| FEEDING AMERICA | Chicago, IL | $5,001,395,215 | 2024 | K31 | published | |
| INTERNATIONAL OLYMPIC COMMITTEE | Switzerland | $4,410,516,368 | 2024 | N60 | inferred 0.65 | women: issues |
| SANOFI-AVENTIS PATIENT ASSISTANCE FOUNDATION | Morristown, NJ | $4,149,829,881 | 2024 | P20 | inferred 0.60 | |
| NORTHWESTERN UNIVERSITY | Evanston, IL | $4,056,663,344 | 2024 | N50 | published | domestic: workers |
| AMERICAN NATIONAL RED CROSS | Washington, DC | $3,916,983,933 | 2024 | P21 | published | shelter: disaster |
| GENENTECH PATIENT FOUNDATION | S San Fran, CA | $3,708,338,423 | 2024 | P60 | published | |
| LILLY CARES FOUNDATION INC | Indianapolis, IN | $2,940,603,036 | 2025 | P99 | published | men: issues |
| BRISTOL-MYERS SQUIBB PATIENT ASSISTANCE FOUNDATION INC | Princeton, NJ | $2,723,409,730 | 2024 | P58 | published | |
| PRAIRIE MEADOWS RACE TRACK & CASINO INC | Altoona, IA | $2,532,959,229 | 2024 | N6A | inferred 0.30 | girls boys: boys |
| NATIONAL ASSOCIATION OF LETTER CARRIERS | Washington, DC | $2,203,167,533 | 2024 | J40 | published | |
| AIDS HEALTHCARE FOUNDATION | Los Angeles, CA | $2,193,782,492 | 2024 | P74 | published | science: research education |
| BANNER UNIVERSITY FAMILY CARE | Phoenix, AZ | $1,956,614,522 | 2024 | P20 | inferred 0.55 | domestic violence |
| BUILDING SERVICE 32BJ HEALTH FUND | New York, NY | $1,946,866,180 | 2024 | J40 | published | |
| NATIONAL COLLEGIATE ATHLETIC ASSOCIATION | Indianapolis, IN | $1,561,767,784 | 2024 | N40 | published | science: research education |
| BIG TEN CONFERENCE INC | Rosemont, IL | $1,468,470,129 | 2024 | N61 | inferred 0.50 | women: issues |
| INLAND COUNTIES REGIONAL CENTER INC | Sn Bernrdno, CA | $1,290,094,337 | 2024 | P82 | published | |
| NORTH LOS ANGELES COUNTY REGIONAL CENTER INC | Chatsworth, CA | $1,174,374,341 | 2024 | P7A | inferred 0.80 | |
| SOUTHEASTERN CONFERENCE | Birmingham, AL | $1,108,919,128 | 2024 | N70 | published | |
| REGIONAL CENTER OF THE EAST BAY INC | San Leandro, CA | $1,070,981,440 | 2024 | P82 | published | |
| LOS ANGELES LOMOD CORPORATION | Los Angeles, CA | $1,055,603,194 | 2024 | L21 | inferred 0.80 | |
| THE EVANGELICAL LUTHERAN GOOD SAMARITAN SOCIETY | Sioux Falls, SD | $1,014,495,873 | 2024 | P75 | published | launch: religious |
| SAN DIEGO IMPERIAL COUNTIES DEVELOPMENTAL SERVICES INC | San Diego, CA | $993,496,415 | 2024 | P82 | published | |
| ALTA CALIFORNIA REGIONAL CENTER INC | Sacramento, CA | $965,776,349 | 2024 | P82 | inferred 0.85 | |
| SAN ANDREAS REGIONAL CENTER | San Jose, CA | $924,151,801 | 2024 | P82 | published | |
| NAVIGATE AFFORDABLE HOUSING PARTNERS INC | Birmingham, AL | $919,273,953 | 2024 | L20 | published | violence: prevention |
| BLUE MERIDIAN PARTNERS INC | New York, NY | $900,250,446 | 2024 | P12 | published | |
| PHARMACY4HUMANITY | Los Angeles, CA | $878,407,307 | 2024 | P80 | published | |
| FEDERATION INTERNATIONALE DE FOOTBALL ASSOCIATION | Switzerland | $872,061,669 | 2024 | N99 | inferred 0.70 | women: issues |
| CONFEDERACION SUDAMERICANA DE FUTBOL | Valois Rivarola Central Luque | $868,671,866 | 2024 | N99 | inferred 0.60 | women: issues |
| REGIONAL CENTER OF ORANGE COUNTY | Santa Ana, CA | $866,613,278 | 2024 | P82 | published | |
| ATLANTIC COAST CONFERENCE | Charlotte, NC | $826,480,916 | 2024 | N40 | published | |
| COMMUNITY CARE INC | Brookfield, WI | $807,551,599 | 2024 | P80 | published | |
| DALIO FAMILY FUND INC | Westport, CT | $806,892,040 | 2024 | P20 | published | violence: gun |
