| BATTELLE MEMORIAL INSTITUTE | $13,526,408,187 | U20 | published | science: research education | Columbus, OH | 2024 |
| RESEARCH TRIANGLE INSTITUTE | $1,254,259,534 | U20 | published | science: research education | Rtp, NC | 2024 |
| COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION | $1,034,784,608 | U20 | inferred 0.80 | science: research education | San Francisco, CA | 2024 |
| NOBLIS INC | $614,468,693 | U20 | published | space: outer | Reston, VA | 2024 |
| SRI INTERNATIONAL | $437,926,151 | U20 | published | space: outer | Menlo Park, CA | 2024 |
| Aleo Network Foundation | $260,535,815 | U20 | inferred 0.50 | | Cheyenne, WY | 2024 |
| ALFRED E MANN FOUNDATION FOR SCIENTIFIC RESEARCH | $257,887,615 | U20 | published | science: research education | Santa Clarita, CA | 2025 |
| BANK OF SWEDEN TERCENTENARY FOUNDATION | $161,339,017 | U20 | inferred 0.60 | science: research education | Atlanta, GA | 2024 |
| MRIGLOBAL | $115,849,749 | U20 | published | science: research education | Kansas City, MO | 2024 |
| CABLE TELEVISION LABORATORIES INC | $75,552,254 | U20 | inferred 0.55 | | Louisville, CO | 2024 |
| GENEVA FOUNDATION 04-15-93 | $60,848,687 | U20 | published | | Tacoma, WA | 2024 |
| SANTA FE INSTITUTE | $51,822,371 | U20 | published | science: research education | Santa Fe, NM | 2024 |
| NORTHWEST INSTITUTE OF RESEARCH INC | $47,440,023 | U20 | inferred 0.60 | science: research education | Erie, PA | 2024 |
| AMPP GLOBAL CENTER INC | $44,631,316 | U20 | inferred 0.60 | | Houston, TX | 2024 |
| PUBLIC LIBRARY OF SCIENCE | $41,335,403 | U20 | published | launch: launch | San Francisco, CA | 2024 |
| NATIONAL COMMISSION ON CERTIFICATION OF PHYSICIANS ASSIST | $36,278,084 | U20 | inferred 0.60 | | Johns Creek, GA | 2025 |
| ENERGETICS TECHNOLOGY CENTER INC | $28,407,479 | U20 | published | science: research education | Indian Head, MD | 2024 |
| CLIMATE CENTRAL INC | $22,272,608 | U20 | published | launch: launch | Princeton, NJ | 2025 |
| WEST VIRGINIA STATE UNIVERSITY RESEARCH AND DEVELOPMENT CORP | $21,949,840 | U20 | inferred 0.50 | science: research education | Institute, WV | 2024 |
| ACADEMY OF MANAGED CARE PHARMACY A NEW JERSEY NONPROFIT CORPORATION | $20,869,863 | U20 | published | science: research education | Alexandria, VA | 2024 |
| UNIVERSITY LICENSE EQUITY HOLDINGS INC | $19,670,419 | U20 | published | | Aurora, CO | 2024 |
| FAJR SCIENTIFIC | $18,174,508 | U20 | published | | Houston, TX | 2024 |
| IIT RESEARCH INSTITUTE | $17,520,000 | U20 | published | science: research education | Chicago, IL | 2024 |
| VIRGINIA HEALTH INFORMATION | $13,708,032 | U20 | published | | Richmond, VA | 2024 |
| ST LOUIS SCIENCE CENTER FOUNDATION | $10,815,081 | U20 | published | space: outer | Saint Louis, MO | 2025 |
| INSTITUTE FOR CREATION RESEARCH | $10,363,954 | U20 | published | space: outer | Dallas, TX | 2024 |
| PATUXENT PARTNERSHIP INC | $9,556,202 | U20 | published | science: research education | Lexington Pk, MD | 2024 |
| SPARK NS INC | $9,000,000 | U20 | published | | Menlo Park, CA | 2024 |
| UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | $8,519,357 | U20 | inferred 0.60 | science: research education | Knoxville, TN | 2024 |
| PUBLIC ARCHAEOLOGY LABORATORY INC | $8,365,042 | U20 | inferred 0.60 | science: research education | Pawtucket, RI | 2024 |
| OREGON COMMUNITY PROGRAMS | $8,064,577 | U20 | published | violence: community | Eugene, OR | 2024 |
| WORLD SCIENCE FOUNDATION | $8,028,935 | U20 | published | science: research education | New York, NY | 2024 |
