| NATIONAL MARROW DONOR PROGRAM | $741,231,321 | E65 | published | survivor: cancer | Minneapolis, MN | 2024 |
| LIFENET HEALTH | $598,564,898 | E65 | published | science: research education | Virginia Bch, VA | 2024 |
| AMERICAN FOUNDATION FOR DONATION AND TRANSPLANTATION | $531,811,631 | E65 | published | science: research education | N Chesterfld, VA | 2024 |
| COMMUNITY BLOOD CENTER | $302,991,373 | E65 | published | science: research education | Dayton, OH | 2024 |
| LIFELINK FOUNDATION INC | $205,771,733 | E65 | published | launch: launch | Tampa, FL | 2024 |
| ALLOSOURCE | $180,054,973 | E65 | published | science: research education | Centennial, CO | 2024 |
| DCI DONOR SERVICES INC | $155,853,313 | E65 | published | | Nashville, TN | 2024 |
| ONELEGACY | $142,795,454 | E65 | published | | Irwindale, CA | 2024 |
| GIFT OF HOPE ORGAN & TISSUE DONOR NETWORK | $141,730,026 | E65 | published | | Itasca, IL | 2024 |
| MID-AMERICA TRANSPLANT SERVICES | $108,143,652 | E65 | published | men: issues | St Louis, MO | 2024 |
| SOUTHWEST TRANSPLANT ALLIANCE INC | $104,988,685 | E65 | published | | Dallas, TX | 2024 |
| MIDWEST TRANSPLANT NETWORK INC | $100,482,288 | E65 | published | | Westwood, KS | 2025 |
| CENTER FOR ORGAN RECOVERY AND EDUCATION | $94,060,552 | E65 | published | science: research education | Pittsburgh, PA | 2024 |
| LIVEONNY INC | $93,277,152 | E65 | published | | Long Island City, NY | 2024 |
| DONOR NETWORK OF ARIZONA | $83,377,123 | E65 | published | | Tempe, AZ | 2024 |
| UPPER MIDWEST ORGAN PROCUREMENT ORGANIZATION INC | $82,460,485 | E65 | published | | Minneapolis, MN | 2024 |
| JOINT RESTORATION FOUNDATION INC | $77,141,318 | E65 | published | science: research education | Centennial, CO | 2024 |
| NEVADA DONOR NETWORK INC | $74,737,363 | E65 | published | | Las Vegas, NV | 2024 |
| DONOR ALLIANCE INC | $71,594,779 | E65 | published | | Denver, CO | 2024 |
| DKMS | $69,106,515 | E65 | published | science: research education | New York, NY | 2024 |
| INFINITE LEGACY INC | $64,038,583 | E65 | published | science: research education | Baltimore, MD | 2025 |
| DONORCONNECT | $62,644,094 | E65 | published | | Murray, UT | 2024 |
| BLOOD CENTERS OF THE PACIFIC | $61,071,568 | E65 | inferred 0.90 | | San Francisco, CA | 2015 |
| NEW JERSEY ORGAN AND TISSUE SHARING NETWORK INC | $59,609,072 | E65 | published | | New Providnce, NJ | 2024 |
| COMMUNITY BLOOD CENTER OF GREATER KANSAS CITY | $43,377,291 | E65 | inferred 0.80 | | Kansas City, MO | 2017 |
| LIFESHARE TRANSPLANT DONOR SERVICES OF OKLAHOMA INC | $42,818,875 | E65 | published | | Oklahoma City, OK | 2024 |
| LIFE CONNECTION OF OHIO | $37,744,994 | E65 | published | science: research education | Maumee, OH | 2025 |
| BERGEN COMMUNITY REGIONAL BLOOD CENTER INC | $36,094,252 | E65 | inferred 0.80 | | Montvale, NJ | 2014 |
| LIFELINE OF OHIO ORGAN PROCUREMENT INC | $34,856,209 | E65 | published | | Columbus, OH | 2025 |
| SOUTHERN LEGACY OF LIFE | $32,670,030 | E65 | published | | Little Rock, AR | 2024 |
| MISSISSIPPI ORGAN RECOVERY AGENCY | $25,281,243 | E65 | published | men: issues | Flowood, MS | 2024 |