| CHILD CARE RESOURCE CENTER INC | Chatsworth, CA | $774,704,879 | 2024 | O40 | published | |
| CENTRAL VALLEY REGIONAL CENTER INC | Fresno, CA | $767,781,282 | 2024 | P82 | published | |
| SOUTH CENTRAL L A REG CENTRAL FOR DVLOPMNTLY DISABLED PERSONS INC | Los Angeles, CA | $762,106,410 | 2024 | P82 | published | |
| PGA TOUR INC | Ponte Vedra, FL | $760,607,406 | 2024 | N6A | inferred 0.85 | |
| UNITED STEELWORKERS | Pittsburgh, PA | $693,986,753 | 2024 | J40 | inferred 0.93 | |
| Senior Health Partners Inc | New York, NY | $675,116,787 | 2016 | P71 | inferred 0.60 | |
| TRI-COUNTIES ASSOCIATION FOR THE DEVELOPMENTALLY DISABLED INC | Santa Barbara, CA | $659,035,578 | 2024 | P7A | inferred 0.70 | |
| GOLDEN GATE REGIONAL CENTER INC | San Francisco, CA | $648,209,787 | 2024 | P82 | published | |
| BAKERRIPLEY | Houston, TX | $635,358,695 | 2024 | P28 | published | women: issues |
| PARK NICOLLET HEALTH SERVICES | St Louis Park, MN | $633,003,802 | 2010 | L21 | published | survivor: cancer |
| EASTER SEALS SOUTHERN CALIFORNIA INC | Irvine, CA | $622,282,926 | 2025 | P20 | inferred 0.70 | women: issues |
| National Football League | New York, NY | $619,557,237 | 2014 | N80 | inferred 0.80 | domestic violence |
| ACTS RETIREMENT-LIFE COMMUNITIES INC | Ft Washington, PA | $619,296,438 | 2024 | P75 | published | |
| MIDWEST FOOD BANK NFP INC | Normal, IL | $579,032,442 | 2025 | P99 | published | shelter: homeless |
| VALLEY MOUNTAIN REGIONAL CENTER INC | Stockton, CA | $573,553,593 | 2024 | P82 | published | |
| LEGAL SERVICES CORPORATION | Washington, DC | $572,829,932 | 2024 | I80 | published | survivor: disaster |
| COASTAL DEVELOPMENTAL SERVICES FOUNDATION | El Segundo, CA | $570,417,760 | 2024 | P82 | inferred 0.80 | |
| NORTH BAY DEVELOPMENTAL DISABILITIES SERVICES INC | Napa, CA | $567,741,036 | 2024 | P82 | published | |
| PRESENCE CHICAGO HOSPITALS NETWORK | Saint Louis, MO | $562,281,879 | 2024 | P75 | published | abuse: substance |
| SAN GABRIEL POMONA VALLEYS DEVELOPMENTAL SERVICES INC | Pomona, CA | $560,358,886 | 2024 | P82 | inferred 0.70 | |
| SUTTER VISITING NURSE ASSOCIATION AND HOSPICE | Sacramento, CA | $559,159,282 | 2024 | P74 | published | women: issues |
| YOUNG LIFE | Colorado Spgs, CO | $556,261,660 | 2024 | O55 | published | launch: religious |
| SEVEN HILLS FOUNDATION INC | Worcester, MA | $541,217,577 | 2024 | P82 | published | abuse: substance |
| EASTERN LOS ANGELES REGIONAL CENTER FOR DEVELOPMENTALLY DISABLED INC | Alhambra, CA | $517,373,887 | 2024 | P82 | published | |
| HARBOR DEVLOPMENTAL DISABILITIES FOUNDATION | Torrance, CA | $516,825,893 | 2024 | P82 | published | |
| LOS ANGELES COUNTY DEVELOPMENTAL SERVICE FOUNDATION | Los Angeles, CA | $513,569,976 | 2024 | P82 | published | |
| FATHER FLANAGANS BOYS HOME | Boys Town, NE | $503,397,755 | 2024 | P73 | published | launch: launch |
| SOUTHWEST KEY PROGRAMS INC | Austin, TX | $496,116,551 | 2024 | P84 | published | violence: community |
| PARTNERSHIP FOR SUPPLY CHAIN MANAGE MENT | Arlington, VA | $490,016,158 | 2024 | P20 | published | |
| CREATIVE TESTING SOLUTIONS | Tempe, AZ | $488,438,501 | 2025 | M99 | published | science: research education |
| YOUTH VILLAGES INC | Bartlett, TN | $483,465,306 | 2024 | P30 | published | shelter: homeless |
| PARK NICOLLET HEALTH SERVICES | St Louis Park, MN | $480,687,128 | 2010 | L21 | published | survivor: cancer |
