| SAMARITAN DAYTOP VILLAGE INC | $351,963,158 | F22 | published | abuse: substance | Briarwood, NY | 2024 |
| COMMUNITY BRIDGES INC | $225,178,320 | F22 | published | abuse: child | Mesa, AZ | 2024 |
| CENTRAL CITY CONCERN INC | $199,965,987 | F22 | published | abuse: substance | Portland, OR | 2024 |
| WELLSPACE HEALTH | $171,466,740 | F22 | published | violence: community | Sacramento, CA | 2024 |
| MOUNTAIN COMPREHENSIVE CARE CENTER INC | $146,356,585 | F22 | published | | Prestonsburg, KY | 2024 |
| BOWEN HEALTH INC | $140,598,460 | F22 | published | abuse: substance | Warsaw, IN | 2024 |
| GATEWAY FOUNDATION INC | $118,229,702 | F22 | published | abuse: substance | Chicago, IL | 2024 |
| HELIO HEALTH INC | $108,834,750 | F22 | published | abuse: substance | Syracuse, NY | 2024 |
| BAY AREA COMMUNITY RESOURCES | $106,932,387 | F22 | published | violence: community | El Cerrito, CA | 2024 |
| PUERTO RICAN ORGNZ TO MOTIVATE ENLIGHTEN & SERVE ADDICTS INC | $91,325,455 | F22 | published | abuse: substance | Bronx, NY | 2024 |
| VALLEY HOPE ASSOCIATION | $89,397,250 | F22 | published | abuse: substance | Norton, KS | 2024 |
| THE FORTUNE SOCIETY INC | $81,875,710 | F22 | published | abuse: substance | Long Island City, NY | 2024 |
| THE NATIVE AMERICAN REHABILITATION ASSOC OF THE NORTHWEST INC | $71,122,610 | F22 | published | abuse: child | Portland, OR | 2024 |
| LOS ANGELES CENTERS FOR ALCOHOL AND DRUG ABUSE | $68,554,161 | F22 | inferred 0.80 | violence: sexual | Santa Fe Spgs, CA | 2024 |
| SCIOTO COUNTY COUNSELING CENTER INC | $56,253,052 | F22 | published | women: issues | Portsmouth, OH | 2024 |
| GATEWAY REHABILITATION CENTER | $55,997,255 | F22 | published | space: for men | Moon Township, PA | 2024 |
| ODYSSEY HOUSE INC | $54,951,378 | F22 | published | abuse: substance | New York, NY | 2024 |
| THE CONNECTION INC | $53,488,954 | F22 | published | violence: community | Middletown, CT | 2024 |
| CUMBERLAND HEIGHTS FOUNDATION INC | $52,940,998 | F22 | published | girls boys: girls | Nashville, TN | 2025 |
| RUSHFORD CENTER INC | $52,846,706 | F22 | published | girls boys: boys | Meriden, CT | 2024 |
| ASHLEY INC | $51,486,930 | F22 | published | science: research education | Hvre De Grace, MD | 2024 |
| NORTHEAST TREATMENT CENTERS INC | $49,978,724 | F22 | published | violence: gun | Philadelphia, PA | 2022 |
| HORIZON HOUSE REHABILITATION SERV INC | $48,325,194 | F22 | published | abuse: substance | Philadelphia, PA | 2023 |
| DAVIS BEHAVIORAL HEALTH INC | $45,951,425 | F22 | published | abuse: substance | Layton, UT | 2024 |
| GATEWAY HEALTHCARE INC | $45,671,057 | F22 | published | abuse: child | Providence, RI | 2024 |
| ODYSSEY HOUSE LOUISIANA INC | $44,160,305 | F22 | published | abuse: substance | New Orleans, LA | 2024 |
| HEGIRA HEALTH INC | $43,994,838 | F22 | published | abuse: substance | Livonia, MI | 2024 |
| CARON OF FLORIDA INC | $40,216,625 | F22 | published | abuse: substance | Wernersville, PA | 2024 |
| STARTCARE INC | $39,542,564 | F22 | published | abuse: substance | Brooklyn, NY | 2024 |
| ISAIAH HOUSE INC | $39,074,101 | F22 | published | abuse: substance | Willisburg, KY | 2024 |
| HIGH WATCH RECOVERY CENTER INC | $37,384,394 | F22 | inferred 0.70 | abuse: substance | Kent, CT | 2024 |
| OUTREACH DEVELOPMENT CORPORATION | $36,969,368 | F22 | published | abuse: substance | Richmond Hill, NY | 2024 |
| CROSSROADS INC | $36,946,784 | F22 | published | abuse: substance | Phoenix, AZ | 2024 |
