| CAN COMMUNITY HEALTH INC | $506,024,240 | G81 | published | | Tampa, FL | 2024 |
| DAP HEALTH INC | $280,264,706 | G81 | published | survivor: cancer | Palm Springs, CA | 2024 |
| CHASE BREXTON HEALTH SERVICES INC | $172,818,534 | G81 | published | | Baltimore, MD | 2024 |
| CARE RESOURCE COMMUNITY HEALTH CENTERS INC | $138,789,620 | G81 | published | | Miami, FL | 2024 |
| AIDS ARMS INC | $124,939,996 | G81 | published | women: issues | Dallas, TX | 2024 |
| EHS INC | $119,895,161 | G81 | published | | Buffalo, NY | 2024 |
| VIVENT HEALTH INC | $109,460,230 | G81 | published | men: issues | Milwaukee, WI | 2024 |
| CARES COMMUNITY HEALTH | $105,005,933 | G81 | published | abuse: substance | Sacramento, CA | 2024 |
| EQUITAS HEALTH INC | $86,300,739 | G81 | published | | Columbus, OH | 2024 |
| AIDS CARE GROUP | $77,454,293 | G81 | published | | Chester, PA | 2024 |
| NASHVILLE C A R E S INC | $75,232,922 | G81 | published | science: research education | Nashville, TN | 2024 |
| HIV-AIDS ALLIANCE FOR REGION TWO | $73,988,017 | G81 | published | abuse: substance | Baton Rouge, LA | 2024 |
| WHITMAN-WALKER CLINIC INC | $62,406,560 | G81 | published | violence: community | Washington, DC | 2024 |
| APICHA COMMUNITY HEALTH CENTER | $42,766,814 | G81 | published | abuse: substance | New York, NY | 2024 |
| AIDS FOUNDATION OF CHICAGO | $41,006,403 | G81 | published | | Chicago, IL | 2024 |
| RESOURCE CENTER OF DALLAS INC | $39,043,469 | G81 | published | men: issues | Dallas, TX | 2024 |
| AIDS SERVICE CENTER OF LOWER MANHATTAN INC | $38,944,219 | G81 | published | abuse: substance | New York, NY | 2024 |
| GAY MENS HEALTH CRISIS INC | $38,735,312 | G81 | published | abuse: substance | New York, NY | 2024 |
| CASCADE AIDS PROJECT | $37,686,765 | G81 | published | space: for men | Portland, OR | 2024 |
| COLORADO HEALTH NETWORK INC | $37,133,026 | G81 | published | | Denver, CO | 2024 |
| LIFELONG HEALTH FOR ALL | $36,175,032 | G81 | published | abuse: substance | Seattle, WA | 2024 |
| AIDS ACTION COALITION OF HUNTSVILLE | $35,895,541 | G81 | published | abuse: substance | Huntsville, AL | 2024 |
| HOUSTON AREA COMMUNITY SERVICES INC | $35,698,862 | G81 | published | | Houston, TX | 2024 |
| HARLEM UNITED COMMUNITY AIDS CENTER INC | $33,655,576 | G81 | published | | New York, NY | 2024 |
| BROADWAY CARES-EQUITY FIGHTS AIDS INC | $32,608,606 | G81 | inferred 0.70 | men: issues | New York, NY | 2024 |
| HOUSING WORKS HEALTH SERVICES III INC | $29,894,125 | G81 | published | science: research education | Brooklyn, NY | 2024 |
| MARY M GOOLEY HEMOPHILIA CENTER INC | $28,668,468 | G81 | inferred 0.50 | | Rochester, NY | 2024 |
| WELLVIEW CARE INC | $28,406,574 | G81 | inferred 0.75 | | Ft Lauderdale, FL | 2025 |
| AFFINITY HEALTH CENTER | $27,749,164 | G81 | published | abuse: substance | Rock Hill, SC | 2024 |
| ALAMO AREA RESOURCE CENTER INC | $26,720,306 | G81 | published | | San Antonio, TX | 2024 |
| CHICAGO HOUSE AND SOCIAL SERVICE AGENCY | $26,435,859 | G81 | published | abuse: substance | Chicago, IL | 2024 |
| FOOD & FRIENDS INC | $25,211,252 | G81 | published | | Washington, DC | 2024 |
| AIDS PROJECT OF THE OZARKS | $23,899,778 | G81 | published | | Springfield, MO | 2024 |
