| PARKINSONS FOUNDATION INC | $84,182,191 | H80 | published | science: research education | New York, NY | 2024 |
| GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT INC | $63,732,557 | H80 | published | science: research education | New York, NY | 2024 |
| FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS FIND | $49,306,331 | H80 | published | women: issues | Switzerland | 2024 |
| HOPELAB FOUNDATION INC | $26,262,011 | H80 | published | survivor: cancer | San Francisco, CA | 2024 |
| PUNCH 4 PARKINSONS CORPORATION | $22,084,703 | H80 | published | | Walpole, MA | 2025 |
| ACCESS TO ADVANCED HEALTH INSTITUTE | $18,401,417 | H80 | published | | Seattle, WA | 2024 |
| ALS THERAPY DEVELOPMENT FOUNDATION INC | $16,066,902 | H80 | published | science: research education | Watertown, MA | 2025 |
| HAE INTERNATIONAL | $6,614,500 | H80 | published | | Fairfax, VA | 2024 |
| SILENT SPRING INSTITUTE INC | $5,758,023 | H80 | published | domestic: workers | Newton, MA | 2024 |
| PREECLAMPSIA FOUNDATION | $5,663,361 | H80 | published | women: issues | Melbourne, FL | 2025 |
| EPIDEMIOLOGIC SOLUTIONS CORPORATION | $4,663,007 | H80 | published | | Westlake, LA | 2024 |
| SPRING POINT PROJECT | $4,041,047 | H80 | published | | Minneapolis, MN | 2025 |
| AMYLOIDOSIS RESEARCH CONSORTIUM INC | $3,777,620 | H80 | published | science: research education | Newton, MA | 2025 |
| CENTER FOR DISEASE DYNAMICS ECONOMICS & POLICY INC | $3,712,319 | H80 | published | | Silver Spring, MD | 2024 |
| LYSOSOMAL AND RARE DISORDERS RESEARCH AND TREATMENT CENTER INC | $3,614,812 | H80 | published | science: research education | Fairfax, VA | 2025 |
| SWINE HEALTH INFORMATION CENTER INC | $3,435,828 | H80 | published | domestic: animals | Manhattan, KS | 2024 |
| DIABETES RESEARCH AND WELLNESS FOUNDATION INC | $3,182,818 | H80 | published | | Bethesda, MD | 2024 |
| CYSTINOSIS RESEARCH FOUNDATION | $3,177,424 | H80 | published | science: research education | Newport Beach, CA | 2024 |
| CURE SANFILIPPO FOUNDATION | $2,781,149 | H80 | published | science: research education | Columbia, SC | 2024 |
| AURUM INSTITUTE USA | $2,527,670 | H80 | published | science: research education | New York, NY | 2025 |
| NEW MEXICO CANCER CARE ALLIANCE | $2,507,567 | H80 | published | | Albuquerque, NM | 2024 |
| CRAY MEDICAL RESEARCH FOUNDATION | $2,118,990 | H80 | published | | Atchison, KS | 2025 |
| NORTHEAST ALS CONSORTIUM INC | $2,066,070 | H80 | published | science: research education | Boston, MA | 2024 |
| HAIRDAO ASSOCIATION | $1,653,828 | H80 | published | | New York, NY | 2025 |
| MENINGITIS FOUNDATION | $1,575,369 | H80 | published | | Minneapolis, MN | 2025 |
| ERASE PTSD NOW | $1,540,954 | H80 | published | science: research education | Chicago, IL | 2025 |
| INTERNATIONAL ESSENTIAL TREMOR FOUNDATION | $1,495,117 | H80 | published | science: research education | Lenexa, KS | 2025 |
| PHELAN MCDERMID SYNDROME FOUNDATION | $1,245,861 | H80 | published | science: research education | Osprey, FL | 2025 |
| LEO AND ANNE ALBERT INSTITUTE FOR BLADDER CANCER AND RESEARCH | $1,106,940 | H80 | published | science: research education | Mission Hills, KS | 2025 |
| FOUNDATION TO ERADICATE DUCHENNE INC | $1,068,787 | H80 | published | science: research education | Alexandria, VA | 2025 |
| ORPHAN DISEASE PATHWAY PROJECT | $1,045,050 | H80 | published | | Miami Beach, FL | 2024 |
