| ISLA CARROLL TURNER FRIENDSHIP TR | $7,197,962 | G25 | published | women: issues | Houston, TX | 2024 |
| MASSACHUSETTS DOWNS SYNDROME CONGRESS INC | $4,754,653 | G25 | inferred 0.85 | | Burlington, MA | 2024 |
| SPACE COAST DISCOVERY INC | $2,223,113 | G25 | published | space: outer | Melbourne, FL | 2024 |
| NATIONAL DOWN SYNDROME CONGRESS | $2,091,467 | G25 | published | | Cincinnati, OH | 2025 |
| JACKS BASKET | $1,928,854 | G25 | published | | Arden Hills, MN | 2025 |
| DOWN SYNDROME ASSOCIATION OF GREATER CINCINNATI | $1,791,033 | G25 | inferred 0.80 | | Cincinnati, OH | 2025 |
| THE DOWN SYNDROME CONNECTION OF THE BAY AREA | $1,420,299 | G25 | published | | Danville, CA | 2025 |
| FUNDACION PUERTORRIQUENA SINDROME DOWN | $1,410,979 | G25 | published | | San Juan, PR | 2025 |
| DOWN SYNDROME ASSOCIATION OF MINNESOTA | $885,400 | G25 | published | | Saint Paul, MN | 2024 |
| CENTRAL OREGON DISABLILITY SUPPORT NETWORK INC | $879,001 | G25 | published | | Bend, OR | 2025 |
| ROCKY MOUNTAIN DOWN SYNDROME ASSOCIATION INC | $808,985 | G25 | published | | Aurora, CO | 2025 |
| MIRACLE MULLEN DOWNS FOUNDATION | $717,546 | G25 | published | | Birmingham, AL | 2025 |
| HOPE STORY | $641,972 | G25 | published | | Richardson, TX | 2024 |
| DOWN SYNDROME DIAGNOSIS NETWORK | $583,386 | G25 | published | | Stillwater, MN | 2024 |
| DOWN SYNDROME ASSOCIATION OF MIDDLE TENNESSEE | $515,526 | G25 | published | | Hermitage, TN | 2025 |
| RED RIVER VALLEY DOWN SYNDROME SOCIETY | $474,069 | G25 | published | | Paris, TX | 2025 |
| ABC HOPES INC | $444,408 | G25 | published | | Corona, CA | 2024 |
| DOWN SYNDROME ASSOCIATION OF SOUTH TEXAS | $441,715 | G25 | published | | San Antonio, TX | 2024 |
| DOWN SYNDROME ASSOCIATION OF HOUSTON INC | $433,519 | G25 | inferred 0.60 | science: research education | Houston, TX | 2024 |
| DOWN FOR DANCE | $417,811 | G25 | published | | Newport Beach, CA | 2025 |
| NON-PROFIT INITIATIVES INC | $417,165 | G25 | published | science: research education | Dade City, FL | 2024 |
| DOWN SYNDROME ASSOCIATION OF CENTRAL OKLAHOMA | $392,986 | G25 | published | | Oklahoma City, OK | 2024 |
| DOWN SYNDROME ASSOCIATION OF THEVALLEY | $335,193 | G25 | published | | Boardman, OH | 2024 |
| NATIONAL ASSOCIATION FOR DOWN SYNDROME | $320,384 | G25 | published | | Park Ridge, IL | 2024 |
| DOWN SYNDROME GROUP OF THE OZARKS | $309,370 | G25 | published | | Springfield, MO | 2024 |
| DOWN SYNDROME NETWORK INC | $307,521 | G25 | published | | Tempe, AZ | 2025 |
| DOWN SYNDROME ASSOCIATION OF CENTRAL KENTUCKY INC | $289,453 | G25 | published | | Lexington, KY | 2024 |
| AMANDAS ADAPTIVE MARTIAL ARTS | $272,932 | G25 | published | | San Diego, CA | 2025 |
| DOWN COUNTRY | $256,996 | G25 | published | | Taylor, MO | 2024 |
| DOWN SYNDROME ALABAMA INC | $249,771 | G25 | published | | Hoover, AL | 2024 |
| DOWN SYNDROME ASSOCIATION OF MEMPHIS | $235,254 | G25 | published | | Cordova, TN | 2025 |
| DOWN SYNDROME ASSOCIATION OF NORTHERN VIRGINIA | $233,359 | G25 | published | | Fairfax, VA | 2025 |
| DOWN SYNDROME ASSOCIATION OF NORTHEAST INDIANA INC | $232,688 | G25 | published | | Fort Wayne, IN | 2025 |
