| GENENTECH PATIENT FOUNDATION | $3,708,338,423 | P60 | published | | S San Fran, CA | 2024 |
| WOUNDED WARRIOR PROJECT INC | $431,679,370 | P60 | published | survivor: suicide | Jacksonville, FL | 2024 |
| GIVEDIRECTLY INC | $206,811,067 | P60 | published | women: issues | New York, NY | 2024 |
| THDF II INC | $110,964,312 | P60 | published | | Atlanta, GA | 2024 |
| HELPING HAND FOR RELIEF & DEVELOPMENT INC | $89,337,007 | P60 | published | shelter: disaster | Southfield, MI | 2024 |
| SOLES 4 SOULS | $88,258,383 | P60 | published | | Nashville, TN | 2024 |
| OPERATION WARM INC | $72,989,518 | P60 | published | | Glen Mills, PA | 2025 |
| UNION RESCUE MISSION | $68,439,679 | P60 | published | launch: religious | Los Angeles, CA | 2024 |
| EMERGENCY ASSISTANCE FOUNDATION INC | $64,602,324 | P60 | published | launch: launch | West Palm Bch, FL | 2025 |
| SHARING LIFE COMMUNITY OUTREACH INC | $36,261,222 | P60 | published | | Mesquite, TX | 2024 |
| INSIGHT HOUSING | $34,105,502 | P60 | published | men: issues | Berkeley, CA | 2024 |
| CENTER FOR FOOD ACTION IN NEW JERSEY | $31,520,821 | P60 | published | | Englewood, NJ | 2024 |
| OPEN DOOR MISSION | $28,588,646 | P60 | published | launch: religious | Omaha, NE | 2024 |
| SHARE OUR SELVES CORPORATION | $28,558,566 | P60 | published | abuse: substance | Newport Beach, CA | 2024 |
| RALEIGH RESCUE MISSION INCORPORATED | $27,098,973 | P60 | published | launch: religious | Raleigh, NC | 2024 |
| MERCY CHEFS INC | $25,409,338 | P60 | published | | Portsmouth, VA | 2024 |
| OLD ORDER AMISH HELPING PROGRAM | $23,361,262 | P60 | published | | Elizabethvle, PA | 2024 |
| GALVESTON COUNTY FOOD BANK | $23,221,103 | P60 | published | | Texas City, TX | 2024 |
| UNION GOSPEL MISSION ASSOCIATION OF ST PAUL | $22,887,789 | P60 | published | launch: religious | Saint Paul, MN | 2024 |
| SHARING AND CARING HANDS INC | $22,208,504 | P60 | published | | Minneapolis, MN | 2025 |
| REAL SERVICES INC | $21,317,307 | P60 | published | abuse: elder | South Bend, IN | 2024 |
| MEMORIAL ASSISTANCE MINISTRIES INC | $20,633,795 | P60 | published | domestic violence | Houston, TX | 2024 |
| ST VINCENT DE PAUL COMMUNITY PHARMACY OF CINCINNATI | $20,548,877 | P60 | published | | Cincinnati, OH | 2024 |
| WEAVERLAND FINANCIAL AID | $20,117,099 | P60 | published | | Lititz, PA | 2024 |
| MAKE-A-WISH FOUNDATION OF METRO NEW YORK AND WESTERN NEW YORK | $19,293,645 | P60 | inferred 0.75 | | New York, NY | 2024 |
| CRISIS ASSISTANCE MINISTRY | $18,570,042 | P60 | published | | Charlotte, NC | 2024 |
| GUADALUPE CENTER INC | $17,992,372 | P60 | published | science: research education | Immokalee, FL | 2024 |
| METROCREST SERVICES | $17,439,454 | P60 | published | | Carrollton, TX | 2024 |
| PHOENIXVILLE AREA COMMUNITY SERVICES INC | $16,947,239 | P60 | published | | Phoenixville, PA | 2024 |
| WATER STREET MINISTRIES | $16,896,885 | P60 | published | shelter: homeless | Lancaster, PA | 2024 |
| FOOD BANK OF NORTHEAST ARKANSAS | $16,694,955 | P60 | published | shelter: homeless | Jonesboro, AR | 2024 |
| CHICAGO ABORTION FUND | $16,166,775 | P60 | inferred 0.70 | women: issues | Chicago, IL | 2024 |
| SUNNYVALE COMMUNITY SERVICES | $16,139,258 | P60 | published | shelter: homeless | Sunnyvale, CA | 2024 |
