| GATES FOUNDATION TRUST | $10,160,927,058 | T20 | published | | Kirkland, WA | 2024 |
| JEN-HSUN & LORI HUANG FOUNDATION | $5,930,032,620 | T20 | published | | Palo Alto, CA | 2024 |
| LILLY ENDOWMENT INC | $5,125,589,390 | T20 | inferred 0.80 | girls boys: girl scouts | Indianapolis, IN | 2025 |
| MICHAEL & SUSAN DELL FOUNDATION | $4,273,133,138 | T20 | published | space: outer | Austin, TX | 2024 |
| GORDON E AND BETTY I MOORE FOUNDATION | $2,663,649,577 | T20 | published | launch: space | Palo Alto, CA | 2024 |
| THE WELLCOME TRUST | $2,242,553,322 | T20 | inferred 0.60 | | United Kingdom | 2024 |
| THE STEPHENS GRETH FOUNDATION | $2,000,834,064 | T20 | published | | Midland, TX | 2024 |
| PETER AND CARMEN LUCIA BUCK FOUNDATION INC | $1,918,181,862 | T20 | published | science: research education | Mystic, CT | 2024 |
| BLOOMBERG FAMILY FOUNDATION INC | $1,642,529,594 | T20 | published | women: issues | New York, NY | 2024 |
| CHAN ZUCKERBERG INITIATIVE FOUNDATION | $1,494,476,554 | T20 | published | girls boys: boys | Palo Alto, CA | 2024 |
| WALTER SCOTT FAMILY FOUNDATION | $1,147,113,015 | T20 | published | | Omaha, NE | 2024 |
| WALTON FAMILY FOUNDATION INC | $1,146,415,772 | T20 | published | launch: aviation | Bentonville, AR | 2024 |
| SHERWOOD FOUNDATION | $943,412,098 | T20 | published | violence: gun | Omaha, NE | 2025 |
| HARVARD PRIVATE CAPITAL HOLDINGS INC | $895,092,664 | T20 | inferred 0.50 | | Boston, MA | 2018 |
| JOHN D & CATHERINE T MACARTHUR FOUNDATION | $890,851,721 | T20 | published | space: for women | Chicago, IL | 2024 |
| ROBERT WOOD JOHNSON FOUNDATION | $855,259,092 | T20 | published | domestic: workers | Princeton, NJ | 2024 |
| CARL VICTOR PAGE MEMORIAL FOUNDATION | $798,559,805 | T20 | published | science: research education | Palo Alto, CA | 2024 |
| RENWICK FOUNDATION-USA | $786,566,835 | T20 | published | | New York, NY | 2025 |
| H&H EVERGREEN FOUNDATION | $728,013,702 | T20 | published | | Menlo Park, CA | 2025 |
| DAVID AND LUCILE PACKARD FOUNDATION | $569,876,756 | T20 | published | science: research education | Los Altos, CA | 2024 |
| PEW MEMORIAL TRUST | $563,705,651 | T20 | inferred 0.60 | | Philadelphia, PA | 2024 |
| KNIGHT FOUNDATION | $520,024,706 | T20 | published | | Beaverton, OR | 2024 |
| LEONA M & HARRY B HELMSLEY CHARITABLE TRUST | $497,259,658 | T20 | published | shelter: disaster | New York, NY | 2024 |
| SHELBY CULLOM DAVIS CHARITABLE FUND INC | $487,136,416 | T20 | published | science: research education | Wilmington, DE | 2024 |
| LAURA AND JOHN ARNOLD FOUNDATION | $486,369,598 | T20 | published | violence: gun | Houston, TX | 2024 |
| MAXWELL HANRAHAN FOUNDATION | $481,434,879 | T20 | published | science: research education | San Francisco, CA | 2024 |
| SAROFIM FOUNDATION | $476,480,689 | T20 | published | women: issues | Houston, TX | 2024 |
| ZOOM FOUNDATION | $450,447,052 | T20 | published | women: issues | Greenwich, CT | 2024 |
| MARINE TOYS FOR TOTS FOUNDATION | $432,326,962 | T20 | published | | Triangle, VA | 2025 |
| SCHOEN FOUNDATION | $428,936,548 | T20 | inferred 0.60 | | Naples, FL | 2024 |
| GRATA VITA FOUNDATION | $427,486,022 | T20 | published | | Overland Park, KS | 2025 |
| MARGOT AND TOM PRITZKER SCIENCE FOUNDATION | $423,325,986 | T20 | published | | Sioux Falls, SD | 2024 |
