| KAISER FOUNDATION HOSPITALS | $38,196,336,924 | E21 | published | survivor: suicide | Oakland, CA | 2024 |
| MASS GENERAL BRIGHAM INCORPORATED AND AFFILIATES GROUP RTN | $24,908,354,094 | E21 | published | launch: launch | Somerville, MA | 2024 |
| MAYO CLINIC GROUP RETURN | $14,891,458,272 | E21 | published | science: research education | Rochester, MN | 2024 |
| BON SECOURS MERCY HEALTH INC | $11,537,795,267 | E21 | published | launch: religious | Blue Ash, OH | 2024 |
| COREWELL HEALTH | $11,491,275,449 | E21 | published | girls boys: girls | Grand Rapids, MI | 2024 |
| BJC HEALTH SYSTEM | $11,251,316,536 | E21 | published | girls boys: girls | Saint Louis, MO | 2024 |
| BANNER HEALTH | $10,839,690,022 | E21 | published | survivor: suicide | Phoenix, AZ | 2024 |
| IHC HEALTH SERVICES INC | $10,650,854,026 | E21 | published | survivor: cancer | Salt Lake Cty, UT | 2024 |
| PROVIDENCE HEALTH & SERVICES WASHINGTON | $9,728,808,188 | E21 | published | survivor: sexual | Renton, WA | 2024 |
| THE CLEVELAND CLINIC FOUNDATION | $9,680,031,802 | E21 | published | abuse: substance | Independence, OH | 2024 |
| HACKENSACK MERIDIAN HEALTH INC | $8,846,442,863 | E21 | published | girls boys: girl scouts | Edison, NJ | 2024 |
| MEMORIAL HERMANN HEALTH SYSTEM | $8,563,610,095 | E21 | published | launch: aviation | Houston, TX | 2024 |
| ADVENTIST HEALTH SYSTEM SUNBELT INC | $8,312,865,593 | E21 | published | women: issues | Altamonte Spg, FL | 2024 |
| MAYO CLINIC | $7,929,118,794 | E21 | published | girls boys: boys girls clubs | Rochester, MN | 2024 |
| ADVOCATE HEALTH AND HOSPITALS CORPORATION | $7,808,910,070 | E21 | published | violence: gun | Downers Grove, IL | 2024 |
| ORLANDO HEALTH INC | $7,296,589,884 | E21 | published | launch: launch | Orlando, FL | 2024 |
| RISANT HEALTH INC | $6,730,942,360 | E21 | published | | Washington, DC | 2024 |
| DUKE UNIVERSITY HEALTH SYSTEM INC | $6,165,109,566 | E21 | published | science: research education | Durham, NC | 2024 |
| UNIVERSITY HOSPITALS HEALTH SYSTEM INC | $5,946,385,392 | E21 | published | | Shaker Hts, OH | 2024 |
| ALLINA HEALTH SYSTEM | $5,929,260,387 | E21 | published | abuse: elder | Minneapolis, MN | 2024 |
| FAIRVIEW HEALTH SERVICES | $5,326,063,577 | E21 | published | shelter: homeless | Minneapolis, MN | 2024 |
| HENRY FORD HEALTH SYSTEM | $5,284,200,687 | E21 | published | space: outer | Detroit, MI | 2024 |
| MULTICARE HEALTH SYSTEM | $5,011,395,222 | E21 | published | shelter: homeless | Tacoma, WA | 2024 |
| BAPTIST HEALTHCARE SYSTEM INC | $4,712,737,148 | E21 | published | abuse: sexual | Louisville, KY | 2024 |
| UMASS MEMORIAL HEALTH CARE INC | $4,571,034,235 | E21 | published | violence: community | Worcester, MA | 2024 |
| DIGNITY COMMUNITY CARE | $4,038,974,109 | E21 | published | | Phoenix, AZ | 2024 |
| PEACEHEALTH | $4,019,939,134 | E21 | published | | Vancouver, WA | 2024 |
| COMMONSPIRIT HEALTH | $3,792,395,078 | E21 | published | violence: community | Phoenix, AZ | 2024 |
| FRANCISCAN ALLIANCE INC | $3,781,825,597 | E21 | published | survivor: cancer | Mishawaka, IN | 2024 |
| TRINITY HEALTH-MICHIGAN | $3,554,925,366 | E21 | published | survivor: suicide | Grand Rapids, MI | 2024 |
| LEE HEALTH SYSTEM INC | $3,504,937,217 | E21 | published | | Fort Myers, FL | 2024 |
| TRINITY HEALTH CORPORATION | $3,292,589,454 | E21 | published | | Livonia, MI | 2024 |
| ADVENTIST HEALTH SYSTEM SUNBELT HEALTHCARE CORPORATION | $3,188,539,500 | E21 | published | science: research education | Altamonte Spg, FL | 2024 |
