| ALLIANCE FOR ENERGY INNOVATION LLC | $1,064,585,917 | U05 | published | science: research education | Golden, CO | 2024 |
| INSTITUTE FOR DEFENSE ANALYSES | $344,675,047 | U05 | published | science: research education | Alexandria, VA | 2024 |
| SOUTHEASTERN UNIVERSITIES RESEARCH ASSOCIATION INC | $251,855,977 | U05 | published | launch: space | Washington, DC | 2024 |
| MEDICAL TECHNOLOGY ENTERPRISE CONSORTIUM | $234,472,156 | U05 | published | science: research education | N Bethesda, MD | 2024 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC | $220,648,490 | U05 | published | | Lawrence, KS | 2024 |
| CNA CORPORATION | $154,356,745 | U05 | inferred 0.80 | abuse: substance | Arlington, VA | 2024 |
| CONVERGENT RESEARCH INC | $112,676,584 | U05 | published | | Cambridge, MA | 2025 |
| PUBLIC INTEREST REGISTRY | $106,377,555 | U05 | published | abuse: sexual | Reston, VA | 2024 |
| INSTITUTE FOR ADVANCED STUDY | $88,930,858 | U05 | published | space: outer | Princeton, NJ | 2024 |
| PARALLAX ADVANCED RESEARCH CORP | $82,994,226 | U05 | published | science: research education | Beavercrk Twp, OH | 2024 |
| ALTARUM INSTITUTE | $43,405,911 | U05 | published | abuse: substance | Novi, MI | 2024 |
| ADVANCED ROBOTICS FOR MANUFACTURING INSTITUTE | $31,939,842 | U05 | published | | Pittsburgh, PA | 2024 |
| PUERTO RICO SCIENCE TECHNOLOGY AND RESEARCH TRUST | $29,674,488 | U05 | published | science: research education | San Juan, PR | 2024 |
| NATIONAL STRATEGIC RESEARCH INSTITUTE | $24,208,530 | U05 | published | space: outer | Lincoln, NE | 2024 |
| UNIVERSITY CITY SCIENCE CENTER | $23,164,735 | U05 | published | science: research education | Philadelphia, PA | 2025 |
| NEW JERSEY INNOVATION INSTITUTE INC | $21,213,735 | U05 | published | science: research education | Newark, NJ | 2024 |
| VIRGINIA TECH APPLIED RESEARCH CORPORATION | $20,320,659 | U05 | published | | Arlington, VA | 2024 |
| NAVIGATION CHARITABLE FUND | $18,953,079 | U05 | published | | Berkeley, CA | 2024 |
| CENTER FOR THE ADVANCEMENT OF SCIENCE IN SPACE INC | $17,343,230 | U05 | published | launch: space | Merritt Is, FL | 2024 |
| SUSTAINABLE MANUFACTURING INNOVATION ALLIANCE CORP | $13,753,264 | U05 | published | | W Henrietta, NY | 2024 |
| MODEL EVALUATION AND THREAT RESEARCH | $13,639,155 | U05 | published | | Covina, CA | 2024 |
| ONE NATION INNOVATION | $12,977,213 | U05 | published | space: outer | Columbia, SC | 2024 |
| CONSTELLATION INSTITUTE INC | $12,615,988 | U05 | published | | Berkeley, CA | 2024 |
| PROJECT LIBERTY INSTITUTE | $11,425,472 | U05 | published | | New York, NY | 2025 |
| CENTER FOR ARTIFICIAL INTELLIGENCE SAFETY INC | $10,235,085 | U05 | published | | San Francisco, CA | 2024 |
| LIGHTCONE FOUNDATION | $9,723,116 | U05 | published | | Sparks, NV | 2024 |
| IUP RESEARCH INSTITUTE | $9,654,077 | U05 | published | science: research education | Indiana, PA | 2024 |
| GOOD FOREVER FOUNDATION | $9,575,776 | U05 | published | | New Orleans, LA | 2024 |
| SECUREBIO INC | $7,324,329 | U05 | published | | Cambridge, MA | 2024 |
| DISTRIBUTED ARTIFICIAL INTELLIGENCE RESEARCH INSTITUTE | $7,130,636 | U05 | published | | Oakland, CA | 2024 |
| CLARITY AI RESEARCH INC | $6,909,526 | U05 | published | | San Francisco, CA | 2024 |
| UNIVERSITIES RESEARCH ASSOCIATION INC | $6,846,655 | U05 | inferred 0.80 | science: research education | Washington, DC | 2024 |
