| SUTTER BAY MEDICAL FOUNDATION | $4,059,293,628 | H90 | published | survivor: cancer | Sacramento, CA | 2024 |
| DANA-FARBER CANCER INSTITUTE | $3,917,771,259 | H30 | published | survivor: cancer | Boston, MA | 2024 |
| GLOBAL FUND TO FIGHT AIDS TUBERCULOSIS AND MALARIA | $3,542,069,209 | H81 | published | | Switzerland | 2024 |
| HOWARD HUGHES MEDICAL INSTITUTE | $2,004,784,057 | H92 | published | space: outer | Chevy Chase, MD | 2024 |
| HEALTH RESEARCH INCORPORATED ELIZABETH WOOD | $912,790,717 | H30 | published | survivor: disaster | Menands, NY | 2025 |
| BROAD INSTITUTE INC | $846,134,426 | H20 | published | science: research education | Cambridge, MA | 2024 |
| MICHAEL J FOX FOUNDATION FOR PARKINSONS RESEARCH | $708,298,921 | H48 | published | science: research education | New York, NY | 2025 |
| SCRIPPS RESEARCH INSTITUTE | $698,624,318 | H92 | published | science: research education | La Jolla, CA | 2024 |
| JACKSON LABORATORY | $652,542,607 | H92 | published | abuse: substance | Bar Harbor, ME | 2024 |
| WELLCOME LEAP INC | $623,665,756 | H12 | published | abuse: substance | San Diego, CA | 2024 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | $616,261,455 | H12 | published | science: research education | Bethesda, MD | 2024 |
| AMERICAN MEDICAL ASSOCIATION | $546,239,123 | H99 | inferred 0.80 | violence: gun | Chicago, IL | 2024 |
| INSTITUT PASTEUR | $409,245,392 | H99 | inferred 0.70 | science: research education | France | 2025 |
| BECKMAN RESEARCH INSTITUTE | $332,532,052 | H30 | published | science: research education | Duarte, CA | 2024 |
| PUBLIC HEALTH SOLUTIONS | $325,747,738 | H00 | published | violence: gun | New York, NY | 2025 |
| RIVERSIDE RESEARCH INSTITUTE | $286,600,214 | H05 | published | science: research education | Fairfax, VA | 2025 |
| ALLEN INSTITUTE | $272,058,206 | H96 | published | science: research education | Seattle, WA | 2024 |
| WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | $222,267,487 | H92 | published | science: research education | Cambridge, MA | 2024 |
| CHDI FOUNDATION INC | $208,882,180 | H12 | published | | Roseland, NJ | 2024 |
| DANA FARBER MASS GENERAL BRIGHAM CANCER CARE INC | $171,278,142 | H30 | published | | Boston, MA | 2024 |
| THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH | $163,308,471 | H90 | published | science: research education | Westbury, NY | 2024 |
| GREATER DELAWARE VALLEY SOCIETY OF TRANSPLANT SURGEONS | $152,878,717 | H9B | published | men: issues | Phila, PA | 2024 |
| THE RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE | $144,438,827 | H99 | inferred 0.80 | | Canada | 2025 |
| ASSOCIATION OF PUBLIC HEALTH LABORATORIES INC | $142,195,492 | H99 | inferred 0.70 | science: research education | Bethesda, MD | 2024 |
| ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION | $138,028,470 | H81 | published | women: issues | Washington, DC | 2024 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $136,776,829 | H92 | published | science: research education | Oklahoma City, OK | 2024 |
| THE MEDICAL UNIVERSITY OF SOUTH CAROLINA FOUNDATION | $136,664,063 | H90 | published | science: research education | Charleston, SC | 2024 |
| AMERICAN ASSOCIATION FOR CANCER RESEARCH | $129,520,731 | H30 | published | survivor: cancer | Philadelphia, PA | 2025 |
| ARC RESEARCH INSTITUTE | $122,280,682 | H99 | published | | Palo Alto, CA | 2024 |
| J DAVID GLADSTONE INSTITUTES | $119,155,911 | H90 | published | science: research education | San Francisco, CA | 2024 |
| SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | $114,401,821 | H92 | published | survivor: cancer | La Jolla, CA | 2024 |
| VAN ANDEL RESEARCH INSTITUTE | $112,738,485 | H30 | published | survivor: cancer | Grand Rapids, MI | 2023 |
| CHILDRENS RESEARCH INSTITUTE | $109,384,265 | H98 | published | science: research education | Washington, DC | 2024 |
