| THE MASTERCARD FOUNDATION | Canada | $6,513,121,957 | 2024 | Q32 | published | girls boys: girls |
| GOOD360 | Alexandria, VA | $3,264,744,236 | 2024 | Q19 | published | survivor: disaster |
| GAVI ALLIANCE | Washington, DC | $2,547,417,284 | 2024 | Q33 | published | women: issues |
| DIRECT RELIEF | Santa Barbara, CA | $2,398,998,642 | 2024 | Q33 | published | abuse: substance |
| INTERNATIONAL COMMITTEE OF THE RED CROSS | Switzerland | $2,299,493,810 | 2024 | Q33 | published | |
| AMERICARES FOUNDATION INC | Stamford, CT | $1,851,063,617 | 2024 | Q12 | published | survivor: disaster |
| THE GOVERNORS OF THE UNIVERSITY OF ALBERTA | Canada | $1,591,498,000 | 2025 | Q30 | published | |
| UNIVERSITY OF WESTERN ONTARIO | Canada | $1,590,882,135 | 2024 | Q11 | published | |
| WORLD VISION | Federal Way, WA | $1,423,305,144 | 2024 | Q33 | published | girls boys: boys girls clubs |
| MAP INTERNATIONAL | Brunswick, GA | $1,379,040,410 | 2024 | Q33 | published | violence: sexual |
| INTERNATIONAL RESCUE COMMITTEE INC | New York, NY | $1,314,041,795 | 2024 | Q71 | published | space: for women |
| COMPASSION INTERNATIONAL INCORPORATED | Colorado Spgs, CO | $953,223,395 | 2018 | Q33 | published | women: issues |
| SAVE THE CHILDREN FEDERATION INC | Fairfield, CT | $920,455,828 | 2024 | Q33 | published | domestic: workers |
| UNITED STATES FUND FOR UNICEF | New York, NY | $835,217,861 | 2024 | Q42 | published | abuse: child |
| COOPERATIVE FOR ASSISTANCE AND RELIEF EVERYWHERE INC | Atlanta, GA | $832,911,696 | 2024 | Q30 | published | survivor: disaster |
| PLAN INTERNATIONAL INC | New York, NY | $779,465,250 | 2024 | Q33 | published | shelter: disaster |
| MEDECINS SANS FRONTIERES USA INC | New York, NY | $776,922,926 | 2024 | Q30 | published | shelter: disaster |
| FAMILY HEALTH INTERNATIONAL | Durham, NC | $539,608,705 | 2024 | Q30 | published | violence: sexual |
| WORLD ECONOMIC FORUM | New York, NY | $528,837,504 | 2024 | Q05 | published | |
| THE ROTARY FOUNDATION OF ROTARY INTERNATIONAL | Evanston, IL | $462,635,498 | 2024 | Q11 | published | |
| RIPPLEWORKS INC | San Francisco, CA | $437,395,417 | 2024 | Q30 | published | shelter: homeless |
| CONVOY OF HOPE | Springfield, MO | $435,592,269 | 2021 | Q33 | published | survivor: disaster |
| THE OXFORD FUNDS | United Kingdom | $432,086,659 | 2024 | Q11 | published | |
| AMERICAN JEWISH JOINT DISTRIBUTION COMMITTEE INC | New York, NY | $412,907,647 | 2024 | Q33 | published | survivor: disaster |
| FOOD FOR THE POOR INC | Coconut Creek, FL | $412,105,034 | 2024 | Q33 | published | violence: community |
| FEED THE CHILDREN INC | Oklahoma City, OK | $386,446,959 | 2024 | Q33 | published | shelter: disaster |
| MERCY CORPS | Portland, OR | $376,251,780 | 2024 | Q33 | published | space: for women |
| HABITAT FOR HUMANITY INTERNATIONAL INC | Atlanta, GA | $370,010,910 | 2024 | Q33 | published | launch: launch |
| CARTER CENTER COLLABORATIVE INC | Atlanta, GA | $367,877,415 | 2024 | Q11 | published | |
| ONE ACRE FUND | Highland Park, IL | $351,753,463 | 2025 | Q30 | published | |
| UNITED ISRAEL APPEAL INC | New York, NY | $350,481,992 | 2024 | Q71 | published | |
| HEART TO HEART INTERNATIONAL INC | Lenexa, KS | $347,317,501 | 2025 | Q33 | published | |
| WORLD CENTRAL KITCHEN INCORPORATED | Washington, DC | $327,840,221 | 2024 | Q33 | published | women: issues |
| CATHOLIC MEDICAL MISSION BOARD INC | New York, NY | $326,399,389 | 2024 | Q30 | published | violence: sexual |
| PROJECT ORBIS INTERNATIONAL INC | New York, NY | $323,437,845 | 2025 | Q30 | published | women: issues |
| PATH | Seattle, WA | $321,942,685 | 2025 | Q30 | published | violence: sexual |
| INTERNATIONAL FELLOWSHIP OF CHRISTIANS & JEWS | Chicago, IL | $318,221,645 | 2024 | Q33 | inferred 0.60 | launch: aviation |
| U S COMMITTEE FOR REFUGEES AND IMMIGRANTS INC | Arlington, VA | $313,999,935 | 2024 | Q70 | inferred 0.80 | |
| INSTITUTE OF INTERNATIONAL EDUCATION INC | New York, NY | $306,381,946 | 2024 | Q22 | published | |