| WILLIAM AND BARBARA MARTIN FOUNDATION | $418,611,637 | T20 | published | | Los Angeles, CA | 2024 |
| THE ERIC AND WENDY SCHMIDT FUND FOR STRATEGIC INNOVATION | $406,766,399 | T20 | published | launch: space | Palo Alto, CA | 2024 |
| STOLLER FOUNDATION | $376,713,820 | T20 | published | | Houston, TX | 2024 |
| TRUBOB FUND | $374,222,133 | T20 | published | | New York, NY | 2024 |
| DUKE ENDOWMENT | $370,592,635 | T20 | inferred 0.80 | girls boys: girls | Charlotte, NC | 2024 |
| SEQUOIA CLIMATE FOUNDATION | $367,685,730 | T20 | published | | Irvine, CA | 2023 |
| VIZO FINANCIAL CORPORATE CREDIT UNION | $342,674,561 | T20 | inferred 0.60 | | Middletown, PA | 2024 |
| THE TEPPER FOUNDATION | $328,766,599 | T20 | published | | New York, NY | 2024 |
| CARL ANGUS DESANTIS FOUNDATION INC | $305,128,072 | T20 | published | | Delray Beach, FL | 2024 |
| PUFFIN BAY FOUNDATION | $301,277,374 | T20 | published | | Biddeford, ME | 2025 |
| POINT REYES FOUNDATION INC | $300,951,652 | T20 | published | | Roseland, NJ | 2024 |
| CHARLES AND LYNN SCHUSTERMAN FAMILY FOUNDATION | $294,559,250 | T20 | published | | Tulsa, OK | 2024 |
| WAVERLEY STREET FOUNDATION | $290,111,328 | T20 | published | | Palo Alto, CA | 2024 |
| DOGWOOD HEALTH TRUST | $238,690,769 | T20 | published | abuse: elder | Asheville, NC | 2024 |
| BANK OF AMERICA CHARITABLE FOUNDATION INC | $218,843,611 | T20 | published | | Charlotte, NC | 2024 |
| CINELLI FAMILY FOUNDATION | $214,182,072 | T20 | published | | Lawrence, KS | 2024 |
| RICHARD KING MELLON FOUNDATION DTD 01-01-47 | $210,921,643 | T20 | published | launch: space | Ligonier, PA | 2024 |
| PATTERSON FAMILY FOUNDATION | $206,307,740 | T20 | published | | Kansas City, MO | 2024 |
| SMILOW FOUNDATION INC | $200,995,119 | T20 | published | | Wilmington, DE | 2024 |
| GENE HAAS FOUNDATION | $195,110,093 | T20 | published | | Oxnard, CA | 2024 |
| JARVIS FOUNDATION | $188,789,753 | T20 | published | | Northbrook, IL | 2025 |
| ALLEN FAMILY PHILANTHROPIES | $180,688,400 | T20 | published | space: outer | Seattle, WA | 2024 |
| TRUIST FOUNDATION INC | $179,189,277 | T20 | published | | Orlando, FL | 2024 |
| SIMONS FOUNDATION INC | $171,400,960 | T20 | published | space: outer | New York, NY | 2024 |
| LEON AND TOBY COOPERMAN FAMILY FOUNDATION | $170,745,366 | T20 | inferred 0.80 | | Boca Raton, FL | 2024 |
| ROBERT & JANICE MCNAIR FOUNDATION | $169,030,389 | T20 | inferred 0.70 | launch: aviation | Houston, TX | 2024 |
| BARBARA NEWINGTON FOUNDATION | $166,412,822 | T20 | published | | Palm Beach, FL | 2025 |
| JOY UNSPEAKABLE FOUNDATION | $165,864,424 | T20 | published | violence: community | Charleston, SC | 2024 |
| HOUSTON ENDOWMENT INC | $160,328,117 | T20 | published | violence: sexual | Houston, TX | 2024 |
| FONDAZIONE CASSA DI RISPARMIO DI FIRENZE | $154,661,493 | T20 | published | science: research education | Italy | 2024 |
| THE CHASE AND STEPHANIE COLEMAN FOUNDATION | $150,834,460 | T20 | published | | New York, NY | 2024 |
| JOHN & TAMI MARICK FOUNDATION INC | $149,149,268 | T20 | published | science: research education | Wilmington, DE | 2024 |
| HUNTER FAMILY FOUNDATION | $148,386,207 | T20 | published | science: research education | Chicago, IL | 2024 |
| FOUNDERS PLEDGE INC | $144,636,466 | T20 | published | science: research education | New York, NY | 2024 |
