERT WOOD JOHNSON FOUNDATION | $855,259,092 | T20 | published | domestic: workers | Princeton, NJ | 2024 |
| COMMONSPIRIT WASHINGTON COMMUNITY CARE | $841,830,622 | E22 | published | space: outer | Phoenix, AZ | 2024 |
| AMERICAN CHEMICAL SOCIETY | $819,099,460 | U33 | published | launch: launch | Washington, DC | 2024 |
| CURTIN UNIVERSITY | $807,436,631 | B43 | published | space: outer | Australia | 2024 |
| NORTON HEALTHCARE INC | $759,365,626 | E21 | published | space: for women | Louisville, KY | 2024 |
| SVMC HOLDINGS INC | $707,034,879 | E20 | published | survivor: cancer | Bridgeport, CT | 2024 |
| PUBLIC BROADCASTING SERVICE | $696,585,777 | A32 | published | space: outer | Arlington, VA | 2024 |
| MAYO CLINIC | $657,549,856 | E21 | published | space: outer | Rochester, MN | 2013 |
| REID HOSPITAL & HEALTH CARE SERVICES INC | $638,485,578 | E22 | published | space: for women | Richmond, IN | 2025 |
| NOBLIS INC | $614,468,693 | U20 | published | space: outer | Reston, VA | 2024 |
| EASTMAN CREDIT UNION | $602,491,997 | W60 | inferred 0.80 | space: outer | Kingsport, TN | 2025 |
| NATIONAL CENTER FOR MANUFACTURING SCIENCES | $568,204,237 | S40 | published | space: outer | Ann Arbor, MI | 2024 |
| STATE CHARTERED CREDIT UNIONS IN FLORIDA | $516,242,984 | W60 | inferred 0.80 | space: outer | Melbourne, FL | 2024 |
| ASSOCIATION OF UNIVERSITIES FOR | $468,809,827 | U31 | published | space: outer | Washington, DC | 2024 |
| LEGACY COMMUNITY HEALTH SERVICES INC | $453,793,852 | E30 | published | space: for men | Houston, TX | 2024 |
| ENVIRONMENTAL DEFENSE FUND INCORPORATED | $443,267,772 | C60 | published | launch: launch | New York, NY | 2024 |
| SRI INTERNATIONAL | $437,926,151 | U20 | published | space: outer | Menlo Park, CA | 2024 |
| MARTHA JEFFERSON HOSPITAL | $408,631,205 | E22 | published | violence: gun | Virginia Bch, VA | 2024 |
| THE ERIC AND WENDY SCHMIDT FUND FOR STRATEGIC INNOVATION | $406,766,399 | T20 | published | launch: space | Palo Alto, CA | 2024 |
| LICKING MEMORIAL HOSPITAL | $399,199,871 | E22 | published | launch: aviation | Newark, OH | 2024 |
| ASSETS UNDER MOVEMENT | $396,906,311 | T30 | published | space: for women | Washington, DC | 2024 |
| OPEN SOCIETY INSTITUTE | $396,477,106 | T23 | published | space: for men | New York, NY | 2024 |
| NORTHEAST GEORGIA PHYSICIANS GROUP INC | $396,365,535 | E21 | published | space: for women | Gainesville, GA | 2024 |
| DOYLESTOWN HOSPITAL | $385,475,843 | E22 | published | girls boys: girl scouts | Doylestown, PA | 2024 |
| NATIONAL GALLERY OF ART | $382,850,886 | A51 | published | launch: space | Landover, MD | 2024 |
| AIR LINE PILOTS ASSOCIATION INTERNATIONAL | $382,120,748 | J40 | inferred 0.90 | space: outer | Mclean, VA | 2024 |
| MERCY CORPS | $376,251,780 | Q33 | published | space: for women | Portland, OR | 2024 |
| CARNEGIE CORPORATION OF NEW YORK | $359,320,735 | B12 | published | survivor: disaster | New York, NY | 2024 |
| SAN FRANCISCO FOUNDATION | $358,598,652 | T30 | published | domestic: workers | San Francisco, CA | 2024 |
| BARNARD COLLEGE | $353,986,942 | B42 | published | space: outer | New York, NY | 2024 |
| NATIONAL GEOGRAPHIC SOCIETY | $340,516,012 | B03 | published | domestic: workers | Washington, DC | 2025 |
