| NATIONAL PHILANTHROPIC TR | $17,794,939,562 | T50 | published | abuse: child | Jenkintown, PA | 2024 |
| DONOR ADVISED CHARITABLE GIVING | $11,676,597,614 | T30 | published | violence: community | Lone Tree, CO | 2024 |
| GATES FOUNDATION TRUST | $10,160,927,058 | T20 | published | | Kirkland, WA | 2024 |
| GATES FOUNDATION | $8,084,056,958 | T22 | published | shelter: disaster | Seattle, WA | 2024 |
| PIVOTAL PHILANTHROPIES FOUNDATION | $7,604,936,235 | T22 | published | survivor: sexual | Redmond, WA | 2024 |
| VANGUARD CHARITABLE ENDOWMENT PROGRAM | $6,666,887,642 | T70 | published | | Malvern, PA | 2024 |
| GS DONOR ADVISED PHILANTHROPY FUND FOR WEALTH MANAGEMENT INC | $6,592,899,306 | T30 | published | girls boys: boys | New York, NY | 2024 |
| JEN-HSUN & LORI HUANG FOUNDATION | $5,930,032,620 | T20 | published | | Palo Alto, CA | 2024 |
| LILLY ENDOWMENT INC | $5,125,589,390 | T20 | inferred 0.80 | girls boys: girl scouts | Indianapolis, IN | 2025 |
| SILICON VALLEY COMMUNITY FOUNDATION | $4,889,245,872 | T31 | published | launch: religious | Mountain View, CA | 2024 |
| MICHAEL & SUSAN DELL FOUNDATION | $4,273,133,138 | T20 | published | space: outer | Austin, TX | 2024 |
| NOVO HOLDINGS A-S | $3,542,774,981 | T99 | published | | Denmark | 2024 |
| NATIONAL CHRISTIAN CHARITABLE FOUNDATION | $3,300,091,756 | T30 | published | domestic violence | Alpharetta, GA | 2024 |
| FUND FOR SCIENCE AND TECHNOLOGY | $3,157,814,947 | T22 | published | | Seattle, WA | 2024 |
| MORGAN STANLEY GLOBAL IMPACT FUNDING TRUST INC | $3,082,075,235 | T90 | published | science: research education | Westfield, NY | 2024 |
| A D F COMMUNITY OUTREACH FOUNDATION INC | $2,878,868,000 | T50 | published | | Mechanicsvlle, MD | 2025 |
| THE SUSAN THOMPSON BUFFETT FOUNDATION | $2,731,854,610 | T22 | published | | Omaha, NE | 2025 |
| GORDON E AND BETTY I MOORE FOUNDATION | $2,663,649,577 | T20 | published | launch: space | Palo Alto, CA | 2024 |
| GOOD VENTURES FOUNDATION | $2,597,571,672 | T22 | published | science: research education | Palo Alto, CA | 2024 |
| AMERICAN ONLINE GIVING FOUNDATION INC | $2,503,754,849 | T30 | published | | Newark, DE | 2025 |
| RENAISSANCE CHARITABLE FOUNDATION INC | $2,436,033,430 | T12 | published | | Indianapolis, IN | 2024 |
| THE WELLCOME TRUST | $2,242,553,322 | T20 | inferred 0.60 | | United Kingdom | 2024 |
| THE CHICAGO COMMUNITY TRUST | $2,143,553,763 | T31 | published | survivor: suicide | Chicago, IL | 2024 |
| THE STEPHENS GRETH FOUNDATION | $2,000,834,064 | T20 | published | | Midland, TX | 2024 |
| PETER AND CARMEN LUCIA BUCK FOUNDATION INC | $1,918,181,862 | T20 | published | science: research education | Mystic, CT | 2024 |
| MERCK PATIENT ASSISTANCE PROGRAM INC | $1,911,974,863 | T21 | published | | Rahway, NJ | 2024 |
| AMERICAN ENDOWMENT FOUNDATION | $1,891,313,285 | T31 | published | science: research education | Hudson, OH | 2024 |
| BANK OF AMERICA CHARITABLE GIFT FUND | $1,664,401,095 | T70 | published | | Boston, MA | 2024 |
| BLOOMBERG FAMILY FOUNDATION INC | $1,642,529,594 | T20 | published | women: issues | New York, NY | 2024 |
| CHAN ZUCKERBERG INITIATIVE FOUNDATION | $1,494,476,554 | T20 | published | girls boys: boys | Palo Alto, CA | 2024 |
| MOODY FOUNDATION | $1,432,337,894 | T22 | published | survivor: suicide | Galveston, TX | 2024 |
| THE SAROFIM FOUNDATION | $1,389,259,579 | T22 | inferred 0.60 | science: research education | Houston, TX | 2023 |
| NOVO NORDISK FONDEN | $1,362,313,838 | T12 | published | science: research education | Denmark | 2024 |
