| AMERICAN KIDNEY FUND INC | $324,644,050 | G99 | inferred 0.70 | science: research education | Rockville, MD | 2025 |
| WASHINGTON INSTITUTE FOR COAGULATION | $112,675,357 | G99 | published | | Seattle, WA | 2024 |
| MINNESOTA MEDICAL FOUNDATION | $79,237,432 | G99 | inferred 0.50 | science: research education | Minneapolis, MN | 2011 |
| GULF COAST CENTER | $45,367,346 | G99 | published | | League City, TX | 2024 |
| SOCIETY OF THORACIC SURGEONS | $42,114,448 | G99 | inferred 0.60 | science: research education | Chicago, IL | 2024 |
| THE HOPE FOUNDATION | $25,657,637 | G99 | published | survivor: cancer | Ann Arbor, MI | 2025 |
| DAFTUAR FAMILY FOUNDATION | $20,414,788 | G99 | published | science: research education | New York, NY | 2024 |
| DDW LLC | $16,906,500 | G99 | inferred 0.60 | science: research education | Bethesda, MD | 2024 |
| SOUTHERN PLAINS TRIBAL HEALTH BOARD FOUNDATION | $14,634,177 | G99 | published | abuse: substance | Oklahoma City, OK | 2024 |
| MONMOUTH CARES INC | $13,269,508 | G99 | published | | West Long Branch, NJ | 2024 |
| CHILDREN'S CANCER RECOVERY FOUNDATION | $12,465,441 | G99 | inferred 0.60 | survivor: cancer | New Oxford, PA | 2016 |
| PARKINSON'S INSTITUTE | $11,834,900 | G99 | inferred 0.60 | | Sunnyvale, CA | 2012 |
| TIDEPOOL PROJECT | $11,691,397 | G99 | published | | Palo Alto, CA | 2024 |
| HUNTINGTONS DISEASE SOCIETY OF AMERICA INC | $11,232,523 | G99 | inferred 0.65 | science: research education | New York, NY | 2025 |
| NORTH AMERICAN SPINE SOCIETY | $10,904,142 | G99 | inferred 0.60 | science: research education | Burr Ridge, IL | 2024 |
| TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION | $9,973,511 | G99 | inferred 0.50 | science: research education | Woodland Hls, CA | 2024 |
| MINNESOTA LIONS VISION FOUNDATION INC | $9,389,998 | G99 | inferred 0.60 | | Saint Paul, MN | 2024 |
| SERVICE COORDINATION UNLIMITED INC | $9,152,149 | G99 | published | | Erie, PA | 2024 |
| VALERIE FUND | $9,029,743 | G99 | inferred 0.50 | survivor: cancer | Maplewood, NJ | 2024 |
| ARTHROSCOPY ASSOCIATION OF NORTH AMERICA INC | $8,947,868 | G99 | inferred 0.60 | science: research education | Rosemont, IL | 2024 |
| The Hole in the Wall Foundation Inc | $8,180,614 | G99 | inferred 0.50 | | Westport, CT | 2009 |
| TRANSIT EMPLOYEES RETIREE HEALTH FUND | $7,976,217 | G99 | published | | Forestville, MD | 2024 |
| GBS CIDP FOUNDATION INTERNATIONAL | $7,799,708 | G99 | published | | Conshohocken, PA | 2025 |
| INFANT TODDLER SERVICE OF JOHNSON INC | $7,405,849 | G99 | published | | Overland Park, KS | 2024 |
| SAN DIEGO EYE BANK | $7,077,118 | G99 | inferred 0.60 | science: research education | San Diego, CA | 2024 |
| ONCOLOGY NURSING SOCIETY | $6,782,265 | G99 | inferred 0.60 | | Pittsburgh, PA | 2025 |
| AMERICAN ACADEMY OF DENTAL SLEEP MEDICINE | $6,581,453 | G99 | published | science: research education | Lisle, IL | 2025 |
| MCLAUGHLIN RESEARCH INSTITUTE FOR BIOMEDICAL SCIENCES | $5,929,875 | G99 | inferred 0.55 | science: research education | Great Falls, MT | 2024 |
| D-TREE INTERNATIONAL INC | $5,035,866 | G99 | published | | Norwell, MA | 2024 |
| SOCIETY OF NEUROINTERVENTIONAL SURGERY | $5,013,221 | G99 | inferred 0.60 | | Fairfax, VA | 2024 |
| AMERICAN MEDICAL SOCIETY FOR SPORTS MEDICINE INC | $4,840,978 | G99 | inferred 0.60 | science: research education | Leawood, KS | 2024 |
| NATIONAL CHILDRENS REHABILITATION CENTER | $4,782,376 | G99 | inferred 0.60 | | Winchester, VA | 2010 |
| BRAIN INJURY ASSOCIATION OF AMERICA INC | $4,505,913 | G99 | inferred 0.50 | | Fairfax, VA | 2025 |