| CODA INC | $36,620,721 | F22 | published | abuse: substance | Portland, OR | 2024 |
| VICTORY PROGRAMS INC | $34,599,798 | F22 | published | shelter: homeless | Boston, MA | 2024 |
| CENTER POINT INC | $34,021,913 | F22 | published | abuse: substance | San Rafael, CA | 2024 |
| SOCIAL MODEL RECOVERY SYSTEMS INC | $33,662,291 | F22 | published | abuse: substance | Covina, CA | 2024 |
| CRI-HELP INC | $33,359,320 | F22 | inferred 0.80 | abuse: substance | N Hollywood, CA | 2024 |
| MARYHAVEN INC | $33,259,858 | F22 | published | abuse: substance | Columbus, OH | 2024 |
| FINGER LAKES AREA COUNSELING AND RECOVERY AGENCY INC | $33,163,986 | F22 | inferred 0.80 | abuse: substance | Clifton Springs, NY | 2024 |
| MCLEOD CENTERS FOR WELLBEING | $32,411,763 | F22 | published | abuse: substance | Charlotte, NC | 2024 |
| TREATMENT ALTERNATIVES FOR STRONGER COMMUNITIES | $31,844,875 | F22 | published | | Chicago, IL | 2024 |
| CROSSROADS TURNING POINTS INC | $31,087,960 | F22 | published | abuse: substance | Pueblo, CO | 2024 |
| STRAIGHT & NARROW INC | $30,492,248 | F22 | published | girls boys: boys | Paterson, NJ | 2024 |
| SACRED HEART REHABILITATION CENTER INC | $30,154,233 | F22 | published | abuse: substance | Richmond, MI | 2024 |
| SHIELDS FOR FAMILIES | $29,894,456 | F22 | published | abuse: substance | Los Angeles, CA | 2024 |
| BUFFALO VALLEY INC | $29,090,397 | F22 | published | abuse: substance | Hohenwald, TN | 2024 |
| FAIRBANKS NATIVE ASSOCIATION | $28,486,929 | F22 | published | | Fairbanks, AK | 2024 |
| PRINCIPLES INC | $28,356,506 | F22 | published | | Pasadena, CA | 2024 |
| THERAPEUTIC HEALTH SERVICES | $28,289,697 | F22 | published | | Seattle, WA | 2024 |
| THE CENTER FOR DRUG FREE LIVING INC | $26,665,423 | F22 | inferred 0.70 | violence: community | Orlando, FL | 2013 |
| MIRMONT ALCOHOL REHABILITATION CENTER | $26,483,015 | F22 | published | | Radnor, PA | 2024 |
| SANTA FE RECOVERY CENTER INC | $25,891,150 | F22 | published | abuse: substance | Santa Fe, NM | 2024 |
| TUERK HOUSE INC | $25,320,311 | F22 | published | | Baltimore, MD | 2024 |
| SERENITY LANE | $24,612,665 | F22 | published | | Coburg, OR | 2024 |
| LIGHTSHARE BEHAVIORAL WELLNESS & RECOVERY INC | $24,382,990 | F22 | published | abuse: substance | Sarasota, FL | 2024 |
| FIRST STEP HOUSE | $24,265,129 | F22 | published | abuse: substance | Salt Lake Cty, UT | 2024 |
| LINES FOR LIFE | $24,115,696 | F22 | published | abuse: substance | Portland, OR | 2024 |
| CODAC INC | $23,963,100 | F22 | published | abuse: substance | Providence, RI | 2024 |
| FAIRBANKS HOSPITAL INC | $23,830,471 | F22 | published | abuse: substance | Indianapolis, IN | 2024 |
| MERAKEY PARKSIDE RECOVERY | $23,724,773 | F22 | inferred 0.85 | | Lafayette Hl, PA | 2024 |
| MARYVILLE INC | $23,489,993 | F22 | published | abuse: substance | Voorhees, NJ | 2024 |
| A SAFE HAVEN FOUNDATION | $23,394,451 | F22 | published | shelter: homeless | Chicago, IL | 2024 |
| ALL RISE FOR JUSTICE | $23,247,885 | F22 | published | abuse: substance | Alexandria, VA | 2025 |
| COVE BEHAVIORAL HEALTH INC | $21,922,575 | F22 | published | abuse: substance | Tampa, FL | 2024 |
| HORIZON SERVICES INC | $21,567,979 | F22 | published | abuse: substance | Hayward, CA | 2024 |
| MIDWESTERN CONNECTICUT COUNCIL OF ALCOHOLISM INC | $21,463,547 | F22 | published | girls boys: girls | Danbury, CT | 2024 |