| CITRUS RESEARCH AND DEVELOPMENT FOUNDATION INC | $105,546,288 | H99 | inferred 0.70 | science: research education | Lake Alfred, FL | 2025 |
| STOWERS INSTITUTE FOR MEDICAL RESEARCH | $102,011,512 | H92 | published | survivor: cancer | Kansas City, MO | 2024 |
| CHAN ZUCKERBERG BIOHUB INC | $99,552,025 | H99 | published | launch: launch | Redwood City, CA | 2024 |
| California Institute for BioMedical | $98,797,059 | H99 | inferred 0.80 | science: research education | La Jolla, CA | 2017 |
| HEALTH RESOURCES IN ACTION INC | $96,369,217 | H05 | inferred 0.55 | violence: gun | Boston, MA | 2024 |
| LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL | $94,550,669 | H90 | published | women: issues | Torrance, CA | 2024 |
| INSTITUTE FOR CANCER RESEARCH | $94,545,853 | H30 | published | science: research education | Philadelphia, PA | 2024 |
| THE GOG FOUNDATION INC | $92,424,680 | H30 | published | science: research education | Edgewater, MD | 2025 |
| BAYLOR RESEARCH INSTITUTE | $89,491,341 | H90 | published | science: research education | Dallas, TX | 2024 |
| MORGRIDGE INSTITUTE FOUNDATION INC | $84,878,840 | H11 | published | | Madison, WI | 2024 |
| PARKINSONS FOUNDATION INC | $84,182,191 | H80 | published | science: research education | New York, NY | 2024 |
| LA JOLLA INSTITUTE FOR IMMUNOLOGY | $84,154,783 | H99 | inferred 0.85 | science: research education | La Jolla, CA | 2024 |
| LOVELACE BIOMEDICAL RESEARCH INSTITUTE | $83,397,041 | H92 | published | | Albuquerque, NM | 2024 |
| PARALYZED VETERANS OF AMERICA | $83,222,092 | H50 | published | science: research education | Washington, DC | 2024 |
| BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON | $81,277,408 | H92 | published | science: research education | Seattle, WA | 2024 |
| LICR FUND INC | $79,026,554 | H11 | published | science: research education | New York, NY | 2024 |
| FOUNDATION FOR THE NATIONAL INSTITUTE OF HEALTH INC | $78,507,209 | H92 | published | survivor: cancer | Rockville, MD | 2024 |
| INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | $77,723,739 | H99 | inferred 0.80 | science: research education | Bangladesh | 2024 |
| FUTURE CRYONICS FOUNDATION | $77,473,702 | H99 | published | science: research education | Cedar Rapids, IA | 2024 |
| THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY | $77,322,000 | H30 | published | science: research education | Philadelphia, PA | 2025 |
| TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | $75,913,310 | H90 | published | launch: launch | Phoenix, AZ | 2024 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | $75,183,345 | H40 | published | | San Antonio, TX | 2024 |
| ARKANSAS CHILDRENS HOSPITAL RESEARCH INSTITUTE | $71,774,036 | H99 | inferred 0.85 | science: research education | Little Rock, AR | 2024 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION INC | $69,153,222 | H00 | published | | San Francisco, CA | 2024 |
| CARDIOVASCULAR RESEARCH FOUNDATION | $68,904,326 | H20 | published | science: research education | New York, NY | 2024 |
| PHILADELPHIA FIGHT | $68,330,571 | H20 | published | | Philadelphia, PA | 2024 |
| AFFINITY PARTNERS NETWORK INC | $67,435,758 | H12 | published | | Jamesburg, NJ | 2024 |
| TRILOGY INC | $66,120,949 | H99 | inferred 0.60 | abuse: substance | Chicago, IL | 2024 |
| STANLEY MANNE CHILDRENS RESEARCH INSTITUTE | $65,057,786 | H11 | published | survivor: cancer | Chicago, IL | 2024 |
| GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT INC | $63,732,557 | H80 | published | science: research education | New York, NY | 2024 |
| LUDWIG INSTITUTE FOR CANCER RESEARCH | $63,043,209 | H30 | inferred 0.80 | launch: launch | New York, NY | 2024 |
| THE V FOUNDATION | $61,639,637 | H12 | published | science: research education | Cary, NC | 2024 |