| POLYBIO RESEARCH FOUNDATION | $4,324,689 | G99 | inferred 0.60 | | Medford, MA | 2024 |
| NATIONAL CAREGIVING FOUNDATION | $4,149,225 | G99 | inferred 0.50 | | Dunkirk, MD | 2024 |
| THE NATIONAL SOCIETY FOR CUTANEOUS | $3,761,675 | G99 | inferred 0.60 | | New York, NY | 2023 |
| AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATION | $3,702,107 | G99 | inferred 0.75 | | Saint Paul, MN | 2022 |
| THALASSEMIA FOUNDATION OF AMERICA INC | $3,550,630 | G99 | inferred 0.60 | science: research education | New York, NY | 2024 |
| AMERICAN INSTITUTE FOR RADIOLOGIC | $3,434,138 | G99 | inferred 0.50 | | Reston, VA | 2020 |
| GATEWAY TO HOPE | $3,343,445 | G99 | published | women: issues | Maplewood, MO | 2025 |
| NATIONAL FOUNDATION FOR INFECTIOUS DISEASES | $3,307,801 | G99 | inferred 0.60 | science: research education | Bethesda, MD | 2024 |
| RHEUMATOLOGY ADVANCED PRACTICE PROVIDERS INC | $2,919,000 | G99 | published | | Holmdel, NJ | 2024 |
| AUTISM SERVICE CENTER OF SAN ANTONIO | $2,673,724 | G99 | inferred 0.60 | science: research education | San Antonio, TX | 2025 |
| DYSTROPHIC EPIDERMOLYSIS BULLOSA RESEARCH ASSN OF AMERICA INC | $2,413,481 | G99 | inferred 0.60 | | Boulder, CO | 2025 |
| Pin Oak Charity Horse Show Association | $2,379,777 | G99 | inferred 0.70 | | Katy, TX | 2016 |
| WORKING DOGS FOR CONSERVATION FOUNDATION | $2,360,188 | G99 | published | | Missoula, MT | 2024 |
| ALS ONE INC | $2,270,157 | G99 | published | science: research education | Whitman, MA | 2024 |
| NATIONAL FOUNDATION FOR AUTISM RESEARCH | $2,075,570 | G99 | published | men: issues | San Diego, CA | 2024 |
| NEUROFIT NETWORKS INC | $2,052,200 | G99 | inferred 0.50 | science: research education | Tucson, AZ | 2024 |
| INTERNATIONAL SOCIETY FOR INFECTIOUS DISEASES INC | $2,023,643 | G99 | published | science: research education | Boston, MA | 2024 |
| DOWN SYNDROME INNOVATIONS INC | $1,978,318 | G99 | inferred 0.60 | | Mission, KS | 2024 |
| PSC PARTNERS SEEKING A CURE | $1,901,852 | G99 | inferred 0.60 | science: research education | Greenwood Village, CO | 2024 |
| EASTERSEALS NEBRASKA | $1,894,720 | G99 | published | | Omaha, NE | 2024 |
| OLIGO NATION | $1,893,730 | G99 | published | | Sebastopol, CA | 2024 |
| CONNECTICUT EYE BANK AND VISUAL RESEARCH | $1,887,324 | G99 | inferred 0.60 | | New Britain, CT | 2014 |
| VILLAGE HEARTBEAT | $1,788,302 | G99 | published | | Charlotte, NC | 2025 |
| ZION KEEPERS INC | $1,762,052 | G99 | published | | Stone Mtn, GA | 2025 |
| SOCIETY TO IMPROVE DIAGNOSIS IN | $1,732,978 | G99 | inferred 0.50 | science: research education | Alpharetta, GA | 2022 |
| SERENITY RECOVERY CONNECTION | $1,710,022 | G99 | published | abuse: substance | Greenwood Vlg, CO | 2025 |
| Skin of Color Society | $1,672,017 | G99 | inferred 0.60 | science: research education | Chicago, IL | 2024 |
| GREAT LAKES HEMOPHILIA FOUNDATION INC | $1,668,508 | G99 | inferred 0.60 | women: issues | Elm Grove, WI | 2024 |
| PAN AMERICAN LEAGUE OF ASSOCIATIONS FOR RHEUMATOLOGY | $1,602,494 | G99 | published | science: research education | Miami, FL | 2024 |
| NATIONAL ARAB AMERICAN MEDICAL ASSOCIATION INC | $1,557,970 | G99 | published | survivor: disaster | Troy, MI | 2024 |
| JOHN W BRICK MENTAL HEALTH FOUNDATION INC | $1,496,942 | G99 | published | science: research education | Timonium, MD | 2024 |
| SIEGEL RARE NEUROIMMUNE ASSOCIATION | $1,493,618 | G99 | published | | Powell, OH | 2024 |
| ALZHEIMER-PARKINSON ASSOCIATION OF IRC INC | $1,485,908 | G99 | inferred 0.60 | men: issues | Vero Beach, FL | 2024 |
