| UNIVERSITY MEDICAL CENTER MANAGEMENT CORPORATON | $792,867,500 | G12 | published | abuse: substance | New Orleans, LA | 2024 |
| THE AGAINST MALARIA FOUNDATION | $119,395,632 | G12 | published | | Kansas City, MO | 2024 |
| MICHIGAN HEALTH ENDOWMENT FUND | $116,075,631 | G12 | published | abuse: elder | Brighton, MI | 2024 |
| CYSTIC FIBROSIS FOUNDATION - GROUP RETURN FOR | $113,971,674 | G12 | inferred 0.90 | science: research education | Bethesda, MD | 2015 |
| AUTISM SPEAKS INC | $28,799,237 | G12 | published | launch: launch | Washington, DC | 2024 |
| JACOB ZABARA FAMILY FOUNDATION | $17,924,842 | G12 | published | | Miami Beach, FL | 2024 |
| EAGLES AUTISM CHALLENGE INC | $14,457,053 | G12 | published | | Philadelphia, PA | 2024 |
| GO2 FOUNDATION FOR LUNG CANCER | $11,982,150 | G12 | published | survivor: cancer | Washington, DC | 2025 |
| TOWNEBANK FOUNDATION | $11,973,465 | G12 | published | | Suffolk, VA | 2024 |
| CUREBOUND INC | $10,968,237 | G12 | published | survivor: cancer | San Diego, CA | 2025 |
| THE FAMILIAL HYPERCHOLESTEROLEMIA FOUNDATION | $10,718,916 | G12 | published | science: research education | Fern Bch, FL | 2025 |
| SHARSHERET INC | $10,522,062 | G12 | published | survivor: cancer | Teaneck, NJ | 2024 |
| AUGIES QUEST TO CURE ALS INC | $10,200,011 | G12 | published | | Denver, CO | 2025 |
| INTEGRATE HEALTH INC | $9,070,002 | G12 | published | launch: launch | Raleigh, NC | 2024 |
| NEUROENDOCRINE TUMOR RESEARCH FOUNDATION | $8,684,021 | G12 | published | science: research education | Quincy, MA | 2025 |
| HOPE & HEROES CHILDRENS CANCER FUND | $8,239,027 | G12 | published | survivor: cancer | New York, NY | 2024 |
| THE ABIM FOUNDATION | $8,164,387 | G12 | published | violence: gun | Philadelphia, PA | 2024 |
| GLOBAL GENES | $7,145,531 | G12 | published | science: research education | Washington, DC | 2024 |
| NFX | $6,883,911 | G12 | published | science: research education | Detroit, MI | 2024 |
| STAYING ALIVE FOUNDATION INC | $5,762,909 | G12 | published | | New York, NY | 2024 |
| HOPE FOR HAITIS CHILDREN MINISTRIES INC | $5,709,423 | G12 | published | shelter: disaster | Cincinnati, OH | 2024 |
| CURE RARE DISEASE INC | $5,335,620 | G12 | published | | Woodbridge, CT | 2024 |
| CLAYTON MEDICAL RESEARCH FOUNDATION INC | $5,236,838 | G12 | inferred 0.60 | science: research education | Carson City, NV | 2024 |
| WU TAIBO FOUNDATION | $5,000,000 | G12 | published | | Las Vegas, NV | 2024 |
| JESSIE REES FOUNDATION | $4,887,459 | G12 | published | | Rcho Sta Marg, CA | 2025 |
| LES TURNER AMYOTROPHIC LATERAL SCLEROSIS FOUNDATION | $4,524,784 | G12 | inferred 0.60 | science: research education | Skokie, IL | 2024 |
| LIVE LIKE BELLA INC | $4,208,511 | G12 | published | | Coral Gables, FL | 2024 |
| JOHN WAYNE CANCER FOUNDATION | $3,928,184 | G12 | published | girls boys: boys girls clubs | Costa Mesa, CA | 2024 |
| THOMPSON FOUNDATION FOR AUTISM & NEURODEVELOPMENT | $3,917,598 | G12 | published | science: research education | Columbia, MO | 2024 |
| COALITION FOR HEMOPHILIA B INC | $3,740,305 | G12 | published | | New York, NY | 2023 |
| PARKER PROJECT INC | $3,732,283 | G12 | published | | Scottsdale, AZ | 2025 |
| KELSEY RESEARCH FOUNDATION | $3,591,902 | G12 | published | survivor: cancer | Houston, TX | 2024 |
