| SIGHT SAVERS INTERNATIONAL INC | $216,230,800 | G41 | published | | Boston, MA | 2025 |
| EYE CARE FOR KIDS | $104,247,404 | G41 | published | | Midvale, UT | 2025 |
| MAB COMMUNITY SERVICES INC | $57,261,156 | G41 | published | | Brookline, MA | 2024 |
| TRAVIS ASSOCIATION FOR THE BLIND | $45,691,034 | G41 | published | | Austin, TX | 2024 |
| CENTRAL ASSOCIATION FOR THE BLIND INC | $28,237,903 | G41 | published | science: research education | Utica, NY | 2025 |
| NATIONAL FEDERATION OF THE BLIND INC | $24,397,357 | G41 | published | science: research education | Baltimore, MD | 2025 |
| KERALINK FOUNDATION INC | $19,990,696 | G41 | published | | Baltimore, MD | 2024 |
| HELP ME SEE INC | $19,712,106 | G41 | published | science: research education | Jersey City, NJ | 2025 |
| FRED HOLLOWS FOUNDATION USA | $16,549,047 | G41 | published | | New York, NY | 2025 |
| SOUTH FLORIDA PUBLIC MEDIA GROUP INC | $15,660,344 | G41 | published | | Miami, FL | 2024 |
| HOUSTON LIGHTHOUSE FOUNDATION INC | $15,275,623 | G41 | published | | Houston, TX | 2024 |
| NATIONAL SOCIETY TO PREVENT BLINDNESS | $14,719,404 | G41 | published | | Chicago, IL | 2024 |
| FOUNDATION FOR BLIND CHILDREN | $14,616,865 | G41 | published | | Phoenix, AZ | 2024 |
| LIGHTHOUSE FOR THE BLIND OF HOUSTON | $13,983,679 | G41 | published | | Houston, TX | 2024 |
| Arthritis Foundation Great Lakes Region Inc | $12,785,112 | G41 | inferred 0.70 | science: research education | Hilliard, OH | 2014 |
| RESTORINGVISION | $12,652,875 | G41 | published | | San Francisco, CA | 2025 |
| KNIGHTS TEMPLAR EYE FOUNDATION INC | $12,597,408 | G41 | published | science: research education | Flower Mound, TX | 2024 |
| SIGHTSAVERS INC | $12,563,876 | G41 | published | | Boston, MA | 2025 |
| CARROLL CENTER FOR THE BLIND INC | $11,269,777 | G41 | published | | Newton, MA | 2024 |
| MISSOURI LIONS EYE RESEARCH FOUNDATION | $11,003,722 | G41 | published | science: research education | Kansas City, MO | 2024 |
| UNIVERSITY OF MARYLAND EYE ASSOCIATION PA | $10,975,634 | G41 | published | | Baltimore, MD | 2024 |
| SOUTH TEXAS LIGHTHOUSE FOR THE BLIND | $9,151,505 | G41 | published | | Corp Christi, TX | 2024 |
| LIGHTHOUSE FOR THE BLIND IN NEW ORLEANS | $8,192,104 | G41 | published | | New Orleans, LA | 2024 |
| SAAVI SERVICES FOR THE BLIND | $7,013,886 | G41 | published | | Tucson, AZ | 2025 |
| BEACON LIGHTHOUSE INC | $6,978,247 | G41 | published | | Wichita Falls, TX | 2024 |
| LIONS EYE BANK OF DELAWARE VALLEY | $6,942,152 | G41 | published | | Philadelphia, PA | 2024 |
| GEORGIA COOPERATIVE SERVICES FOR THE BLIND INC | $6,322,074 | G41 | published | | Columbus, GA | 2024 |
| GLAUCOMA FOUNDATION INC | $5,962,992 | G41 | published | science: research education | New York, NY | 2025 |
| ALZHEIMER'S DISEASE & RELATED DISORDERS | $5,591,306 | G41 | inferred 0.55 | | Southfield, MI | 2015 |
| LEAGUE FOR THE BLIND AND DISABLED INC | $5,501,713 | G41 | published | | Fort Wayne, IN | 2024 |
| CONEXUS | $4,815,895 | G41 | published | science: research education | N Chesterfld, VA | 2024 |
| JBI INTERNATIONAL INC | $4,662,953 | G41 | published | | New York, NY | 2025 |
| CONKLIN DAVIS CENTER FOR THE VISUALLY IMPAIRED INC | $4,612,162 | G41 | published | | Daytona Beach, FL | 2024 |
| VISION FORWARD ASSOCIATION INCORPORATED | $4,610,037 | G41 | published | | West Allis, WI | 2025 |
