| PUBLIC HEALTH MANAGEMENT CORPORATION | $762,918,719 | F21 | published | abuse: child | Philadelphia, PA | 2024 |
| COASTAL HORIZONS CENTER INC | $84,295,628 | F21 | published | abuse: sexual | Wilmington, NC | 2024 |
| VALLEY CITIES COUNSELING AND CONSULTATION | $69,322,296 | F21 | published | abuse: sexual | Kent, WA | 2024 |
| TRUTH INITIATIVE FOUNDATION | $52,987,573 | F21 | published | launch: launch | Washington, DC | 2024 |
| EVERGREEN TREATMENT SERVICES | $50,823,616 | F21 | published | abuse: substance | Seattle, WA | 2025 |
| DCCCA INC | $40,655,264 | F21 | published | abuse: substance | Lawrence, KS | 2024 |
| CASA-TRINITY INC | $28,040,422 | F21 | published | abuse: substance | Dansville, NY | 2024 |
| TRI-COUNTY HUMAN SERVICES INC | $25,439,833 | F21 | published | abuse: substance | Lakeland, FL | 2024 |
| PHOENIX MULTISPORT INC | $23,059,622 | F21 | published | launch: launch | Denver, CO | 2024 |
| LEAD | $21,034,682 | F21 | published | violence: community | Allentown, NJ | 2024 |
| ODYSSEY INC | $18,297,260 | F21 | published | abuse: substance | Louisa, KY | 2024 |
| STARS NASHVILLE | $15,511,432 | F21 | published | violence: community | Nashville, TN | 2024 |
| RIVERSIDE CNTY LATINO COMMISISON ON ALCOHOL & DRUG ABUSE SERVICES INC | $14,999,567 | F21 | published | abuse: substance | Coachella, CA | 2024 |
| PRAIRIE RIDGE INTEGRATED BEHAVIORAL HEALTHCARE | $14,865,213 | F21 | published | abuse: substance | Mason City, IA | 2024 |
| FAMILY AND MEDICAL COUNSELING SERVICE INC | $13,750,397 | F21 | published | | Washington, DC | 2024 |
| HEALING PLACE INC | $12,405,357 | F21 | inferred 0.50 | shelter: homeless | Louisville, KY | 2024 |
| SOLEDAD ENRICHMENT ACTION INC | $11,803,605 | F21 | published | violence: community | Los Angeles, CA | 2024 |
| REACH OUT WEST END | $10,994,202 | F21 | published | violence: community | Upland, CA | 2024 |
| NORTHPOINTE COUNCIL INC | $10,879,007 | F21 | published | abuse: substance | Niagara Falls, NY | 2025 |
| NATIONAL CENTER FOR ADVOCACY AND RECOVERY INC | $10,030,323 | F21 | published | abuse: substance | Robbinsville, NJ | 2024 |
| YOUTH FIRST INC | $9,535,417 | F21 | published | abuse: child | Evansville, IN | 2024 |
| PINAL HISPANIC COUNCIL | $9,486,593 | F21 | published | abuse: substance | Tucson, AZ | 2024 |
| NEW JERSEY PREVENTION NETWORK INC | $9,250,540 | F21 | published | abuse: substance | Lakewood, NJ | 2024 |
| PATHWAYS BEHAVIORAL SERVICES INC | $8,237,200 | F21 | published | abuse: substance | Waterloo, IA | 2024 |
| MILE HIGH COUNCIL ON ALCOHOLISM AND DRUG ABUSE | $7,902,137 | F21 | published | abuse: substance | Aurora, CO | 2024 |
| SPOKANE TREATMENT AND RECOVERY SERVICES | $7,674,043 | F21 | inferred 0.70 | shelter: homeless | Spokane, WA | 2024 |
| THE COUNCIL OF SOUTHEAST PENNSYLVANIA INC | $7,437,940 | F21 | published | abuse: substance | Doylestown, PA | 2024 |
| FAMILIES AGAINST NARCOTICS INC | $6,963,414 | F21 | published | abuse: substance | Clinton Twp, MI | 2024 |
| WEST BRANCH DRUG & ALCOHOL ABUSE COMMISSION INC | $6,934,836 | F21 | published | abuse: substance | Williamsport, PA | 2024 |
| HUSTLE RECOVERY | $6,696,889 | F21 | published | abuse: substance | Ashland City, TN | 2025 |
| CDAC BEHAVIORAL HEALTHCARE INC | $6,318,598 | F21 | published | abuse: substance | Pensacola, FL | 2024 |
| PREVENTED | $6,248,678 | F21 | published | abuse: substance | Saint Louis, MO | 2024 |
| FIGHTING BACK SANTA MARIA VALLEY | $6,133,346 | F21 | published | violence: community | Santa Maria, CA | 2024 |