| JEWISH COMMUNAL FUND | $1,337,028,835 | T70 | published | | New York, NY | 2024 |
| FIDELITY FOUNDATION | $1,327,179,367 | T22 | inferred 0.60 | science: research education | Boston, MA | 2024 |
| PATTERSON FAMILY FOUNDATION | $1,174,628,172 | T22 | inferred 0.60 | men: issues | Kansas City, MO | 2021 |
| WALTER SCOTT FAMILY FOUNDATION | $1,147,113,015 | T20 | published | | Omaha, NE | 2024 |
| FORD FOUNDATION | $1,147,097,733 | T21 | published | domestic: workers | New York, NY | 2024 |
| WALTON FAMILY FOUNDATION INC | $1,146,415,772 | T20 | published | launch: aviation | Bentonville, AR | 2024 |
| FREEDOM TOGETHER FOUNDATION | $1,132,105,563 | T21 | published | domestic: workers | New York, NY | 2024 |
| THE LEON LEVINE FOUNDATION | $1,119,307,403 | T21 | inferred 0.60 | science: research education | Charlotte, NC | 2024 |
| CHARITIES AID FOUNDATION AMERICA | $1,059,508,784 | T30 | published | | Alexandria, VA | 2024 |
| SIGNATRY CHARITABLE TRUST | $1,038,691,653 | T11 | published | | Sioux Falls, SD | 2024 |
| FOSTER CHARITABLE TRUST | $1,000,000,000 | T99 | inferred 0.45 | | Marina Del Rey, CA | 2023 |
| SERGEY BRIN FAMILY FOUNDATION | $985,621,463 | T22 | published | shelter: disaster | San Francisco, CA | 2024 |
| HOWARD G BUFFETT FOUNDATION | $964,734,519 | T99 | published | violence: community | Decatur, IL | 2025 |
| PIVOTAL PHILANTHROPIES OPPORTUNITY FOUNDATION | $955,644,953 | T22 | published | | Redmond, WA | 2024 |
| PIVOTAL PHILANTHROPIES PATHWAYS FOU NDATION | $955,633,753 | T22 | published | | Redmond, WA | 2024 |
| PIVOTAL PHILANTHROPIES MOMENTUM FOUNDATION | $955,633,407 | T22 | published | | Redmond, WA | 2024 |
| RAYMOND JAMES CHARITABLE ENDOWMENT FUND | $955,087,502 | T30 | published | launch: aviation | St Petersburg, FL | 2024 |
| SHERWOOD FOUNDATION | $943,412,098 | T20 | published | violence: gun | Omaha, NE | 2025 |
| FOUNDATION TO PROMOTE OPEN SOCIETY | $935,043,439 | T22 | published | domestic: workers | New York, NY | 2024 |
| W K KELLOGG FOUNDATION TRUST-T/A 5315 | $918,847,590 | T21 | published | | Battle Creek, MI | 2024 |
| HARVARD PRIVATE CAPITAL HOLDINGS INC | $895,092,664 | T20 | inferred 0.50 | | Boston, MA | 2018 |
| JOHN D & CATHERINE T MACARTHUR FOUNDATION | $890,851,721 | T20 | published | space: for women | Chicago, IL | 2024 |
| GLAXOSMITHKLINE PATIENT ACCESS PROGRAMS FOUNDATION | $868,148,691 | T23 | published | | Philadelphia, PA | 2025 |
| PAUL M ANGELL FAMILY FOUNDATION | $866,996,211 | T22 | published | | Chicago, IL | 2024 |
| ROBERT WOOD JOHNSON FOUNDATION | $855,259,092 | T20 | published | domestic: workers | Princeton, NJ | 2024 |
| PAYPAL CHARITABLE GIVING FUND | $813,412,937 | T30 | published | | Washington, DC | 2024 |
| CARL VICTOR PAGE MEMORIAL FOUNDATION | $798,559,805 | T20 | published | science: research education | Palo Alto, CA | 2024 |
| RENWICK FOUNDATION-USA | $786,566,835 | T20 | published | | New York, NY | 2025 |
| WILLIAM & FLORA HEWLETT FOUNDATION | $784,700,540 | T21 | published | domestic: workers | Menlo Park, CA | 2024 |
| GREATER KANSAS CITY COMMUNITY FOUNDATION | $781,787,887 | T31 | published | science: research education | Kansas City, MO | 2024 |
| J PAUL GETTY TRUST | $767,436,645 | T23 | published | | Los Angeles, CA | 2024 |
| FOUNDATION FOR THE CAROLINAS | $761,389,623 | T31 | published | shelter: animal | Charlotte, NC | 2024 |
| GREATER HORIZONS | $754,144,636 | T11 | published | shelter: homeless | Kansas City, MO | 2024 |
