| WORLD FEDERATION OF HEMOPHILIA USA | $1,095,526,264 | G20 | published | science: research education | Albany, NY | 2024 |
| CYSTIC FIBROSIS FOUNDATION | $355,798,320 | G20 | published | science: research education | Bethesda, MD | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATIONS OF NEW YORK STATE INC | $274,118,557 | G20 | published | men: issues | New York, NY | 2024 |
| UNITED CEREBRAL PALSY OF NEW YORK CITY INC | $242,730,314 | G20 | published | | New York, NY | 2024 |
| THE CENTER FOR DISCOVERY INC | $171,818,211 | G20 | published | | Harris, NY | 2025 |
| CENTER FOR DISABILITY SERVICES INC | $125,771,990 | G20 | published | women: issues | Albany, NY | 2024 |
| UPSTATE CEREBRAL PALSY INC | $124,592,778 | G20 | published | | Utica, NY | 2024 |
| MARCH OF DIMES INC | $85,191,655 | G20 | published | abuse: substance | Arlington, VA | 2025 |
| UNITED CEREBRAL PALSY ASSOCIATION OF GREATER SUFFOLK INC | $64,778,495 | G20 | published | | Hauppauge, NY | 2025 |
| HEMOPHILIA OF GEORGIA INC | $53,788,955 | G20 | published | | Sandy Springs, GA | 2024 |
| PILLAR CARE CONTINUUM INC | $52,908,973 | G20 | published | | East Hanover, NJ | 2024 |
| NEW JERSEY INSTITUTE FOR DISABILITIES INC | $51,334,047 | G20 | published | | Edison, NJ | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF NASSAU COUNTY INC | $46,110,280 | G20 | published | | Roosevelt, NY | 2024 |
| UNITED CEREBRAL PALSY OF QUEENS | $45,060,876 | G20 | published | | Jamaica, NY | 2024 |
| LADACIN NETWORK INC | $36,943,349 | G20 | published | | Ocean, NJ | 2024 |
| CEREBRAL PALSY OF WESTCHESTER INC | $34,026,972 | G20 | published | | Rye Brook, NY | 2025 |
| EASTER SEALS SERVING DC-MD-VA INC | $30,880,621 | G20 | published | | Silver Spring, MD | 2024 |
| PROVAIL | $30,864,176 | G20 | published | | Seattle, WA | 2024 |
| N-LOREM FOUNDATION | $30,807,703 | G20 | published | | Carlsbad, CA | 2025 |
| UNITED CEREBRAL PALSY OF GREATER SACRAMENTO INC | $26,739,831 | G20 | published | | Sacramento, CA | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF THE NORTH COUNTRY INC | $22,836,282 | G20 | published | women: issues | Canton, NY | 2024 |
| UNITED CEREBRAL PALSY HEARTLAND | $19,822,193 | G20 | published | | Saint Louis, MO | 2024 |
| NORTH JERSEY ELKS DEVELOPMENTAL DISABILITIES AGENCY | $19,597,738 | G20 | published | | Clifton, NJ | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF METRO BOSTON INC | $18,638,380 | G20 | published | | Watertown, MA | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF MIAMI INC | $17,795,369 | G20 | published | | Hialeah, FL | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF THE ROCHESTER AREA INC | $17,615,424 | G20 | published | | Rochester, NY | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF NIAGARA COUNTY INC | $17,438,487 | G20 | published | | Niagara Falls, NY | 2024 |
| ADULT RESOURCES CENTER INC | $17,225,496 | G20 | published | | Brooklyn, NY | 2024 |
| COMMUNITY LIVING AND SUPPORT SERVICES INC | $14,236,188 | G20 | published | | Pittsburgh, PA | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF GREATER CLEVELAND INC | $12,917,177 | G20 | published | | Cleveland, OH | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF ORANGE COUNTY INC | $12,908,123 | G20 | published | | Santa Ana, CA | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF CENTRAL CALIFORNIA INC | $12,525,029 | G20 | published | | Fresno, CA | 2024 |
