| NATIONAL MULTIPLE SCLEROSIS SOCIETY | $161,966,823 | G50 | published | men: issues | New York, NY | 2024 |
| MUSCULAR DYSTROPHY ASSOCIATION | $64,160,032 | G50 | published | science: research education | Chicago, IL | 2025 |
| THE OAK CLINIC | $62,213,011 | G50 | published | | Green, OH | 2024 |
| THE MULTIPLE MYELOMA RESEARCH FOUNDATION INC | $36,523,356 | G50 | published | science: research education | Norwalk, CT | 2025 |
| AMYOTROPHIC LATERAL SCLEROSIS ASSN | $20,939,101 | G50 | published | launch: religious | Arlington, VA | 2024 |
| ATLANTA NEUROSCIENCE INSTITUTE INC | $14,126,053 | G50 | published | | Atlanta, GA | 2025 |
| AMERICAN PARKINSON DISEASE ASSOC | $12,091,858 | G50 | published | science: research education | Staten Island, NY | 2025 |
| MULTIPLE SCLEROSIS ASSOCIATION OF AMERICA INC | $10,916,638 | G50 | published | launch: launch | Cherry Hill, NJ | 2024 |
| BOYER CHILDRENS CLINIC | $10,615,717 | G50 | published | | Seattle, WA | 2024 |
| BROADSCOPE DISABILITY SERVICES INC | $6,797,360 | G50 | published | | Greenfield, WI | 2025 |
| TOURETTE ASSOCIATION OF AMERICA INC | $5,236,564 | G50 | published | science: research education | Bayside, NY | 2024 |
| BONE HEALTH AND OSTEOPOROSIS FOUNDATION | $3,962,010 | G50 | published | launch: launch | Arlington, VA | 2025 |
| PARKINSON VOICE PROJECT INC | $3,608,362 | G50 | published | launch: launch | Richardson, TX | 2024 |
| PROJECT ALS INC | $3,298,805 | G50 | published | science: research education | Huntingtown, MD | 2024 |
| FOUNDATION FOR UCP OF GREATER SACRAMENTO | $3,047,375 | G50 | published | | Sacramento, CA | 2024 |
| ACCELERATED CURE PROJECT INC | $2,852,560 | G50 | published | science: research education | Waltham, MA | 2024 |
| NEVER SURRENDER INC | $2,818,004 | G50 | published | | Hermantown, MN | 2024 |
| ANSWER ALS | $2,817,907 | G50 | published | science: research education | New Orleans, LA | 2024 |
| PETER COHEN FOUNDATION | $2,797,874 | G50 | published | | Seattle, WA | 2024 |
| PERIPHERAL NERVE SOCIETY | $2,579,205 | G50 | published | science: research education | Roseville, MN | 2025 |
| INTERNATIONAL F O P ASSOCIATION INC | $2,421,587 | G50 | inferred 0.80 | science: research education | North Kansas City, MO | 2024 |
| PARKINSON STUDY GROUP INC | $1,837,674 | G50 | published | science: research education | East Boston, MA | 2024 |
| AMERICAN ACADEMY FOR CEREBRAL PALSY AND DEVELOPMENT MEDICINE | $1,649,442 | G50 | published | science: research education | Milwaukee, WI | 2024 |
| DYSAUTONOMIA FOUNDATION INC | $1,558,104 | G50 | published | | New York, NY | 2024 |
| NATIONAL COMMISSION ON ORTHOTIC AND PROSTHETIC EDUCATION INC | $1,528,749 | G50 | published | | Alexandria, VA | 2025 |
| PARKINSON ASSOCIATION OF THE ROCKIES | $1,484,519 | G50 | published | | Denver, CO | 2024 |
| ARTHROSCOPY ASSOCIATION OF NORTH AMERICA EDUCATION FOUNDATION | $1,336,605 | G50 | published | | Rosemont, IL | 2024 |
| PARKINSONS EXERCISE AND WELLNESS CENTER | $1,270,547 | G50 | published | | Overland Park, KS | 2024 |
| DREAMS GO ON | $1,045,620 | G50 | published | | Hollidaysburg, PA | 2025 |
| DYSIMMUNE NEUROMUSCULAR DISEASES FOUNDATION | $1,000,004 | G50 | published | science: research education | Lexington, MA | 2025 |