| BRAZOS VALLEY COUNCIL ON ALCOHOL & SUBSTANCE ABUSE | $5,902,123 | F21 | published | abuse: substance | Bryan, TX | 2024 |
| THE MIRACLES CLUB | $5,873,625 | F21 | published | | Portland, OR | 2024 |
| RECOVERY CAFE | $5,785,688 | F21 | published | | Seattle, WA | 2024 |
| CENTER OF HOPE | $5,633,712 | F21 | published | abuse: substance | Anniston, AL | 2024 |
| RACING FOR RECOVERY | $5,578,888 | F21 | published | abuse: substance | Holland, OH | 2024 |
| PIMA PREVENTION PARTNERSHIP | $5,164,772 | F21 | published | | Tucson, AZ | 2024 |
| COMMUNITY ACTION AGAINST ADDICTION | $5,157,035 | F21 | published | abuse: substance | Cleveland, OH | 2024 |
| THE AMAAD INSTITUTE | $5,129,024 | F21 | published | shelter: homeless | Los Angeles, CA | 2024 |
| PRO YOUTH AND FAMILIES INC | $4,847,122 | F21 | published | abuse: child | Sacramento, CA | 2024 |
| FELLOWSHIP HOUSE INC | $4,641,905 | F21 | inferred 0.50 | abuse: substance | Birmingham, AL | 2024 |
| SAMADHI CENTER INC | $4,475,470 | F21 | published | abuse: substance | Kingston, NY | 2024 |
| FOOTPRINTS INC | $4,472,321 | F21 | published | abuse: substance | Kansas City, MO | 2024 |
| NAMI MINNESOTA | $4,405,220 | F21 | inferred 0.60 | survivor: suicide | Saint Paul, MN | 2024 |
| D A R E AMERICA | $4,403,883 | F21 | published | abuse: substance | Santa Monica, CA | 2024 |
| END OVERDOSE | $4,167,809 | F21 | published | | Pasadena, CA | 2024 |
| FAMILYWISE SERVICES | $4,113,751 | F21 | published | violence: prevention | Minneapolis, MN | 2024 |
| ARIZONA YOUTH PARTNERSHIP | $4,076,362 | F21 | published | abuse: substance | Tucson, AZ | 2024 |
| SONG FOR CHARLIE | $4,059,733 | F21 | published | abuse: substance | Pasadena, CA | 2025 |
| SAVE THE MICHAELS OF THE WORLD INC | $4,007,856 | F21 | published | abuse: substance | Newfane, NY | 2024 |
| CALIFORNIANS FOR DRUG FREE YOUTH INC | $3,979,762 | F21 | published | abuse: substance | San Diego, CA | 2024 |
| THE POWER OF U INCORPORATED | $3,895,990 | F21 | published | abuse: substance | Elizabeth City, NC | 2024 |
| URBAN OUNCE OF PREVENTION BEHAVIORAL HEALTH SERVICES INC | $3,840,573 | F21 | published | abuse: substance | Akron, OH | 2024 |
| GREATER NEW ORLEANS TEEN CHALLENGE INC | $3,831,430 | F21 | published | | Metairie, LA | 2024 |
| ALCOHOL & SUBSTANCE ABUSE COUNCIL | $3,828,477 | F21 | published | abuse: substance | Watertown, NY | 2025 |
| TRC THE RECOVERY CENTER | $3,786,382 | F21 | published | abuse: substance | Oklahoma City, OK | 2022 |
| WV GAME CHANGERS INC | $3,743,823 | F21 | published | | Fairmont, WV | 2024 |
| PREVENTION RESEARCH INSTITUTE INC | $3,539,483 | F21 | published | abuse: substance | Lexington, KY | 2024 |
| ASHES TO GLORY FOUNDATION | $3,522,658 | F21 | published | abuse: substance | Livonia, MI | 2025 |
| PREVENTION ACTION ALLIANCE | $3,434,074 | F21 | published | abuse: substance | Columbus, OH | 2024 |
| INDIANA TEEN CHALLENGE INC | $3,411,755 | F21 | inferred 0.50 | | Lebanon, IN | 2024 |
| UTAH SUPPORT ADVOCATES FOR RECOVERY AWARENESS | $3,325,320 | F21 | published | abuse: substance | Salt Lake Cty, UT | 2024 |
| THRIVE IRC INC | $3,308,242 | F21 | published | abuse: substance | Vero Beach, FL | 2024 |
| NORTH CAROLINA CHAMBER FOUNDATION | $3,301,288 | F21 | published | | Raleigh, NC | 2024 |
| LEFLORE COUNTY YOUTH SERVICES INC | $3,238,458 | F21 | published | abuse: child | Poteau, OK | 2024 |
| HARTFORD COMMUNITIES THAT CARE INC | $3,148,842 | F21 | published | violence: prevention | Hartford, CT | 2024 |
