| DANA-FARBER CANCER INSTITUTE | $3,917,771,259 | H30 | published | survivor: cancer | Boston, MA | 2024 |
| HEALTH RESEARCH INCORPORATED ELIZABETH WOOD | $912,790,717 | H30 | published | survivor: disaster | Menands, NY | 2025 |
| BECKMAN RESEARCH INSTITUTE | $332,532,052 | H30 | published | science: research education | Duarte, CA | 2024 |
| DANA FARBER MASS GENERAL BRIGHAM CANCER CARE INC | $171,278,142 | H30 | published | | Boston, MA | 2024 |
| AMERICAN ASSOCIATION FOR CANCER RESEARCH | $129,520,731 | H30 | published | survivor: cancer | Philadelphia, PA | 2025 |
| VAN ANDEL RESEARCH INSTITUTE | $112,738,485 | H30 | published | survivor: cancer | Grand Rapids, MI | 2023 |
| INSTITUTE FOR CANCER RESEARCH | $94,545,853 | H30 | published | science: research education | Philadelphia, PA | 2024 |
| THE GOG FOUNDATION INC | $92,424,680 | H30 | published | science: research education | Edgewater, MD | 2025 |
| THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY | $77,322,000 | H30 | published | science: research education | Philadelphia, PA | 2025 |
| LUDWIG INSTITUTE FOR CANCER RESEARCH | $63,043,209 | H30 | inferred 0.80 | launch: launch | New York, NY | 2024 |
| NSABP FOUNDATION INC | $44,121,085 | H30 | published | science: research education | Pittsburgh, PA | 2024 |
| CENTRE COUNTY CANCER CENTER | $43,304,913 | H30 | published | | State College, PA | 2024 |
| CANCER RESEARCH INSTITUTE INC | $35,485,656 | H30 | published | science: research education | New York, NY | 2024 |
| NRG ONCOLOGY FOUNDATION INC | $35,451,240 | H30 | published | | Pittsburgh, PA | 2024 |
| TORREY PINES INSTITUTE FOR MOLECULAR STUDIES INC | $30,210,535 | H30 | inferred 0.70 | abuse: substance | Port St Lucie, FL | 2013 |
| BARBARA ANN KARMANOS CANCER INSTITUTE | $27,111,385 | H30 | published | science: research education | Detroit, MI | 2024 |
| ADDGENE INC | $26,391,816 | H30 | published | science: research education | Watertown, MA | 2024 |
| LOUISIANA CANCER RESEARCH CENTER OF LSU HEALTH SCIENCES CENTER IN NO | $25,078,516 | H30 | published | | New Orleans, LA | 2024 |
| MARY CROWLEY MEDICAL RESEARCH CENTER | $20,603,348 | H30 | published | science: research education | Royse City, TX | 2024 |
| JONSSON CANCER CENTER FOUNDATION- UCLA | $14,178,276 | H30 | inferred 0.80 | | Los Angeles, CA | 2024 |
| CHORDOMA FOUNDATION | $13,413,691 | H30 | published | science: research education | Durham, NC | 2025 |
| COMMONWEALTH CANCER CONSORTIUM INC | $13,409,685 | H30 | inferred 0.85 | | Cambridge, MA | 2024 |
| SOCIETY FOR IMMUNOTHERAPY OF CANCER INC | $12,836,586 | H30 | inferred 0.60 | science: research education | Milwaukee, WI | 2024 |
| ULTA BEAUTY CHARITABLE FOUNDATION | $11,854,534 | H30 | published | space: outer | Bolingbrook, IL | 2025 |
| INTERNATIONAL MYELOMA SOCIETY | $11,815,468 | H30 | published | science: research education | United Kingdom | 2024 |
| COUNT ME IN INC | $11,767,611 | H30 | published | | Cambridge, MA | 2022 |
| CANCER RESEARCH AND BIOSTATISTICS | $11,321,174 | H30 | published | science: research education | Seattle, WA | 2024 |
| CANCER RESEARCH AMERICA NFCR INC | $11,095,696 | H30 | published | survivor: cancer | Rockville, MD | 2024 |
| AMERICAN INSTITUTE FOR CANCER RESEARCH | $11,011,192 | H30 | published | survivor: cancer | Arlington, VA | 2024 |
| AMERICAN ASTHMA FOUNDATION | $10,930,897 | H30 | inferred 0.85 | science: research education | San Francisco, CA | 2011 |
| PREVENT CANCER FOUNDATION | $10,018,961 | H30 | published | science: research education | Alexandria, VA | 2025 |
| TRANSLATIONAL RESEARCH IN ONCOLOGY US INC | $9,656,261 | H30 | published | | Los Angeles, CA | 2024 |