| CARBON CONTAINMENT LAB | $6,164,854 | U05 | published | | New Haven, CT | 2024 |
| CENTER FOR HUMANE TECHNOLOGY | $5,785,317 | U05 | published | | San Francisco, CA | 2024 |
| STOCKHOLM ENVIRONMENT INSTITUTE USINC | $5,634,166 | U05 | published | science: research education | Somerville, MA | 2025 |
| AMERICAN GEOLOGICAL INSTITUTE | $5,344,231 | U05 | inferred 0.60 | science: research education | Alexandria, VA | 2024 |
| APPRISE INCORPORATED | $5,130,331 | U05 | published | | Princeton, NJ | 2024 |
| PACIFIC NEUROSCIENCE INSTITUTE FOUNDATION | $5,059,533 | U05 | published | science: research education | Santa Monica, CA | 2024 |
| INDIANA BIOSCIENCES RESEARCH INSTITUTE INC | $5,013,560 | U05 | published | science: research education | Indianapolis, IN | 2024 |
| CENTER FOR RESPONSIBLE INNOVATION LTD | $4,631,047 | U05 | published | | Washington, DC | 2024 |
| FUTURE HOUSE INC | $4,511,466 | U05 | published | science: research education | San Francisco, CA | 2024 |
| MIPI ALLIANCE INC | $4,226,274 | U05 | published | | Bridgewater, NJ | 2024 |
| INTERNATIONAL ASSOCIATION FOR SAFE AND ETHICAL ARTIFICIAL | $4,002,265 | U05 | published | | San Diego, CA | 2024 |
| KUYR INSTITUTE | $4,000,000 | U05 | published | | High Springs, FL | 2024 |
| CREIGHTON UNIVERSITY-BOYS TOWN HEALTHCARE FOUNDATION | $3,804,323 | U05 | published | | Omaha, NE | 2025 |
| ERGO IMPACT INC | $3,731,127 | U05 | published | | San Francisco, CA | 2025 |
| LARTA INSTITUTE | $3,728,805 | U05 | published | science: research education | Los Angeles, CA | 2024 |
| INSTITUTE FOR SECURITY AND TECHNOLOGY | $3,587,978 | U05 | published | | Oakland, CA | 2024 |
| SEEDING LABS A NON PROFIT CORPORATION | $3,454,637 | U05 | published | science: research education | Boston, MA | 2024 |
| SPG INSTITUTE INC | $3,117,756 | U05 | inferred 0.40 | | Chantilly, VA | 2019 |
| BERKELEY GEOCHRONOLOGY CENTER | $3,000,316 | U05 | published | space: outer | Berkeley, CA | 2025 |
| FINREGLAB INC | $2,899,572 | U05 | published | | Washington, DC | 2024 |
| BAPTIST CLINICAL RESEARCH INSTITUTE INC | $2,825,194 | U05 | published | science: research education | Memphis, TN | 2024 |
| THE NASW FOUNDATION INC | $2,744,213 | U05 | published | survivor: cancer | Washington, DC | 2024 |
| CENTER FOR AUTOMOTIVE RESEARCH | $2,731,015 | U05 | published | | Ann Arbor, MI | 2024 |
| NATIONAL INSTITUTE OF INNOVATION AND TECHNOLOGY INC | $2,581,251 | U05 | published | | Saratoga Spgs, NY | 2024 |
| FAMILY ONLINE SAFETY INSTITUTE - US | $2,581,018 | U05 | published | | Washington, DC | 2024 |
| INSTITUTE OF NOETIC SCIENCES | $2,453,927 | U05 | published | science: research education | Novato, CA | 2024 |
| CORRIM CONSORTIUM FOR RESEARCH ON RENEWABLE INDUSTRIAL MATERIALS | $2,379,626 | U05 | published | | Corvallis, OR | 2024 |
| AURELIA INSTITUTE INC | $2,291,384 | U05 | published | space: outer | Cambridge, MA | 2024 |
| NANOTECHNOLOGY ENTERPRISES INC | $1,948,788 | U05 | inferred 0.45 | science: research education | Columbia, MO | 2011 |
| THOUSAND BRAINS PROJECT | $1,750,000 | U05 | published | | Santa Rosa, CA | 2024 |
| DRYAD | $1,612,856 | U05 | published | science: research education | Davis, CA | 2024 |
| THE ALABAMA A&M UNIV RESEARCH INNOVATION SCIENCE AND ENGINEERING | $1,557,785 | U05 | published | space: outer | Normal, AL | 2024 |
| TECHFREEDOM | $1,459,546 | U05 | published | | Washington, DC | 2024 |
| JAPAN ELECTRIC POWER INFORMATION CENTER USA | $1,439,447 | U05 | published | | Washington, DC | 2025 |