| INTERNATIONAL SEAKEEPERS SOCIETY INC | $8,006,477 | U20 | published | science: research education | Coral Gables, FL | 2025 |
| NORTH CAROLINA ADVANCED ENERGY CORPORATION | $7,935,080 | U20 | inferred 0.80 | | Raleigh, NC | 2024 |
| DELTARES USA INC | $7,781,063 | U20 | published | | Silver Spring, MD | 2024 |
| AMERICAN FROZEN FOOD INSTITUTE | $7,322,596 | U20 | inferred 0.55 | science: research education | Culpeper, VA | 2025 |
| CHABOT SPACE & SCIENCE CENTER FOUNDATION | $7,253,978 | U20 | published | space: outer | Oakland, CA | 2024 |
| SOCIETY FOR INFORMATION DISPLAY | $6,758,358 | U20 | inferred 0.55 | | Campbell, CA | 2024 |
| OAK CREST INSTITUTE OF SCIENCE | $6,470,203 | U20 | published | | Monrovia, CA | 2024 |
| MCNC ENDOWMENT | $6,131,857 | U20 | published | science: research education | Research Triangle Park, NC | 2024 |
| AMERICAN CENTER FOR OPTICS MANUFACTURING INC | $5,914,556 | U20 | published | | Fairport, NY | 2025 |
| HUMAN CELL ATLAS INC | $5,842,219 | U20 | published | | Cambridge, MA | 2024 |
| OFFSHORE OPERATORS COMMITTEE | $5,746,682 | U20 | inferred 0.60 | | Kenner, LA | 2024 |
| KAPHAN FOUNDATION | $5,733,988 | U20 | published | | Seattle, WA | 2024 |
| MIND RESEARCH INSTITUTE INC | $5,670,095 | U20 | published | | Irvine, CA | 2024 |
| TECHNOVATION | $5,596,256 | U20 | published | girls boys: girls | Menlo Park, CA | 2024 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $5,271,618 | U20 | inferred 0.60 | science: research education | Columbia, SC | 2024 |
| BUCKMINSTER FULLER INSTITUTE | $5,041,849 | U20 | published | science: research education | San Francisco, CA | 2024 |
| ASH REGISTRY INC | $4,973,130 | U20 | published | | Washington, DC | 2024 |
| SYSTEMS BUILDING RESEARCH ALLIANCE | $4,930,518 | U20 | inferred 0.60 | science: research education | New York, NY | 2024 |
| CONSORTIUM OF UNIVERSITIES FOR THE ADVANCEMENT OF HYDROLOGIC SCIENCE | $4,807,688 | U20 | published | science: research education | Arlington, MA | 2024 |
| IQM RESEARCH INSTITUTE | $4,600,511 | U20 | published | space: outer | Ann Arbor, MI | 2024 |
| AMERICAN SOCIETY FOR MASS SPECTROMETRY | $4,420,698 | U20 | published | science: research education | Santa Fe, NM | 2024 |
| KANSAS HEALTH INSTITUTE | $4,399,442 | U20 | published | | Topeka, KS | 2024 |
| GEOTHERMAL RESOURCES COUNCIL | $4,338,973 | U20 | published | | Palm Springs, CA | 2024 |
| MEAT FOUNDATION | $4,226,202 | U20 | inferred 0.82 | science: research education | Arlington, VA | 2024 |
| BARROW ARCTIC SCIENCE CONSORTIUM | $3,800,382 | U20 | inferred 0.55 | | Barrow, AK | 2010 |
| SEISMOLOGICAL SOCIETY OF AMERICA | $3,704,560 | U20 | inferred 0.70 | science: research education | Albany, CA | 2025 |
| NATIONAL ACADEMY OF INVENTORS INC | $3,652,522 | U20 | published | science: research education | Tampa, FL | 2024 |
| LOW IMPACT DEVELOPMENT CENTER INC | $3,462,048 | U20 | published | | Beltsville, MD | 2024 |
| EARTHWATCH INSTITUTE INC | $3,396,186 | U20 | published | science: research education | Newton, MA | 2024 |
| MENTAL HEALTH EMPOWERMENT PROJECT INC | $3,089,440 | U20 | published | | Albany, NY | 2025 |
| BAY AREA DISRUPTOR AND STARTUP SUPPORT LABS | $2,783,979 | U20 | published | | Alameda, CA | 2023 |
| INSTITUTE FOR THE ADVANCEMENT OF FOOD AND NUTRITION SCIENCES | $2,771,086 | U20 | published | science: research education | Washington, DC | 2024 |
| MATERIALS TECHNOLOGY INSTITUTE INC | $2,697,035 | U20 | inferred 0.60 | | Saint Louis, MO | 2025 |
