| SANOFI-AVENTIS PATIENT ASSISTANCE FOUNDATION | Morristown, NJ | $4,149,829,881 | 2024 | P20 | inferred 0.60 | |
| AMERICAN NATIONAL RED CROSS | Washington, DC | $3,916,983,933 | 2024 | P21 | published | shelter: disaster |
| GENENTECH PATIENT FOUNDATION | S San Fran, CA | $3,708,338,423 | 2024 | P60 | published | |
| LILLY CARES FOUNDATION INC | Indianapolis, IN | $2,940,603,036 | 2025 | P99 | published | men: issues |
| BRISTOL-MYERS SQUIBB PATIENT ASSISTANCE FOUNDATION INC | Princeton, NJ | $2,723,409,730 | 2024 | P58 | published | |
| AIDS HEALTHCARE FOUNDATION | Los Angeles, CA | $2,193,782,492 | 2024 | P74 | published | science: research education |
| BANNER UNIVERSITY FAMILY CARE | Phoenix, AZ | $1,956,614,522 | 2024 | P20 | inferred 0.55 | domestic violence |
| INLAND COUNTIES REGIONAL CENTER INC | Sn Bernrdno, CA | $1,290,094,337 | 2024 | P82 | published | |
| NORTH LOS ANGELES COUNTY REGIONAL CENTER INC | Chatsworth, CA | $1,174,374,341 | 2024 | P7A | inferred 0.80 | |
| REGIONAL CENTER OF THE EAST BAY INC | San Leandro, CA | $1,070,981,440 | 2024 | P82 | published | |
| THE EVANGELICAL LUTHERAN GOOD SAMARITAN SOCIETY | Sioux Falls, SD | $1,014,495,873 | 2024 | P75 | published | launch: religious |
| SAN DIEGO IMPERIAL COUNTIES DEVELOPMENTAL SERVICES INC | San Diego, CA | $993,496,415 | 2024 | P82 | published | |
| ALTA CALIFORNIA REGIONAL CENTER INC | Sacramento, CA | $965,776,349 | 2024 | P82 | inferred 0.85 | |
| SAN ANDREAS REGIONAL CENTER | San Jose, CA | $924,151,801 | 2024 | P82 | published | |
| BLUE MERIDIAN PARTNERS INC | New York, NY | $900,250,446 | 2024 | P12 | published | |
| PHARMACY4HUMANITY | Los Angeles, CA | $878,407,307 | 2024 | P80 | published | |
| REGIONAL CENTER OF ORANGE COUNTY | Santa Ana, CA | $866,613,278 | 2024 | P82 | published | |
| COMMUNITY CARE INC | Brookfield, WI | $807,551,599 | 2024 | P80 | published | |
| DALIO FAMILY FUND INC | Westport, CT | $806,892,040 | 2024 | P20 | published | violence: gun |
| CENTRAL VALLEY REGIONAL CENTER INC | Fresno, CA | $767,781,282 | 2024 | P82 | published | |
| SOUTH CENTRAL L A REG CENTRAL FOR DVLOPMNTLY DISABLED PERSONS INC | Los Angeles, CA | $762,106,410 | 2024 | P82 | published | |
| JACKSON ELECTRIC MEMBERSHIP CORP | Jefferson, GA | $685,551,827 | 2024 | P43 | inferred 0.45 | |
| Senior Health Partners Inc | New York, NY | $675,116,787 | 2016 | P71 | inferred 0.60 | |
| WITHLACOOCHEE RIVER ELECTRIC COOPERATIVE INC | Dade City, FL | $674,641,546 | 2025 | P43 | inferred 0.45 | |
| TRI-COUNTIES ASSOCIATION FOR THE DEVELOPMENTALLY DISABLED INC | Santa Barbara, CA | $659,035,578 | 2024 | P7A | inferred 0.70 | |
| GOLDEN GATE REGIONAL CENTER INC | San Francisco, CA | $648,209,787 | 2024 | P82 | published | |
| BAKERRIPLEY | Houston, TX | $635,358,695 | 2024 | P28 | published | women: issues |
| EASTER SEALS SOUTHERN CALIFORNIA INC | Irvine, CA | $622,282,926 | 2025 | P20 | inferred 0.70 | women: issues |
| ACTS RETIREMENT-LIFE COMMUNITIES INC | Ft Washington, PA | $619,296,438 | 2024 | P75 | published | |
| MIDWEST FOOD BANK NFP INC | Normal, IL | $579,032,442 | 2025 | P99 | published | shelter: homeless |
| VALLEY MOUNTAIN REGIONAL CENTER INC | Stockton, CA | $573,553,593 | 2024 | P82 | published | |
| COASTAL DEVELOPMENTAL SERVICES FOUNDATION | El Segundo, CA | $570,417,760 | 2024 | P82 | inferred 0.80 | |
| NORTH BAY DEVELOPMENTAL DISABILITIES SERVICES INC | Napa, CA | $567,741,036 | 2024 | P82 | published | |
