| BREAKTHROUGH T1D | $301,723,973 | G80 | published | launch: religious | New York, NY | 2024 |
| THE RARE DISEASE CHARITABLE FOUNDATION | $162,843,174 | G80 | inferred 0.60 | | Lexington, MA | 2022 |
| AMERICAN DIABETES ASSOCIATION INC | $152,241,578 | G80 | published | shelter: disaster | Arlington, VA | 2024 |
| MAKE- A- WISH FOUNDATION OF AMERICA | $136,767,956 | G80 | inferred 0.60 | | Phoenix, AZ | 2024 |
| FUND FOR PUBLIC HEALTH IN NEW YORK INC | $98,316,171 | G80 | published | women: issues | New York, NY | 2024 |
| JOSLIN DIABETES CENTER INC | $77,259,482 | G80 | published | girls boys: boys | Charlestown, MA | 2024 |
| HEMOSTASIS AND THROMBOSIS CENTER OF NEVADA | $28,961,379 | G80 | published | | Las Vegas, NV | 2024 |
| LYMPHOMA RESEARCH FOUNDATION | $14,181,182 | G80 | published | survivor: cancer | New York, NY | 2024 |
| MALARIA CONSORTIUM US INC | $10,418,949 | G80 | published | | Hermitage, PA | 2025 |
| CHILDRENS AUTISM CENTERINCORPORATED | $10,232,383 | G80 | published | | Fort Wayne, IN | 2024 |
| EB RESEARCH PARTNERSHIP INC | $8,244,493 | G80 | published | science: research education | New York, NY | 2025 |
| CHILDRENS DIABETES FOUNDATION | $7,353,008 | G80 | published | science: research education | Aurora, CO | 2025 |
| NO BABY BLISTERS | $7,131,665 | G80 | published | | Winston Salem, NC | 2025 |
| DUP 15Q ALLIANCE | $7,033,311 | G80 | published | science: research education | Matthews, NC | 2025 |
| POSITUDES INC | $7,010,357 | G80 | published | women: issues | Westbury, NY | 2024 |
| GLOBAL VIRUS NETWORK INC | $6,627,320 | G80 | published | science: research education | Tampa, FL | 2024 |
| FOUNDATION FOR PRADER WILLI RESEARCH | $6,173,660 | G80 | published | science: research education | Covina, CA | 2024 |
| ASSOCIATION OF IMMUNIZATION MANAGERS | $6,009,882 | G80 | published | | Rockville, MD | 2024 |
| NORTHERN OHIO HANDICAPPED FUND | $5,750,901 | G80 | published | | Middlefield, OH | 2025 |
| CHI ST JOSEPHS CHILDREN | $5,623,014 | G80 | published | survivor: cancer | Phoenix, AZ | 2024 |
| NATIONAL MPS SOCIETY INC | $5,554,247 | G80 | inferred 0.80 | science: research education | Durham, NC | 2025 |
| CHRISTINA FOUNDATION INC | $5,020,191 | G80 | inferred 0.60 | shelter: homeless | New York, NY | 2024 |
| THE INTERNATIONAL WALDENSTROMS MACROGLOBULINEMIA FOUNDATION INC | $4,463,374 | G80 | published | science: research education | Chicago, IL | 2024 |
| XENOTHERAPEUTICS INC | $4,224,636 | G80 | published | | Manchester, NH | 2024 |
| T-1 TODAY INC | $4,138,638 | G80 | published | | West Chester, OH | 2024 |
| UNITED MITOCHONDRIAL DISEASE FOUNDATION INC | $4,062,127 | G80 | published | | Pittsburgh, PA | 2024 |
| UNITED CEREBRAL PALSY INC | $3,983,092 | G80 | published | | Vienna, VA | 2024 |
| DAVIS PHINNEY FOUNDATION | $3,589,340 | G80 | inferred 0.55 | | Louisville, CO | 2024 |
| HALO HOUSE FOUNDATION | $3,506,522 | G80 | published | | Houston, TX | 2024 |
| TAKING CONTROL OF YOUR DIABETES | $3,343,170 | G80 | published | | San Diego, CA | 2024 |
| IMMUNE TOLERANCE INSTITUTE INC | $3,197,548 | G80 | published | | San Francisco, CA | 2010 |
| FIDEC INC | $3,192,675 | G80 | published | science: research education | Coral Gables, FL | 2025 |