| COMMUNITY RESEARCH INITIATIVE OF NEW ENGLAND INC | $23,660,538 | G81 | published | | Boston, MA | 2024 |
| HEALTH SERVICES OF NORTH TEXAS INC | $23,516,336 | G81 | published | abuse: substance | Denton, TX | 2025 |
| PROJECT ANGEL FOOD | $22,660,322 | G81 | published | science: research education | Los Angeles, CA | 2024 |
| AIDS CENTER OF QUEENS COUNTY INC | $22,423,634 | G81 | published | | Richmond Hill, NY | 2024 |
| MONTGOMERY AIDS OUTREACH INC | $22,407,934 | G81 | inferred 0.60 | | Montgomery, AL | 2021 |
| ASIAN AND PACIFIC ISLANDER WELLNESS CENTER INC | $22,136,062 | G81 | published | abuse: substance | San Francisco, CA | 2024 |
| BAILEY HOUSE INC | $20,628,432 | G81 | published | | Brooklyn, NY | 2024 |
| ELTON JOHN AIDS FOUNDATION INC | $20,298,674 | G81 | published | girls boys: girls | New York, NY | 2024 |
| IDENTITY INC | $20,242,318 | G81 | published | abuse: substance | Gaithersburg, MD | 2024 |
| SOUTHERN ARIZONA AIDS FOUNDATION | $19,642,722 | G81 | published | violence: sexual | Tucson, AZ | 2024 |
| BIG BEND CARES INC | $19,343,915 | G81 | inferred 0.60 | | Tallahassee, FL | 2024 |
| COASTAL BEND WELLNESS FOUNDATION INC | $19,135,326 | G81 | published | abuse: substance | Corp Christi, TX | 2024 |
| AIDS ALABAMA INC | $18,838,386 | G81 | published | | Birmingham, AL | 2024 |
| VALLEY AIDS COUNCIL | $18,806,849 | G81 | published | abuse: substance | Harlingen, TX | 2024 |
| PROJECT RESPONSE INC | $18,441,709 | G81 | published | | Melbourne, FL | 2024 |
| INTERFAITH RESIDENCE | $18,366,284 | G81 | published | | Saint Louis, MO | 2024 |
| ACADIANA CONCERN FOR AIDS RELIEF EDUCATION AND SUPPORT INC | $18,350,612 | G81 | published | abuse: substance | Lafayette, LA | 2024 |
| ACTION WELLNESS | $17,939,440 | G81 | published | abuse: substance | Philadelphia, PA | 2024 |
| SAINT MICHAELS CLINICS INC | $17,125,809 | G81 | published | abuse: substance | Newark, NJ | 2024 |
| VIVENT HEALTH TEXAS INC | $17,008,892 | G81 | published | men: issues | Austin, TX | 2024 |
| PEER WASHINGTON | $16,872,437 | G81 | published | | Seattle, WA | 2024 |
| PINNACLE FAMILY HEALTH INC | $16,022,334 | G81 | published | men: issues | West Monroe, LA | 2025 |
| HEALTH EMERGENCY ASSISTANCE OF DETROIT | $15,848,565 | G81 | published | | Detroit, MI | 2024 |
| AIDS FOUNDATION HOUSTON INC | $15,515,171 | G81 | published | shelter: homeless | Houston, TX | 2024 |
| HAWAII HEALTH & HARM REDUCTION CENTER | $15,288,588 | G81 | published | abuse: substance | Honolulu, HI | 2024 |
| LGBT LIFE CENTER | $15,163,243 | G81 | published | | Norfolk, VA | 2024 |
| SAN ANTONIO AIDS FOUNDATION | $14,904,133 | G81 | published | shelter: homeless | San Antonio, TX | 2024 |
| BIRMINGHAM AIDS OUTREACH INC | $14,836,769 | G81 | published | | Birmingham, AL | 2023 |
| HEALTH CARE ADVOCATES INTERNATIONAL INC | $14,624,514 | G81 | published | abuse: substance | Stratford, CT | 2024 |
| SHOUT IT NOW | $13,583,797 | G81 | published | | Seattle, WA | 2024 |
| NATIONAL ATAXIA FOUNDATION INC | $13,032,062 | G81 | inferred 0.60 | science: research education | Minneapolis, MN | 2025 |
| ADVANCING CONNECTICUT TOGETHER INC | $12,352,705 | G81 | published | abuse: substance | Hartford, CT | 2024 |
| EMPOWER U INC | $12,283,310 | G81 | published | abuse: substance | Miami, FL | 2023 |