| 12 & 12 INC | $21,270,040 | F22 | inferred 0.85 | abuse: substance | Tulsa, OK | 2021 |
| ATLANTICARE HEALTH SYSTEM INC | $20,955,192 | F22 | published | abuse: substance | Pleasantville, NJ | 2021 |
| CAMELOT OF STATEN ISLAND INC | $20,544,862 | F22 | published | abuse: substance | Staten Island, NY | 2024 |
| HEALTHCARE ALTERNATIVE SYSTEMS INC | $20,068,098 | F22 | published | abuse: substance | Chicago, IL | 2024 |
| HEARTVIEW FOUNDATION | $20,047,410 | F22 | published | abuse: substance | Bismarck, ND | 2024 |
| THE SOUTHEASTERN COUNCIL ON ALCOHOLISM AND DRUG DEPENDENCE INC | $19,685,355 | F22 | published | abuse: substance | New London, CT | 2024 |
| NEW DIRECTIONS NORTHWEST INC | $19,052,461 | F22 | published | | Baker City, OR | 2024 |
| WESTCARE GULFCOAST-FLORIDA INC | $18,789,391 | F22 | published | abuse: substance | Henderson, NV | 2024 |
| SEATTLE DRUG & NARCOTIC CENTER SEADRUNER | $18,695,555 | F22 | published | men: issues | Seattle, WA | 2024 |
| MERIDIAN HEALTHCARE | $18,694,565 | F22 | inferred 0.85 | abuse: substance | Youngstown, OH | 2024 |
| THRIVE WELLNESS AND RECOVERY INC | $18,335,226 | F22 | published | abuse: substance | Watertown, NY | 2024 |
| EVERGREEN RECOVERY CENTERS | $18,239,499 | F22 | published | abuse: child | Everett, WA | 2024 |
| TRUENORTH WELLNESS SERVICES | $17,928,965 | F22 | published | abuse: substance | Hanover, PA | 2024 |
| CONNECTICUT RENAISSANCE INC | $17,880,994 | F22 | published | abuse: substance | Shelton, CT | 2024 |
| AREA SUBSTANCE ABUSE COUNCIL | $17,815,816 | F22 | published | abuse: substance | Cedar Rapids, IA | 2024 |
| NET TREATMENT SERVICES INC | $17,677,837 | F22 | published | violence: community | Philadelphia, PA | 2022 |
| LOWER EASTSIDE SERVICE CENTER INC | $17,603,901 | F22 | published | abuse: substance | New York, NY | 2024 |
| SUNDOWN M RANCH CORPORATION | $17,469,377 | F22 | published | | Selah, WA | 2025 |
| SOUTHWEST BEHAVIORAL CARE INC | $17,338,537 | F22 | published | abuse: substance | Charleroi, PA | 2024 |
| CASA ESPERANZA INC | $17,277,081 | F22 | published | abuse: substance | Malden, MA | 2024 |
| DISCOVERY INSTITUTE FOR ADDICTIVE DISORDERS INC | $17,243,934 | F22 | published | | Marlboro, NJ | 2024 |
| PIKE COUNTY RECOVERY COUNCIL INC | $17,124,794 | F22 | published | women: issues | Waverly, OH | 2024 |
| STEPPINGSTONE INC | $16,934,436 | F22 | published | abuse: substance | Fall River, MA | 2024 |
| BRANDYWINE COUNSELING & COMMUNITY SERVICES INC | $16,801,444 | F22 | published | abuse: substance | Wilmington, DE | 2024 |
| HOPE IS ALIVE MINISTRIES INC | $16,559,709 | F22 | published | | Oklahoma City, OK | 2024 |
| NATIONAL ASSOCIATION ON DRUG ABUSE PROBLEMS NEW YORK STATE INC | $16,551,659 | F22 | published | abuse: substance | New York, NY | 2024 |
| SET FREE ALASKA | $16,457,516 | F22 | published | abuse: substance | Wasilla, AK | 2025 |
| VARP INC | $16,415,578 | F22 | published | abuse: substance | Sn Bernrdno, CA | 2024 |
| COMMUNITY HUMAN SERVICES | $16,338,949 | F22 | published | violence: community | Monterey, CA | 2024 |
| TUBMAN | $16,155,471 | F22 | published | abuse: elder | Minneapolis, MN | 2024 |
| NARCOTICS ANONYMOUS WORLD SERVICES INC | $16,130,813 | F22 | published | | Chatsworth, CA | 2024 |
| HORIZON HOUSE INC | $15,902,206 | F22 | published | abuse: substance | Philadelphia, PA | 2023 |
| ALETHEIA HOUSE INC | $15,893,638 | F22 | published | abuse: substance | Birmingham, AL | 2024 |