| PARKINSON RESEARCH FOUNDATION INC | $3,163,049 | G80 | published | science: research education | Sarasota, FL | 2025 |
| ST LOUIS EFFORT FOR AIDS INC | $3,104,810 | G80 | inferred 0.70 | men: issues | St Louis, MO | 2017 |
| PARKINSON & MOVEMENT DISORDER ALLIANCE | $2,916,236 | G80 | inferred 0.50 | | Phoenix, AZ | 2024 |
| National Multiple Sclerosis Society | $2,726,490 | G80 | inferred 0.85 | | Charlotte, NC | 2009 |
| DEMENTIA SOCIETY INC | $2,478,907 | G80 | published | | Doylestown, PA | 2025 |
| SET FOUNDATION INC | $2,432,207 | G80 | published | | Lake Oswego, OR | 2025 |
| PINK FUND INC | $2,422,800 | G80 | published | | Bingham Farms, MI | 2024 |
| COLLEGE DIABETES NETWORK INC | $2,133,964 | G80 | published | | Boston, MA | 2024 |
| ALABAMA GAME CHANGERS | $2,110,438 | G80 | published | | Vestavia, AL | 2024 |
| DEVELOPMENTAL FX-THE DEVELOPMENTAL & FRAGILE X RESOURCE CENTRE | $2,037,683 | G80 | published | | Denver, CO | 2024 |
| ALZHEIMER'S DISEASE & RELATED DISORDER | $1,901,877 | G80 | inferred 0.85 | | Santa Barbara, CA | 2015 |
| MS COMPREHENSIVE CARE CENTER | $1,798,683 | G80 | published | women: issues | Teaneck, NJ | 2024 |
| MISSION MSA | $1,758,498 | G80 | published | science: research education | Chicago, IL | 2024 |
| THE LATINO ALZHEIMERS AND MEMORY DISORDERS ALLIANCE | $1,637,715 | G80 | published | | Cicero, IL | 2023 |
| THE BLOSSER CENTER FOR DYSLEXIA RESOURCES | $1,630,303 | G80 | published | | Portland, OR | 2024 |
| EPILEPSY FOUNDATION OF NORTHCENTRAL | $1,521,486 | G80 | inferred 0.85 | | Rockford, IL | 2017 |
| Alzheimers Association | $1,499,576 | G80 | inferred 0.85 | | Charlotte, NC | 2015 |
| FACE TO FACE ENRICHMENT CENTER | $1,389,902 | G80 | published | | Baton Rouge, LA | 2024 |
| WAKE UP NARCOLEPSY INC | $1,370,014 | G80 | published | | Worcester, MA | 2024 |
| ANGIOMA ALLIANCE | $1,358,856 | G80 | published | science: research education | Charlottesville, VA | 2024 |
| LGS FOUNDATION | $1,248,197 | G80 | published | science: research education | San Diego, CA | 2024 |
| KABUKI SYNDROME FOUNDATION | $1,238,474 | G80 | published | | Northbrook, IL | 2024 |
| BRIAN GRANT FOUNDATION | $1,193,994 | G80 | published | science: research education | Portland, OR | 2025 |
| EHE FOUNDATION | $1,165,807 | G80 | published | science: research education | Hobart, WI | 2025 |
| PROJECT SLEEP | $1,117,298 | G80 | published | science: research education | Los Angeles, CA | 2024 |
| EPILEPSY FOUNDATION OF COLORADO | $1,091,392 | G80 | inferred 0.80 | | Greenwood Vlg, CO | 2025 |
| DIABETES TECHNOLOGY SOCIETY | $1,029,388 | G80 | published | science: research education | Burlingame, CA | 2025 |
| HEMOPHILIA ALLIANCE FOUNDATION | $1,026,732 | G80 | published | | Clearwater, FL | 2024 |
| CAMP HO MITA KODA FOUNDATION | $993,349 | G80 | published | women: issues | Newbury, OH | 2024 |
| ALD CONNECT INC | $982,449 | G80 | published | | Middleton, MA | 2025 |
| AMERICAN SYRINGOMYELIA ALLIANCE PROJECT INC | $969,539 | G80 | inferred 0.75 | | Longview, TX | 2023 |
| JAR OF HOPE | $963,776 | G80 | published | | Manalapan, NJ | 2025 |
| HOUSTON VA RESEARCH & EDUCATION FOUNDATION | $962,334 | G80 | published | science: research education | Houston, TX | 2024 |