| ANGEL FUND INC | $895,977 | H80 | published | science: research education | Wakefield, MA | 2024 |
| ZEENAT QURESHI STROKE INSTITUTE | $855,877 | H80 | published | | Johns Creek, GA | 2024 |
| APFED | $846,943 | H80 | published | launch: launch | Atlanta, GA | 2025 |
| MONOAMINE OXIDASE DEFICIENCY FOUNDATION | $845,166 | H80 | published | | Galveston, TX | 2025 |
| THE FOCUS FOUNDATION INC | $795,002 | H80 | published | science: research education | Crofton, MD | 2024 |
| DION FOUNDATION FOR CHILDREN WITH RARE DISEASES INC | $776,008 | H80 | published | | Marshfield, MA | 2024 |
| BEHAVIORAL DIABETES INSTITUTE | $725,848 | H80 | published | | San Diego, CA | 2024 |
| SPIROVATION INC | $721,436 | H80 | published | | Chapel Hill, NC | 2025 |
| NATIONAL DIABETES & OBESITY RESEARCH CENTER AT TRADITION MS | $716,841 | H80 | published | | Diamondhead, MS | 2024 |
| SLC6A1 CONNECT | $716,694 | H80 | published | science: research education | Frisco, TX | 2024 |
| MILAS MIRACLE FOUNDATION INC | $706,872 | H80 | published | | Longmont, CO | 2024 |
| CDG CARE | $706,435 | H80 | published | science: research education | Colorado Spgs, CO | 2025 |
| CENTER FOR NEW DATA | $697,064 | H80 | published | science: research education | Sacramento, CA | 2025 |
| LONGER LIFE FOUNDATION | $684,353 | H80 | published | | Chesterfield, MO | 2025 |
| SLEEP CONSORTIUM | $665,000 | H80 | published | | West Palm Bch, FL | 2024 |
| SENECA DIABETES FOUNDATION | $657,184 | H80 | published | | Irving, NY | 2025 |
| THE MICHAEL STERN PARKINSONS RESEARCH FOUNDATION | $475,311 | H80 | inferred 0.60 | science: research education | New York, NY | 2014 |
| LET EVERY WOMAN KNOW - ALASKA | $474,196 | H80 | published | survivor: cancer | Anchorage, AK | 2025 |
| CURED NFP | $465,036 | H80 | published | | Northbrook, IL | 2024 |
| CENTRAL NEW YORK LYME AND TICK-BORNE DISEASE ALLIANCE INC | $402,030 | H80 | published | | Manlius, NY | 2025 |
| NEUROIMMUNE NORTH CAROLINA | $397,452 | H80 | published | | Raleigh, NC | 2025 |
| AMERICAN FOUNDATION FOR ADDICTION RESEARCH | $375,592 | H80 | published | | Cave Creek, AZ | 2025 |
| A LONG SWIM | $373,936 | H80 | published | | Barrington, IL | 2024 |
| RE CHILDRENS PROJECT INC | $362,132 | H80 | published | | Darien, CT | 2011 |
| SOCIETY OF SURGERY OF THE ALIMENTARY TRACT FOUNDATION | $313,920 | H80 | published | science: research education | Beverly, MA | 2024 |
| WILL HARDY FOUNDATION | $289,977 | H80 | published | science: research education | Henrico, VA | 2024 |
| ALTERNATING HEMIPLEGIA OF CHILDHOOD FOUNDATION INC | $283,334 | H80 | published | science: research education | Southfield, MI | 2024 |
| INTERNATIONAL RESEARCH FOUNDATION FOR RSD-CRPS INC | $275,697 | H80 | published | science: research education | Tampa, FL | 2025 |
| MYT1L PROJECT FOUNDATION INC | $241,518 | H80 | published | science: research education | Albany, NY | 2025 |
| FIELD CENTER FOR CHILDRENS INTEGRATED DEVELOPMENT INC | $221,497 | H80 | published | | Upr Montclair, NJ | 2024 |
| MUSIC MOVEMENT | $215,276 | H80 | published | | Chicago, IL | 2025 |
| COUNTDOWN FOR A CURE INC | $209,420 | H80 | published | | Atlanta, GA | 2024 |
| DEFEAT MSA ALLIANCE DEFEAT MULTIPLE SYSTEM ATROPHY ALLIANCE | $206,676 | H80 | published | | St Clr Shores, MI | 2025 |
| RAMPY MS RESEARCH FOUNDATION | $197,319 | H80 | published | science: research education | Bentonville, AR | 2024 |