| SHALLOW FORD FOUNDATION INC | $3,477,386 | G12 | published | women: issues | Clemmons, NC | 2024 |
| INVESTIGATIVE RESEARCH CENTER INC | $3,212,970 | G12 | published | | Arlington, VA | 2024 |
| SHAAREI ZION YERUSHALYIM INC | $3,095,000 | G12 | published | | Brooklyn, NY | 2024 |
| COOKIES FOR KIDS CANCER | $2,947,127 | G12 | published | | Califon, NJ | 2024 |
| THE DEGREGORIO FAMILY FOUNDATION INC | $2,898,144 | G12 | published | | Pleasantville, NY | 2025 |
| LUNG CANCER FOUNDATION OF AMERICA | $2,800,681 | G12 | published | survivor: cancer | Los Angeles, CA | 2025 |
| TOWN FAIR TIRE FOUNDATION INC | $2,707,607 | G12 | published | | East Haven, CT | 2024 |
| BRINGING HOPE HOME INC | $2,697,982 | G12 | published | | Malvern, PA | 2024 |
| KING HUSSEIN CANCER FOUNDATION USA INC | $2,584,317 | G12 | published | | Washington, DC | 2024 |
| MESOTHELIOMA APPLIED RESEARCH FOUNDATION INC | $2,531,496 | G12 | published | | Washington, DC | 2025 |
| 24 FOUNDATION INC | $2,523,606 | G12 | published | survivor: cancer | Charlotte, NC | 2024 |
| SOUTHERN CHESTER COUNTY EMERGENCY MEDICAL SERVICES INC | $2,313,237 | G12 | published | | West Grove, PA | 2025 |
| THE HEALTHFUND OF MINNESOTA | $2,257,316 | G12 | inferred 0.55 | | Minneapolis, MN | 2013 |
| POETICE | $2,217,909 | G12 | published | | Holland, MI | 2025 |
| LANCE ARMSTRONG FOUNDATION ENDOWMENT | $2,214,295 | G12 | inferred 0.60 | survivor: cancer | Austin, TX | 2010 |
| TRIPLE NEGATIVE BREAST CANCERFOUNDATION INC | $2,050,907 | G12 | published | science: research education | Norwood, NJ | 2024 |
| GAMECHANGER CHARITY | $1,987,671 | G12 | published | | Dana Point, CA | 2025 |
| TEAM LAFONTAINE UCANCERVIVE FOUNDATION | $1,978,674 | G12 | published | | Bloomfld Hls, MI | 2024 |
| CARIBBEAN CHRISTIAN CENTRE FOR THE DEAF INC | $1,920,278 | G12 | published | | Zeeland, MI | 2024 |
| COOL KIDS CAMPAIGN FOUNDATION INC | $1,903,595 | G12 | published | | Towson, MD | 2025 |
| BRADENS HOPE FOR CHILDHOOD CANCER | $1,768,120 | G12 | published | | Olathe, KS | 2024 |
| STEVE RUMMLER HOPE NETWORK | $1,720,691 | G12 | published | abuse: substance | Saint Paul, MN | 2025 |
| GABBY KRAUSE FOUNDATION | $1,713,142 | G12 | published | | Centennial, CO | 2025 |
| DANNY DID FOUNDATION | $1,697,246 | G12 | published | | Evanston, IL | 2024 |
| LUNG CANCER INITIATIVE | $1,688,025 | G12 | published | survivor: cancer | Raleigh, NC | 2025 |
| TEAM JACK FOUNDATION INC | $1,648,755 | G12 | published | | Atkinson, NE | 2024 |
| OLLIE HINKLE HEART FOUNDATION | $1,607,691 | G12 | published | science: research education | Saint Louis, MO | 2024 |
| THE CANCER FOUNDATION INC | $1,565,032 | G12 | published | | Athens, GA | 2025 |
| MICHAELS WAY | $1,541,667 | G12 | published | | Fort Washington, PA | 2025 |
| HUMAN POWERED POTENTIAL INC | $1,493,849 | G12 | published | | Durango, CO | 2025 |
| TRIUMPH OVER KID CANCER FOUNDATION | $1,446,741 | G12 | published | survivor: cancer | Corp Christi, TX | 2025 |
| HELLO HOUSING | $1,426,601 | G12 | published | | San Anselmo, CA | 2024 |
| USHER III INITIATIVE INC | $1,421,660 | G12 | published | science: research education | Chicago, IL | 2024 |
| ENDURING HEARTS INC | $1,402,577 | G12 | published | science: research education | Marietta, GA | 2025 |