| ASPIRE DEVELOPMENTAL SERVICES INC | $12,406,323 | G20 | published | women: issues | Lynn, MA | 2024 |
| ORANGE COUNTY CEREBRAL PALSY ASSOC INC | $11,967,559 | G20 | published | | Goshen, NY | 2024 |
| AMERICAN SOCIETY OF HUMAN GENETICS | $10,714,126 | G20 | inferred 0.70 | science: research education | Rockville, MD | 2024 |
| ACCESSABILITIES INC | $9,895,370 | G20 | published | | Butler, PA | 2024 |
| CEREBRAL PALSY INC | $9,504,218 | G20 | published | | Green Bay, WI | 2025 |
| MIRACLEFEET | $8,724,313 | G20 | published | | Chapel Hill, NC | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF CENTRAL ARIZONA | $8,114,306 | G20 | published | | Phoenix, AZ | 2024 |
| Arthritis Foundation Northeast Region Inc | $6,868,101 | G20 | inferred 0.60 | | New York, NY | 2015 |
| MIDWEST ASIAN HEALTH ASSOCIATION - MAHA | $6,004,483 | G20 | published | | Chicago, IL | 2024 |
| NEW YORK CITY FOUNDATION FOR CEREBRAL PALSY INC | $5,500,958 | G20 | published | | New York, NY | 2024 |
| ST FRANCOIS CO BOARD FOR THE DEVELOPMENTALLY DISABLED | $5,254,109 | G20 | published | | Farmington, MO | 2024 |
| HUNTINGTON STUDY GROUP LTD | $5,041,772 | G20 | published | science: research education | Rochester, NY | 2024 |
| ELMHURST INC | $4,911,543 | G20 | published | | Bath, ME | 2024 |
| ALS UNITED GREATER NEW YORK INC | $4,470,387 | G20 | inferred 0.60 | science: research education | New York, NY | 2024 |
| HEMOPHILIA FOUNDATION OF MICHIGAN | $4,413,608 | G20 | published | | Ypsilanti, MI | 2025 |
| JSCREENORG INC | $4,219,298 | G20 | published | | Atlanta, GA | 2024 |
| INCLUSION CONNECTIONS | $4,059,989 | G20 | published | | Olathe, KS | 2025 |
| MUCOLIPIDOSIS TYPE IV FOUNDATION INC | $3,776,356 | G20 | published | science: research education | Atlanta, GA | 2024 |
| LANCASTER CLEFT PALATE CLINIC | $3,563,451 | G20 | published | | Lancaster, PA | 2024 |
| UNITED CEREBRAL PALSY ASSOCIATION OF SAN DIEGO COUNTY | $3,392,257 | G20 | published | | San Diego, CA | 2024 |
| POLG FOUNDATION | $3,364,753 | G20 | published | science: research education | New York, NY | 2025 |
| CYSTIC FIBROSIS RESEARCH FUND | $3,033,288 | G20 | published | science: research education | Ardmore, PA | 2025 |
| UNITED CEREBRAL PALSY ASSOCIATION INC OF STANISLAUS COUNTY | $3,014,270 | G20 | published | | Modesto, CA | 2024 |
| AMYOTROPHIC LATERAL SCLEROSIS ASSN | $2,795,826 | G20 | inferred 0.90 | science: research education | Westborough, MA | 2021 |
| CHILDREN'S CANCER FUND OF AMERICA INC | $2,589,913 | G20 | inferred 0.50 | | Brentwood, TN | 2015 |
| ORGANIZATION OF TERATOLOGY INFORMATION SPECIALISTS NFP | $2,346,081 | G20 | published | women: issues | Brentwood, TN | 2024 |
| HELENS PINK SKY FOUNDATION | $2,248,524 | G20 | inferred 0.70 | science: research education | Minnetrista, MN | 2025 |
| THE FAMILIESCN2A FOUNDATION INC | $2,240,971 | G20 | published | science: research education | E Longmeadow, MA | 2025 |
| PRECEDE FOUNDATION INC | $2,062,871 | G20 | inferred 0.60 | | Red Hook, NY | 2025 |
| UNITED CEREBRAL PALSY ASSOCIATION OF THE TRI-COUNTIES INC | $2,031,706 | G20 | published | | Queensbury, NY | 2024 |
| WILLIAMS SYNDROME ASSOCIATION INC | $2,016,743 | G20 | published | | Newark, NJ | 2024 |
| PROJECT 8P FOUNDATION | $1,888,508 | G20 | published | | New York, NY | 2024 |
| MYHRE SYNDROME FOUNDATION | $1,722,681 | G20 | published | | Keller, TX | 2024 |
| NATIONAL SOCIETY TO PREVENT BLINDNESS | $1,634,236 | G20 | inferred 0.90 | | Houston, TX | 2024 |
