| SANOFI-AVENTIS PATIENT ASSISTANCE FOUNDATION | $4,149,829,881 | P20 | inferred 0.60 | | Morristown, NJ | 2024 |
| BANNER UNIVERSITY FAMILY CARE | $1,956,614,522 | P20 | inferred 0.55 | domestic violence | Phoenix, AZ | 2024 |
| DALIO FAMILY FUND INC | $806,892,040 | P20 | published | violence: gun | Westport, CT | 2024 |
| EASTER SEALS SOUTHERN CALIFORNIA INC | $622,282,926 | P20 | inferred 0.70 | women: issues | Irvine, CA | 2025 |
| PARTNERSHIP FOR SUPPLY CHAIN MANAGE MENT | $490,016,158 | P20 | published | | Arlington, VA | 2024 |
| RUSH MEDICAL GROUP | $475,026,740 | P20 | published | science: research education | Chicago, IL | 2024 |
| JEWISH AGENCY FOR ISRAEL | $455,512,779 | P20 | inferred 0.55 | | Israel | 2024 |
| ACTION FOR BOSTON COMMUNITY DEVELOPMENT | $446,082,448 | P20 | published | abuse: substance | Boston, MA | 2024 |
| LUTHERAN SERVICES FLORIDA INC | $443,658,918 | P20 | published | survivor: disaster | Tampa, FL | 2024 |
| BARNARDOS | $435,212,820 | P20 | published | | United Kingdom | 2024 |
| FAMILY ENDEAVORS INC | $408,185,445 | P20 | inferred 0.70 | shelter: disaster | San Antonio, TX | 2024 |
| LOS ANGELES REGIONAL FOOD BANK | $373,458,836 | P20 | inferred 0.70 | women: issues | Vernon, CA | 2025 |
| CATHOLIC CHARITIES DIOCESE OF FORT WORTH | $365,542,304 | P20 | published | abuse: child | Fort Worth, TX | 2024 |
| GOODWILL OF CENTRAL AND NORTHERN ARIZONA | $351,927,904 | P20 | inferred 0.70 | launch: religious | Phoenix, AZ | 2025 |
| SAMARITAN HEALTH SERVICES INC | $327,760,439 | P20 | published | abuse: child | Corvallis, OR | 2024 |
| RESOURCES FOR HUMAN DEVELOPMENT INC | $325,713,965 | P20 | published | violence: gun | Philadelphia, PA | 2024 |
| CATHOLIC COMMUNITY SERVICES OF WESTERN WASHINGTON | $317,162,695 | P20 | published | | Seattle, WA | 2024 |
| PRIDE INDUSTRIES | $307,804,321 | P20 | published | launch: launch | Roseville, CA | 2024 |
| SERVICES FOR THE UNDERSERVED INC | $297,260,782 | P20 | inferred 0.70 | abuse: substance | New York, NY | 2024 |
| BANCROFT A NEW JERSEY NONPROFIT CORPORATION | $286,765,384 | P20 | published | | Cherry Hill, NJ | 2024 |
| SCO FAMILY OF SERVICES | $266,823,599 | P20 | published | abuse: substance | Garden City, NY | 2024 |
| TIDES CENTER | $265,402,095 | P20 | published | space: outer | San Francisco, CA | 2024 |
| JSI RESEARCH & TRAINING INSTITUTE INC | $258,533,218 | P20 | inferred 0.55 | violence: sexual | Boston, MA | 2024 |
| MERS MISSOURI GOODWILL INDUSTRIES | $251,650,956 | P20 | published | | Saint Louis, MO | 2024 |
| UNITED MOVEMENT ORGANIZED KINDNESS | $242,107,947 | P20 | published | | Las Vegas, NV | 2024 |
| CHRISTIAN APPALACHIAN PROJECT INC | $237,184,582 | P20 | published | domestic violence | Mount Vernon, KY | 2024 |
| COMMUNITY TEAMWORK INC | $224,582,625 | P20 | published | shelter: homeless | Lowell, MA | 2024 |
| CAMELOT COMMUNITY CARE INC | $224,579,741 | P20 | published | abuse: child | Clearwater, FL | 2024 |
| RISING GROUND INC | $218,053,221 | P20 | published | survivor: sexual | New York, NY | 2024 |
| KANSAS UNIVERSITY PHYSICIANS INC | $216,602,851 | P20 | published | | Kansas City, KS | 2016 |
| CHILDRENS COUNCIL OF SAN FRANCISCO | $212,863,585 | P20 | published | abuse: child | San Francisco, CA | 2024 |
| COMMUNITY ASSISTANCE RESOURCES & EXTENDED SERVICES INC | $211,305,349 | P20 | published | | New York, NY | 2024 |
| BOWERY RESIDENTS COMMITTEE INC | $206,902,613 | P20 | published | abuse: substance | New York, NY | 2024 |
