| LILLY CARES FOUNDATION INC | $2,940,603,036 | P99 | published | men: issues | Indianapolis, IN | 2025 |
| MIDWEST FOOD BANK NFP INC | $579,032,442 | P99 | published | shelter: homeless | Normal, IL | 2025 |
| DISTRICT COUNCIL 37 HEALTH AND SECURITY FUND | $238,932,255 | P99 | inferred 0.60 | | New York, NY | 2024 |
| ILLINOIS NETWORK OF CHILD CARE RESOURCE AND REFERRAL AGENCIES | $196,245,221 | P99 | published | | Bloomington, IL | 2024 |
| PRESBYTERIAN HOMES | $115,807,574 | P99 | published | | Skokie, IL | 2024 |
| BAY AREA COMMUNITY SERVICES INC | $115,603,119 | P99 | inferred 0.60 | abuse: substance | Oakland, CA | 2024 |
| ABRAXAS ALLIANCE INC | $112,703,949 | P99 | published | | Pittsburgh, PA | 2024 |
| JEVS HUMAN SERVICES | $102,738,285 | P99 | inferred 0.60 | | Philadelphia, PA | 2024 |
| NATIONAL COUNCIL ON AGING INC | $77,891,453 | P99 | inferred 0.60 | | Arlington, VA | 2024 |
| EDWARD CHARLES FOUNDATION | $67,600,579 | P99 | published | launch: religious | Beverly Hills, CA | 2024 |
| NORTHEAST KINGDOM HUMAN SERVICES INC | $64,783,507 | P99 | inferred 0.60 | abuse: substance | Newport, VT | 2024 |
| SAN ISABEL ELECTRIC ASSOCIATION INC | $62,411,395 | P99 | inferred 0.50 | | Pueblo, CO | 2024 |
| PENNSYLVANIA ASSOCIATION OF AREA AGENCY ON AGING DIRECTORS INC | $61,989,721 | P99 | inferred 0.60 | science: research education | Harrisburg, PA | 2024 |
| MATTHEW O JONES FAMILY FOUNDATION | $56,287,854 | P99 | published | women: issues | Vista, CA | 2024 |
| GREATER WISCONSIN AGENCY ON AGING RESOURCES INC | $47,222,491 | P99 | inferred 0.60 | abuse: elder | Madison, WI | 2024 |
| SALESFORCEORG | $45,460,583 | P99 | inferred 0.55 | | San Francisco, CA | 2014 |
| STEVEN AND ELEANOR HAUSSIER FOUNDATION INC | $43,622,040 | P99 | published | | Cincinnati, OH | 2025 |
| FOODBANK OF MONMOUTH AND OCEAN COUNTIES INC | $43,316,113 | P99 | published | girls boys: boys girls clubs | Neptune, NJ | 2024 |
| COORDINATED CARE SERVICES INC | $41,211,546 | P99 | inferred 0.60 | abuse: substance | Rochester, NY | 2024 |
| ILLINOIS COALITION AGAINST SEXUAL ASSAULT | $34,357,587 | P99 | inferred 0.45 | survivor: sexual | Springfield, IL | 2024 |
| YOUTH OPPORTUNITIES UPHELD INC | $33,356,076 | P99 | inferred 0.50 | | Worcester, MA | 2018 |
| GEORGIA HAP ADMINISTRATORS INC | $31,738,612 | P99 | inferred 0.45 | | Tucker, GA | 2024 |
| NYSARC INC | $31,312,038 | P99 | inferred 0.60 | | Herkimer, NY | 2024 |
| HOPES COMMUNITY ACTION PARTNERSHIP INCORPORATED | $30,334,427 | P99 | inferred 0.60 | | Hoboken, NJ | 2024 |
| YAD SARAH | $29,779,000 | P99 | published | domestic violence | Israel | 2024 |
| FASHION DELIVERS CHARITABLE FOUNDATION INC | $29,215,479 | P99 | inferred 0.60 | survivor: disaster | New York, NY | 2013 |
| GAY AND LESBIAN COMMUNITY CENTER OF SOUTHERN NEVADA INC | $28,591,060 | P99 | published | survivor: sexual | Las Vegas, NV | 2025 |
| COURAGE CENTER | $28,461,841 | P99 | inferred 0.60 | abuse: child | Minneapolis, MN | 2012 |
| AIDS SERVICE ASSOCIATION OF PINELLAS INC | $27,797,459 | P99 | inferred 0.60 | abuse: substance | Lakewood Ranch, FL | 2024 |
| CASSIA SERVICES | $27,283,416 | P99 | published | | Edina, MN | 2024 |
| DIAKON CHILD FAMILY & COMMUNITY MINISTRIES | $27,103,968 | P99 | inferred 0.60 | women: issues | Topton, PA | 2024 |
| ACTION PACT INC | $26,753,168 | P99 | inferred 0.60 | | Waycross, GA | 2024 |
| COMMUNITY PARTNERS IN ACTION INC | $23,621,325 | P99 | inferred 0.60 | girls boys: boys | Hartford, CT | 2024 |
