| WELLCOME LEAP INC | $623,665,756 | H12 | published | abuse: substance | San Diego, CA | 2024 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | $616,261,455 | H12 | published | science: research education | Bethesda, MD | 2024 |
| CHDI FOUNDATION INC | $208,882,180 | H12 | published | | Roseland, NJ | 2024 |
| AFFINITY PARTNERS NETWORK INC | $67,435,758 | H12 | published | | Jamesburg, NJ | 2024 |
| THE V FOUNDATION | $61,639,637 | H12 | published | science: research education | Cary, NC | 2024 |
| DELTA HEALTH ALLIANCE INC | $41,800,985 | H12 | published | | Stoneville, MS | 2024 |
| CLEARWATER VALLEY HOSPITAL & CLINICS INC | $33,258,118 | H12 | published | | Orofino, ID | 2025 |
| COMMONWEALTH FOUNDATION FOR CANCER RESEARCH FOUNDATION | $25,046,690 | H12 | published | science: research education | Richmond, VA | 2024 |
| ECOG RESEARCH AND EDUCATION FOUNDATION INC | $24,696,161 | H12 | inferred 0.80 | science: research education | Philadelphia, PA | 2024 |
| USAGAINSTALZHEIMERS | $19,588,127 | H12 | published | launch: launch | Washington, DC | 2025 |
| DOLPHINS CYCLING CHALLENGE INC | $14,629,930 | H12 | published | | Miami Gardens, FL | 2024 |
| THE ASSOCIATION FOR FRONTOTEMPORAL DEGENERATION | $14,420,554 | H12 | published | men: issues | Kng Of Prussa, PA | 2024 |
| LUNGEVITY FOUNDATION | $14,237,969 | H12 | published | survivor: cancer | Chicago, IL | 2024 |
| HEALTH EFFECTS INSTITUTE | $13,252,068 | H12 | published | science: research education | Boston, MA | 2024 |
| LIFE SCIENCE CARES INC | $12,525,481 | H12 | published | science: research education | Cambridge, MA | 2024 |
| CHILDRENS ONCOLOGY GROUP FOUNDATION | $10,371,058 | H12 | published | survivor: cancer | Philadelphia, PA | 2024 |
| American Diabetes Association Research Foundation Inc | $9,794,159 | H12 | inferred 0.85 | launch: religious | Arlington, VA | 2021 |
| UROLOGY CARE FOUNDATION INC | $9,577,107 | H12 | published | launch: launch | Linthicum Hts, MD | 2025 |
| JETT FOUNDATION INC | $7,446,726 | H12 | published | girls boys: boys | Norwell, MA | 2025 |
| WINGS FOR LIFE USA - SPINAL CORD RESEARCH FOUNDATION INC | $7,156,526 | H12 | published | | Santa Monica, CA | 2025 |
| FOUNDATION FOR RESEARCH | $6,556,157 | H12 | published | science: research education | Carson City, NV | 2024 |
| PSI FOUNDATION | $6,538,666 | H12 | inferred 0.50 | | Canada | 2024 |
| ST LOUIS LIFE SCIENCES PROJECT | $6,056,883 | H12 | published | science: research education | Saint Louis, MO | 2024 |
| LEUKEMIA RESEARCH FOUNDATION INC | $6,035,635 | H12 | published | science: research education | Northfield, IL | 2024 |
| OPEN MEDICINE FOUNDATION INC | $5,487,605 | H12 | published | science: research education | Agoura Hills, CA | 2025 |
| THE PATRICK AND CATHERINE DONAGHUE MEDICAL RESEARCH FOUNDATION | $5,411,101 | H12 | inferred 0.45 | abuse: substance | Hartford, CT | 2025 |
| FOUNDATION FOR ANGELMAN SYNDROME THERAPEUTICS | $5,388,260 | H12 | published | science: research education | Austin, TX | 2024 |
| FRATERNAL ORDER OF EAGLES FOUNDATION | $5,161,252 | H12 | published | abuse: child | Grove City, OH | 2024 |
| CITIZENS UNITED FOR RESEARCH IN EPILEPSY | $4,989,172 | H12 | published | science: research education | Chicago, IL | 2025 |
| NASHVILLE WINE AUCTION | $4,761,580 | H12 | published | | Nashville, TN | 2025 |
| MACULAR DEGENERATION ASSOCIATION | $4,633,596 | H12 | published | science: research education | Sarasota, FL | 2025 |
| HAYMAKERS FOR HOPE INC | $4,610,827 | H12 | published | survivor: cancer | Wellesley, MA | 2024 |