| NEBRASKA ORGAN RECOVERY SYSTEM | $22,450,629 | E65 | published | | Omaha, NE | 2024 |
| MID-SOUTH TRANSPLANT FOUNDATION INC | $20,692,124 | E65 | published | | Memphis, TN | 2025 |
| REGENERATIVE BIOLOGICS INC | $17,049,246 | E65 | published | | Alachua, FL | 2025 |
| LIFESHARE COMMUNITY BLOOD SERVICES INC | $15,900,583 | E65 | inferred 0.85 | | Elyria, OH | 2014 |
| VISIONGIFT | $15,049,710 | E65 | published | science: research education | Portland, OR | 2024 |
| UNITED TISSUE NETWORK INC | $9,694,642 | E65 | published | science: research education | Phoenix, AZ | 2024 |
| LIFESHARE TISSUE SERVICES INC | $9,691,479 | E65 | published | | Oklahoma City, OK | 2024 |
| HAWAII ORGAN PROCUREMENT ORGANIZATION | $7,597,340 | E65 | published | | Honolulu, HI | 2024 |
| VISION SHARE INC | $7,280,178 | E65 | published | | Chicago, IL | 2024 |
| ROCKY MOUNTAIN LIONS EYE BANK | $6,932,989 | E65 | published | | Aurora, CO | 2024 |
| INDEPENDENT BLOOD AND TISSUE | $6,745,447 | E65 | inferred 0.60 | science: research education | Orlando, FL | 2011 |
| LIONS EYE BANK OF WISCONSIN INC | $5,830,407 | E65 | published | | Madison, WI | 2025 |
| RHODE ISLAND BLOOD CENTER | $5,584,325 | E65 | inferred 0.80 | | Providence, RI | 2019 |
| KERALINK INTERNATIONAL INC | $4,967,151 | E65 | published | | Baltimore, MD | 2024 |
| THE PRIORY IN THE US OF AMER OF THE MST VEN ORD OF THE HOSP OF ST JOHN | $4,904,123 | E65 | published | | Washington, DC | 2025 |
| SAN ANTONIO EYE BANK | $4,791,422 | E65 | published | | San Antonio, TX | 2024 |
| SIGHT CONSERVATION OF N E N Y INC | $3,864,540 | E65 | published | | Albany, NY | 2025 |
| FLORIDA LIONS EYE BANK INC | $3,733,246 | E65 | published | | Miami, FL | 2024 |
| EVERSIGHT INTERNATIONAL | $3,499,849 | E65 | inferred 0.85 | launch: religious | Ann Arbor, MI | 2024 |
| OLD DOMINION EYE FOUNDATION INC | $2,643,806 | E65 | inferred 0.90 | | N Chesterfld, VA | 2024 |
| CALIFORNIA TRANSPLANT SERVICES INC | $2,584,979 | E65 | published | | Carlsbad, CA | 2024 |
| NORAS GIFT FOUNDATION INC | $2,499,532 | E65 | published | | Houston, TX | 2024 |
| EAST TENNESSEE LIONS EYE BANK | $2,481,728 | E65 | published | | Knoxville, TN | 2024 |
| FLORIDA TISSUE SERVICES INC | $2,326,352 | E65 | published | | Virginia Bch, VA | 2024 |
| DONATE LIFE CALIFORNIA | $2,076,421 | E65 | published | | West Sacramento, CA | 2024 |
| RESTORE LIFE USA INC | $1,940,183 | E65 | published | science: research education | Elizabethton, TN | 2024 |
| NETWORK FOR HOPE MEMORIAL FUND | $1,486,402 | E65 | published | | Cincinnati, OH | 2024 |
| ENVISION SIGHT INC | $1,437,576 | E65 | inferred 0.80 | | Boise, ID | 2024 |
| BATON ROUGE REGIONAL EYE BANK INC | $1,358,368 | E65 | published | | Baton Rouge, LA | 2025 |
| NORTH AMERICAN TRANSPLANT COORDINATORS ORGANIZATION | $1,323,017 | E65 | published | | Oak Hill, VA | 2024 |
| IOPO FOUNDATION INC | $1,014,674 | E65 | published | | Indianapolis, IN | 2025 |
| DONATE LIFE NORTHWEST | $908,486 | E65 | published | | Portland, OR | 2024 |
| THE LIVING BANK INTERNATIONAL | $763,022 | E65 | published | | Houston, TX | 2024 |
| MATCHINGDONORS COM INC | $669,779 | E65 | published | | Canton, MA | 2024 |
