| WEIZMANN INSTITUTE OF SCIENCE | $891,074,542 | U50 | published | | Israel | 2024 |
| COLD SPRING HARBOR LABORATORY | $232,693,889 | U50 | published | science: research education | Cold Spg Hbr, NY | 2024 |
| THE ALLEN INSTITUTE FOR ARTIFICIAL INTELLIGENCE | $205,844,739 | U50 | published | science: research education | Seattle, WA | 2024 |
| AMERICAN TYPE CULTURE COLLECTION | $198,027,310 | U50 | published | science: research education | Manassas, VA | 2024 |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES | $181,393,442 | U50 | published | men: issues | La Jolla, CA | 2024 |
| DONALD DANFORTH PLANT SCIENCE CENTER | $63,779,784 | U50 | published | girls boys: girl scouts | Saint Louis, MO | 2024 |
| MARINE BIOLOGICAL LABORATORY | $55,357,167 | U50 | published | science: research education | Woods Hole, MA | 2024 |
| INSTITUTE FOR SYSTEMS BIOLOGY | $42,255,091 | U50 | published | science: research education | Seattle, WA | 2024 |
| INTERNATIONAL CENTER OF INSECT PHYSIOLOGY AND ECOLOGY | $39,329,669 | U50 | published | science: research education | Kenya | 2025 |
| Immune Disease Institute Inc | $36,276,153 | U50 | inferred 0.80 | science: research education | Boston, MA | 2011 |
| MIND EDUCATION | $31,260,780 | U50 | published | science: research education | Irvine, CA | 2024 |
| CORIELL INSTITUTE FOR MEDICAL RESEARCH INC | $25,210,396 | U50 | published | science: research education | Camden, NJ | 2024 |
| SAGE BIONETWORKS | $24,549,384 | U50 | published | survivor: cancer | Seattle, WA | 2024 |
| CASUALTY ACTUARIAL SOCIETY | $23,998,429 | U50 | inferred 0.50 | science: research education | Arlington, VA | 2024 |
| TALL TIMBERS RESEARCH INC | $22,954,861 | U50 | published | science: research education | Tallahassee, FL | 2025 |
| NORTH CAROLINA BIOTECHNOLOGY CENTER | $21,049,562 | U50 | published | science: research education | Durham, NC | 2024 |
| THE EARTH SPECIES PROJECT | $20,793,212 | U50 | inferred 0.60 | space: outer | Berkeley, CA | 2024 |
| BOTANICAL RESEARCH INSTITUTE OF TEXAS INC | $20,491,336 | U50 | published | science: research education | Fort Worth, TX | 2025 |
| MOUNT DESERT ISLAND BIOLOGICAL LABORATORY | $20,469,754 | U50 | published | launch: launch | Bar Harbor, ME | 2024 |
| NEW YORK STRUCTURAL BIOLOGY CENTER INC | $19,952,697 | U50 | published | science: research education | New York, NY | 2024 |
| BERMUDA INSTITUTE OF OCEAN SCIENCES BIOS INC | $16,851,664 | U50 | published | space: outer | Bermuda | 2024 |
| PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION | $16,698,460 | U50 | published | | Beltsville, MD | 2025 |
| BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH INC | $15,540,935 | U50 | published | science: research education | Ithaca, NY | 2024 |
| J CRAIG VENTER INSTITUTE INC | $14,407,483 | U50 | published | space: outer | San Diego, CA | 2024 |
| RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS INC | $12,093,553 | U50 | inferred 0.40 | science: research education | Mahwah, NJ | 2024 |
| KEYSTONE SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY | $11,371,337 | U50 | published | science: research education | Silverthorne, CO | 2024 |
| BIOMEDICAL RESEARCH & LONGEVITY SOCIETY INC | $10,365,903 | U50 | published | science: research education | Ft Lauderdale, FL | 2025 |
| TWO BLADES FOUNDATION | $9,981,596 | U50 | published | science: research education | Evanston, IL | 2024 |
| SOCIETY FOR THE PROTECTION OF UNDERGROUND NETWORKS | $9,205,437 | U50 | published | | Dover, DE | 2024 |
| MISSISSIPPI STATE UNIVERSITY RESEARCH AND TECHNOLOGY CORP | $9,146,909 | U50 | inferred 0.50 | | Ms State, MS | 2024 |
| BIONEXUS FOUNDATION INC | $9,120,346 | U50 | published | science: research education | Manassas, VA | 2024 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $9,034,127 | U50 | inferred 0.70 | science: research education | Mercer Island, WA | 2018 |