| SCARRING ALOPECIA FOUNDATION | $179,512 | H80 | published | science: research education | Pikesville, MD | 2025 |
| INTERNATIONAL DYSLEXIA ASSOCIATION- ROCKY MOUNTIAN BRANCH | $176,006 | H80 | published | | Boulder, CO | 2025 |
| ORTHOPAEDIC ASSOCIATES OF GRAND RAPIDS RESEARCH & EDUCATION INST | $174,787 | H80 | published | | Grand Rapids, MI | 2024 |
| ELLYN SATTER INSTITUTE INC | $169,831 | H80 | published | | Waukon, IA | 2024 |
| RENEGADE RESEARCH | $159,837 | H80 | published | science: research education | Brighton, MI | 2024 |
| CELIAC COMMUNITY FOUNDATION OF NORTHERN CALIFORNIA | $158,193 | H80 | published | | Sebastopol, CA | 2025 |
| JACK S THOUSAND DAYS FOUNDATION INC | $155,914 | H80 | published | | Van Alstyne, TX | 2025 |
| LOST ENZYME PROJECT | $155,646 | H80 | published | | Chandler, AZ | 2025 |
| ALL GREATER GOOD FOUNDATION | $154,539 | H80 | published | | Beverly Hills, CA | 2024 |
| PROPIONIC ACIDEMIA FOUNDATION | $152,254 | H80 | published | | Deerfield, IL | 2025 |
| HUGS SICKLE CELL FOUNDATION INC | $148,500 | H80 | published | | N Las Vegas, NV | 2022 |
| DYSLEXIC ADVANTAGE | $134,734 | H80 | published | | Edmonds, WA | 2025 |
| ALLIANCE AGAINST DIABETES | $132,330 | H80 | published | | Las Vegas, NV | 2023 |
| BACK TO HEALING INC | $123,981 | H80 | published | launch: religious | Snellville, GA | 2024 |
| CHORD FOUNDATION | $115,753 | H80 | published | science: research education | New Hyde Park, NY | 2025 |
| 1J FOUNDATION | $114,580 | H80 | published | | Chicago, IL | 2025 |
| A DAPPLE A DAY EQUINE CENTER | $109,440 | H80 | published | | Queensbury, NY | 2024 |
| BIOLOGICAL IMMUNITY RESEARCH INSTITUTE 08-01-00 | $107,752 | H80 | published | | Scottsdale, AZ | 2024 |
| RADLER FOUNDATION FOR INNOVATION AND EDUCATION INC | $102,589 | H80 | published | | Greenfield, WI | 2025 |
| INTERNATIONAL SOCIETY FOR MANNOSIDOSIS & RELATED DISEASE INC | $101,101 | H80 | published | | San Jose, CA | 2025 |
| THREE BUTTERFLIES SIDS FOUNDATION | $98,676 | H80 | published | science: research education | Phoenix, AZ | 2023 |
| AMERICAN SOCIETY FOR RICKETTSIOLOGY INC | $97,218 | H80 | published | | South Miami, FL | 2025 |
| SELECTIVE MUTISM RESEARCH INSTITUTE | $90,711 | H80 | published | | Flourtown, PA | 2025 |
| INSTITUTE FOR BLADDER AND PROSTATE RESEARCH INC | $87,410 | H80 | published | | New York, NY | 2024 |
| PRIMARY ALDOSTERONISM FOUNDATION | $85,863 | H80 | published | | Phoenix, AZ | 2024 |
| XERODERMA PIGMENTOSUM FAMILY SUPPORT GROUP | $85,358 | H80 | published | | Sacramento, CA | 2024 |
| AVERY HUFFMAN DIPG FOUNDATION | $78,939 | H80 | published | | Auburn, WA | 2025 |
| ASCLEPIUS SNAKEBITE FOUNDATION | $78,452 | H80 | published | | Aurora, CO | 2025 |
| TAKE AIM AT CANCER INC | $70,000 | H80 | inferred 0.90 | | Atlanta, GA | 2012 |
| EMERSYN RAY AURICH MEMORIAL FOUNDATION LTD | $68,820 | H80 | published | | Littleton, CO | 2025 |
| DON AND MILLIE NELMS FOUNDATION | $67,963 | H80 | published | | Fayetteville, AR | 2024 |
| DRUG & ALCOHOL TRAINING INC | $67,481 | H80 | published | | Norman, OK | 2025 |
| EPENDYMOMA RESEARCH FOUNDATION | $64,952 | H80 | published | science: research education | Lexington, MA | 2025 |
| VENTI-NOW | $60,654 | H80 | published | | Montgomery, OH | 2022 |
| NEUROSTRUCTURAL RESEARCH LABS INC | $60,478 | H80 | inferred 0.70 | science: research education | Tampa, FL | 2013 |