| ST CATHERINES CENTER FOR CHILDREN | $22,465,511 | P99 | inferred 0.55 | abuse: substance | Albany, NY | 2024 |
| HARC INC | $21,893,885 | P99 | published | | Hartford, CT | 2024 |
| THE MONTGOMERY COUNTY COALITION FOR THE HOMELESS INC | $21,834,649 | P99 | published | men: issues | Rockville, MD | 2024 |
| BETTER TOGETHER STRENGTHENING FAMILIES INC | $20,364,256 | P99 | published | abuse: child | Naples, FL | 2024 |
| OVERLAND MISSIONS INC | $20,044,347 | P99 | published | launch: religious | Cocoa, FL | 2024 |
| GIVING HOPE INC | $17,806,238 | P99 | published | abuse: sexual | New Orleans, LA | 2025 |
| SOUTHEASTERN COMMUNITY ACTION PARTNERSHIP INC | $17,025,452 | P99 | published | | Lumberton, NC | 2024 |
| SOUTHERN IOWA ELECTRIC COOPERATIVE INC | $16,813,472 | P99 | inferred 0.45 | | Bloomfield, IA | 2025 |
| HIV ALLIANCE | $16,748,260 | P99 | inferred 0.60 | abuse: substance | Eugene, OR | 2024 |
| CLEARPOINT FINANCIAL SOLUTIONS INC | $16,657,625 | P99 | inferred 0.60 | | Richmond, VA | 2013 |
| ASSOCIATION FOR THE DEVELOPMENTALLY | $16,460,060 | P99 | inferred 0.60 | | Westerville, OH | 2018 |
| SANDBERG GOLDBERG BERNTHAL FAMILY FOUNDATION | $16,198,698 | P99 | published | women: issues | San Francisco, CA | 2024 |
| SOUTHEAST BRONX NEIGHBORHOOD CENTERS INC | $16,186,911 | P99 | inferred 0.70 | | Bronx, NY | 2024 |
| HOPE FOR YOUTH INC | $16,075,169 | P99 | inferred 0.75 | violence: community | Amityville, NY | 2024 |
| RAINBOW OF CHALLENGES INC | $15,581,908 | P99 | inferred 0.70 | | Hope, AR | 2024 |
| MURPHY-HARPST CHILDRENS CENTERS INC | $15,522,371 | P99 | inferred 0.60 | abuse: substance | Cedartown, GA | 2024 |
| HARVEST TIME INTERNATIONAL INC | $15,201,645 | P99 | published | men: issues | Sanford, FL | 2024 |
| STRONG CITY BALTIMORE INC | $14,803,870 | P99 | inferred 0.60 | violence: community | Baltimore, MD | 2018 |
| PUERTO RICAN CULTURAL CENTER | $14,719,775 | P99 | inferred 0.60 | violence: community | Chicago, IL | 2024 |
| Volunteers of America of Indiana Inc | $14,654,592 | P99 | inferred 0.60 | abuse: substance | Indianapolis, IN | 2017 |
| NEW JERSEY REENTRY | $14,203,717 | P99 | published | shelter: disaster | Kearny, NJ | 2024 |
| THE PITON FOUNDATION | $14,138,026 | P99 | inferred 0.45 | science: research education | Denver, CO | 2013 |
| CLADDAGH COMMISSION INC | $13,994,903 | P99 | inferred 0.70 | | Derby, NY | 2015 |
| SENIOR COMMUNITY SERVICES INC | $13,929,324 | P99 | published | | Lakewood, NJ | 2024 |
| KIEVE-WAVUS EDUCATION INC | $13,620,719 | P99 | published | girls boys: boys | Nobleboro, ME | 2024 |
| MINNESOTA MASONIC CHARITIES | $13,538,629 | P99 | published | launch: aviation | Bloomington, MN | 2024 |
| GREEN RIBBON LEGACY INC | $13,369,519 | P99 | published | | Westwood, KS | 2025 |
| VITALITY UNLIMITED | $13,024,618 | P99 | published | | Elko, NV | 2025 |
| FILTER OF HOPE INC | $12,823,069 | P99 | inferred 0.60 | launch: religious | Tuscaloosa, AL | 2025 |
| THIRD OPTION FOUNDATION | $12,799,102 | P99 | published | | Reston, VA | 2024 |
| AMERICAN CORPORATE PARTNERS | $12,622,541 | P99 | published | | New York, NY | 2025 |
| CATHOLIC CHARITIES LEGAL SERVICES ARCHDIOCESE OF MIAMI INC | $12,325,314 | P99 | inferred 0.60 | abuse: child | Miami, FL | 2024 |
| HELP-NEW MEXICO INC | $12,315,409 | P99 | inferred 0.50 | | Albuquerque, NM | 2024 |