| IANS FRIENDS FOUNDATION INC | $1,401,311 | G12 | published | | Atlanta, GA | 2024 |
| TEAM PHENOMENAL HOPE INC | $1,378,212 | G12 | published | science: research education | Maspeth, NY | 2024 |
| DAVES HOUSE INC | $1,342,578 | G12 | published | shelter: homeless | Orlando, FL | 2025 |
| MISSION CLINICAL SERVICES | $1,339,420 | G12 | published | abuse: child | Hot Springs, AR | 2024 |
| THE BAKER INSTITUTE FOR CHILDREN WITH HEARING LOSS | $1,327,907 | G12 | published | | Palo Alto, CA | 2025 |
| PRAYERS FROM MARIA FOUNDATION | $1,309,120 | G12 | published | | Rocky River, OH | 2024 |
| VISION-AID INCORPORATED | $1,298,591 | G12 | published | science: research education | Lexington, MA | 2024 |
| RACE TO ERASE MS | $1,286,955 | G12 | inferred 0.80 | | Encino, CA | 2024 |
| CONGENITAL HYPERINSULINISM INTERNATIONAL | $1,275,774 | G12 | published | science: research education | Glen Ridge, NJ | 2024 |
| A BREATH OF HOPE LUNG FOUNDATION | $1,259,978 | G12 | published | survivor: cancer | Bloomington, MN | 2025 |
| EMILIO NARES FOUNDATION | $1,251,293 | G12 | published | | San Diego, CA | 2025 |
| KNAPP MEDICAL CENTER FOUNDATION INC | $1,223,483 | G12 | published | | Weslaco, TX | 2024 |
| HILL COUNTRY RIDE FOR AIDS INC | $1,208,252 | G12 | published | | Austin, TX | 2024 |
| TOUCHED BY TYPE 1 INC | $1,204,012 | G12 | published | | Altamonte Spg, FL | 2025 |
| PARKINSON FOUNDATION OF THE NATIONAL CAPITAL AREA | $1,201,164 | G12 | published | | Olney, MD | 2024 |
| INCYTE CHARITABLE GIVING FOUNDATION | $1,200,000 | G12 | published | | Wilmington, DE | 2025 |
| BRANDON MERRITT CHARITABLE FOUNDATION INC | $1,182,173 | G12 | published | | Doral, FL | 2025 |
| DIABETES RESEARCH CONNECTION | $1,176,901 | G12 | published | | Del Mar, CA | 2024 |
| BINA STROKE AND BRAIN INJURY ASSISTANCE INC | $1,167,097 | G12 | published | | Brooklyn, NY | 2024 |
| HNC LIVING FOUNDATION | $1,162,460 | G12 | published | survivor: cancer | Overland Park, KS | 2024 |
| THE GALA OF HOPE FOUNDATION INC | $1,147,182 | G12 | published | survivor: cancer | Beavercreek, OH | 2025 |
| ILLINOIS CANCERCARE FOUNDATION | $1,141,590 | G12 | published | | Peoria, IL | 2024 |
| DISABILITY RESOURCE IN HOMESERVICES INC | $1,076,601 | G12 | published | | Festus, MO | 2024 |
| PARTNERS FOUNDATION | $1,065,993 | G12 | published | | Downingtown, PA | 2024 |
| MEMORIAL HEALTH SYSTEMS FOUNDATION INC | $1,047,974 | G12 | published | | Daytona Beach, FL | 2024 |
| NORTH CAROLINA DENTAL SOCIETY FOUNDATION INC | $1,047,407 | G12 | published | | Cary, NC | 2024 |
| GEORGIA ALLIANCE FOR BREAST CANCER INC | $1,044,773 | G12 | published | survivor: cancer | Peachtree Cor, GA | 2024 |
| FRIENDS OF DBA | $1,015,967 | G12 | published | | Strongsville, OH | 2025 |
| SHARPE-STRUMIA RESEARCH FOUNDATION OF THE BRYN MAWR HOSPITAL | $1,005,190 | G12 | published | science: research education | Bryn Mawr, PA | 2024 |
| DANNY BUTLER MEMORIAL FUND INC | $968,701 | G12 | published | | Rye, NY | 2024 |
| MADELYNS FUND | $962,910 | G12 | published | | Charlotte, NC | 2025 |
| WARDS FOUNDATION | $954,879 | G12 | published | | Charlotte, NC | 2024 |
| CAREITY FOUNDATION | $953,953 | G12 | published | women: issues | Fort Worth, TX | 2024 |
| 17 STRONG | $929,770 | G12 | published | | Pismo Beach, CA | 2025 |