| HEMOPHILIA FOUNDATION OF SOUTHERN CALIFORNIA | $1,464,570 | G99 | inferred 0.60 | men: issues | Pasadena, CA | 2024 |
| HELPING EVERYONE REACH OUTSTANDING EDUCATIONAL SUCCESS | $1,453,139 | G99 | published | science: research education | Richardson, TX | 2024 |
| NEW YORK SOCIETY FOR GASTROINTESTINAL ENDOSCOPY INC | $1,409,333 | G99 | inferred 0.60 | | East Dundee, IL | 2024 |
| HIGH HOPES NEUROLOGICAL RECOVERY GROUP INC | $1,406,515 | G99 | inferred 0.60 | | Newport Beach, CA | 2024 |
| NEW YORK SECTION OF THE AMERICAN UROLOGICAL ASSOCIATION INC | $1,368,978 | G99 | inferred 0.60 | science: research education | Seaford, NY | 2024 |
| MAGIC FOUNDATION | $1,346,987 | G99 | inferred 0.60 | | Warrenville, IL | 2025 |
| PARKINSONS RESOURCES OF OREGON | $1,337,680 | G99 | inferred 0.60 | | Beaverton, OR | 2025 |
| THE STEVEN S MEZZIO CHARITABLE TRUST | $1,311,378 | G99 | published | | New York, NY | 2025 |
| IGNITE COLLECTIVE INC | $1,305,652 | G99 | published | | Mammoth Lakes, CA | 2025 |
| EPILEPSY FOUNDATION OF NORTHEASTERN NEW YORK INC | $1,280,221 | G99 | inferred 0.60 | | Albany, NY | 2025 |
| BAKER GORDON EDUCATIONAL SYMPOSIUM INC | $1,257,350 | G99 | published | | Coconut Grove, FL | 2025 |
| UNITED CEREBRAL PALSY ASSOCIATION | $1,252,527 | G99 | inferred 0.60 | | Kailua, HI | 2017 |
| JORDAN ELIZABETH HARRIS FOUNDATION | $1,247,114 | G99 | published | | Fort Worth, TX | 2024 |
| HEMOPHILIA ASSOCIATION OF NEW JERSEY | $1,179,964 | G99 | inferred 0.60 | women: issues | East Brunswick, NJ | 2024 |
| Hidradenitis Suppurativa Foundation Inc | $1,179,185 | G99 | inferred 0.50 | science: research education | Cary, NC | 2022 |
| TEDYS TEAM INC | $1,142,549 | G99 | published | | Plainville, MA | 2024 |
| HFM CAMPING ADVENTURES | $1,097,040 | G99 | published | | Ypsilanti, MI | 2025 |
| BRAIN INJURY ASSOCIATION OF VA INC | $1,082,510 | G99 | inferred 0.50 | science: research education | Richmond, VA | 2024 |
| CHILDRENS CANCER FUND OF NEW MEXICO | $1,056,342 | G99 | inferred 0.50 | | Albuquerque, NM | 2024 |
| Sensory Processing Disorder Foundation | $1,024,084 | G99 | inferred 0.60 | | Greenwood Village, CO | 2015 |
| SOCIETY OF GYNECOLOGIC SURGEONS | $1,016,242 | G99 | inferred 0.60 | women: issues | Burnsville, MN | 2025 |
| SOCIETY FOR BIOPSYCHOSOCIAL SCIENCE AND MEDICINE INC | $1,009,567 | G99 | published | science: research education | Mclean, VA | 2024 |
| FOUNDATION FOR DERMATOLOGY EDUCATION | $1,006,423 | G99 | published | | Chicago, IL | 2024 |
| AMERICAN ACADEMY OF ESTHETIC DENTISTRY | $1,000,439 | G99 | inferred 0.70 | science: research education | Mclean, VA | 2024 |
| FOUNDATION FOR ICHTHYOSIS AND RELATED SKIN TYPES | $966,515 | G99 | inferred 0.60 | | Lansdale, PA | 2024 |
| GILDAS CLUB TWIN CITIES INC | $939,814 | G99 | published | | Minnetonka, MN | 2024 |
| JEWISH UNION FOUNDATION OF NEW JERSEY INC | $923,045 | G99 | published | | Teaneck, NJ | 2024 |
| MARGARET M DYSON TR UW FBO MARGARET M DYSON VISION RESEARCH INSTITUTE | $917,395 | G99 | inferred 0.60 | | Poughkeepsie, NY | 2025 |
| FRIENDS OF THE CHILDREN - HE SAPA | $877,222 | G99 | published | | Rapid City, SD | 2024 |
| AMERICAN COLLEGE OF VETERINARY | $875,933 | G99 | inferred 0.60 | | Sacramento, CA | 2024 |
| DIABETES HANDS FOUNDATION | $845,075 | G99 | inferred 0.60 | | Berkeley, CA | 2016 |
| PENINSULA PLASTIC SURGERY FOUNDATION | $835,853 | G99 | published | | Los Altos, CA | 2025 |
| MY BREAST CANCER SUPPORT | $827,530 | G99 | published | | Portsmouth, NH | 2025 |
| BRAIN INJURY ASSOCIATION OF NC | $824,315 | G99 | inferred 0.60 | | Raleigh, NC | 2024 |