| ADVANCED MEDICAL RESEARCH FOUNDATION INC | $9,383,947 | H30 | published | science: research education | Chestnut Hill, MA | 2025 |
| ISRAEL CANCER RESEARCH FUND INC | $9,064,574 | H30 | inferred 0.80 | science: research education | New York, NY | 2024 |
| FRIENDS OF CANCER RESEARCH | $7,499,449 | H30 | published | science: research education | Washington, DC | 2024 |
| LUNG CANCER RESEARCH FOUNDATION | $7,405,105 | H30 | published | survivor: cancer | Philadelphia, PA | 2024 |
| BIOMEDICAL RESEARCH INSTITUTE | $6,920,488 | H30 | inferred 0.60 | science: research education | Rockville, MD | 2025 |
| FOUNDATION FOR THE ACCREDITATION OF CELLULAR THERAPY | $6,858,508 | H30 | published | | Omaha, NE | 2025 |
| FOR PETES SAKE CANCER RESPITE FOUNDATION | $6,769,366 | H30 | published | | Plymouth Mtng, PA | 2024 |
| VETERANS HEALTH FOUNDATION | $6,253,661 | H30 | inferred 0.60 | | Pittsburgh, PA | 2025 |
| THE RICBAC FOUNDATION | $5,238,971 | H30 | published | | Newtonville, MA | 2024 |
| PAPANICOLAOU CORPS FOR CANCER RESEARCH INC | $5,036,644 | H30 | published | science: research education | Deerfield Bch, FL | 2024 |
| ABRAHAM J AND PHYLLIS KATZ CORD BLOOD FOUNDATION | $4,435,828 | H30 | published | science: research education | Cleveland, OH | 2024 |
| AMERICAN THYROID ASSOCIATION INC | $3,775,307 | H30 | inferred 0.50 | science: research education | Alexandria, VA | 2024 |
| MAINE CANCER FOUNDATION | $3,579,973 | H30 | published | survivor: cancer | Falmouth, ME | 2025 |
| EQUAL HOPE | $3,407,105 | H30 | published | survivor: cancer | Chicago, IL | 2024 |
| LANIADO DEVELOPMENT FUND INC | $3,248,048 | H30 | published | | Brooklyn, NY | 2024 |
| AMERICAN-ITALIAN CANCER FOUNDATION | $3,238,988 | H30 | published | men: issues | New York, NY | 2024 |
| CLL GLOBAL RESEARCH FOUNDATION | $3,170,285 | H30 | published | survivor: cancer | Houston, TX | 2025 |
| DR LARRY & ANN LAIKS CHARITABLE TR UAD 31 OCT 2000 AS AMENDED | $2,903,700 | H30 | published | | Sarasota, FL | 2024 |
| WESTERN STATES CANCER RESEARCH NCORP | $2,459,545 | H30 | inferred 0.80 | | Denver, CO | 2023 |
| CHILDRENS CANCER THERAPY DEVELOPMENT INSTITUTE | $2,370,110 | H30 | inferred 0.90 | science: research education | Hillsboro, OR | 2024 |
| THE LEONARD AND MADLYN ABRAMSON FAMILY CANCER RESEARCH INSTITUTE | $2,360,577 | H30 | published | science: research education | Philadelphia, PA | 2024 |
| SBARRO HEALTH RESEARCH ORGANIZATION INC | $2,310,201 | H30 | published | science: research education | Philadelphia, PA | 2024 |
| CHILDRENS CANCER FUND OF DALLAS INC | $2,275,389 | H30 | published | | Dallas, TX | 2024 |
| LATINAS CONTRA CANCER | $2,269,146 | H30 | published | survivor: cancer | San Jose, CA | 2024 |
| SAMUEL WAXMAN CANCER RESEARCH FOUNDATION | $2,210,348 | H30 | inferred 0.90 | science: research education | New York, NY | 2024 |
| ELLISON INSTITUTE RESEARCH FOUNDATION | $2,134,752 | H30 | published | science: research education | Los Angeles, CA | 2024 |
| TEXAS ONCOLOGY FOUNDATION INC | $2,112,896 | H30 | published | survivor: cancer | Dallas, TX | 2024 |
| CHRISTINE SAPIENZA COLON CANCER | $2,091,636 | H30 | inferred 0.85 | | Wsahington, DC | 2015 |
| GLIOBLASTOMA FOUNDATION INC | $2,055,218 | H30 | published | science: research education | Durham, NC | 2024 |
| PROTON COLLABORATIVE GROUP INC | $1,879,415 | H30 | published | | Warrenville, IL | 2024 |
| PROJECT DS INC | $1,831,423 | H30 | published | | Morrisville, NC | 2025 |
| SHELBY LAVINE FAMILY FOUNDATION | $1,773,434 | H30 | published | | Addison, TX | 2024 |