| WELLSTAR HEALTH SYSTEM INC | $3,081,488,520 | E21 | published | launch: launch | Marietta, GA | 2024 |
| COREWELL HEALTH | $2,928,506,457 | E21 | published | | Grand Rapids, MI | 2021 |
| PRESBYTERIAN HEALTHCARE SERVICES | $2,898,794,768 | E21 | published | violence: prevention | Albuquerque, NM | 2024 |
| FROEDTERT MEMORIAL LUTHERAN HOSPITAL INC | $2,872,787,804 | E21 | published | abuse: elder | Milwaukee, WI | 2024 |
| THE NEBRASKA MEDICAL CENTER | $2,799,901,402 | E21 | published | survivor: cancer | Omaha, NE | 2024 |
| CHILDRENS HEALTHCARE OF ATLANTA INC | $2,772,950,050 | E21 | published | | Brookhaven, GA | 2024 |
| SUTTER HEALTH | $2,685,790,764 | E21 | published | women: issues | Sacramento, CA | 2024 |
| WAKEMED | $2,599,042,078 | E21 | published | science: research education | Raleigh, NC | 2024 |
| MASS GENERAL BRIGHAM INCORPORATED | $2,444,998,724 | E21 | published | launch: launch | Somerville, MA | 2024 |
| HH MEDSTAR HEALTH INC | $2,399,792,762 | E21 | published | science: research education | Columbia, MD | 2024 |
| SHARP HEALTHCARE | $2,192,680,289 | E21 | published | survivor: suicide | San Diego, CA | 2024 |
| SSM HEALTH CARE ST LOUIS | $2,192,307,272 | E21 | published | violence: sexual | Saint Louis, MO | 2024 |
| OHIOHEALTH CORPORATION | $2,182,011,764 | E21 | published | violence: sexual | Columbus, OH | 2024 |
| PRISMA HEALTH-MIDLANDS | $2,076,553,749 | E21 | published | women: issues | Greenville, SC | 2024 |
| BON SECOURS RICHMOND HEALTH SYSTEM | $2,045,591,727 | E21 | published | | Cincinnati, OH | 2023 |
| BJC HEALTH SYSTEM | $2,042,365,571 | E21 | published | shelter: disaster | Saint Louis, MO | 2024 |
| MAYO CLINIC | $2,021,770,805 | E21 | published | science: research education | Rochester, MN | 2015 |
| JOHN MUIR HEALTH | $2,018,584,584 | E21 | published | survivor: cancer | Walnut Creek, CA | 2024 |
| COREWELL HEALTH | $1,957,749,115 | E21 | published | | Grand Rapids, MI | 2024 |
| WASHINGTON HOSPITAL CENTER CORPORATION | $1,907,162,276 | E21 | published | women: issues | Columbia, MD | 2024 |
| LOMA LINDA MERCANTILE | $1,776,065,757 | E21 | published | | Sn Bernrdno, CA | 2024 |
| COREWELL HEALTH | $1,742,616,269 | E21 | published | women: issues | Grand Rapids, MI | 2012 |
| TEXAS HEALTH RESOURCES | $1,638,711,331 | E21 | published | | Arlington, TX | 2024 |
| ERLANGER HEALTH | $1,623,655,937 | E21 | published | science: research education | Chattanooga, TN | 2024 |
| BAYCARE HEALTH SYSTEMS INC | $1,605,385,449 | E21 | published | launch: religious | Clearwater, FL | 2024 |
| BAPTIST HEALTH OF SOUTH FLORIDA INC | $1,433,239,151 | E21 | published | survivor: cancer | Coral Gables, FL | 2024 |
| SSM HEALTH CARE CORPORATION | $1,391,036,296 | E21 | published | men: issues | Saint Louis, MO | 2024 |
| HIGHMARK HEALTH | $1,378,645,187 | E21 | published | launch: aviation | Pittsburgh, PA | 2014 |
| BAYLOR SCOTT & WHITE HEALTH | $1,370,393,240 | E21 | published | | Dallas, TX | 2024 |
| FROEDTERT THEDACARE HEALTH INC | $1,350,935,059 | E21 | published | | Milwaukee, WI | 2024 |
| COREWELL HEALTH | $1,345,891,330 | E21 | published | women: issues | Grand Rapids, MI | 2021 |
| SENTARA HEALTH | $1,261,880,759 | E21 | published | violence: gun | Virfinia Beach, VA | 2024 |
| CHRISTUS HEALTH | $1,261,646,593 | E21 | published | survivor: disaster | Irving, TX | 2024 |
| GUNDERSEN LUTHERAN ADMINISTRATIVE SERVICES INC | $1,251,736,689 | E21 | published | | La Crosse, WI | 2024 |