| THE PROGERIA RESEARCH FOUNDATION INC | $4,458,016 | H12 | published | science: research education | Peabody, MA | 2025 |
| THE CURETIVITY FOUNDATION | $4,396,120 | H12 | published | science: research education | Darien, CT | 2024 |
| INTERNATIONAL RETT SYNDROME FOUNDATION | $4,265,935 | H12 | published | science: research education | Cincinnati, OH | 2025 |
| REGENMED DEVELOPMENT ORGANIZATION | $4,133,217 | H12 | published | science: research education | Winstonsalem, NC | 2024 |
| LESLIE AND SHEILA KLEIN FOUNDATION INC | $4,071,225 | H12 | published | | New Canaan, CT | 2025 |
| COMING TOGETHER FOR A CURE INC | $4,005,322 | H12 | published | science: research education | Wichita, KS | 2024 |
| THE IGA NEPHROPATHY FOUNDATION OF AMERICA INC | $3,995,717 | H12 | published | | Wall Township, NJ | 2025 |
| PARTNERSHIP FOR CURES | $3,881,316 | H12 | published | science: research education | Chicago, IL | 2024 |
| FLORIDA BREAST CANCER COALITION RESEARCH FOUNDATION | $3,857,492 | H12 | published | survivor: cancer | Oviedo, FL | 2024 |
| PSFC | $3,836,963 | H12 | published | | Fairfax, CA | 2024 |
| ZOLL FOUNDATION INC | $3,826,946 | H12 | published | science: research education | Chelmsford, MA | 2024 |
| RARE VILLAGE FOUNDATION | $3,660,787 | H12 | published | | Mckinney, TX | 2025 |
| IMPROVECARENOW INC | $3,561,453 | H12 | published | | Essex, VT | 2025 |
| T J MARTELL FOUNDATION | $3,536,897 | H12 | published | science: research education | New York, NY | 2024 |
| HOPE FOR DEPRESSION RESEARCH FOUNDATION | $3,352,342 | H12 | published | science: research education | New York, NY | 2024 |
| LEVELUP KIDS INC | $3,137,594 | H12 | published | | Kansas City, MO | 2025 |
| MORGAN ADAMS FOUNDATION | $3,011,334 | H12 | published | science: research education | Denver, CO | 2024 |
| PROJECT PURPLE INC | $2,996,848 | H12 | published | science: research education | Seymour, CT | 2024 |
| THE SAMUEL AND JEAN FRANKEL HEALTH AND RESEARCH FOUNDATION | $2,950,874 | H12 | inferred 0.60 | survivor: sexual | Bloomfld Hls, MI | 2024 |
| UNIVERSITY OF TOKYO NEW YORK OFFICE INC | $2,735,367 | H12 | published | science: research education | New York, NY | 2024 |
| CANCER FREE KIDS PEDIATRIC CANCER RESEARCH ALLIANCE | $2,620,809 | H12 | published | | Cincinnati, OH | 2024 |
| COALITION FOR NATIONAL TRAUMA RESEARCH | $2,524,205 | H12 | published | | San Antonio, TX | 2024 |
| HEAD FOR THE CURE | $2,493,421 | H12 | published | survivor: cancer | Kansas City, MO | 2024 |
| THE NASPGHAN FOUNDATION | $2,269,887 | H12 | published | science: research education | Ambler, PA | 2024 |
| JCRT FOUNDATION INC | $2,240,886 | H12 | published | science: research education | Wakefield, MA | 2024 |
| DETECTOGETHER INC | $2,117,348 | H12 | published | survivor: cancer | Westborough, MA | 2025 |
| RUNX1 FOUNDATION | $2,110,160 | H12 | published | science: research education | Santa Barbara, CA | 2025 |
| ADEWUNMI DESALU PARKINSONS FOUNDATION INC | $2,030,963 | H12 | published | | Atlanta, GA | 2025 |
| PARIS BRAIN INSTITUTE AMERICA INC | $1,985,780 | H12 | published | | New York, NY | 2024 |
| THE PINK AGENDA INC | $1,932,915 | H12 | published | | New York, NY | 2025 |
| FOOD ALLERGY FUND | $1,915,611 | H12 | published | | New York, NY | 2024 |
| GUADALUPE REGIONAL MEDICAL FOUNDATION | $1,881,416 | H12 | published | | Seguin, TX | 2024 |
| AMERICAN FOUNDATION FOR CHILDREN WITH AIDS INC | $1,870,984 | H12 | published | | Harrisburg, PA | 2025 |
| THE LILABEAN FOUNDATION INC | $1,807,658 | H12 | published | | Silver Spring, MD | 2025 |