| CHICANOS POR LA CAUSA INC | $205,541,106 | P20 | published | survivor: sexual | Phoenix, AZ | 2024 |
| UNION ELECTRIC MEMBERSHIP CORP | $204,861,227 | P20 | inferred 0.55 | | Monroe, NC | 2024 |
| INDIANA MEMBERS CREDIT UNION | $199,653,124 | P20 | published | | Indianapolis, IN | 2025 |
| HEALTHRIGHT 360 | $198,784,591 | P20 | inferred 0.55 | abuse: substance | San Francisco, CA | 2024 |
| ACTION INC | $191,163,293 | P20 | published | shelter: homeless | Gloucester, MA | 2024 |
| LUTHERAN SOCIAL SERVICE OF MINNESOTA | $187,248,443 | P20 | published | survivor: disaster | Saint Paul, MN | 2024 |
| SOUTH MIDDLESEX OPPORTUNITY COUNCIL INC | $184,132,886 | P20 | published | abuse: substance | Framingham, MA | 2024 |
| OPTIONS FOR LEARNING | $182,022,578 | P20 | inferred 0.80 | abuse: child | West Covina, CA | 2024 |
| COMMUNITY ACTION PARTNERSHIP OF KERN | $181,276,675 | P20 | published | women: issues | Bakersfield, CA | 2024 |
| CATHOLIC CHARITIES OF THE ARCHDIOCESE OF CHICAGO | $174,675,811 | P20 | inferred 0.80 | shelter: homeless | Chicago, IL | 2024 |
| UTAH FOOD BANK | $162,591,435 | P20 | inferred 0.85 | | S Salt Lake, UT | 2024 |
| FRESNO COUNTY ECONOMIC OPPORTUNITIES COMMISSION | $158,886,554 | P20 | published | shelter: homeless | Fresno, CA | 2024 |
| HOMEFIRST INC | $147,009,628 | P20 | inferred 0.70 | | Brooklyn, NY | 2010 |
| EZER MIZION | $145,048,443 | P20 | published | science: research education | Israel | 2024 |
| ASSOCIATED CATHOLIC CHARITIES INC | $142,725,884 | P20 | published | violence: gun | Timonium, MD | 2024 |
| LILIUOKALANI TRUST | $141,922,459 | P20 | inferred 0.55 | girls boys: boys girls clubs | Honolulu, HI | 2024 |
| HEART SHARE HUMAN SERVICES OF NEW YORK | $140,109,675 | P20 | published | launch: launch | Brooklyn, NY | 2024 |
| UNBOUND | $137,245,696 | P20 | published | space: for women | Kansas City, KS | 2025 |
| BRONXWORKS INC | $133,938,301 | P20 | published | abuse: elder | Bronx, NY | 2024 |
| THE NEIGHBORHOOD HOUSE ASSN | $130,446,549 | P20 | published | abuse: substance | San Diego, CA | 2024 |
| FRIENDS OF THE WORLD FOOD PROGRAM INC | $129,769,960 | P20 | published | women: issues | Washington, DC | 2024 |
| SHARITY MINISTRIES INC | $129,043,524 | P20 | inferred 0.55 | | Atlanta, GA | 2020 |
| LUTHERAN SOCIAL SERVICES OF ILLINOIS | $128,422,164 | P20 | inferred 0.70 | | Des Plaines, IL | 2024 |
| SCOTT & WHITE CARE PLANS | $126,286,333 | P20 | published | abuse: substance | Temple, TX | 2024 |
| LUTHERAN SOCIAL SERVICE OF THE SOUTH INC | $125,518,410 | P20 | published | abuse: child | Austin, TX | 2024 |
| CONCEPTS OF INDEPENDENCE INC | $125,112,141 | P20 | inferred 0.70 | | New York, NY | 2024 |
| CONNECTIONS COMMUNITY SUPPORT | $124,570,711 | P20 | inferred 0.55 | abuse: substance | Wilmington, DE | 2019 |
| SELFHELP COMMUNITY SERVICES INC | $121,869,317 | P20 | published | | New York, NY | 2024 |
| CATHOLIC CHARITIES OF THE DIOCESE OF ROCHESTER | $120,379,765 | P20 | inferred 0.80 | | Rochester, NY | 2024 |
| CATHOLIC CHARITIES NEIGHBORHOOD SERVICES INC | $120,374,927 | P20 | published | abuse: substance | Brooklyn, NY | 2024 |
| TIMASHEV FAMILY FOUNDATION | $119,727,944 | P20 | published | | New York, NY | 2024 |
| URBAN RESOURCE INSTITUTE | $119,597,920 | P20 | published | violence: prevention | New York, NY | 2024 |
| GOOD SHEPHERD SERVICES | $119,522,799 | P20 | published | domestic violence | New York, NY | 2024 |
| EASTERSEALS-GOODWILL NORTHERN ROCKY MOUNTAIN INC | $114,456,343 | P20 | inferred 0.70 | | Great Falls, MT | 2024 |
