| BROAD INSTITUTE INC | $846,134,426 | H20 | published | science: research education | Cambridge, MA | 2024 |
| CARDIOVASCULAR RESEARCH FOUNDATION | $68,904,326 | H20 | published | science: research education | New York, NY | 2024 |
| PHILADELPHIA FIGHT | $68,330,571 | H20 | published | | Philadelphia, PA | 2024 |
| LIONS WORLD VISION INSTITUTE INC | $52,217,947 | H20 | inferred 0.80 | | Tampa, FL | 2024 |
| JOHN P MCGOVERN FOUNDATION | $37,128,352 | H20 | inferred 0.55 | women: issues | Houston, TX | 2024 |
| EVERSIGHT | $34,039,876 | H20 | inferred 0.82 | launch: religious | Ann Arbor, MI | 2024 |
| GREENWOOD GENETIC CENTER INC | $30,858,954 | H20 | published | science: research education | Greenwood, SC | 2024 |
| NEW YORK STEM CELL FOUNDATION INC | $25,906,400 | H20 | published | science: research education | New York, NY | 2024 |
| ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES | $24,030,198 | H20 | published | science: research education | Seattle, WA | 2025 |
| PUERTO RICO COMMUNITY FOR CLINICAL SERVICES RESEARCH AND HEALTH | $18,448,660 | H20 | published | abuse: substance | San Juan, PR | 2024 |
| THE AMERICAN SOCIETY OF GENE & CELL THERAPY | $16,914,337 | H20 | published | | Waukesha, WI | 2024 |
| NATIONAL BLEEDING DISORDERS FOUNDATION | $16,570,137 | H20 | inferred 0.80 | girls boys: girls | New York, NY | 2024 |
| INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS INC | $12,803,951 | H20 | inferred 0.60 | science: research education | Charlotte, NC | 2025 |
| THE ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY | $12,169,218 | H20 | inferred 0.80 | science: research education | Rockville, MD | 2025 |
| CHILDRENS BURN FOUNDATION | $11,242,734 | H20 | inferred 0.60 | | Sherman Oaks, CA | 2024 |
| PKD FOUNDATION | $11,009,122 | H20 | inferred 0.80 | science: research education | Kansas City, MO | 2024 |
| JEFFREY MODELL FOUNDATION INC | $10,208,043 | H20 | inferred 0.90 | science: research education | New York, NY | 2024 |
| AMERICAN SOCIETY FOR TRANSPLANTATION & CELLULAR THERAPY | $8,492,524 | H20 | published | science: research education | Chicago, IL | 2024 |
| RIORDAN CLINIC INC | $6,735,681 | H20 | inferred 0.60 | science: research education | Wichita, KS | 2024 |
| NATIONAL OVARIAN CANCER COALITION INC | $5,376,100 | H20 | published | survivor: cancer | Dallas, TX | 2024 |
| FSHD SOCIETY | $4,942,571 | H20 | published | science: research education | Abington, MA | 2024 |
| TEXAS HEALTH RESEARCH & EDUCATION INSTITUTE | $4,905,286 | H20 | published | | Arlington, TX | 2024 |
| HEARING HEALTH FOUNDATION | $4,678,817 | H20 | published | science: research education | New York, NY | 2024 |
| CAMPBELL FOUNDATION | $4,454,525 | H20 | inferred 0.80 | science: research education | Germantown, TN | 2024 |
| PEDIATRIC CANCER RESEARCH FOUNDATION | $4,224,824 | H20 | inferred 0.80 | survivor: cancer | Irvine, CA | 2024 |
| HUNTINGTON S DISEASE FOUNDATION | $4,081,669 | H20 | published | science: research education | New York, NY | 2025 |
| HAUPTMAN-WOODWARD MEDICAL RESEARCH INSTITUTE INC | $3,944,553 | H20 | published | science: research education | Buffalo, NY | 2024 |
| CENTER FOR HUMAN GENETICS INC | $3,179,113 | H20 | published | science: research education | Cambridge, MA | 2024 |
| NATIONAL KIDNEY FOUNDATION INC | $3,174,101 | H20 | inferred 0.60 | | Chicago, IL | 2024 |
| EYE BANK ASSOCIATION OF AMERICA INC | $3,123,103 | H20 | inferred 0.60 | | Chantilly, VA | 2024 |
| PORTER HILLS HOME HEALTH WEST | $3,051,045 | H20 | published | | Grand Rapids, MI | 2024 |