| PERSONAL ENRICHMENT PROGRAM INC | $973,331 | G50 | published | | Marina Del Rey, CA | 2024 |
| RIDE FOR LIFE INC | $969,522 | G50 | published | | Stony Brook, NY | 2024 |
| FACIAL PAIN RESEARCH FOUNDATION INC | $957,731 | G50 | published | | Gainesville, FL | 2024 |
| SHINING STARS THERAPEUTIC RIDING PROGRAM INC | $955,574 | G50 | published | | Gettysburg, PA | 2024 |
| ALS IN THE HEARTLAND INC | $862,046 | G50 | published | | Omaha, NE | 2025 |
| Arthritis Foundation Southeast Region Inc | $835,245 | G50 | inferred 0.70 | science: research education | Atlanta, GA | 2013 |
| NEXT STEP ATLANTA INC | $832,100 | G50 | published | | Alpharetta, GA | 2024 |
| TEXAS NEUROFIBROMATOSIS FOUNDATION | $802,784 | G50 | published | | Flower Mound, TX | 2025 |
| ROAD 2 RECOVERY FOUNDATION | $784,270 | G50 | published | | San Diego, CA | 2024 |
| AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATION OF MICHIGAN INC | $765,935 | G50 | published | | Southfield, MI | 2024 |
| Arthritis Foundation Inc New York Chapter | $750,135 | G50 | inferred 0.70 | | New York, NY | 2009 |
| LIFE ROLLS ON FOUNDATION | $735,516 | G50 | published | | Los Angeles, CA | 2024 |
| FUNDACION DE ESCLEROSIS MULTIPLE DE PUERTO RICO INC | $614,621 | G50 | published | | Guaynabo, PR | 2025 |
| NEXTSTEP ORLANDO INC | $590,673 | G50 | published | | Orlando, FL | 2024 |
| EMPOWER PARKINSON INC | $589,187 | G50 | published | | Tully, NY | 2024 |
| AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATION | $561,774 | G50 | published | | Del Mar, CA | 2024 |
| WESTERN TRAUMA ASSOCIATION | $515,163 | G50 | published | science: research education | Batavia, IL | 2024 |
| MS IMPOSSIBLE | $508,674 | G50 | published | | Issaquah, WA | 2025 |
| RACING FOR ALS INC | $506,322 | G50 | published | | Apex, NC | 2025 |
| CINDIS HOPE INC | $496,703 | G50 | published | | Georgetown, TX | 2025 |
| OSTEOPOROSIS FOUNDATION OF NEW MEXICO | $489,181 | G50 | published | | Albuquerque, NM | 2024 |
| PARALYZED VETERANS OF AMERICA SPINAL CORD INJURY EDUCATION AND T | $480,278 | G50 | published | | Washington, DC | 2024 |
| PENNSYLVANIA TOURETTE SYNDROME ALLIANCE INC | $469,746 | G50 | published | | Hanover, PA | 2024 |
| NEW YORK STATE RHEUMATOLOGY SOCIETY INC | $462,095 | G50 | published | | Smithtown, NY | 2025 |
| CLUB PARKINSONS OF KANSAS | $453,613 | G50 | published | | Wichita, KS | 2024 |
| AMERICAN ORTHOPEDIC FOUNDATION | $425,591 | G50 | published | | Des Plaines, IL | 2024 |
| CURE VCP DISEASE INC | $423,616 | G50 | published | | Warner Robins, GA | 2025 |
| JAIN FOUNDATION INC | $384,162 | G50 | published | science: research education | Seattle, WA | 2024 |
| PARKINSONS SUPPORT AND WELLNESS INC | $368,634 | G50 | published | | Cincinnati, OH | 2025 |
| VIRGINIA GENTLEMENS FOUNDATION INC | $350,901 | G50 | published | science: research education | Virginia Bch, VA | 2024 |
| NEXTGEN ALS INC | $322,742 | G50 | published | | Greenville, WI | 2025 |
| GLOBAL NERVE FOUNDATION | $278,600 | G50 | published | launch: launch | Kennesaw, GA | 2024 |
| LILLY AND BLAIR FOUNDATION | $276,912 | G50 | published | | Oakton, VA | 2024 |
| EVANS FOUNDATION FOR MOLECULARMEDICINE | $276,813 | G50 | published | science: research education | San Marcos, CA | 2024 |
| A C T FOR MULTIPLE SCLEROSIS | $266,890 | G50 | published | | Palm Desert, CA | 2024 |