| JOSEPH P KENNEDY JR FOUNDATION | $901,348 | G80 | inferred 0.55 | | Washington, DC | 2025 |
| READSOURCE INC | $873,006 | G80 | published | | Atlanta, GA | 2024 |
| PARKINSONS WELLNESS FOUNDATION | $855,901 | G80 | published | | New York, NY | 2025 |
| IRON PHI FOUNDATION | $841,577 | G80 | published | | Oxford, OH | 2024 |
| SOFT POWER HEALTH TR | $814,286 | G80 | published | violence: sexual | Purchase, NY | 2024 |
| LUPUS LA | $805,983 | G80 | published | science: research education | Encino, CA | 2025 |
| IMAGINE A WAY | $787,614 | G80 | published | | Leander, TX | 2024 |
| WILSON DISEASE ASSOCIATION | $784,791 | G80 | inferred 0.60 | | New York, NY | 2024 |
| VWD CONNECT FOUNDATION INC | $772,374 | G80 | published | | Wellington, FL | 2024 |
| APPLE GROUP INC | $753,119 | G80 | published | | Jonesboro, AR | 2025 |
| HEREDITARY NEUROLOGICAL DISEASE CENTRE INC | $745,896 | G80 | published | | Wichita, KS | 2025 |
| LYME DISEASE BIOBANK FOUNDATION | $745,615 | G80 | published | | Portland, OR | 2024 |
| HYPOPARATHYROIDISM ASSOCIATION INC | $700,642 | G80 | published | | Frisco, TX | 2025 |
| PARASITES WITHOUT BORDERS INC | $693,957 | G80 | published | space: outer | Prt Washingtn, NY | 2024 |
| PXE INTERNATIONAL INC | $692,622 | G80 | published | | Damascus, MD | 2024 |
| CREATE CURES FOUNDATION | $689,760 | G80 | published | science: research education | Santa Monica, CA | 2024 |
| DIABETESSISTERS | $674,756 | G80 | published | women: issues | Wake Forest, NC | 2025 |
| JACOBS CURE INC | $657,654 | G80 | inferred 0.75 | | Rye, NY | 2012 |
| ANDREWS FIREFLY FUND | $649,177 | G80 | published | | Austin, TX | 2024 |
| PRION ALLIANCE INC | $635,871 | G80 | published | launch: launch | Cambridge, MA | 2025 |
| INTERNATIONAL ALLIANCE FOR DIABETES ACTION | $630,356 | G80 | published | | Boston, MA | 2024 |
| VASCULAR BIRTHMARKS FOUNDATION INC | $623,212 | G80 | published | | Latham, NY | 2025 |
| Make-A-Wish Foundation of the Texas Plains | $619,456 | G80 | inferred 0.60 | space: outer | Amarillo, TX | 2009 |
| ESOPHAGEAL CANCER ACTION NETWORK INC | $617,412 | G80 | published | survivor: cancer | Stevenson, MD | 2024 |
| MOG PROJECT INC | $595,048 | G80 | published | | Gaithersburg, MD | 2025 |
| AMYOTROPHIC LATERAL SCLEROSIS NORTH TEXAS CHAPTER | $570,341 | G80 | inferred 0.70 | | Irving, TX | 2010 |
| INTERNATIONAL HEPATO-PANCREATO BILIARY ASSOCIATION INC | $558,929 | G80 | published | science: research education | Rochester, MN | 2024 |
| DOWN SYNDROME FOUNDATION OF FLORIDA INC | $557,578 | G80 | published | | Orlando, FL | 2024 |
| MACKENZIES MISSION | $555,079 | G80 | published | | Reston, VA | 2025 |
| PROJECT LYME | $546,084 | G80 | published | | New York, NY | 2024 |
| SICKLE CELL DISEASE ASSOCIATION OF ILLINOIS | $545,780 | G80 | inferred 0.85 | | Chicago, IL | 2024 |
| AFRICAN LEADERS MALARIA ALLIANCE INC | $510,310 | G80 | published | | Sprngfld Gdns, NY | 2024 |
| TED COMMUNITY ORGANIZATION | $492,544 | G80 | published | | Pacific Grove, CA | 2025 |
| FUNDACION PEDIATRICA DE DIABETES INC | $491,427 | G80 | published | | Guaynabo, PR | 2024 |
| CURE ADSSL1 | $489,578 | G80 | published | | Glendale, CA | 2025 |