| FINDING HOPE FOR FRRS1L | $2,543,539 | H20 | published | | Fort Collins, CO | 2025 |
| EDUCATIONAL AND RESEARCH FOUNDATION FOR THE AMERICAN ACADEMY OF FACIAL | $2,302,168 | H20 | inferred 0.60 | domestic violence | Alexandria, VA | 2024 |
| NATIONAL FRAGILE X FOUNDATION | $2,291,142 | H20 | published | | Washington, DC | 2025 |
| LISA WENDEL MEMORIAL FOUNDATION | $2,249,730 | H20 | inferred 0.60 | | Iselin, NJ | 2024 |
| SAINT PAUL VI INSTITUTE FOR THE STUDY OF HUMAN REPRODUCTION INC | $2,110,997 | H20 | inferred 0.85 | women: issues | Omaha, NE | 2024 |
| GLOMCON FOUNDATION | $2,090,584 | H20 | published | | Wilmington, DE | 2024 |
| CEREBRAL PALSY ALLIANCE RESEARCH FOUNDATION | $1,980,845 | H20 | published | science: research education | New York, NY | 2025 |
| MAS SAJADY INC | $1,970,887 | H20 | published | | Newport Beach, CA | 2016 |
| SPINAL RESEARCH FOUNDATION | $1,887,546 | H20 | published | science: research education | Reston, VA | 2024 |
| HIP SOCIETY | $1,858,799 | H20 | inferred 0.80 | | Schaumburg, IL | 2025 |
| AMDEC FOUNDATION INC | $1,796,844 | H20 | inferred 0.50 | | New York, NY | 2012 |
| WIPE OUT KIDS CANCER INC | $1,729,744 | H20 | inferred 0.60 | survivor: cancer | Dallas, TX | 2024 |
| CALIFORNIA ACADEMY OF FAMILY PHYSICIANS FOUNDATION | $1,714,765 | H20 | inferred 0.60 | abuse: substance | Sacramento, CA | 2024 |
| THE CAMERON AND HAYDEN LORD FOUNDATION | $1,618,596 | H20 | published | | New York, NY | 2025 |
| GORDON ROSS MEDICAL FOUNDATION | $1,600,084 | H20 | inferred 0.70 | survivor: sexual | Pasadena, CA | 2025 |
| WORLD MOLECULAR IMAGING SOCIETY | $1,450,951 | H20 | published | science: research education | Culver City, CA | 2024 |
| ANDERSON ORTHOPAEDIC RESEARCH INSTITUTE | $1,447,921 | H20 | inferred 0.60 | science: research education | Alexandria, VA | 2024 |
| HUMAN GROWTH FOUNDATION | $1,445,726 | H20 | inferred 0.60 | | Greenvale, NY | 2024 |
| AMERICAN PANCREATIC ASSOCIATION | $1,408,136 | H20 | inferred 0.80 | science: research education | Cooper City, FL | 2025 |
| NATIONAL HEADACHE FOUNDATION | $1,406,193 | H20 | inferred 0.80 | girls boys: girls | Chicago, IL | 2024 |
| FOUNDATION FOR RESEARCH INTO SEXUALLY TRANSMITTED DISEASES INC | $1,397,461 | H20 | inferred 0.60 | | New York, NY | 2024 |
| INTERNATIONAL SOCIETY FOR AUTISM | $1,236,560 | H20 | published | science: research education | Kansas City, MO | 2024 |
| ALSTROM ANGELS CORP | $1,222,674 | H20 | published | | Lubbock, TX | 2024 |
| EVERYONE READING INC | $1,126,950 | H20 | published | | Brooklyn, NY | 2024 |
| ROSENFELD HEART FOUNDATION INC | $1,113,789 | H20 | inferred 0.75 | | Rye Brook, NY | 2024 |
| CENTER FOR HUMAN APPEAREANCE RESEARCH & EDUCATIONAL FUND INC | $1,075,424 | H20 | inferred 0.80 | | Philadelphia, PA | 2024 |
| CHILDRENS AIRWAY FIRST FOUNDATION | $1,029,297 | H20 | published | | Austin, TX | 2024 |
| THE OLEY FOUNDATION INC | $993,449 | H20 | inferred 0.60 | science: research education | Albany, NY | 2024 |
| FLORIDA CHAPTER OF THE AMERICAN ACADEMY OF PEDIATRICS INC | $889,549 | H20 | inferred 0.60 | | Tallahassee, FL | 2024 |
| WISCONSIN PARKINSON ASSOCIATION INC | $888,005 | H20 | inferred 0.80 | | Brookfield, WI | 2024 |
| THE RUTH K BROAD BIOMEDICAL RESEARCH FOUNDATION INC | $879,876 | H20 | inferred 0.70 | science: research education | Durham, NC | 2024 |
| INTERNATIONAL ZEBRAFISH SOCIETY INC | $845,766 | H20 | published | science: research education | Milwaukee, WI | 2024 |
| PACHYONYCHIA CONGENITA FUND | $816,533 | H20 | published | science: research education | Holladay, UT | 2024 |