| INSTITUTE OF HEALTH AND ENVIRONMENTAL RESEARCH INCORPORATE | $1,341,904 | U05 | published | science: research education | Columbus, OH | 2021 |
| FOUNDATION FOR PSYCHO-CULTURAL RESEARCH | $1,293,077 | U05 | published | | Pacific Plsds, CA | 2023 |
| METROPOLITAN UNIFIED FIBER NETWORK CONSORTIUM | $1,281,647 | U05 | published | | Madison, WI | 2024 |
| THE GRIDWISE ALLIANCE INC | $1,173,695 | U05 | published | | Washington, DC | 2024 |
| Aerospace Medical Association | $1,147,415 | U05 | inferred 0.60 | launch: space | Alexandria, VA | 2010 |
| SPECULATIVE TECHNOLOGIES INC | $1,123,799 | U05 | published | | Claymont, DE | 2025 |
| ETHOS INC | $1,073,309 | U05 | published | girls boys: boys girls clubs | Elkhart, IN | 2024 |
| NORTH AMERICAN COUNCIL FOR FREIGHT EFFICIENCY | $1,020,501 | U05 | published | | Fort Wayne, IN | 2024 |
| WINDFALL FOR HUMANITY INC | $1,000,000 | U05 | published | | San Diego, CA | 2025 |
| OARC INC | $975,949 | U05 | published | | Indianapolis, IN | 2025 |
| ENGINEERING BIOLOGY RESEARCH CONSORTIUM | $973,996 | U05 | published | | Emeryville, CA | 2024 |
| CHOROIDEREMIA RESEARCH FOUNDATION INC | $964,837 | U05 | published | science: research education | Springfield, MA | 2024 |
| SOL FOUNDATION FOR ADVANCED SCIENTIFIC AND POLICY RESEARCH | $937,625 | U05 | published | science: research education | Redwood City, CA | 2024 |
| CENTER FOR CYBER SAFETY AND EDUCATION | $918,922 | U05 | published | women: issues | Alexandria, VA | 2025 |
| POLARIS RESEARCH INSTITUTE INC | $900,120 | U05 | published | | Berkeley, CA | 2025 |
| NATIONAL STATES GEOGRAPHIC INFORMATION COUNCIL | $879,065 | U05 | inferred 0.50 | | Myrtle Beach, SC | 2025 |
| AI FUTURES PROJECT INC | $760,281 | U05 | published | | Berkeley, CA | 2024 |
| FUTURE OF LIFE FOUNDATION | $711,130 | U05 | published | | Campbell, CA | 2023 |
| CENTER FOR FINANCIAL STABILITY INC | $671,633 | U05 | published | science: research education | New York, NY | 2024 |
| DCIIA RETIREMENT RESEARCH CENTER | $659,350 | U05 | published | | Jupiter, FL | 2024 |
| MOORE INSTITUTE FOR PLASTIC POLLUTION RESEARCH | $620,794 | U05 | published | | Long Beach, CA | 2024 |
| ASAPBIO | $609,930 | U05 | published | | San Francisco, CA | 2025 |
| WEST LIBERTY UNIVERSITY RESEARCH | $603,597 | U05 | inferred 0.40 | | Wheeling, WV | 2015 |
| TWO FRONTIERS PROJECT INC | $538,377 | U05 | published | science: research education | Fort Collins, CO | 2024 |
| BHAKTIVEDANTA INSTITUTE FOR HIGHER STUDIES INC | $519,862 | U05 | published | science: research education | Gainesville, FL | 2025 |
| INNOVATION ACCELERATOR FOUNDATION | $501,685 | U05 | inferred 0.40 | | Omaha, NE | 2018 |
| CAIDP | $501,578 | U05 | published | | Washington, DC | 2025 |
| JAPAN AUTOMOBILE TRANSPORT TECHNOLOGY ASSOCIATION | $491,978 | U05 | inferred 0.60 | | Washington, DC | 2025 |
| CHARIN INC | $471,375 | U05 | published | | Washington, DC | 2025 |
| IPTI- RESEARCH ORGANIZATION FOR TEC HNOLOGY AND INNOVATION INC | $460,318 | U05 | inferred 0.40 | | Albany, NY | 2024 |
| 39 ALPHA RESEARCH | $456,977 | U05 | published | | Tempe, AZ | 2025 |
| INSTITUTE FOR PHYSICAL SCIENCES INC | $432,519 | U05 | inferred 0.60 | science: research education | Vienna, VA | 2017 |
| HUMAN SPACE PROGRAM INC | $427,809 | U05 | published | space: outer | Natick, MA | 2025 |
| NOVAGEN RESEARCH FUND | $425,000 | U05 | published | | N Bethesda, MD | 2024 |