| MINNESOTA OVARIAN CANCER ALLIANCE INC | $1,717,552 | H30 | published | survivor: cancer | Minneapolis, MN | 2025 |
| RIVKIN CENTER FOR OVARIAN CANCER | $1,700,018 | H30 | published | survivor: cancer | Seattle, WA | 2024 |
| IOWA ONCOLOGY RESEARCH ASSOCIATION | $1,677,253 | H30 | published | | Des Moines, IA | 2024 |
| A JUST HARVEST | $1,652,663 | H30 | published | | Chicago, IL | 2024 |
| PROSTATE CANCER RESEARCH INSTITUTE | $1,630,544 | H30 | published | men: issues | Culver City, CA | 2024 |
| MAPLE TREE CANCER ALLIANCE | $1,624,801 | H30 | published | survivor: cancer | Dayton, OH | 2024 |
| HEART OF THE BRAIN FOUNDATION | $1,596,349 | H30 | published | | Los Angeles, CA | 2024 |
| AIM-HI ACCELERATOR FUND INC | $1,566,732 | H30 | published | | Rockville, MD | 2024 |
| CANCER RESEARCH FOUNDATION | $1,547,723 | H30 | published | | Chicago, IL | 2024 |
| BREAST CANCER RESEARCH FOUNDATION OF ALABAMA | $1,489,062 | H30 | published | | Mountain Brk, AL | 2024 |
| BEAR NECESSITIES PEDIATRIC CANCER FOUNDATION | $1,484,979 | H30 | published | survivor: cancer | Chicago, IL | 2024 |
| BREM FOUNDATION TO DEFEAT BREAST CANCER INC | $1,375,820 | H30 | published | survivor: cancer | Silver Spring, MD | 2024 |
| SOUTHERN NEVADA CANCER RESEARCH FOUNDATION INC | $1,364,125 | H30 | published | | Las Vegas, NV | 2024 |
| ARMS WIDE OPEN CHILDHOOD CANCER FOUNDATION | $1,328,797 | H30 | published | | Marlboro, NJ | 2025 |
| TARGETCANCER FOUNDATION INC | $1,261,609 | H30 | published | science: research education | Cambridge, MA | 2024 |
| MARGARET E EARLY MEDICAL RESEARCH TR | $1,255,286 | H30 | inferred 0.85 | | Glendale, CA | 2025 |
| SCOTT HAMILTON CARES FOUNDATION INC | $1,223,837 | H30 | published | survivor: cancer | Franklin, TN | 2024 |
| SOCIETY OF HEMATOLOGIC ONCOLOGY | $1,220,034 | H30 | published | science: research education | The Woodlands, TX | 2024 |
| KESTREL TR | $1,216,632 | H30 | published | | Darien, CT | 2025 |
| STACHESTRONG INC | $1,192,360 | H30 | published | | Vestal, NY | 2025 |
| CANCER RESEARCH FOUNDATION | $1,174,975 | H30 | published | science: research education | Chicago, IL | 2024 |
| CURE CHILDHOOD CANCER ASSOCIATION | $1,170,867 | H30 | published | | Rochester, NY | 2024 |
| CANCER LEAGUE OF COLORADO INC | $1,153,555 | H30 | published | | Englewood, CO | 2024 |
| EAGLES FIFTH DISTRICT CANCER TELETHON | $1,116,076 | H30 | published | | Rochester, MN | 2024 |
| HERS BREAST CANCER FOUNDATION | $1,062,313 | H30 | published | survivor: cancer | Fremont, CA | 2024 |
| REBOOT RX INC | $1,047,549 | H30 | published | | Winchester, MA | 2024 |
| ETHOS DISCOVERY | $1,043,991 | H30 | published | science: research education | San Diego, CA | 2024 |
| TAYLOR FAMILY RESEARCH FOUNDATION | $1,003,078 | H30 | published | | Maumee, OH | 2024 |
| REELIN FOR RESEARCH INC | $989,218 | H30 | published | | Greensboro, NC | 2024 |
| ROYAL DAMES OF CANCER RESEARCH INC | $974,801 | H30 | published | science: research education | Ft Lauderdale, FL | 2025 |
| HIPPOCRATIC CANCER RESEARCH FOUNDATION INC | $939,408 | H30 | published | science: research education | Wheeling, IL | 2024 |
| JEFFREY PRIDE FOUNDATION INC | $859,177 | H30 | published | science: research education | Barrington, IL | 2024 |
| CANVIVE FOUNDATION | $853,316 | H30 | published | survivor: cancer | San Diego, CA | 2025 |
| SOCIETY FOR INTEGRATIVE ONCOLOGY INC | $835,644 | H30 | published | science: research education | Pepper Pike, OH | 2024 |
| SOCIETY FOR MELANOMA RESEARCH LTD | $829,603 | H30 | published | | Albuquerque, NM | 2024 |
| UNIVERSITY OF CHICAGO CANCER RESEARCH FOUNDATION | $811,607 | H30 | published | | Chicago, IL | 2024 |