| DOWN SYNDROME ASSOCIATION OF CENTRAL CALIFORNIA | $229,268 | G25 | published | | Fresno, CA | 2024 |
| ASOCIACION PARA LA SUPERACION DEL NINO CON SINDROME DOWN | $219,278 | G25 | published | | Aguadilla, PR | 2025 |
| DOWN SYNDROME ASSOCIATION OF GREATER TOLEDO | $213,885 | G25 | inferred 0.90 | | Maumee, OH | 2024 |
| ANGELS IN DISGUISE INC | $213,620 | G25 | published | | Louisville, KY | 2024 |
| Carter's Kids - Organization for the Advancement of Research and Treatment | $200,245 | G25 | inferred 0.80 | science: research education | Fayetteville, AR | 2014 |
| THE SPINA BIFIDA COALITION INC | $183,729 | G25 | inferred 0.40 | | Cincinnati, OH | 2025 |
| DOWN SYNDROME ASSOCIATION OF ACADIANA INC | $174,113 | G25 | published | | Lafayette, LA | 2024 |
| DOWNSIDE UP | $170,336 | G25 | published | | Hixson, TN | 2025 |
| DOWN SYNDROME ASSOCIATION OF BRAZOS VALLEY | $167,424 | G25 | published | | Bryan, TX | 2025 |
| DOWN SYNDROME ASSOCIATION OF LOS ANGELES INC | $157,710 | G25 | inferred 0.75 | | Los Angeles, CA | 2024 |
| ISABEL GRACE PHOTOGRAPHY | $154,730 | G25 | published | | Manor, TX | 2024 |
| DOWN SYNDROME NETWORK OF NORTHERN NEVADA | $153,594 | G25 | published | | Reno, NV | 2024 |
| UPS FOR DOWNS NFP | $146,989 | G25 | published | | Schaumburg, IL | 2024 |
| UPSIDE DOWNS INC | $143,760 | G25 | published | | Thibodaux, LA | 2024 |
| ZOES TOOLBOX | $142,804 | G25 | published | | Spring, TX | 2023 |
| DOWN SYNDROME ASSOCIATION OF MIAMI INC | $127,563 | G25 | published | | Miami, FL | 2025 |
| GREEN RIVER AREA DOWN SYNDROME ASSOCIATION INC | $126,718 | G25 | published | | Owensboro, KY | 2024 |
| COASTAL BRINGING UP DOWN SYNDROME OF SOUTHEASTERN NC INC | $123,690 | G25 | published | | Wilmington, NC | 2025 |
| SOUTHERN ARIZONA NETWORK FOR DOWN SYNDROME | $121,258 | G25 | published | | Vail, AZ | 2025 |
| BLACK DOWN SYNDROME ASSOCIATION | $119,815 | G25 | published | | Desoto, TX | 2024 |
| BUDDY CRUISE INC | $115,010 | G25 | published | | Lithia, FL | 2025 |
| CHASING DREAMS INC | $107,782 | G25 | published | | Valparaiso, IN | 2025 |
| EVERYONE BELONGS INC | $107,514 | G25 | published | | Redlands, CA | 2022 |
| COUNTRY CLUB AT MUIRFIELD VILLAGE FOUNDATION | $103,502 | G25 | published | | Dublin, OH | 2025 |
| COLORADO SPRINGS DOWN SYNDROME ASSOCIATION INC | $101,550 | G25 | inferred 0.85 | | Colorado Spgs, CO | 2025 |
| INLAND VALLEY DOWN SYNDROME ASSOCIATION | $100,268 | G25 | published | | Rancho Cucamonga, CA | 2025 |
| DOWN SYNDROME ASSOCIATION FOR FAMILIES | $97,163 | G25 | published | | Lincoln, NE | 2024 |
| TOUCH OF CARE PACKET INC | $93,447 | G25 | published | | Spring Valley, NY | 2024 |
| TRISOMY 18 SUPPORT INC | $90,139 | G25 | published | | Flushing, MI | 2024 |
| PANHANDLE DOWN SYNDROME GUILD | $90,036 | G25 | published | | Amarillo, TX | 2024 |
| Spina Bifida of CFL Inc | $88,222 | G25 | inferred 0.60 | | Orlando, FL | 2022 |
| DOWN SYNDROME CONNECTION OF NWA INC | $85,330 | G25 | published | | Rogers, AR | 2025 |
| DOWN SYNDROME ASSOCIATION OF SOUTHWEST LOUISIANA INC | $84,244 | G25 | published | | Lake Charles, LA | 2025 |