| HOPE FOR CHILDREN RESEARCH FOUNDATION INC | $266,013 | G50 | published | | Ramsey, NJ | 2024 |
| MIAMI SCI WELLNESS INC | $263,506 | G50 | published | | Miami, FL | 2024 |
| MS - JUST KEEP MOVING INC | $252,991 | G50 | published | | Waukesha, WI | 2025 |
| MONTEREY BAY POWER OVER PARKINSONS INC | $250,978 | G50 | published | | Monterey, CA | 2025 |
| MS FITNESS CHALLENGE INC | $249,400 | G50 | published | | Celebration, FL | 2025 |
| SOUTHEASTERN FRACTURE CONSORTIUM | $246,077 | G50 | published | | Chapel Hill, NC | 2025 |
| YOGA MOVES MS | $241,372 | G50 | published | | Franklin, MI | 2024 |
| ADULT & PEDIATRIC SPINE RESEARCH FOUNDATION INC | $226,343 | G50 | published | | San Anselmo, CA | 2024 |
| DAMIEN THE LEPER SOCIETY INC | $203,741 | G50 | published | | Destin, FL | 2025 |
| PATELLOFEMORAL FOUNDATION INC | $200,076 | G50 | published | | Litchfield, CT | 2024 |
| SOCIAL & AFFECTIVE NEUROSCIENCE SOCIETY | $199,127 | G50 | published | | Garden City, NY | 2025 |
| INTERNATIONAL LEAGUE OF ASSOCIATIONS FOR RHEUMATOLOGY | $195,741 | G50 | published | science: research education | Brookhaven, GA | 2024 |
| PARKINSONS MOVEMENT CENTER | $184,728 | G50 | inferred 0.60 | | Berkley, MI | 2023 |
| BEST DAY EVER FOUNDATION | $183,542 | G50 | published | | Indianapolis, IN | 2025 |
| ONE STEP CLOSER THERAPEUTIC RIDING | $171,829 | G50 | published | | Morgan Hill, CA | 2025 |
| PEACHTREE ORTHOPAEDIC CLINICFOUNDATION INC | $170,472 | G50 | published | launch: religious | Atlanta, GA | 2025 |
| NWI PARKINSONS INC | $165,385 | G50 | published | | Highland, IN | 2024 |
| CAMER RAND FUND INC | $162,490 | G50 | published | | Dedham, MA | 2024 |
| UNITED STATES BONE AND JOINT INITIATIVE NFP | $159,826 | G50 | published | | Warrenville, IL | 2022 |
| MSFORWARD | $152,879 | G50 | published | | Omaha, NE | 2024 |
| ALLIANCE AGAINST HMERF INC | $152,594 | G50 | published | | Lagrange, GA | 2024 |
| NOAHS HOPE HOPE 4 BRIDGET FOUNDATION | $151,183 | G50 | published | | Huntley, IL | 2025 |
| WILLIAMS MS FOUNDATION | $150,000 | G50 | published | | Maple Valley, WA | 2024 |
| CARTER FOUNDATION FOR NEUROLOGIC RESEARCH INC | $150,000 | G50 | published | | Wellesley, MA | 2025 |
| RHEUMATOLOGY ASSOCIATION OF IOWA INC | $145,127 | G50 | published | | Des Moines, IA | 2025 |
| UNITED CANCER SOCIETY | $140,923 | G50 | published | | Waco, TX | 2022 |
| MY STRENGTH WELLNESS PROGRAM INC | $139,112 | G50 | published | | Rch Cucamonga, CA | 2024 |
| THE JOSHUA FRASE FOUNDATION FOR CONGENITAL MYOPATHY RESEARCH INC | $138,527 | G50 | published | | Ponte Vedra, FL | 2024 |
| UNITED SPINAL ASSOCIATION INC | $138,179 | G50 | published | | Midlothian, VA | 2025 |
| LAMPLIGHTERS ORTHOPAEDIC ASSOCIATION | $126,537 | G50 | published | science: research education | Chicago, IL | 2025 |
| OSCF ONE STEP CLOSER FOUNDATION INC | $109,553 | G50 | published | | Beverly Hills, CA | 2025 |
| MEYROW FOUNDATION | $108,502 | G50 | published | | San Diego, CA | 2024 |
| UNITED SPINAL ASSOCIATION INC | $108,439 | G50 | published | women: issues | Cary, NC | 2024 |
| PICKALS FOUNDATION INC | $104,016 | G50 | published | | West Orange, NJ | 2018 |
| TALIA DUFF FOUNDATION INC | $102,554 | G50 | published | | Ipswich, MA | 2024 |