| PRESENCE CHICAGO HOSPITALS NETWORK | Saint Louis, MO | $562,281,879 | 2024 | P75 | published | abuse: substance |
| SAN GABRIEL POMONA VALLEYS DEVELOPMENTAL SERVICES INC | Pomona, CA | $560,358,886 | 2024 | P85 | inferred 0.20 | |
| SUTTER VISITING NURSE ASSOCIATION AND HOSPICE | Sacramento, CA | $559,159,282 | 2024 | P74 | published | women: issues |
| SEVEN HILLS FOUNDATION INC | Worcester, MA | $541,217,577 | 2024 | P82 | published | abuse: substance |
| EASTERN LOS ANGELES REGIONAL CENTER FOR DEVELOPMENTALLY DISABLED INC | Alhambra, CA | $517,373,887 | 2024 | P82 | published | |
| HARBOR DEVLOPMENTAL DISABILITIES FOUNDATION | Torrance, CA | $516,825,893 | 2024 | P82 | published | |
| LOS ANGELES COUNTY DEVELOPMENTAL SERVICE FOUNDATION | Los Angeles, CA | $513,569,976 | 2024 | P82 | published | |
| FATHER FLANAGANS BOYS HOME | Boys Town, NE | $503,397,755 | 2024 | P73 | published | launch: launch |
| SOUTHWEST KEY PROGRAMS INC | Austin, TX | $496,116,551 | 2024 | P84 | published | violence: community |
| PARTNERSHIP FOR SUPPLY CHAIN MANAGE MENT | Arlington, VA | $490,016,158 | 2024 | P20 | published | |
| YOUTH VILLAGES INC | Bartlett, TN | $483,465,306 | 2024 | P30 | published | shelter: homeless |
| COBB ELECTRIC MEMBERSHIP CORPORATION | Marietta, GA | $476,195,986 | 2025 | P20 | inferred 0.25 | |
| RUSH MEDICAL GROUP | Chicago, IL | $475,026,740 | 2024 | P20 | published | science: research education |
| JEWISH AGENCY FOR ISRAEL | Israel | $455,512,779 | 2024 | P20 | inferred 0.55 | |
| COMPASS CONNECTIONS | San Antonio, TX | $448,681,852 | 2024 | P30 | published | abuse: child |
| ACTION FOR BOSTON COMMUNITY DEVELOPMENT | Boston, MA | $446,082,448 | 2024 | P20 | published | abuse: substance |
| LUTHERAN SERVICES FLORIDA INC | Tampa, FL | $443,658,918 | 2024 | P20 | published | survivor: disaster |
| UNITED POWER INC | Brighton, CO | $437,797,222 | 2025 | P99 | inferred 0.40 | |
| BARNARDOS | United Kingdom | $435,212,820 | 2024 | P20 | published | |
| WOUNDED WARRIOR PROJECT INC | Jacksonville, FL | $431,679,370 | 2024 | P60 | published | survivor: suicide |
| NRLCA VEBA TRUST | Alexandria, VA | $423,780,744 | 2024 | P43 | published | |
| WALTON EMC | Monroe, GA | $420,877,567 | 2024 | P99 | inferred 0.20 | |
| FAMILY ENDEAVORS INC | San Antonio, TX | $408,185,445 | 2024 | P20 | inferred 0.70 | shelter: disaster |
| L C IND INC | Durham, NC | $408,056,988 | 2024 | P86 | published | |
| HOSPITAL FOR SICK CHILDREN FOUNDATION | Canada | $405,635,408 | 2024 | P34 | published | |
| COMMUNITY OPTIONS INC | Princeton, NJ | $392,932,284 | 2024 | P80 | published | |
| LIFESPACE COMMUNITIES INC | Wdm, IA | $391,189,293 | 2024 | P75 | published | |
| KERN REGIONAL CENTER | Bakersfield, CA | $379,330,046 | 2024 | P82 | published | |
| LOS ANGELES REGIONAL FOOD BANK | Vernon, CA | $373,458,836 | 2025 | P20 | inferred 0.70 | women: issues |
| YMCA OF SAN DIEGO COUNTY | San Diego, CA | $371,820,304 | 2024 | P27 | published | abuse: child |
| NYSARC INC | New York, NY | $370,470,018 | 2024 | P82 | published | |
| CATHOLIC CHARITIES DIOCESE OF FORT WORTH | Fort Worth, TX | $365,542,304 | 2024 | P20 | published | abuse: child |
| LOMA LINDA UNIVERSITY SHARED SERVICES | Loma Linda, CA | $358,030,594 | 2024 | P01 | inferred 0.60 | science: research education |
| ACACIA CENTER FOR JUSTICE | New York, NY | $353,995,304 | 2024 | P84 | published | |