| ZACK S PLACE ENRICHMENT CENTER INC | $1,621,478 | G20 | published | science: research education | Woodstock, VT | 2025 |
| JACKS CORNER FOUNDATION INC | $1,547,111 | G20 | published | | Southport, CT | 2025 |
| STXBP1 FOUNDATION | $1,420,429 | G20 | published | | Holly Springs, NC | 2024 |
| GENETIC ALLIANCE INC | $1,350,741 | G20 | published | | Damascus, MD | 2024 |
| AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATION | $1,341,750 | G20 | inferred 0.80 | men: issues | Kent, WA | 2021 |
| EASTER SEALS NORTH TEXAS INC | $1,190,741 | G20 | published | women: issues | Fort Worth, TX | 2024 |
| HOLIMONT SNOWSPORTS INC | $1,098,471 | G20 | published | | Ellicottville, NY | 2024 |
| CHILDRENS CRANIOFACIAL ASSOCIATION | $1,071,253 | G20 | published | | Dallas, TX | 2025 |
| LOU BERTEOTTI FOUNDATION | $1,013,781 | G20 | published | | Knox, PA | 2025 |
| MICHIGAN UNITED CEREBRAL PALSY | $1,012,155 | G20 | published | | Southfield, MI | 2024 |
| LUPUS AND ALLIED DISEASES ASSOCIATION INC | $987,432 | G20 | inferred 0.60 | science: research education | Verona, NY | 2024 |
| CONGENITAL HEART SURGEONS SOCIETY | $935,575 | G20 | published | science: research education | Beverly, MA | 2024 |
| AMYOTROPHIC LATERAL SCLEROSIS | $819,713 | G20 | inferred 0.60 | science: research education | Indianapolis, IN | 2021 |
| COMMUNITY CHOICES PROPERTIES | $800,004 | G20 | published | | Johnstown, PA | 2024 |
| DOUGLAS COUNTY DISABILITIES COALITION INC | $791,381 | G20 | published | | Douglasville, GA | 2025 |
| PARKINSON FOUNDATION OF WESTERN PENNSYLVANIA | $769,639 | G20 | published | | Pittsburgh, PA | 2025 |
| CSNK2A1 FOUNDATION | $754,167 | G20 | published | science: research education | Burlingame, CA | 2024 |
| CACNA1A FOUNDATION INC | $710,127 | G20 | published | science: research education | Norwalk, CT | 2025 |
| LITTLE BABY FACE FOUNDATION | $701,584 | G20 | published | | New York, NY | 2024 |
| HAPPY BREW INC | $684,196 | G20 | published | | Jacksonville, FL | 2025 |
| NEUROFIBROMATOSIS INCORPORATED NORTHEAST | $675,651 | G20 | inferred 0.80 | | Burlington, MA | 2024 |
| TEAM TELOMERE INC | $674,132 | G20 | published | science: research education | Missoula, MT | 2025 |
| THERAPIES FOR INHERITED NEUROPATHIES INC | $661,134 | G20 | published | | Baltimore, MD | 2025 |
| DELIGHTED TO DOULA BIRTH SERVICES NONPROFIT CORPORATION | $591,575 | G20 | published | | Dallas, TX | 2024 |
| FABRY SUPPORT & INFORMATION GROUP | $570,712 | G20 | published | | Concordia, MO | 2025 |
| THE SICKLE CELL ASSOCIATION OF NEW JERSEY INC | $561,970 | G20 | published | | Newark, NJ | 2025 |
| HELP 4 HD INTERNATIONAL | $537,795 | G20 | published | | Elk Grove, CA | 2025 |
| SICKLE CELL-THALASSEMIA PATIENTS NETWORKS INC | $483,355 | G20 | published | | Brooklyn, NY | 2024 |
| NATIVE SONS OF THE GOLDEN WEST CHARITABLE FOUNDATION | $478,255 | G20 | inferred 0.50 | | San Francisco, CA | 2024 |
| KCNQ2 CURE ALLIANCE INC | $458,475 | G20 | published | | Denver, CO | 2024 |
| TOVA COMMUNITY HEALTH INC | $456,167 | G20 | published | | Wilmington, DE | 2025 |
| PRISMS INC | $439,157 | G20 | published | science: research education | Herndon, VA | 2025 |
| UTAH CHAPTER NATIONAL HEMOPHILIA FOUNDATION | $410,136 | G20 | published | men: issues | Millcreek, UT | 2024 |
| CRESCENT FOUNDATION | $402,308 | G20 | published | science: research education | Philadelphia, PA | 2024 |