| RUSH MEDICAL GROUP | Chicago, IL | $475,026,740 | 2024 | P20 | published | science: research education |
| TENNIS AUSTRALIA A LIMITED | Australia | $469,347,896 | 2024 | N66 | published | |
| UNITED STATES TENNIS ASSOCIATION INC | Purchase, NY | $468,615,021 | 2024 | N60 | inferred 0.85 | science: research education |
| JEWISH AGENCY FOR ISRAEL | Israel | $455,512,779 | 2024 | P20 | inferred 0.55 | |
| COMPASS CONNECTIONS | San Antonio, TX | $448,681,852 | 2024 | P30 | published | abuse: child |
| ACTION FOR BOSTON COMMUNITY DEVELOPMENT | Boston, MA | $446,082,448 | 2024 | P20 | published | abuse: substance |
| ELDERHOSTEL INC | Boston, MA | $445,959,787 | 2024 | N50 | published | science: research education |
| LUTHERAN SERVICES FLORIDA INC | Tampa, FL | $443,658,918 | 2024 | P20 | published | survivor: disaster |
| LEGAL AID SOCIETY | New York, NY | $439,700,805 | 2024 | I80 | published | abuse: child |
| HOUSTON FOOD BANK | Houston, TX | $435,363,433 | 2024 | K31 | inferred 0.93 | girls boys: boys girls clubs |
| BARNARDOS | United Kingdom | $435,212,820 | 2024 | P20 | published | |
| WOUNDED WARRIOR PROJECT INC | Jacksonville, FL | $431,679,370 | 2024 | P60 | published | survivor: suicide |
| NRLCA VEBA TRUST | Alexandria, VA | $423,780,744 | 2024 | P43 | published | |
| FRONT PORCH COMMUNITIES AND SERVICES | Glendale, CA | $422,856,176 | 2024 | L22 | published | |
| FAMILY ENDEAVORS INC | San Antonio, TX | $408,185,445 | 2024 | P20 | inferred 0.70 | shelter: disaster |
| L C IND INC | Durham, NC | $408,056,988 | 2024 | P86 | published | |
| METROPOLITAN BOSTON HOUSING PARTNERSHIP INC | Boston, MA | $406,351,112 | 2024 | L20 | published | shelter: homeless |
| HOSPITAL FOR SICK CHILDREN FOUNDATION | Canada | $405,635,408 | 2024 | P34 | published | |
| MOSAIC | Omaha, NE | $401,546,990 | 2024 | L99 | published | |
| CALIFORNIA AFFORDABLE HOUSING INITIATIVES INC | Oakland, CA | $394,029,380 | 2011 | L30 | published | |
| COMMUNITY OPTIONS INC | Princeton, NJ | $392,932,284 | 2024 | P80 | published | |
| LIFESPACE COMMUNITIES INC | Wdm, IA | $391,189,293 | 2024 | P75 | published | |
| AIR LINE PILOTS ASSOCIATION INTERNATIONAL | Mclean, VA | $382,120,748 | 2024 | J40 | inferred 0.90 | space: outer |
| KERN REGIONAL CENTER | Bakersfield, CA | $379,330,046 | 2024 | P82 | published | |
| LOS ANGELES REGIONAL FOOD BANK | Vernon, CA | $373,458,836 | 2025 | P20 | inferred 0.70 | women: issues |
| YMCA OF SAN DIEGO COUNTY | San Diego, CA | $371,820,304 | 2024 | P27 | published | abuse: child |
| NYSARC INC | New York, NY | $370,470,018 | 2024 | P82 | published | |
| CATHOLIC CHARITIES DIOCESE OF FORT WORTH | Fort Worth, TX | $365,542,304 | 2024 | P20 | published | abuse: child |
| LOMA LINDA UNIVERSITY SHARED SERVICES | Loma Linda, CA | $358,030,594 | 2024 | P01 | inferred 0.60 | science: research education |
| ACACIA CENTER FOR JUSTICE | New York, NY | $353,995,304 | 2024 | P84 | published | |
| NORTHEAST PENNSYLVANIA CENTER FOR INDEPENDENT LIVING | Scranton, PA | $353,634,974 | 2024 | P8X | published | |
| GOODWILL OF CENTRAL AND NORTHERN ARIZONA | Phoenix, AZ | $351,927,904 | 2025 | P20 | inferred 0.70 | launch: religious |
| NATIONAL BASKETBALL PLAYERS ASSOCIATION | New York, NY | $347,641,101 | 2024 | J40 | inferred 0.80 | |
| ACACIA NETWORK HOUSING INC | Bronx, NY | $347,422,708 | 2024 | L41 | published | |
| FAR NORTHERN COORDINATING COUNCIL ON DEVELOPMENTAL DISABILITIES | Redding, CA | $344,977,951 | 2024 | P11 | published | |