| BIOGENERATOR | $8,693,429 | U50 | published | science: research education | St Louis, MO | 2024 |
| PORTLAND VA RESEARCH FOUNDATION INC | $8,469,506 | U50 | published | | Portland, OR | 2025 |
| SPECIES360 | $7,510,799 | U50 | inferred 0.50 | science: research education | Bloomington, MN | 2024 |
| PRINCE WILLIAM SOUND SCIENCE & TECHNOLOGY INSTITUTE | $6,895,720 | U50 | inferred 0.60 | space: outer | Cordova, AK | 2024 |
| GLOBAL TALENT LAB INC | $5,875,376 | U50 | inferred 0.55 | | Baltimore, MD | 2023 |
| MASSACHUSETTS BIOMEDICAL INITIATIVES | $5,595,536 | U50 | published | science: research education | Worcester, MA | 2025 |
| ROCKY MOUNTAIN BIOLOGICAL LABORATORY AT GOTHIC | $5,147,911 | U50 | published | science: research education | Crested Butte, CO | 2024 |
| POPULATION BIOLOGY FOUNDATION | $5,063,676 | U50 | published | | Grand Junction, CO | 2024 |
| UNIVERSITY ENTERPRISE LABORATORIES INC | $4,485,387 | U50 | published | science: research education | Saint Paul, MN | 2024 |
| CALIFORNIA COUNCIL ON SCIENCE AND TECHNOLOGY | $4,191,798 | U50 | published | | Sacramento, CA | 2024 |
| CONSULTATIVE GROUP ON BIOLOGICAL DIVERSITY | $4,017,759 | U50 | published | science: research education | San Francisco, CA | 2024 |
| THE BIOMIMICRY INSTITUTE | $3,948,697 | U50 | published | | Bozeman, MT | 2024 |
| INSTITUTE FOR MARINE MAMMAL STUDIES INC | $3,905,374 | U50 | published | | Gulfport, MS | 2024 |
| BOSTON BIOSTATISTICS RESEARCH FDN INC | $3,546,375 | U50 | published | science: research education | Framingham, MA | 2024 |
| INTEGRAL ECOLOGY RESEARCH CENTER | $3,140,874 | U50 | published | | Blue Lake, CA | 2024 |
| MICROSCOPY SOCIETY OF AMERICA | $3,036,579 | U50 | published | science: research education | Wakefield, MA | 2025 |
| AMERICAN INSTITUTE OF BIOLOGICAL SCIENCES INC | $2,864,258 | U50 | published | launch: aviation | Herndon, VA | 2024 |
| TURNER INSTITUTE OF ECOAGRICULTURE INC | $2,850,833 | U50 | published | science: research education | Atlanta, GA | 2024 |
| CALIFORNIA DENTAL ASSOCIATION FOUNDATION | $2,770,863 | U50 | published | | Sacramento, CA | 2024 |
| CENTER FOR GLOBAL HEALTH INNOVATION INC | $2,692,294 | U50 | inferred 0.50 | science: research education | Atlanta, GA | 2023 |
| CONSERVATION SCIENCE PARTNERS INC | $2,646,272 | U50 | published | science: research education | Truckee, CA | 2024 |
| ROMANO FOUNDATION INC | $2,510,815 | U50 | published | | Denver, CO | 2024 |
| THE NATIONAL CENTER FOR SCIENCE EDUCATION INC | $2,470,847 | U50 | published | launch: launch | Oakland, CA | 2025 |
| INTERNATIONAL SOCIETY FOR COMPUTATIONAL BIOLOGY INC | $2,444,199 | U50 | published | science: research education | Leesburg, VA | 2024 |
| INTERNATIONAL LIFE SCIENCES INSTITUTE | $2,389,972 | U50 | published | science: research education | Washington, DC | 2024 |
| ASSOCIATION OF BIOMOLECULAR RESOURCE FACILITIES | $2,323,601 | U50 | published | science: research education | Lexington, KY | 2024 |
| ORGANIZATION FOR HUMAN BRAIN MAPPING INC | $2,318,252 | U50 | published | science: research education | Roseville, MN | 2025 |
| THE HUMAN FACTORS & ERGONOMICS SOCIETY | $2,296,139 | U50 | published | | Washington, DC | 2024 |
| ASSOCIATION FOR THE ADVANCEMENT OF SUSTAINABILITY IN HIGHER EDUCATION | $2,224,688 | U50 | published | | Boston, MA | 2025 |
| SCIENCE COMMUNICATION LAB INC | $2,162,079 | U50 | published | science: research education | Berkeley, CA | 2024 |
| AIRABLE RESEARCH LAB | $2,133,267 | U50 | published | | Worthington, OH | 2024 |
| US TERM LIMITS FOUNDATION | $2,064,535 | U50 | published | | Washington, DC | 2024 |
| THE NATIONAL CENTER FOR GENOME RESOURCES | $2,050,951 | U50 | published | science: research education | Santa Fe, NM | 2024 |