| DOWN SYNDROME ASSOCIATION OF TULSA | $82,504 | G25 | published | | Broken Arrow, OK | 2024 |
| DOWN SYNDROME AFFILIATES IN ACTION | $74,917 | G25 | inferred 0.60 | | Missoula, MT | 2025 |
| DOWN SYNDROME FAMILY SUPPORT & ADVOCACY GROUP | $74,620 | G25 | published | | Granger, IN | 2025 |
| HOME OF THE HOMIES | $74,487 | G25 | published | | Mesa, AZ | 2025 |
| DOWN SYNDROME ASSOCIATION OF GREATER NEW ORLEANS | $72,455 | G25 | published | | New Orleans, LA | 2024 |
| ARKANSAS DOWN SYNDROME ASSOCIATION | $71,776 | G25 | published | | Little Rock, AR | 2024 |
| GULF COAST DOWN SYNDROME SOCIETY INC | $68,918 | G25 | published | | Diberville, MS | 2024 |
| DOWN TO DEFEND | $66,908 | G25 | published | abuse: sexual | Comstock Park, MI | 2025 |
| CAPITAL AREA DOWN SYNDROME ASSOCIATION | $65,962 | G25 | published | | Holt, MI | 2018 |
| ZIONS CARE | $65,115 | G25 | published | | Bennettsville, SC | 2020 |
| DOWN RIGHT PERFECT INC | $64,885 | G25 | published | | Baltimore, MD | 2025 |
| MANASOTA BUDS INC | $64,010 | G25 | published | | Bradenton, FL | 2025 |
| ANGELS FOR HIGHER INC | $59,689 | G25 | published | | Corona, CA | 2025 |
| GRAND STRAND DOWN SYNDROME SOCIETY | $56,813 | G25 | published | | Myrtle Beach, SC | 2025 |
| CENTRE COUNTY DOWN SYNDROME SOCIETY | $56,685 | G25 | published | | State College, PA | 2024 |
| GIFTS FROM THE HEART FOR DOWNS | $56,095 | G25 | published | | Tillson, NY | 2013 |
| LORETTA MCGOWAN FOUNDATION INC | $55,000 | G25 | published | | Rutherford, NJ | 2025 |
| DOWN SYNDROME ASSOCIATION OF THE HUDSON VALLEY INC | $54,830 | G25 | inferred 0.70 | | Hopewell Jct, NY | 2024 |
| SOUTHEASTERN NEW MEXICO DOWN SYNDROME FOUNDATION | $53,102 | G25 | published | | Roswell, NM | 2024 |
| DOWN SYNDROME SOCIETY OF RHODE ISLAND INC | $49,339 | G25 | published | | West Warwick, RI | 2024 |
| DOWN SYNDROME INTEREST GROUP OF DELAWARE COUNTY | $43,461 | G25 | inferred 0.70 | | Springfield, PA | 2024 |
| FAMILIES EXPLORING DOWN SYNDROME | $42,927 | G25 | published | | Sterling Hts, MI | 2017 |
| THE FALCONS NEST INC | $40,387 | G25 | published | | Royal Plm Bch, FL | 2025 |
| TREASURE VALLEY DOWN SYNDROME SUPPORT GROUP INC | $40,253 | G25 | published | | Meridian, ID | 2024 |
| CHESTER COUNTY DOWN SYNDROME INTEREST GROUP | $40,096 | G25 | published | | West Chester, PA | 2025 |
| DOWN SYNDROME FAMILY RESOURCE CENTER | $40,059 | G25 | published | | La Puente, CA | 2024 |
| MONTANA DOWN SYNDROME ASSOCIATION | $39,697 | G25 | published | | Missoula, MT | 2018 |
| 21 FRIENDS INC | $39,453 | G25 | published | | Rochester, MA | 2024 |
| EAST TEXAS DOWN SYNDROME GROUP | $38,802 | G25 | inferred 0.80 | | Longview, TX | 2015 |
| DOWN SYNDROME ASSOCIATION OF SOUTH GEORGIA | $37,316 | G25 | published | | Hahira, GA | 2024 |
| CENTRAL ILLINOIS DOWNS SYNDROME ORGANIZATION | $36,870 | G25 | inferred 0.60 | | Normal, IL | 2025 |
| DOWN SYNDROME NETWORK OF GREATER GREENSBORO | $36,411 | G25 | published | | Greensboro, NC | 2023 |
| EAST TEXAS DOWN SYNDROME GROUP INC | $35,773 | G25 | published | | Tyler, TX | 2024 |
| DOWN SYNDROME CONNECTIONS LAS VEGAS | $32,775 | G25 | published | | Las Vegas, NV | 2025 |