| NORCLIFFE FOUNDATION | $140,494,753 | T20 | inferred 0.80 | space: outer | Seattle, WA | 2024 |
| ROOTS AND WINGS FOUNDATION INC | $136,161,197 | T20 | published | violence: gun | Seattle, WA | 2024 |
| DUNARD FUND LTD | $135,006,531 | T20 | inferred 0.60 | | Northbrook, IL | 2024 |
| DISTRIBUTION COOPERATIVE INC | $129,740,919 | T20 | published | | Mc Donough, GA | 2024 |
| BETTY WOLD JOHNSON FOUNDATION | $129,171,070 | T20 | published | | West Palm Bch, FL | 2024 |
| MUNGER CHARITABLE TR NUMBER EIGHT | $128,699,032 | T20 | published | | Pasadena, CA | 2024 |
| MUNGER CHARITABLE TR NUMBER ONE | $128,383,529 | T20 | published | | Pasadena, CA | 2024 |
| MUNGER CHARITABLE TR NUMBER SIX | $128,383,034 | T20 | published | | Pasadena, CA | 2024 |
| MUNGER CHARITABLE TR NUMBER FOUR | $128,382,977 | T20 | published | | Pasadena, CA | 2024 |
| ROB AND MELANI WALTON FOUNDATION | $125,815,076 | T20 | published | girls boys: girl scouts | Bentonville, AR | 2024 |
| ABBVIE FOUNDATION | $125,199,092 | T20 | published | girls boys: girls | North Chicago, IL | 2025 |
| THE WALLACE FOUNDATION | $124,078,120 | T20 | published | girls boys: boys girls clubs | New York, NY | 2024 |
| GIVE FORWARD FOUNDATION | $122,811,160 | T20 | published | | San Francisco, CA | 2024 |
| STOWERS FOUNDATION | $122,427,069 | T20 | published | abuse: child | Leawood, KS | 2024 |
| HELEN AND SANFORD DILLER FAMILY FOUNDATION | $121,447,642 | T20 | published | | San Mateo, CA | 2024 |
| 199 PHILANTHROPIC FUND | $120,314,561 | T20 | published | | New York, NY | 2024 |
| KARSH FAMILY FOUNDATION | $119,543,750 | T20 | published | women: issues | Beverly Hills, CA | 2025 |
| ENDLESS SUCCESS FOUNDATION INC | $119,021,163 | T20 | published | | Indianapolis, IN | 2024 |
| J HOWARD PEW FREEDOM TR | $116,614,774 | T20 | published | | Philadelphia, PA | 2024 |
| SILVER FAMILY FOUNDATION | $115,459,845 | T20 | published | abuse: child | Portland, OR | 2024 |
| THE SAMUEL ROBERTS NOBLE FOUNDATION | $114,212,278 | T20 | published | girls boys: girl scouts | Ardmore, OK | 2024 |
| CHARITYVEST INC | $113,380,722 | T20 | published | | Fairfield, CT | 2024 |
| THE UNITED METHODIST RETIREMENT HOMES INC | $113,193,566 | T20 | published | | Durham, NC | 2024 |
| THE BAT HANADIV FOUNDATION NO 3 | $111,116,023 | T20 | published | | New York, NY | 2024 |
| THE AYCO CHARITABLE FOUNDATION | $111,086,243 | T20 | inferred 0.80 | science: research education | Cohoes, NY | 2025 |
| STEPHEN AND RENEE BISCIOTTI FOUNDATION INC | $109,650,698 | T20 | published | | Baltimore, MD | 2024 |
| DIETRICH FOUNDATION | $107,295,535 | T20 | published | girls boys: boy scouts | Pittsburgh, PA | 2024 |
| THE HEINZ ENDOWMENTS | $105,097,047 | T20 | published | space: for women | Pittsburgh, PA | 2024 |
| HALL FAMILY FOUNDATION | $102,807,352 | T20 | published | | Kansas City, MO | 2024 |
| THE RICHARD M SCHULZE FAMILY FOUNDATION | $102,779,990 | T20 | published | | Minneapolis, MN | 2024 |
| KINDER FOUNDATION | $102,263,053 | T20 | published | | Houston, TX | 2025 |
| DORIS DUKE CHARITABLE FOUNDATION INC | $101,724,041 | T20 | published | violence: prevention | New York, NY | 2024 |
| ASBJORNSON FOUNDATION | $101,566,288 | T20 | published | | Tulsa, OK | 2024 |
| BLUE HORIZONS FOUNDATION | $100,814,828 | T20 | published | | Gorham, ME | 2024 |