| ALZHEIMERS DISEASE RESEARCH FOUNDATION | $56,659,835 | H83 | published | science: research education | Wellesley Hls, MA | 2025 |
| ABBOTT FUND | $55,570,056 | H99 | inferred 0.50 | abuse: sexual | Abbott Park, IL | 2024 |
| HENNEPIN HEALTHCARE RESEARCH INSTITUTE | $54,717,221 | H90 | published | abuse: substance | Minneapolis, MN | 2024 |
| DEAN MCGEE EYE INSTITUTE | $53,585,210 | H41 | published | | Oklahoma City, OK | 2024 |
| GEORGE S ECCLES AND DELORES DORE ECCLES FOUNDATION | $52,369,983 | H99 | inferred 0.60 | survivor: sexual | Salt Lake Cty, UT | 2024 |
| LIONS WORLD VISION INSTITUTE INC | $52,217,947 | H20 | inferred 0.80 | | Tampa, FL | 2024 |
| HUNTSMAN CANCER FOUNDATION | $51,876,352 | H11 | published | survivor: cancer | Salt Lake Cty, UT | 2024 |
| Massachusetts Biomedical Research Corporation | $51,245,924 | H05 | inferred 0.80 | science: research education | Charlestown, MA | 2009 |
| FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS FIND | $49,306,331 | H80 | published | women: issues | Switzerland | 2024 |
| AMERICAN COLLEGE OF CHEST PHYSICIANS | $48,404,043 | H99 | inferred 0.80 | science: research education | Glenview, IL | 2025 |
| SIR MORTIMER B DAVIS JEWISH GENERAL HOSPITAL | $47,967,963 | H99 | inferred 0.70 | | Canada | 2024 |
| CRITICAL PATH INSTITUTE | $46,783,745 | H99 | published | launch: launch | Tucson, AZ | 2024 |
| GARY AND MARY WEST HEALTH INSTITUTE | $44,564,569 | H92 | published | abuse: elder | La Jolla, CA | 2024 |
| ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY FOUNDATION | $44,527,686 | H31 | published | | Chicago, IL | 2024 |
| HENDERSON-WESSENDORFF FOUNDATION | $44,288,793 | H99 | inferred 0.45 | girls boys: girl scouts | Richmond, TX | 2024 |
| NSABP FOUNDATION INC | $44,121,085 | H30 | published | science: research education | Pittsburgh, PA | 2024 |
| CENTRE COUNTY CANCER CENTER | $43,304,913 | H30 | published | | State College, PA | 2024 |
| DELTA HEALTH ALLIANCE INC | $41,800,985 | H12 | published | | Stoneville, MS | 2024 |
| CONQUER CANCER FDN OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY | $41,435,619 | H11 | published | survivor: cancer | Alexandria, VA | 2024 |
| AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH INC | $41,229,959 | H03 | published | science: research education | Linthicum, MD | 2025 |
| NATIONAL BLOOD TESTING PARTNERS INC | $41,109,844 | H19 | inferred 0.50 | | Stone Mountain, GA | 2024 |
| LEDUCQ FOUNDATION FOR CARDIOVASCULAR RESEARCH | $40,540,832 | H43 | published | | Houston, TX | 2024 |
| COLORADO PREVENTION CENTER | $39,223,624 | H05 | published | science: research education | Aurora, CO | 2024 |
| INTERNATIONAL BRAIN RESEARCH ORGANIZATION | $37,244,420 | H03 | published | science: research education | New York, NY | 2024 |
| JOHN P MCGOVERN FOUNDATION | $37,128,352 | H20 | inferred 0.55 | women: issues | Houston, TX | 2024 |
| SOCIETY FOR NEUROSCIENCE | $36,716,820 | H03 | published | science: research education | Washington, DC | 2024 |
| FOUNDATION FIGHTING BLINDNESS INC | $36,615,169 | H41 | published | science: research education | Columbia, MD | 2024 |
| BLISS CARES INC | $36,602,971 | H81 | published | | Orlando, FL | 2024 |
| PALO ALTO VETERANS INSTITUTE FOR RESEARCH | $35,854,131 | H00 | published | violence: community | Palo Alto, CA | 2024 |
| CANCER RESEARCH INSTITUTE INC | $35,485,656 | H30 | published | science: research education | New York, NY | 2024 |
| NRG ONCOLOGY FOUNDATION INC | $35,451,240 | H30 | published | | Pittsburgh, PA | 2024 |
| EVERY CURE INC | $34,822,357 | H99 | published | | Philadelphia, PA | 2025 |
| THE FOUNDATION FOR AIDS RESEARCH | $34,783,944 | H81 | published | violence: sexual | New York, NY | 2024 |
| TRANSCELERATE BIOPHARMA INC | $34,242,546 | H99 | published | launch: launch | West Conshohocken, PA | 2025 |
| EVERSIGHT | $34,039,876 | H20 | inferred 0.82 | launch: religious | Ann Arbor, MI | 2024 |