| METROLINA ASSOCIATION FOR THE BLIND INC | $4,579,491 | G41 | published | | Charlotte, NC | 2024 |
| SOCIETY FOR THE BLIND | $4,544,317 | G41 | published | | Sacramento, CA | 2024 |
| THE ARMENIAN EYECARE PROJECT | $4,535,414 | G41 | published | | Glendora, CA | 2024 |
| ALZHEIMER'S DISEASE AND RELATED DISORDER | $4,326,670 | G41 | inferred 0.60 | | Clearwater, FL | 2015 |
| VISTA CENTER FOR THE BLIND AND VISUALLY IMPAIRED | $3,936,943 | G41 | published | | Palo Alto, CA | 2024 |
| KLEB INC | $3,796,243 | G41 | published | | Louisville, KY | 2024 |
| PENRICKTON CENTER FOR BLIND CHILDREN | $3,715,857 | G41 | published | | Taylor, MI | 2024 |
| AMERICAN ACADEMY OF OPTOMETRY FOUNDATION INC | $3,442,243 | G41 | published | science: research education | Winter Park, FL | 2024 |
| ST LOUIS SOCIETY FOR THE BLIND AND VISUALLY IMPAIRED | $3,332,745 | G41 | published | | Saint Louis, MO | 2025 |
| National Multiple Sclerosis | $3,236,661 | G41 | inferred 0.50 | | Denver, CO | 2009 |
| HORIZONS FOR THE BLIND INC | $3,141,887 | G41 | published | | Crystal Lake, IL | 2025 |
| AMERICAN COUNCIL OF THE BLIND INC | $2,940,926 | G41 | published | | Alexandria, VA | 2025 |
| VALLEY CENTER FOR THE BLIND | $2,913,942 | G41 | published | | Fresno, CA | 2024 |
| LIONS MEDICAL EYE BANK AND RESEARCH CENTER OF EASTERN VIRGINIA INC | $2,735,126 | G41 | published | | Norfolk, VA | 2024 |
| CENTRAL OHIO LIONS EYE BANK INC | $2,564,434 | G41 | published | science: research education | Columbus, OH | 2024 |
| LOUISIANA CENTER FOR THE BLIND INC | $2,537,504 | G41 | published | | Ruston, LA | 2024 |
| AMERICAN GLAUCOME SOCIETY INC | $2,520,856 | G41 | published | science: research education | San Francisco, CA | 2024 |
| OKLAHOMA LIONS SIGHT CONSERVATION FDN INC | $2,490,046 | G41 | published | | Oklahoma City, OK | 2024 |
| VISION RESOURCES OF CENTRAL PENNSYLVANIA | $2,272,116 | G41 | published | | Harrisburg, PA | 2024 |
| PREVENTION OF BLINDNESS SOCIETY OF METROPOLITAN WASHINGTON INC | $2,240,399 | G41 | published | | Washington, DC | 2024 |
| DELTA GAMMA CENTER FOR CHILDREN WITH VISUAL IMPAIRMENTS | $2,214,697 | G41 | published | | Saint Louis, MO | 2024 |
| MALI WELLNESS FOUNDATION | $2,204,323 | G41 | published | women: issues | Provo, UT | 2024 |
| CENTER FOR SIGHT & HEARING | $2,088,672 | G41 | published | | Rockford, IL | 2024 |
| OREGON LIONS SIGHT AND HEARING FOUNDATION INC | $2,076,382 | G41 | published | | Portland, OR | 2024 |
| ALZHEIMER'S DISEASE AND RELATED DISORDER | $2,055,276 | G41 | inferred 0.60 | science: research education | Cincinnati, OH | 2015 |
| THE SLE LUPUS FOUNDATION | $2,049,123 | G41 | inferred 0.60 | | New York, NY | 2014 |
| MANA-SOTA LIGHTHOUSE FOR THE BLIND INC | $2,038,425 | G41 | published | | Sarasota, FL | 2024 |
| EYE CARE FOR KIDS - GROUP RETURN | $1,969,139 | G41 | published | | Midvale, UT | 2025 |
| EPILEPSY FOUNDATION OF GREATER | $1,841,660 | G41 | inferred 0.75 | | Los Angeles, CA | 2017 |
| LIGHTHOUSE CENTER FOR VITAL LIVING | $1,769,006 | G41 | published | | Duluth, MN | 2024 |
| NATIONAL FEDERATION OF THE BLIND OF SOUTH CAROLINA | $1,757,227 | G41 | published | | Columbia, SC | 2024 |
| VISION REHABILITATION SERVICES OF GEORGIA INC | $1,669,903 | G41 | published | | Smyrna, GA | 2023 |
| RETINA SOCIETY INC | $1,663,904 | G41 | published | science: research education | Boston, MA | 2023 |
| BLIND & VISUALLY IMPAIRED CENTER OF MONTEREY COUNTY INC | $1,662,712 | G41 | published | | Pacific Grove, CA | 2024 |