| CHASE RICHARDS FOUNDATION | $748,353 | H20 | published | | Encino, CA | 2024 |
| CONFERENCE FOR FOOD PROTECTION INC | $729,289 | H20 | inferred 0.60 | | Hghlnds Ranch, CO | 2025 |
| VISION OF CHILDREN | $664,851 | H20 | inferred 0.60 | | San Diego, CA | 2025 |
| DONALD E MCMAHON FOUNDATION | $629,288 | H20 | inferred 0.60 | | Houston, TX | 2025 |
| GREAT PLAINS DIABETES RESEARCH INC | $623,384 | H20 | inferred 0.60 | | Wichita, KS | 2025 |
| SOUTHERN CALIFORNIA SOCIETY OF GASTROENTEROLOGY | $622,097 | H20 | inferred 0.80 | | Brea, CA | 2025 |
| UNIVERSITY OF COLORADO CHILDRENS DIA | $604,357 | H20 | inferred 0.60 | | Brentwood, NY | 2025 |
| RALSTON VOLUNTEER FIRE DEPARTMENT AND RESCUE SQUAD INC | $568,222 | H20 | published | | Ralston, NE | 2024 |
| ERIK & ESE BANCK CLINICAL RESEARCH CENTER INC | $565,496 | H20 | inferred 0.80 | | San Diego, CA | 2024 |
| THE KAT6A FOUNDATION INC | $545,829 | H20 | published | | Bellmore, NY | 2024 |
| THE UNITED LEUKODYSTROPHY FOUNDATION INC | $518,325 | H20 | inferred 0.70 | science: research education | Chicago, IL | 2025 |
| JOHN B PIERCE FOUNDATION | $517,443 | H20 | inferred 0.60 | science: research education | New Haven, CT | 2024 |
| THE C STEPHEN AND FRANCES B FOSTER FOUNDATION | $512,062 | H20 | inferred 0.85 | science: research education | Weston, MA | 2025 |
| RILITE FOUNDATION | $475,539 | H20 | published | science: research education | Charlottesvle, VA | 2024 |
| RIVERSIDE HEALTHCARE ASSOCIATION INC | $469,706 | H20 | published | science: research education | Newport News, VA | 2011 |
| FOUNDATION OF THE MINNESOTA MEDICAL ASSOCIATION | $467,265 | H20 | inferred 0.55 | launch: launch | Minneapolis, MN | 2024 |
| THORACIC SURGERY DIRECTORS ASSOCIATION | $467,218 | H20 | inferred 0.50 | | Chicago, IL | 2024 |
| JGJ GENE RESEARCH INC | $457,500 | H20 | published | | Washington, DC | 2025 |
| SCLERODERMA FOUNDATION OF GREATER CHICAGO | $456,038 | H20 | inferred 0.80 | | Chicago, IL | 2024 |
| RESEARCH FOUNDATION OF THE AMERICAN SOCIETY OF COLON & RECTAL SURGEONS | $454,709 | H20 | inferred 0.80 | | Bannockburn, IL | 2024 |
| CHANNELING HOPE FOUNDATION | $421,003 | H20 | published | science: research education | San Antonio, TX | 2025 |
| CURE CMT | $420,833 | H20 | published | | Eatonton, GA | 2025 |
| NEBRASKA CATTLEMEN RESEARCH AND EDUCATION FOUNDATION | $405,900 | H20 | inferred 0.60 | science: research education | Lincoln, NE | 2024 |
| INTERNATIONAL FOXP1 FOUNDATION | $405,298 | H20 | published | science: research education | Chadds Ford, PA | 2025 |
| STURGE-WEBER FOUNDATION | $392,112 | H20 | inferred 0.60 | | Aurora, CO | 2024 |
| VITIS RESEARCH AND DEVELOPMENT CORPORATION | $390,300 | H20 | inferred 0.60 | | Mcallen, TX | 2025 |
| ALZHEIMERS TEXAS INC | $376,821 | H20 | inferred 0.80 | | Austin, TX | 2024 |
| HAWAII PARKINSON ASSOCIATION INC | $371,296 | H20 | inferred 0.60 | | Honolulu, HI | 2024 |
| FOUNDATION FOR A CURE FOR MITOCHONDRIAL DISEASE INC | $368,254 | H20 | published | | Cheshire, CT | 2024 |
| PARKINSON ASSOCIATION OF THE CAROLINAS | $367,501 | H20 | published | | Charlotte, NC | 2024 |
| FULTON POST INC | $362,104 | H20 | published | | Mc Connellsbg, PA | 2024 |
| PARALYZED VETERANS OF AMERICA | $354,681 | H20 | inferred 0.60 | | Memphis, TN | 2024 |
| PARALYZED VETERANS OF AMERICA | $353,275 | H20 | inferred 0.60 | | Palo Alto, CA | 2024 |
| FAM177A1 RESEARCH FUND | $333,831 | H20 | published | | Mercer Island, WA | 2025 |
| KACHELMACHER MEMORIAL INC | $332,679 | H20 | inferred 0.50 | | Logan, OH | 2024 |
| HOPE FOR PDCD FOUNDATION | $325,204 | H20 | published | | Folsom, CA | 2025 |