| ORLANDO HEALTH MEDICAL GROUP INC | $1,251,734,346 | E21 | published | | Orlando, FL | 2024 |
| BILLINGS CLINIC | $1,225,617,600 | E21 | published | abuse: substance | Billings, MT | 2024 |
| PARKVIEW HEALTH SYSTEM INC | $1,212,089,211 | E21 | published | girls boys: girls | Fort Wayne, IN | 2024 |
| CAPE COD HEALTHCARE INC | $1,190,796,411 | E21 | published | survivor: cancer | Hyannis, MA | 2024 |
| MAYO CLINIC | $1,180,538,123 | E21 | published | science: research education | Rochester, MN | 2014 |
| ST LUKES HOSPITAL OF KANSAS CITY | $1,157,790,152 | E21 | published | science: research education | Kansas City, MO | 2023 |
| MAYO CLINIC | $1,082,111,859 | E21 | published | science: research education | Rochester, MN | 2013 |
| APPALACHIAN REGIONAL HEALTHCARE INC | $1,078,005,401 | E21 | published | women: issues | Lexington, KY | 2024 |
| AULTMAN HEALTH FOUNDATION GROUP RETURN | $1,049,448,649 | E21 | published | abuse: substance | Canton, OH | 2024 |
| ST JOSEPH HOSPITAL OF ORANGE | $970,104,268 | E21 | published | launch: religious | Orange, CA | 2024 |
| CHRISTUS SPOHN HEALTH SYSTEM CORPORATION | $959,806,528 | E21 | published | men: issues | Corp Christi, TX | 2024 |
| UNIVERSITY HOSPITALS HEALTH SYSTEM INC | $954,845,315 | E21 | published | | Shaker Hts, OH | 2024 |
| WEST VIRGINIA UNIVERSITY MEDICAL CORPORATION | $954,634,085 | E21 | published | science: research education | Morgantown, WV | 2024 |
| MISSION HOSPITAL REGIONAL MEDICAL CENTER | $954,165,802 | E21 | published | girls boys: boys girls clubs | Mission Viejo, CA | 2024 |
| MERCY HEALTH SERVICES IOWA CORP | $933,901,198 | E21 | published | abuse: child | Sioux City, IA | 2024 |
| WELLMONT HEALTH SYSTEM | $933,212,443 | E21 | published | launch: launch | Johnson City, TN | 2024 |
| WELLSPAN HEALTH | $920,651,702 | E21 | published | abuse: child | York, PA | 2024 |
| VIRGINIA HOSPITAL CENTER ARLINGTON HEALTH SYSTEM | $896,410,115 | E21 | published | | Arlington, VA | 2024 |
| ADVENTIST HEALTH SYSTEM-WEST | $890,277,866 | E21 | published | launch: religious | Roseville, CA | 2024 |
| OWENSBORO HEALTH REGIONAL HOSPITAL | $888,669,741 | E21 | published | | Owensboro, KY | 2024 |
| BAPTIST HEALTH MEDICAL GROUP INC | $878,201,034 | E21 | published | women: issues | Coral Gables, FL | 2024 |
| ST LUKES HEALTH SYSTEM | $868,714,674 | E21 | published | girls boys: girl scouts | Boise, ID | 2024 |
| NORTHBAY HEALTHCARE GROUP | $850,099,076 | E21 | published | | Fairfield, CA | 2024 |
| ALEGENT HEALTH - BERGAN MERCY HEALTH SYSTEM | $838,440,326 | E21 | published | science: research education | Phoenix, AZ | 2024 |
| HEALTH CARE LA IPA | $837,058,775 | E21 | published | | Westlake Vlg, CA | 2024 |
| GEISINGER SYSTEM SERVICES | $836,870,045 | E21 | published | survivor: cancer | Danville, PA | 2024 |
| THE JOHNS HOPKINS HEALTH SYSTEM CORPORATION | $783,774,051 | E21 | published | science: research education | Baltimore, MD | 2024 |
| ALBANY MED HEALTH SYSTEM | $773,245,082 | E21 | published | science: research education | Albany, NY | 2013 |
| FLOYD HEALTHCARE MANAGEMENT INC | $772,081,569 | E21 | published | abuse: child | Rome, GA | 2024 |
| NORTON HEALTHCARE INC | $759,365,626 | E21 | published | space: for women | Louisville, KY | 2024 |
| HARTFORD HEALTH CARE CORPORATION | $714,767,257 | E21 | published | abuse: substance | Hartford, CT | 2024 |
| ADENA HEALTH SYSTEM | $704,434,969 | E21 | published | abuse: child | Chillicothe, OH | 2024 |
| THE CARLE FOUNDATION | $693,331,990 | E21 | published | science: research education | Urbana, IL | 2024 |