| SOCIETY OF ST VINCENT DE PAUL COUNCIL OF SEATTLE-KING COUNTY | $12,100,731 | P99 | published | | Seattle, WA | 2024 |
| SOUTH CAROLINA ASSOCIATION OF COMMUNITY ACTION PARTNERSHIPS | $11,844,037 | P99 | inferred 0.60 | women: issues | Columbia, SC | 2025 |
| DC ACTION FOR CHILDREN TODAY DC ACT | $11,673,970 | P99 | published | | Washington, DC | 2024 |
| LINDNER CENTER OF HOPE PROFESSIONAL ASSOCIATES | $11,619,356 | P99 | published | | Mason, OH | 2024 |
| THE ARC OF SOUTHWEST GEORGIA INC | $11,533,443 | P99 | published | | Albany, GA | 2022 |
| COMMUNITY ACTION PARTNERSHIP OF GREATER ST JOSEPH | $11,497,857 | P99 | inferred 0.60 | | St Joseph, MO | 2024 |
| CITYSQUARE | $11,369,022 | P99 | published | shelter: homeless | Paris, TX | 2024 |
| RENAISSANCE SOCIAL SERVICES INC | $11,152,200 | P99 | published | abuse: substance | Chicago, IL | 2024 |
| NATIONAL COUNCIL OF THE UNITED STATES SOCIETY OF ST VINCENT DE PA | $11,078,812 | P99 | published | survivor: disaster | Maryland Hts, MO | 2024 |
| BI-BETT | $11,027,129 | P99 | published | | Walnut Creek, CA | 2024 |
| EXCEPTIONAL COMMUNITY SERVICES INC | $10,922,110 | P99 | published | | Monroe, GA | 2023 |
| EMMAUS COMMUNITY OF PITTSBURGH | $10,846,547 | P99 | published | | Pittsburgh, PA | 2024 |
| CHILD HEALTH AND DEVELOPMENT INSTITUTE OF CONNECTICUT INC | $10,721,923 | P99 | published | science: research education | Farmington, CT | 2024 |
| MAKE-A-WISH FOUNDATION OF GREATER PENNSYLVANIA AND WEST VIRGINIA INC | $10,492,562 | P99 | inferred 0.60 | space: outer | Pittsburgh, PA | 2024 |
| TREHAB | $10,362,535 | P99 | inferred 0.70 | shelter: homeless | Montrose, PA | 2024 |
| HIGHT IMPACTO INC | $10,240,401 | P99 | published | | Ft Lauderdale, FL | 2024 |
| ATWORK | $10,238,422 | P99 | published | launch: religious | Bellevue, WA | 2024 |
| ELEVATE COMMUNITY SERVICES INC | $10,221,952 | P99 | published | | Fresno, CA | 2024 |
| NEW BEGINNINGS INC | $10,080,906 | P99 | published | | Windsor Mill, MD | 2024 |
| LIFE LEARNING CENTER INC | $10,027,539 | P99 | published | abuse: substance | Covington, KY | 2025 |
| HANUL FAMILY ALLIANCE | $9,953,544 | P99 | published | | Chicago, IL | 2024 |
| MAKE-A-WISH FOUNDATION OF MISSOURI AND KANSAS | $9,720,451 | P99 | published | | Ballwin, MO | 2024 |
| RONALD MCDONALD HOUSE CHARITIES OF CENTRAL OHIO INC | $9,276,271 | P99 | inferred 0.50 | girls boys: girls | Columbus, OH | 2025 |
| HISPANIC UNITY OF FLORIDA INC | $9,262,583 | P99 | inferred 0.60 | survivor: disaster | Hollywood, FL | 2024 |
| NORTH CAROLINA JUSTICE CENTER | $9,153,266 | P99 | published | | Raleigh, NC | 2024 |
| LIVING UNITED FOR CHANGE IN ARIZONA | $8,986,361 | P99 | published | | Phoenix, AZ | 2024 |
| ST VINCENT DE PAUL SALVAGE BUREAU | $8,817,449 | P99 | published | shelter: homeless | Coeur D Alene, ID | 2024 |
| AbbVie Employee Assistance Fund Inc | $8,759,468 | P99 | inferred 0.60 | | North Chicago, IL | 2020 |
| DIAPER BANK OF NORTH CAROLINA | $8,621,703 | P99 | published | | Hillsborough, NC | 2024 |
| NEW CASTLE COUNTY HEAD START INC | $8,441,364 | P99 | inferred 0.60 | women: issues | Newark, DE | 2024 |
| NONPROFIT MANAGEMENT SERVICES | $8,353,741 | P99 | inferred 0.60 | | Aurora, CO | 2021 |
| CELERITY GLOBAL DEVELOPMENT | $8,338,198 | P99 | inferred 0.60 | | Los Angeles, CA | 2016 |
| BRIGHT NUTRITION | $8,323,755 | P99 | published | | Brownsville, TX | 2024 |
| BRIDGEPORT RESCUE MISSION INC | $8,191,409 | P99 | published | launch: religious | Bridgeport, CT | 2024 |