| SOUTH SOUND CARE FOUNDATION | $1,721,415 | H12 | published | | Tacoma, WA | 2025 |
| ORTHOPAEDIC FOOT & ANKLE FOUNDATION | $1,701,279 | H12 | published | | Schaumburg, IL | 2024 |
| RUNWAY TO HOPE INC | $1,672,877 | H12 | published | | Orlando, FL | 2024 |
| KIDNEY CANCER COALITION INC | $1,662,446 | H12 | published | | Philadelphia, PA | 2024 |
| THE DONNA FOUNDATION INC | $1,605,859 | H12 | published | survivor: cancer | Atlantic Beach, FL | 2024 |
| HAROLD PUMP FOUNDATION | $1,588,911 | H12 | published | | Sherman Oaks, CA | 2024 |
| FOX CHASE CANCER CENTER FOUNDATION | $1,440,713 | H12 | published | science: research education | Philadelphia, PA | 2024 |
| VICTORY HOUSTON INC | $1,435,720 | H12 | published | | Houston, TX | 2024 |
| COG RESEARCH FOUNDATION LLC | $1,417,189 | H12 | published | survivor: cancer | Arcadia, CA | 2024 |
| RANDY SHAVER CANCER RESEARCH AND COMMUNITY FUND | $1,402,656 | H12 | published | women: issues | Minnetonka, MN | 2025 |
| TORCH RELAY FOR CHILDRENS MIRACLE NETWORK INC | $1,360,936 | H12 | published | | Orlando, FL | 2025 |
| RECEPTIONS FOR RESEARCH - THE GREG OLSEN FOUNDATION INC | $1,345,731 | H12 | published | science: research education | Ft Lauderdale, FL | 2024 |
| KURE IT INC | $1,328,154 | H12 | published | | Newport Beach, CA | 2024 |
| PIPERS ANGELS FOUNDATION INC | $1,313,636 | H12 | published | | Jupiter, FL | 2024 |
| MORGAN PRESSEL FOUNDATION INC | $1,235,757 | H12 | published | science: research education | Boca Raton, FL | 2024 |
| ALS HOPE FOUNDATION | $1,229,699 | H12 | published | science: research education | Ft Washington, PA | 2024 |
| NORTH AMERICAN NEUROENDOCRINE TUMOR SOCIETY | $1,205,114 | H12 | published | | Albany, NY | 2024 |
| BEN B & IRIS MARGOLIS PRIVATE FDN FOR MEDICAL RESEARCH 068350 | $1,203,069 | H12 | inferred 0.60 | | Brentwood, NY | 2025 |
| SHOOT FOR A CURE | $1,176,379 | H12 | published | | Burbank, CA | 2024 |
| ADENOID CYSTIC CARCINOMA RESEARCHFOUNDATION | $1,159,582 | H12 | published | science: research education | Needham, MA | 2025 |
| MICHAEL TOSHIO CURE FOR CANCER FOUNDATION | $1,125,029 | H12 | published | | Burlingame, CA | 2024 |
| GREATER OHIO BLEEDING DISORDERS FOUNDATION INC | $1,122,808 | H12 | published | men: issues | Cleveland, OH | 2024 |
| STICHTING TUBERCULOSIS VACCINE INITIATIVE | $1,098,057 | H12 | published | | Netherlands | 2025 |
| CARLY WANG RESOURCE INC | $1,097,915 | H12 | published | | Brea, CA | 2025 |
| FORE BATTEN FOUNDATION | $1,072,285 | H12 | published | | Scottsdale, AZ | 2024 |
| SOUTH ASIA ADVOCATES | $1,052,941 | H12 | published | women: issues | Kirkland, WA | 2024 |
| A FOUNDATION BUILDING STRENGTH INC | $1,048,763 | H12 | published | science: research education | Palo Alto, CA | 2024 |
| ALZHEIMERS RESEARCH FOUNDATION INC | $1,020,639 | H12 | published | | Saint Simons Island, GA | 2025 |
| CHILDRENS INTERSTITIAL LUNG DISEASE FOUNDATION INC | $996,082 | H12 | published | | Cincinnati, OH | 2025 |
| HOPE FUNDS FOR CANCER RESEARCH | $995,442 | H12 | published | | Newport, RI | 2025 |
| CASTLEMAN DISEASE COLLABORATIVE NETWORK | $979,030 | H12 | published | science: research education | Paso Robles, CA | 2024 |
| GRAEME MCDANIEL FOUNDATION | $893,013 | H12 | published | | Katy, TX | 2025 |
| ASXL RARE RESEARCH ENDOWMENT FOUNDATION | $887,604 | H12 | published | | Gorham, ME | 2024 |
| CANCER AWARENESS THROUGH RESEARCH AND EDUCATION ASSOCIATION | $867,764 | H12 | published | science: research education | Carefree, AZ | 2024 |