| GOOD PLUS FOUNDATION INC | $16,085,944 | P60 | published | space: for men | New York, NY | 2024 |
| WALGREENS ASSISTANCE INC | $15,021,036 | P60 | published | | Deerfield, IL | 2024 |
| BUCKS COUNTY OPPORTUNITY COUNCIL INC | $14,888,469 | P60 | published | | Doylestown, PA | 2024 |
| AREA IV AGENCY ON AGING AND COMMUNITY ACTION PROGRAMS INC | $14,410,908 | P60 | published | shelter: homeless | Lafayette, IN | 2024 |
| COMMUNITY CRISIS SERVICES AND FOOD BANK | $14,374,216 | P60 | published | shelter: homeless | Iowa City, IA | 2024 |
| FRY PLUMBING AND HEATING NON PROFIT | $14,316,014 | P60 | published | | Washington, DC | 2022 |
| HCA HOPE FUND | $14,146,396 | P60 | published | domestic violence | Nashville, TN | 2025 |
| LIGHT OF LIFE MINISTRIES INC | $14,118,104 | P60 | published | launch: religious | Pittsburgh, PA | 2024 |
| NORTH FULTON COMMUNITY CHARITIES INC | $13,856,821 | P60 | published | | Roswell, GA | 2024 |
| NOURISH UP | $13,797,742 | P60 | published | shelter: homeless | Charlotte, NC | 2024 |
| THE SOCIETY OF ST VINCENT DE PAUL DIOCESAN COUNCIL OF AUSTIN | $13,763,607 | P60 | inferred 0.85 | launch: religious | Austin, TX | 2024 |
| RESCUE MISSION OF TRENTON | $13,725,998 | P60 | published | launch: religious | Trenton, NJ | 2024 |
| SHEPHERD COMMUNITY INC | $13,716,624 | P60 | published | | Indianapolis, IN | 2024 |
| BLESSINGS IN A BACKPACK INC | $13,693,534 | P60 | published | | Louisville, KY | 2024 |
| RITTER CENTER | $13,160,539 | P60 | published | abuse: substance | San Rafael, CA | 2024 |
| ELEVATE CHARITIES | $13,131,509 | P60 | published | | San Juan Capo, CA | 2025 |
| CARITAS OF WACO | $13,113,737 | P60 | published | | Waco, TX | 2024 |
| TOGETHER INC OF METROPOLITIAN OMAHA | $13,030,002 | P60 | published | shelter: homeless | Omaha, NE | 2025 |
| EMERGENCY FAMILY ASSISTANCE ASSOCIATION INC | $12,773,018 | P60 | published | shelter: homeless | Boulder, CO | 2024 |
| RHODE ISLAND RESCUE MINISTRIES | $12,458,593 | P60 | published | | Providence, RI | 2024 |
| UNITED FOOD BANK AND SERVICES OF PLANT CITY INC | $12,044,278 | P60 | published | | Plant City, FL | 2024 |
| SPRINGFIELD RESCUE MISSION INC | $11,679,701 | P60 | published | launch: religious | Springfield, MA | 2024 |
| CATHEDRAL SOUP KITCHEN INC | $11,147,507 | P60 | published | shelter: homeless | Camden, NJ | 2025 |
| HOPEPHL | $11,049,296 | P60 | published | violence: gun | Philadelphia, PA | 2024 |
| COMMUNITY SERVICES LEAGUE OF JACKSON COUNTY | $10,729,037 | P60 | published | shelter: homeless | Independence, MO | 2024 |
| PUYALLUP FOOD BANK | $10,316,462 | P60 | published | | Puyallup, WA | 2024 |
| COMMUNITY SERVICES AGENCY | $10,239,009 | P60 | published | | Mountain View, CA | 2024 |
| URBAN MINISTRIES OF WAKE COUNTY INC | $10,231,914 | P60 | published | shelter: homeless | Raleigh, NC | 2024 |
| ST JOHN CENTER INC | $10,093,951 | P60 | inferred 0.85 | shelter: homeless | Louisville, KY | 2024 |
| CRISIS CONTROL MINISTRY INC | $10,036,033 | P60 | published | | Winston Salem, NC | 2024 |
| GRACEWORKS MINISTRIES INC | $9,919,950 | P60 | published | shelter: homeless | Franklin, TN | 2024 |
| FRIENDLY HOUSE INC | $9,767,246 | P60 | published | shelter: homeless | Worcester, MA | 2024 |
| FISH OF VANCOUVER | $9,629,481 | P60 | published | | Vancouver, WA | 2024 |