| S & G FOUNDATION | $743,968,400 | T22 | published | | Albany, NY | 2024 |
| H&H EVERGREEN FOUNDATION | $728,013,702 | T20 | published | | Menlo Park, CA | 2025 |
| ALICE L WALTON FOUNDATION | $721,949,474 | T22 | published | shelter: homeless | Bentonville, AR | 2024 |
| ROCKEFELLER PHILANTHROPY ADVISORS INC | $706,026,148 | T50 | published | abuse: sexual | New York, NY | 2024 |
| IMPACTASSETS INC | $680,266,004 | T70 | published | science: christian science | Bethesda, MD | 2024 |
| THE MA-RAN FOUNDATION | $673,837,712 | T22 | inferred 0.60 | | Atlanta, GA | 2024 |
| LETTIE PATE EVANS FOUNDATION INC TRUSTEE OF THE RESTRICTED FUND UW | $665,581,251 | T90 | published | | Atlanta, GA | 2025 |
| DONORS FUND INC | $663,839,363 | T30 | published | science: research education | Lakewood, NJ | 2024 |
| ROBERT W WOODRUFF FOUNDATION INC | $632,382,206 | T21 | published | shelter: animal | Atlanta, GA | 2025 |
| CONRAD N HILTON FOUNDATION | $619,701,927 | T22 | published | domestic: workers | Westlake Vlg, CA | 2024 |
| DAVID AND LUCILE PACKARD FOUNDATION | $569,876,756 | T20 | published | science: research education | Los Altos, CA | 2024 |
| PEW MEMORIAL TRUST | $563,705,651 | T20 | inferred 0.60 | | Philadelphia, PA | 2024 |
| GEORGE KAISER FAMILY FOUNDATION | $549,695,640 | T11 | published | girls boys: girl scouts | Tulsa, OK | 2024 |
| MARCUS FOUNDATION INC | $547,934,030 | T22 | inferred 0.60 | | Atlanta, GA | 2024 |
| THE BLACKBAUD GIVING FUND | $545,823,387 | T12 | published | science: research education | Daniel Island, SC | 2025 |
| GEORGE AND BEVERLY RAWLINGS ENDOWMENT FOUNDATION INC | $543,702,980 | T22 | published | shelter: animal | Lagrange, KY | 2024 |
| APELLA HEALTH MANAGEMENT INC | $524,676,090 | T11 | published | | Spartanburg, SC | 2024 |
| KNIGHT FOUNDATION | $520,024,706 | T20 | published | | Beaverton, OR | 2024 |
| VOLKSWAGEN-STIFTUNG | $512,061,151 | T21 | published | science: research education | Salt Lake Cty, UT | 2024 |
| JEWISH COMMUNITY FEDERATION OF S F MARIN PENINSULA & SONOMA COUNTIES | $505,170,712 | T70 | published | | San Francisco, CA | 2024 |
| LEONA M & HARRY B HELMSLEY CHARITABLE TRUST | $497,259,658 | T20 | published | shelter: disaster | New York, NY | 2024 |
| ARIE AND IDA CROWN MEMORIAL | $496,729,479 | T22 | inferred 0.60 | | Chicago, IL | 2024 |
| DECHOMAI FOUNDATION INC | $494,612,669 | T70 | published | | Jacksonville, FL | 2024 |
| SHELBY CULLOM DAVIS CHARITABLE FUND INC | $487,136,416 | T20 | published | science: research education | Wilmington, DE | 2024 |
| LAURA AND JOHN ARNOLD FOUNDATION | $486,369,598 | T20 | published | violence: gun | Houston, TX | 2024 |
| MAXWELL HANRAHAN FOUNDATION | $481,434,879 | T20 | published | science: research education | San Francisco, CA | 2024 |
| SUZANNE AND WALTER SCOTT FOUNDATION | $480,205,807 | T90 | published | | Omaha, NE | 2024 |
| SAROFIM FOUNDATION | $476,480,689 | T20 | published | women: issues | Houston, TX | 2024 |
| NOVO FOUNDATION | $473,629,747 | T99 | published | domestic: workers | Hurley, NY | 2024 |
| PEW CHARITABLE TRUSTS | $467,971,224 | T30 | published | | Washington, DC | 2024 |
| DECHOMAI ASSET TRUST | $459,598,859 | T30 | published | | Jacksonville, FL | 2024 |
| ZOOM FOUNDATION | $450,447,052 | T20 | published | women: issues | Greenwich, CT | 2024 |
| XIE FOUNDATION | $438,452,054 | T22 | published | | Sunnyvale, CA | 2024 |
| W K KELLOGG FOUNDATION | $435,271,895 | T21 | published | domestic: workers | Battle Creek, MI | 2024 |