| NEWARK AIDS CONSORTIUM INC | $12,114,968 | G81 | published | | Newark, NJ | 2024 |
| EQUAL ACCESS INTERNATIONAL | $11,460,639 | G81 | published | survivor: sexual | Washington, DC | 2024 |
| THE ALIVENESS PROJECT INC | $11,369,637 | G81 | inferred 0.80 | men: issues | Minneapolis, MN | 2024 |
| DAVE PURCHASE PROJECT | $11,355,890 | G81 | published | | Tacoma, WA | 2024 |
| HARBORPATH INC | $10,917,977 | G81 | published | | Charlotte, NC | 2024 |
| AID ATLANTA INC | $10,493,546 | G81 | published | abuse: substance | Atlanta, GA | 2025 |
| IRIS HOUSE A CENTER FOR WOMAN LIVING WITH HIV INC | $10,356,991 | G81 | published | abuse: substance | New York, NY | 2024 |
| ALLIES FOR HEALTH & WELLBEING | $10,035,018 | G81 | published | abuse: substance | Pittsburgh, PA | 2024 |
| SOUTHWEST LOUISIANA AIDS COUNCIL | $9,908,228 | G81 | published | abuse: substance | Lake Charles, LA | 2024 |
| NATIONAL MINORITY AIDS COUNCIL DBA AIDS PROGRAMS OF THE NATIONAL | $9,792,777 | G81 | published | | Washington, DC | 2024 |
| LEEWAY INC | $9,731,186 | G81 | published | | New Haven, CT | 2024 |
| AIDS COUNCIL OF NORTHEASTERN NEW YORK INC | $9,510,908 | G81 | published | abuse: substance | Albany, NY | 2024 |
| LIVWELL COMMUNITY HEALTH SERVICES INC | $9,089,067 | G81 | published | | Paducah, KY | 2024 |
| ST MARYS CENTER INC | $7,807,812 | G81 | published | abuse: elder | New York, NY | 2024 |
| POSITIVELY U INC | $7,753,651 | G81 | published | | Winter Haven, FL | 2024 |
| BUILDING CHANGES | $7,741,301 | G81 | published | launch: launch | Seattle, WA | 2024 |
| HEALTH SERVICES CENTER INC | $7,304,042 | G81 | published | abuse: substance | Anniston, AL | 2024 |
| AIDS SUPPORT GROUP OF CAPE COD INC | $7,228,084 | G81 | published | | Provincetown, MA | 2024 |
| LATINO COMMISSION ON AIDS INC | $7,022,172 | G81 | published | | New York, NY | 2024 |
| RAFIKI COALITION FOR HEALTH AND WELLNESS | $6,890,179 | G81 | published | abuse: substance | San Francisco, CA | 2024 |
| AIDS OUTREACH CENTER INC | $6,323,820 | G81 | published | | Fort Worth, TX | 2024 |
| ALZHEIMER'S DISEASE & RELATED DISORDERS | $6,311,744 | G81 | inferred 0.60 | | Chicago, IL | 2015 |
| WYOMING VALLEY AIDS COUNCIL | $6,188,985 | G81 | published | | Wilkes Barre, PA | 2024 |
| AIDS CARE OCEAN STATE INC | $6,182,374 | G81 | published | | Providence, RI | 2024 |
| MOTHERS2MOTHERS UNITED STATES INC | $5,910,095 | G81 | published | women: issues | Los Angeles, CA | 2024 |
| BUDDIES OF NEW JERSEY INC | $5,447,338 | G81 | published | abuse: substance | Hackensack, NJ | 2024 |
| PROJECT NEW HOPE | $5,421,921 | G81 | published | shelter: homeless | Glendale, CA | 2024 |
| PROJECT SUNSHINE INC | $5,283,622 | G81 | published | | New York, NY | 2024 |
| CARE 4 U MANAGEMENT | $5,226,375 | G81 | published | abuse: substance | Miami, FL | 2024 |
| AHF MCO OF FLORIDA INC | $5,123,607 | G81 | published | | Los Angeles, CA | 2024 |
| VOCES LATINAS CORPORATION | $5,029,272 | G81 | published | violence: prevention | Jackson Hts, NY | 2024 |
| TOUCH TOGETHER OUR UNITY CAN HEAL INC | $5,022,153 | G81 | published | abuse: substance | Congers, NY | 2024 |
| HIV RESOURCE CONSORTIUM INC | $5,006,343 | G81 | published | | Tulsa, OK | 2024 |
| WALL-LAS MEMORIAS PROJECT | $4,890,079 | G81 | published | | Los Angeles, CA | 2024 |