| CHRISTIAN COMMUNITY FOUNDATION INC | $337,552,115 | T31 | published | shelter: disaster | Colorado Spgs, CO | 2024 |
| CLEVELAND CLINIC MERCY HOSPITAL | $331,123,927 | E3O | published | space: for women | Independence, OH | 2020 |
| WELLSPRING PHILANTROPIC FUND INC | $329,254,342 | T22 | published | space: for men | New York, NY | 2023 |
| PUBLIC HEALTH SOLUTIONS | $325,747,738 | H00 | published | violence: gun | New York, NY | 2025 |
| UNIVERSITY OF NEW ENGLAND | $322,835,606 | B43 | published | space: outer | Biddeford, ME | 2024 |
| THE SEATTLE FOUNDATION | $314,722,382 | T31 | published | violence: gun | Seattle, WA | 2024 |
| SECOND HARVEST OF SILICON VALLEY | $309,823,067 | K31 | published | launch: launch | San Jose, CA | 2024 |
| EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE | $309,538,440 | B50 | published | shelter: disaster | Blacksburg, VA | 2024 |
| NEW YORK UNIVERSITY IN ABU DHABI CORPORATION | $297,458,935 | B11 | published | space: outer | New York, NY | 2024 |
| GREATER HOUSTON COMMUNITY FOUNDATION | $293,284,617 | T31 | published | science: christian science | Houston, TX | 2024 |
| PARTNERS IN HEALTH A NONPROFIT CORPORATION | $284,697,820 | E70 | published | survivor: disaster | Boston, MA | 2024 |
| JOHNS HOPKINS UNIVERSITY | $280,524,446 | B43 | inferred 0.50 | survivor: sexual | Baltimore, MD | 2024 |
| TIDES CENTER | $265,402,095 | P20 | published | space: outer | San Francisco, CA | 2024 |
| DEPAUW UNIVERSITY | $263,810,956 | B42 | published | space: outer | Greencastle, IN | 2024 |
| JOHN TEMPLETON FOUNDATION | $258,662,276 | T99 | published | space: outer | West Conshohocken, PA | 2024 |
| BIOLA UNIVERSITY INC | $257,536,275 | B43 | published | space: outer | La Mirada, CA | 2024 |
| SOUTHEASTERN UNIVERSITIES RESEARCH ASSOCIATION INC | $251,855,977 | U05 | published | launch: space | Washington, DC | 2024 |
| SKOOKUM EDUCATIONAL PROGRAMS | $247,596,570 | J33 | inferred 0.60 | space: outer | Bremerton, WA | 2024 |
| AMERICAN MUSEUM OF NATURAL HISTORY | $246,764,235 | A56 | published | launch: space | New York, NY | 2024 |
| PROFESSIONAL CONTRACT SERVICES INC | $246,080,465 | P80 | published | space: outer | Austin, TX | 2024 |
| THE COMMUNITY FDN OF MIDDLE TN INC | $239,914,601 | T31 | published | domestic: workers | Nashville, TN | 2024 |
| PHILLIPS EXETER ACADEMY | $239,865,952 | B25 | published | space: outer | Exeter, NH | 2024 |
| DOGWOOD HEALTH TRUST | $238,690,769 | T20 | published | abuse: elder | Asheville, NC | 2024 |
| SPENCER FOUNDATION | $235,611,615 | B99 | published | space: for women | Chicago, IL | 2024 |
| CHARLES STEWART MOTT FOUNDATION | $228,318,921 | T99 | published | violence: sexual | Flint, MI | 2024 |
| W M KECK FOUNDATION | $220,502,754 | T22 | published | space: outer | Los Angeles, CA | 2024 |
| GLOBAL TECHNOLOGY INDUSTRY ASSOCIATION | $216,871,482 | S41 | inferred 0.80 | space: outer | Downers Grove, IL | 2024 |
| WGBH EDUCATIONAL FOUNDATION | $215,642,285 | A30 | published | launch: space | Brighton, MA | 2024 |
| CORPORATION OF HAVERFORD COLLEGE | $212,487,281 | B42 | published | space: outer | Haverford, PA | 2024 |
| SAINT PAUL & MINNESOTA FOUNDATION | $210,840,402 | T31 | published | space: for women | Saint Paul, MN | 2025 |