| SCIENCE OLYMPIAD | $2,695,556 | U20 | published | science: research education | Oak Brook, IL | 2024 |
| VETERANS BIO-MEDICAL RESEARCH INSTITUTE INC | $2,462,324 | U20 | inferred 0.70 | science: research education | East Orange, NJ | 2025 |
| Sovrin Foundation | $2,182,771 | U20 | inferred 0.50 | | Salt Lake City, UT | 2025 |
| FOUNDATION FOR ANIMAL CARE ANDEDUCATION | $2,180,950 | U20 | published | | San Diego, CA | 2024 |
| V M I RESEARCH LABORATORIES | $2,129,593 | U20 | inferred 0.70 | space: outer | Lexington, VA | 2024 |
| TALCOTT MOUNTAIN SCIENCE CENTER FOR STUDENT INVOLVEMENT INC | $2,010,319 | U20 | published | space: outer | Avon, CT | 2024 |
| INDIANA ACADEMY OF SCIENCE | $2,004,721 | U20 | published | science: research education | Indianapolis, IN | 2024 |
| ELDRED FOUNDATION INC | $1,943,349 | U20 | inferred 0.72 | | Westminster, CO | 2025 |
| CASCADIA RESEARCH COLLECTIVE | $1,933,245 | U20 | inferred 0.80 | science: research education | Olympia, WA | 2024 |
| ORIENT LAND TRUST | $1,865,227 | U20 | published | space: outer | Villa Grove, CO | 2025 |
| PARTNERSHIP FOR CLEAN COMPETITION RESEARCH COLLABORATIVE | $1,770,212 | U20 | published | science: research education | Colorado Spgs, CO | 2025 |
| HEALTHY BRAINS GLOBAL INITIATIVE INC | $1,709,559 | U20 | published | | Rutherford, CA | 2024 |
| BUILDING CHANGE INC | $1,703,145 | U20 | published | | Richmond, VA | 2025 |
| TREOBYTES INC | $1,649,155 | U20 | published | science: research education | San Diego, CA | 2025 |
| CHERRY MARKETING INSTITUTE INC | $1,645,954 | U20 | inferred 0.60 | | Dewitt, MI | 2024 |
| OPENREVIEW FOUNDATION | $1,628,726 | U20 | published | | Newton Highlands, MA | 2024 |
| IF FOUNDATION | $1,490,355 | U20 | published | survivor: sexual | Washington, DC | 2024 |
| HOROLOGICAL SOCIETY OF NEW YORK INC | $1,481,171 | U20 | published | | New York, NY | 2024 |
| GEOSYNTHETIC INSTITUTE | $1,468,430 | U20 | inferred 0.65 | | Folsom, PA | 2024 |
| FREE SOFTWARE FOUNDATION INC | $1,362,457 | U20 | inferred 0.50 | | Boston, MA | 2024 |
| SCIENCE ATL INC | $1,358,008 | U20 | published | space: outer | Decatur, GA | 2024 |
| ELEMENTARY INSTITUTE OF SCIENCE | $1,329,443 | U20 | published | science: research education | San Diego, CA | 2024 |
| INDEPENDENT PROFESSIONAL SEEDMEN | $1,308,194 | U20 | inferred 0.60 | | Fayettevlle, AR | 2024 |
| DECENTRALIZED TRAILS & RESEARCH ALL | $1,282,594 | U20 | published | science: research education | San Diego, CA | 2025 |
| BIOINNOVATIONS INSTITUTE | $1,276,935 | U20 | published | | Natick, MA | 2025 |
| DELAWARE DATA INNOVATION LAB INC | $1,267,928 | U20 | inferred 0.50 | | Wilmington, DE | 2021 |
| CALIFORNIA TOMATO RESEARCH INSTITUTE | $1,217,725 | U20 | inferred 0.60 | | Woodland, CA | 2025 |
| HIGHER ORBITS FOUNDATION | $1,158,465 | U20 | published | space: outer | Aurora, CO | 2024 |
| START International Inc | $1,122,938 | U20 | inferred 0.60 | space: outer | Fort Collins, CO | 2025 |
| COVINGTON LIFE SCIENCES PARTNERS INC | $1,107,434 | U20 | published | | Covington, KY | 2024 |
| HOP RESEARCH COUNCIL | $1,055,178 | U20 | inferred 0.75 | science: research education | Hubbard, OR | 2025 |
| EXPERIMENT FOUNDATION | $1,047,139 | U20 | published | | Berkeley, CA | 2025 |
| THE CENTER FOR THE RESEARCH OF EARLY CHRISTIAN DOCUMENTS | $1,044,092 | U20 | published | | Plano, TX | 2024 |
| HDA RESEARCH FOUNDATION | $1,014,506 | U20 | inferred 0.50 | | Washington, DC | 2024 |
| IDAHO DAIRY ENVIRONMENTAL ACTION LEAGUE RESEARCH FOUNDATION INC | $971,769 | U20 | published | | Twin Falls, ID | 2025 |