| TOGETHER | $3,142,765 | F21 | published | abuse: substance | Tumwater, WA | 2024 |
| COMMUNITY IMPACT NC INC | $3,069,513 | F21 | inferred 0.80 | abuse: substance | Wilson, NC | 2024 |
| PEER COACH ACADEMY COLORADO INC | $3,053,605 | F21 | published | | Colorado Spgs, CO | 2025 |
| WEST VIRGINIA SECONDARY SCHOOL ACTIVITIES COMMISSION | $3,050,394 | F21 | published | | Parkersburg, WV | 2024 |
| PACT COALITION FOR SAFE AND DRUG-FREE COMMUNITIES | $3,008,280 | F21 | published | girls boys: boys girls clubs | Las Vegas, NV | 2024 |
| NEW FUTURES INC | $3,004,628 | F21 | published | abuse: substance | Concord, NH | 2025 |
| ICARRE FOUNDATION | $2,961,466 | F21 | published | abuse: substance | Baltimore, MD | 2024 |
| MN PREVENTION & RECOVERY ALLIANCE LLC | $2,673,983 | F21 | published | | Minneapolis, MN | 2025 |
| SAN JUAN COUNTY PARTNERSHIP INC | $2,631,315 | F21 | published | abuse: substance | Farmington, NM | 2024 |
| HELP COMMITTEE AND BOYS & GIRLS CLUB OF THE HI-LINE | $2,535,133 | F21 | published | girls boys: boys girls clubs | Havre, MT | 2024 |
| WASHINGTON REGIONAL ALCOHOL PROGRAM | $2,506,132 | F21 | published | | Tysons, VA | 2024 |
| B RILEY SOBER HOUSE | $2,423,333 | F21 | published | abuse: substance | Cleveland, OH | 2025 |
| NARCOTICS PREVENTION ASSOCIATION INC | $2,363,485 | F21 | published | | Los Angeles, CA | 2024 |
| DAMASCUS HOUSE INC | $2,320,984 | F21 | inferred 0.80 | | Baltimore, MD | 2024 |
| ABILENE RECOVERY COUNCIL | $2,193,095 | F21 | published | abuse: substance | Abilene, TX | 2023 |
| SURVIVING OUR LOSSES AND CONTINUING EVERYDAY INC | $2,189,386 | F21 | published | | Portsmouth, OH | 2024 |
| BREVARD PREVENTION COALITION INC | $2,136,147 | F21 | published | abuse: substance | Melbourne, FL | 2024 |
| EAST TEXAS COUNCIL ON ALCOHOLISM AND DRUG ABUSE | $2,072,874 | F21 | published | abuse: substance | Longview, TX | 2024 |
| COUNCIL ON ALCOHOL & DRUG ABUSE FOR GREATER NEW ORLEANS | $2,040,069 | F21 | published | abuse: substance | New Orleans, LA | 2024 |
| ABILENE RESTORATION MINISTRIES | $1,993,824 | F21 | published | abuse: substance | Abilene, TX | 2024 |
| PALM BEACH COUNTY SUBSTANCE ABUSE COALITION | $1,960,697 | F21 | published | abuse: substance | Boynton Beach, FL | 2024 |
| STRENGTH IN PEERS | $1,938,961 | F21 | published | abuse: substance | New Market, VA | 2024 |
| ILLUMINATE COMMUNITY RECOVERY SERVICES | $1,919,736 | F21 | published | abuse: substance | Franktown, CO | 2025 |
| COLORADO METH PROJECT INC | $1,909,699 | F21 | published | launch: launch | Broomfield, CO | 2025 |
| AKRON-URBAN MINORITY ALCOHOLISM DRUG ABUSE OUTREACH PROGRAM INC | $1,903,918 | F21 | published | violence: prevention | Akron, OH | 2024 |
| URBAN MINORITY ALCOHOLISM & DRUG ABUSE OUTREACH PROGRAM OF CINCINNA | $1,800,901 | F21 | published | violence: prevention | Cincinnati, OH | 2024 |
| HIGH DESERT CHILD ADOLESCENT FAMILY SERVICE CENTER | $1,778,720 | F21 | published | abuse: substance | Victorville, CA | 2024 |
| CORNERSTONE FAMILY COUNSELING SERVICES | $1,721,069 | F21 | published | | Oakhurst, CA | 2025 |
| FASD UNITED INC | $1,688,245 | F21 | published | women: issues | Washington, DC | 2024 |
| DRUG PREVENTION RESOURCES INC | $1,661,492 | F21 | published | abuse: substance | Waxahachie, TX | 2024 |
| WARRIORS 4 CHRIST RECOVERY MINISTRIES | $1,625,855 | F21 | published | | Jackson, OH | 2025 |
| PERMIAN BASIN REGIONAL COUNCIL ON ALCOHOL AND DRUG ABUSE | $1,623,639 | F21 | published | abuse: substance | Odessa, TX | 2024 |