| FIRST COAST BLOOD ALLIANCE INC | $656,566 | E65 | inferred 0.60 | | Jacksonville, FL | 2013 |
| GIFT OF LIFE INC | $608,654 | E65 | published | | Overland Park, KS | 2025 |
| AUSTIN RECOVERY INC | $593,497 | E65 | published | abuse: substance | Austin, TX | 2023 |
| DONATE LIFE SOUTH CAROLINA | $461,870 | E65 | published | | Greenville, SC | 2025 |
| THE TRANSPLANT ASSOCIATION OF TEXAS | $448,030 | E65 | published | | San Antonio, TX | 2024 |
| ARMENIAN BONE MARROW DONOR REGISTRY CORP | $371,498 | E65 | published | science: research education | Glendale, CA | 2025 |
| J J S LEGACY | $371,178 | E65 | published | | Bakersfield, CA | 2024 |
| FRIENDS OF FLORENCE INC | $370,437 | E65 | inferred 0.60 | | Florence, OR | 2025 |
| TENNESSEE COUNTY CLERKS ORGAN DONOR AWARENESS FOUNDATION | $361,577 | E65 | published | | Nashville, TN | 2024 |
| SIMON KEITH FOUNDATION | $332,725 | E65 | published | | Las Vegas, NV | 2024 |
| NATIONAL BODY DONOR PROGRAM | $329,000 | E65 | published | | Saint Louis, MO | 2025 |
| ANDY TALLEY BONE MARROW FOUNDATION | $289,212 | E65 | published | science: research education | Devon, PA | 2025 |
| DEVELOPMENTAL THERAPEUTICS INC | $251,000 | E65 | published | | Cincinnati, OH | 2025 |
| LIFESHARE NETWORK INC | $209,285 | E65 | published | | Oklahoma City, OK | 2024 |
| LIONS EYE BANK FOUNDATION | $200,396 | E65 | published | | Houston, TX | 2024 |
| CELLULAR ANALYTICS INC | $158,665 | E65 | inferred 0.60 | | Paramus, NJ | 2010 |
| LIONS EYE BANK OF TEXAS | $104,268 | E65 | published | | Houston, TX | 2024 |
| UNSTOPPABLE JOY CO | $99,351 | E65 | inferred 0.60 | | Berlin, MD | 2024 |
| EQUINE PARTNERS INC | $98,176 | E65 | inferred 0.60 | | Hopkinton, MA | 2013 |
| SILVER LINING FUND INC | $95,119 | E65 | inferred 0.80 | | Canfield, OH | 2025 |
| JORDAN VALLEY AMBULANCE SERVICE | $85,637 | E65 | inferred 0.85 | | Jordan Valley, OR | 2024 |
| BRUNSWICK SEARCH & RESCUE | $66,004 | E65 | published | | Supply, NC | 2023 |
| HEALTH NAVIGATOR FOUNDATION INC | $65,268 | E65 | published | | New York, NY | 2024 |
| WICHITA EYE FOUNDATION | $54,815 | E65 | published | | Wichita, KS | 2024 |
| LIONS CLUB OF ERIE SAVE-AN-EYE FUND INC | $49,662 | E65 | published | | Erie, PA | 2024 |
| SUMMIT FOR STEM CELL FOUNDATION | $48,496 | E65 | published | science: research education | San Marcos, CA | 2025 |
| HATZALAH OF NEWARK EMS INC | $43,938 | E65 | published | | Newark, NJ | 2024 |
| WORLD CHILDRENS TRANSPLANT FUND | $41,023 | E65 | published | | Encino, CA | 2024 |
| MULTICULTURAL MIRACLE DONOR FOUNDATION | $30,887 | E65 | published | | Ft Lauderdale, FL | 2025 |
| ARKANSAS LIONS EYE BANK AND LABORATORY | $27,561 | E65 | published | | Little Rock, AR | 2024 |
| A GIFT OF LIFE THE HEART AND LUNG TRANSPLANT SUPPORT GROUP INC | $21,740 | E65 | published | | Shelton, CT | 2025 |
| MELVIN JONES DISTRICT 13 OH4 LIONS EYE CARE FOUNDATION | $20,340 | E65 | published | | Canfield, OH | 2025 |
| FLOOD SISTERS KIDNEY FOUNDATION | $11,208 | E65 | published | | Chappaqua, NY | 2022 |
| INTERNATIONAL ASSOCIATION OF LIONS CLUBS | $11,195 | E65 | published | | Washington, MO | 2016 |
| MICHAEL'S FUND INC | $8,973 | E65 | inferred 0.70 | | Fall River, MA | 2024 |