| READERS DIGEST PARTNERS FOR SIGHT FOUNDATION | $1,619,997 | G41 | published | science: research education | Mount Kisco, NY | 2024 |
| HOUSTON AREA PARKINSON SOCIETY | $1,599,958 | G41 | inferred 0.50 | | Houston, TX | 2024 |
| WISCONSIN COUNCIL OF THE BLIND & VISUALLY IMPAIRED INC | $1,593,491 | G41 | published | | Madison, WI | 2024 |
| AMERICAN COUNCIL OF THE BLIND ENTERPRISES AND SERVICES INC | $1,579,143 | G41 | published | | Brooklyn Center, MN | 2025 |
| TOLEDO SOCIETY FOR THE BLIND INC | $1,570,703 | G41 | published | | Toledo, OH | 2024 |
| MID-SOUTH LIONS SIGHT AND HEARING SERVICE | $1,542,271 | G41 | published | | Memphis, TN | 2024 |
| CENTER FOR THE VISUALLY IMPAIRED FOUNDATION INC | $1,539,317 | G41 | published | | Atlanta, GA | 2024 |
| NATIONAL MULTIPLE SCLEROSIS SOCIETY | $1,468,933 | G41 | inferred 0.60 | science: research education | Atlanta, GA | 2015 |
| National Multiple Sclerosis Society | $1,457,304 | G41 | inferred 0.55 | science: research education | Greensboro, NC | 2012 |
| PARKINSONS RESEARCH AND EDUCATION FOUNDATION INC | $1,400,388 | G41 | inferred 0.70 | | Boca Raton, FL | 2023 |
| NATIONAL BRAILLE ASSOCIATION INC | $1,387,945 | G41 | published | | Rochester, NY | 2025 |
| LIONS VISION SERVICES A SOUTH CAROLINA CHARITY | $1,376,011 | G41 | published | | Columbia, SC | 2024 |
| BERKS COUNTY ASSOCIATION FOR THE BLIND INC | $1,355,808 | G41 | published | | Reading, PA | 2024 |
| LUPUS FOUNDATION OF AMERICA GEORGIA CHAPTER INC | $1,335,629 | G41 | inferred 0.60 | men: issues | Marietta, GA | 2023 |
| INDO-AMERICAN EYE CARE SOCIETY INC | $1,307,087 | G41 | published | | Rochester, NY | 2024 |
| INTERNATIONAL RETINAL RESEARCH FOUNDATION INC | $1,239,787 | G41 | published | | Birmingham, AL | 2024 |
| AMYOTROPHIC LATERAL SCLEROSIS | $1,214,799 | G41 | inferred 0.60 | | West Des Moines, IA | 2021 |
| EYE CORPS INC | $1,187,196 | G41 | published | | Dallas, TX | 2024 |
| EYE SURGEONS INTERNATIONAL | $1,135,430 | G41 | published | | Napa, CA | 2025 |
| BUCKS COUNTY ASSOCIATION FOR THE BLIND AND VISUALLY IMPAIRED | $1,109,803 | G41 | published | | Newtown, PA | 2024 |
| BLINDNESS-LEARNING IN NEW DIMENSIONS INC | $1,086,247 | G41 | published | | Minneapolis, MN | 2022 |
| RHODE ISLAND CHAPTER | $1,054,058 | G41 | inferred 0.60 | science: research education | Warwick, RI | 2013 |
| COMBAT BLINDNESS INTERNATIONAL INC | $1,043,379 | G41 | published | science: research education | Middleton, WI | 2025 |
| OLSON HUNTSMAN VISION FOUNDATION | $1,026,554 | G41 | published | | Salt Lake Cty, UT | 2024 |
| KENTUCKY LIONS EYE FOUNDATION INC | $980,614 | G41 | published | | Louisville, KY | 2024 |
| CLEAR VISION FOUNDATION | $972,451 | G41 | published | | Eugene, OR | 2025 |
| NATIONAL SOCIETY TO PREVENT BLINDNESS | $966,505 | G41 | inferred 0.85 | | Milwaukee, WI | 2024 |
| SOUTHERN TIER ASSOCIATION FOR THE VISUALLY IMPAIRED INCORPORATED | $954,878 | G41 | published | | Elmira, NY | 2024 |
| CABELL WAYNE ASSOCIATION OF THE BLIND INC | $927,279 | G41 | published | | Huntington, WV | 2024 |
| BLAIR CLEARFIELD ASSOCIATION FOR THE BLIND AND VISUALLY IMPAIRED | $925,097 | G41 | published | | Altoona, PA | 2024 |
| ASSOCIATION FOR THE BLIND AND VISUALLY IMPAIRED | $917,785 | G41 | published | | Grand Rapids, MI | 2024 |
| THOMAS HARTMAN FOUNDATION | $907,459 | G41 | inferred 0.50 | | East Islip, NY | 2011 |