| NORTHEAST PENNSYLVANIA CENTER FOR INDEPENDENT LIVING | Scranton, PA | $353,634,974 | 2024 | P8X | published | |
| GOODWILL OF CENTRAL AND NORTHERN ARIZONA | Phoenix, AZ | $351,927,904 | 2025 | P20 | inferred 0.70 | launch: religious |
| FAR NORTHERN COORDINATING COUNCIL ON DEVELOPMENTAL DISABILITIES | Redding, CA | $344,977,951 | 2024 | P11 | published | |
| PACIFIC CLINICS | Los Gatos, CA | $339,429,241 | 2024 | P30 | published | abuse: sexual |
| SAMARITAN HEALTH SERVICES INC | Corvallis, OR | $327,760,439 | 2024 | P20 | published | abuse: child |
| RESOURCES FOR HUMAN DEVELOPMENT INC | Philadelphia, PA | $325,713,965 | 2024 | P20 | published | violence: gun |
| NEW YORK STATE INDUSTRIES FOR THE DISABLED INC | Albany, NY | $323,421,174 | 2024 | P80 | inferred 0.70 | |
| OPERATING ENGINEERS HEALTH & WELFARE FUND | Pasadena, CA | $319,856,070 | 2024 | P87 | inferred 0.00 | |
| ACCESS SERVICES INCORPORATED | El Monte, CA | $317,506,661 | 2024 | P52 | published | |
| CATHOLIC COMMUNITY SERVICES OF WESTERN WASHINGTON | Seattle, WA | $317,162,695 | 2024 | P20 | published | |
| ELWYN OF PENNSYLVANIA AND DELAWARE | Elwyn, PA | $308,616,200 | 2024 | P82 | published | |
| PRIDE INDUSTRIES | Roseville, CA | $307,804,321 | 2024 | P20 | published | launch: launch |
| CHILD DEVELOPMENT ASSOCIATES INCORPORATED | Bonita, CA | $307,153,597 | 2024 | P37 | published | |
| CENTRAL FLORIDA BEHAVIORAL HEALTH NETWORK INC | Tampa, FL | $304,199,504 | 2024 | P30 | published | abuse: substance |
| NATIONAL YOUTH ADVOCATE PROGRAM | Columbus, OH | $302,719,234 | 2025 | P02 | published | |
| YOUNG ADULT INSTITUTE INC | New York, NY | $297,444,544 | 2024 | P82 | published | |
| SERVICES FOR THE UNDERSERVED INC | New York, NY | $297,260,782 | 2024 | P20 | inferred 0.70 | abuse: substance |
| VINFEN CORPORATION | Cambridge, MA | $295,744,297 | 2024 | P80 | published | abuse: substance |
| BANCROFT A NEW JERSEY NONPROFIT CORPORATION | Cherry Hill, NJ | $286,765,384 | 2024 | P20 | published | |
| CARROLL ELECTRIC COOPERATIVE CORPORATION | Berryville, AR | $285,505,825 | 2024 | P20 | inferred 0.10 | |
| SCO FAMILY OF SERVICES | Garden City, NY | $266,823,599 | 2024 | P20 | published | abuse: substance |
| TIDES CENTER | San Francisco, CA | $265,402,095 | 2024 | P20 | published | space: outer |
| SPECIAL SERVICE FOR GROUPS INC | Los Angeles, CA | $264,215,489 | 2024 | P84 | published | abuse: substance |
| SPRINGPOINT SENIOR LIVING INC | Wall Township, NJ | $259,287,063 | 2024 | P75 | published | |
| JSI RESEARCH & TRAINING INSTITUTE INC | Boston, MA | $258,533,218 | 2024 | P20 | inferred 0.55 | violence: sexual |
| THE NEW YORK FOUNDLING | New York, NY | $256,905,246 | 2024 | P30 | published | abuse: child |
| BRUNSWICK ELECTRIC MEMBERSHIP CORP | Shallotte, NC | $254,802,534 | 2025 | P20 | inferred 0.10 | |
| LUTHERAN SENIOR SERVICES | Saint Louis, MO | $254,513,817 | 2024 | P75 | published | |
| MERS MISSOURI GOODWILL INDUSTRIES | Saint Louis, MO | $251,650,956 | 2024 | P20 | published | |
| PEOPLE INC | Williamsville, NY | $250,571,798 | 2024 | P82 | published | |
| SKOOKUM EDUCATIONAL PROGRAMS | Bremerton, WA | $247,596,570 | 2024 | P20 | inferred 0.30 | space: outer |
| PROFESSIONAL CONTRACT SERVICES INC | Austin, TX | $246,080,465 | 2024 | P80 | published | space: outer |
| HOSPICE OF THE VALLEY | Phoenix, AZ | $244,171,708 | 2024 | P74 | published | |