| JERRY ROMANO FOUNDATION INC | $2,009,663 | U50 | published | | Denver, CO | 2024 |
| US POULTRY & EGG HAROLD E FORD FOUNDATION INC | $1,987,729 | U50 | published | science: research education | Tucker, GA | 2024 |
| THE RNA SOCIETY | $1,965,555 | U50 | published | | Raleigh, NC | 2024 |
| ASSOCIATION FOR APPLIED SPORT PSYCHOLOGY | $1,886,573 | U50 | published | science: research education | Indianapolis, IN | 2025 |
| SOCIETY FOR WILDERNESS STEWARDSHIP | $1,871,196 | U50 | published | science: research education | Missoula, MT | 2024 |
| ATAXIA TELANGIECTASIA CHILDRENS PROJECT INC | $1,808,873 | U50 | published | science: research education | Coconut Creek, FL | 2024 |
| NUCLEATE BIO INC | $1,759,669 | U50 | published | | Brighton, MA | 2025 |
| SOCIETY FOR DEVELOPMENTAL BIOLOGY INC | $1,632,587 | U50 | published | science: research education | Rockville, MD | 2024 |
| CENTER FOR HUMANS AND NATURE NFP | $1,595,633 | U50 | published | | Libertyville, IL | 2025 |
| PROTEIN SOCIETY | $1,527,651 | U50 | published | science: research education | Hacienda Hts, CA | 2024 |
| RESEARCH COLLABORATORY AT ASU | $1,466,768 | U50 | published | science: research education | Tempe, AZ | 2024 |
| GULF SPECIMEN MARINE LABORATORIES INC | $1,466,019 | U50 | published | | Panacea, FL | 2024 |
| SOCIAL SCIENCE RESEARCH AND EVALUATION INC | $1,462,896 | U50 | inferred 0.50 | science: research education | Lincoln, MA | 2024 |
| VTTMSI MOLECULAR SCIENCES INSTITUTE | $1,451,133 | U50 | inferred 0.80 | science: research education | Milpitas, CA | 2012 |
| FRESHWATER SOCIETY | $1,422,614 | U50 | published | | Saint Paul, MN | 2024 |
| SOCIETY FOR INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY | $1,367,211 | U50 | published | science: research education | Fairfax, VA | 2024 |
| INTERNATIONAL FOUNDATION FOR SCIENCE | $1,319,363 | U50 | inferred 0.50 | | Stockholm | 2023 |
| BIOUTAH INSTITUTE | $1,287,101 | U50 | published | science: research education | Salt Lake Cty, UT | 2024 |
| ANCIENT FOREST SOCIETY | $1,199,590 | U50 | published | | S Lake Tahoe, CA | 2024 |
| INTERNATIONAL SOCIETY FOR THE STUDY OF XENOBIOTICS | $1,182,107 | U50 | published | science: research education | Washington, DC | 2024 |
| BRAIN TRAUMA FOUNDATION INC | $1,161,568 | U50 | published | science: research education | Menlo Park, CA | 2024 |
| AMERICAN SOCIETY FOR BIOETHICS AND HUMANITIES | $1,154,659 | U50 | published | | Schaumburg, IL | 2024 |
| LEMUR CONSERVATION FOUNDATION INC | $1,149,366 | U50 | published | shelter: animal | Myakka City, FL | 2025 |
| PENNSYLVANIA CENTER FOR POULTRY AND LIVESTOCK EXCELLENCE | $1,036,337 | U50 | published | | Harrisburg, PA | 2024 |
| NORTH AMERICAN ORNITHOLOGICAL | $1,007,173 | U50 | inferred 0.50 | science: research education | Falls Church, VA | 2016 |
| OIKONOS-ECOSYSTEM KNOWLEDGE | $995,702 | U50 | published | science: research education | Kailua, HI | 2024 |
| ORGANIC SYNTHESES INC WAYNE STATE UNIVERSITY | $954,475 | U50 | published | science: research education | Waco, TX | 2024 |
| INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOS | $938,662 | U50 | published | science: research education | Canada | 2024 |
| ARBORCREST GARDENS INC | $933,884 | U50 | published | | Boone, NC | 2024 |
| CARBON REMOVAL INSTITUTE | $930,010 | U50 | published | | Brooklyn, NY | 2024 |
| FONDATION SANTE | $918,664 | U50 | published | science: research education | Great Neck, NY | 2024 |
| AGRONOMIC SCIENCE FOUNDATION INC | $911,288 | U50 | inferred 0.40 | science: research education | Fitchburg, WI | 2025 |
| FOUNDATION FOR ANTHROPOLOGICAL RESEARCH AND ENVIRONMENTAL STUDIES | $906,670 | U50 | published | science: research education | Rupert, ID | 2024 |
| FORWARD BIOLABS INC | $889,457 | U50 | published | | Madison, WI | 2024 |
| URBAN FOREST INSTITUTE | $878,676 | U50 | published | | Sn Luis Obisp, CA | 2025 |