| TRIUMPH GULF COAST INC | $113,038,235 | P20 | published | | Tallahassee, FL | 2024 |
| EL CENTRO DEL BARRIO INC | $112,479,468 | P20 | published | | San Antonio, TX | 2025 |
| HOPELINK | $108,992,829 | P20 | published | | Redmond, WA | 2024 |
| GOODWILL INDUSTRIES OF NORTH CENTRAL WISC INC | $108,674,556 | P20 | published | men: issues | Menasha, WI | 2025 |
| SAMARITAS | $106,378,070 | P20 | published | abuse: child | Detroit, MI | 2024 |
| PIONEER HUMAN SERVICES | $105,291,649 | P20 | published | girls boys: boys | Seattle, WA | 2024 |
| SUPPORTED LIVING AND EMPLOYMENT SERVICES INC | $104,768,327 | P20 | published | | Springfield, MO | 2024 |
| NEW HAMPSHIRE CATHOLIC CHARITIES INC | $101,389,992 | P20 | published | abuse: child | Manchester, NH | 2024 |
| CATHOLIC GUARDIAN SERVICES | $100,459,249 | P20 | inferred 0.70 | abuse: child | Bronx, NY | 2024 |
| CATHOLIC CHARITIES COMMUNITY SERVICES ARCHDIOCESE OF NEW YORK | $100,407,749 | P20 | inferred 0.80 | survivor: disaster | New York, NY | 2024 |
| BOSTON HEALTH CARE FOR THE HOMELESS PROGRAM INC | $100,284,272 | P20 | published | abuse: substance | Boston, MA | 2024 |
| DISMAS CHARITIES INC | $99,913,171 | P20 | published | abuse: substance | Louisville, KY | 2025 |
| FARMLINK PROJECT | $99,269,299 | P20 | published | | Los Angeles, CA | 2024 |
| CATHOLIC CHARITIES DIOCESE OF SAN DIEGO | $99,121,061 | P20 | published | men: issues | San Diego, CA | 2024 |
| VOLUNTEERS OF AMERICA INC | $98,922,215 | P20 | inferred 0.85 | shelter: homeless | Everett, WA | 2024 |
| CATHOLIC CHARITIES OF THE ARCHDIOCESE OF GALVESTON-HOUSTON | $95,893,911 | P20 | published | shelter: disaster | Houston, TX | 2024 |
| FLEMING-MASON ENERGY COOPERATIVE INC | $95,315,728 | P20 | inferred 0.60 | | Flemingsburg, KY | 2025 |
| BIRCH FAMILY SERVICES INC | $95,000,494 | P20 | published | | New York, NY | 2024 |
| JEWISH CHILD CARE ASSOCIATION OF NEW YORK | $90,998,234 | P20 | published | girls boys: girls | Brooklyn, NY | 2024 |
| TALBERT HOUSE | $89,072,551 | P20 | published | abuse: substance | Cincinnati, OH | 2024 |
| MAKING OPPORTUNITY COUNT INC | $89,000,614 | P20 | published | abuse: child | Fitchburg, MA | 2024 |
| PORTABLE PRACTICAL EDUCATIONAL PREPARATION INC | $88,091,215 | P20 | published | abuse: substance | Tucson, AZ | 2024 |
| JEWISH COMMUNITY COUNCIL OF GREATER CONEY ISLAND INC | $87,823,979 | P20 | published | violence: gun | Brooklyn, NY | 2024 |
| KAWERAK INC | $86,867,929 | P20 | inferred 0.60 | | Nome, AK | 2024 |
| LIFEPLAN NY INC | $86,561,602 | P20 | published | | Utica, NY | 2024 |
| COTTON ELECTRIC COOPERATIVE INC | $85,953,898 | P20 | inferred 0.62 | | Walters, OK | 2025 |
| CHILDRENS HOME & AID SOCIETY OF ILLINOIS | $85,729,842 | P20 | published | violence: community | Chicago, IL | 2024 |
| Angel Food Ministries Inc | $85,297,396 | P20 | inferred 0.60 | | Good Hope, GA | 2010 |
| HOPE OF THE VALLEY RESCUE MISSION | $85,134,218 | P20 | published | launch: religious | North Hills, CA | 2024 |
| MOUNT SINAI HEALTH SYSTEM EXECUTIVE V P FOR FINANCE | $84,755,522 | P20 | published | | New York, NY | 2024 |
| LUTHERAN COMMUNITY SERVICES NORTHWEST | $84,705,248 | P20 | published | violence: prevention | Tacoma, WA | 2024 |
| TRI-COUNTY COMMUNITY ACTION AGENCY INC | $84,676,235 | P20 | inferred 0.70 | women: issues | Bridgeton, NJ | 2024 |
| NORTH SUFFOLK COMMUNITY SERVICES INC | $83,764,786 | P20 | inferred 0.55 | violence: prevention | Chelsea, MA | 2024 |