| RESIDENTIAL ENERGY ASSISTANCE PARTNERSHIP INC | $9,253,272 | P60 | published | | San Antonio, TX | 2024 |
| CHICAGO CHESED FUND INC | $9,162,422 | P60 | published | | Lincolnwood, IL | 2024 |
| CATIES CLOSET INC | $9,142,228 | P60 | published | | Dracut, MA | 2024 |
| CARDINAL MCINTYRE FUND FOR CHARITY | $8,882,577 | P60 | inferred 0.70 | | Los Angeles, CA | 2024 |
| LAS VEGAS RESCUE MISSION | $8,882,461 | P60 | published | launch: religious | Las Vegas, NV | 2024 |
| MID AMERICA ASSISTANCE COALITION INC | $8,876,844 | P60 | published | | Kansas City, MO | 2024 |
| OREGON COMMUNITY WAREHOUSE INC | $8,850,976 | P60 | published | domestic violence | Portland, OR | 2025 |
| NOURISHPHX | $8,796,983 | P60 | published | | Phoenix, AZ | 2024 |
| DISTRICT 7 HUMAN RESOURCES DEVELOPMENT COUNCIL | $8,778,638 | P60 | published | shelter: homeless | Billings, MT | 2024 |
| SOCIETY OF ST VINCENT DE PAUL CENTRAL COUNCIL OF PITTSBURGH | $8,564,684 | P60 | published | men: issues | West Mifflin, PA | 2024 |
| JESUS HOUSE OF HOPE INC | $8,535,131 | P60 | published | | Stuart, FL | 2024 |
| INTERFAITH ASSISTANCE MINISTRY INC | $8,516,421 | P60 | published | | Hendersonvlle, NC | 2025 |
| MY BROTHERS KEEPER INC | $8,392,874 | P60 | published | | North Easton, MA | 2024 |
| FOOD FOR OTHERS INC | $8,374,804 | P60 | published | | Fairfax, VA | 2024 |
| WASHINGTON GORGE ACTION PROGRAMS | $8,216,195 | P60 | published | abuse: substance | Bingen, WA | 2024 |
| UNITEDHEALTHCARE CHILDRENS FOUNDATION INC | $8,213,071 | P60 | published | | Minneapolis, MN | 2025 |
| COMMUNITY ACTION AGENCY OF GREATER KANSAS CITY | $8,169,858 | P60 | published | | Kansas City, MO | 2024 |
| HEALTHCARE FOR THE HOMELESS-HOUSTON | $7,937,974 | P60 | published | | Houston, TX | 2024 |
| SOUTH SUBURBAN PADS | $7,913,395 | P60 | published | shelter: homeless | Homewood, IL | 2024 |
| UNITED FOOD FORCE INC | $7,631,910 | P60 | published | | Mcdonough, GA | 2024 |
| DES MOINES AREA RELIGIOUS COUNCIL | $7,540,511 | P60 | published | space: outer | Des Moines, IA | 2024 |
| SNOWCAP COMMUNITY SERVICES | $7,478,493 | P60 | published | | Fairview, OR | 2024 |
| ARLINGTON CHARITIES INC | $7,468,931 | P60 | published | | Arlington, TX | 2025 |
| FATHERS HEART STREET MINISTRY | $7,383,877 | P60 | published | shelter: homeless | Oregon City, OR | 2024 |
| UNIVERSITY DISTRICT SERVICE LEAGUE | $7,338,158 | P60 | published | | Seattle, WA | 2024 |
| INFANT CRISIS SERVICES | $7,018,259 | P60 | published | | Oklahoma City, OK | 2025 |
| IMMERSE ARKANSAS | $6,999,955 | P60 | published | abuse: child | Little Rock, AR | 2024 |
| SOUTH COUNTY OUTREACH | $6,908,274 | P60 | inferred 0.60 | | Irvine, CA | 2024 |
| SECOND MILE MISSON CENTER | $6,890,433 | P60 | published | | Missouri City, TX | 2025 |
| NEIGHBORHOOD FOOD PANTRIES | $6,870,673 | P60 | published | | West Chicago, IL | 2024 |
| MESILLA VALLEY COMMUNITY OF HOPE INCORPORATED | $6,857,233 | P60 | published | women: issues | Las Cruces, NM | 2024 |
| RESCUE MISSION OF MIDDLE GEORGIA INC | $6,803,985 | P60 | published | violence: prevention | Macon, GA | 2024 |
| ECHO OF BRANDON INC | $6,794,267 | P60 | published | shelter: homeless | Brandon, FL | 2024 |
| AFYA FOUNDATION INC | $6,699,796 | P60 | published | | Yonkers, NY | 2024 |