| AAM FOUNDATION | Novato, CA | $300,813,850 | 2024 | Q33 | published | shelter: homeless |
| GLOBAL IMPACT | Washington, DC | $290,357,767 | 2024 | Q12 | published | women: issues |
| CHURCH WORLD SERVICE INC | Elkhart, IN | $279,865,803 | 2024 | Q33 | published | survivor: disaster |
| MATTHEW 25 MINISTRIES INC | Blue Ash, OH | $279,440,386 | 2024 | Q19 | published | launch: religious |
| KINGSWAY CHARITIES INC | Bristol, TN | $266,303,035 | 2024 | Q30 | published | launch: religious |
| AMERICAN COMMITTEE FOR THE WEIZMANN INSTITUTE OF SCIENCE INC | New York, NY | $262,912,000 | 2024 | Q11 | published | science: research education |
| MERCY SHIPS INTERNATIONAL | Lindale, TX | $250,375,032 | 2025 | Q33 | published | |
| CLINTON HEALTH ACCESS INITIATIVE INC | Boston, MA | $246,122,771 | 2024 | Q33 | published | launch: launch |
| INTERNATIONAL MEDICAL CORPS | Los Angeles, CA | $235,323,065 | 2024 | Q33 | published | shelter: disaster |
| CENTRO INTERNACIONAL DE MEJORAMIENTO DE MAIZ Y TRIGO | Alexandria, VA | $220,531,073 | 2024 | Q31 | published | science: research education |
| CIEE INC | Carolina, PR | $218,141,529 | 2024 | Q22 | published | |
| CHILDRENS HUNGER FUND | Rnch Cascades, CA | $215,110,859 | 2025 | Q33 | published | |
| WORLD RESOURCES INSTITUTE | Washington, DC | $213,044,770 | 2024 | Q05 | published | science: research education |
| CHILDFUND INTERNATIONAL USA | Richmond, VA | $210,435,038 | 2024 | Q33 | published | |
| WORLD RELIEF CORPORATION O NATIONAL | Baltimore, MD | $205,941,236 | 2024 | Q33 | published | shelter: disaster |
| ACADEMY FOR EDUCATIONAL DEVELOPMENT | Washington, DC | $202,437,786 | 2011 | Q33 | inferred 0.50 | |
| MYRIAD USA INC | New York, NY | $200,540,834 | 2024 | Q30 | published | girls boys: girls |
| JEWISH NATIONAL FUND -KEREN KAYEMETH LEISRAEL- INC | Rockville Ctr, NY | $197,058,808 | 2024 | Q30 | published | shelter: disaster |
| AMERICAN HOSPITAL OF PARIS | France | $183,048,533 | 2023 | Q30 | published | |
| FRIENDS OF THE ISRAEL DEFENSE FORCES | New York, NY | $182,806,815 | 2025 | Q12 | published | |
| DKT INTERNATIONAL INC | Washington, DC | $182,329,221 | 2025 | Q30 | published | |
| AMERICAN NEAR EAST REFUGEE AID INC | Washington, DC | $176,317,328 | 2024 | Q30 | published | girls boys: girls |
| ROMANIAN-AMERICAN FOUNDATION | Montclair, NJ | $170,796,519 | 2024 | Q32 | inferred 0.60 | |
| THE CARTER CENTER INC | Atlanta, GA | $163,882,063 | 2024 | Q70 | published | women: issues |
| ACDI VOCA | Washington, DC | $162,518,399 | 2024 | Q31 | published | women: issues |
| HEIFER PROJECT INTERNATIONAL | Little Rock, AR | $162,027,025 | 2024 | Q33 | published | women: issues |
| ACTION AGAINST HUNGER USA | New York, NY | $160,756,238 | 2024 | Q30 | published | space: for women |
| PROJECT HOPE - THE PEOPLE-TO-PEOPLE HEALTH FOUNDATION INC | Washington, DC | $157,270,945 | 2025 | Q30 | published | women: issues |
| RISE AGAINST HUNGER | Raleigh, NC | $155,585,447 | 2025 | Q33 | published | violence: community |
| FOOD FOR THE HUNGRY INC | Phoenix, AZ | $155,404,798 | 2024 | Q11 | published | |
| CENTRO INTERNATIONAL DE AGRICULTURA TROPICAL INCORPORATED | Medley, FL | $153,085,609 | 2024 | Q31 | published | science: research education |
| AMERICAN FRIENDS OF THE TEL AVIV UNIVERSITY INC | New York, NY | $152,576,474 | 2024 | Q11 | published | science: research education |
| ISLAMIC DEVELOPMENT & EMPOWERMENT IN AMERICA | Alexandria, VA | $147,232,658 | 2024 | Q12 | published | survivor: disaster |
| INTERNATIONAL RESEARCH AND EXCHANGES BOARD INC | Washington, DC | $146,620,152 | 2024 | Q20 | published | science: research education |
| AMERICAN FRIENDS OF MAGEN DAVID ADOM | New York, NY | $142,280,773 | 2024 | Q11 | published | launch: religious |
| WORLD EDUCATION SERVICES INC | New York, NY | $139,593,000 | 2024 | Q22 | published | |
| MANA NUTRITIVE AID PRODUCTS INC | Matthews, NC | $138,046,810 | 2024 | Q33 | published | |
| CONFLICT AND DEVELOPMENT FOUNDATION | Castroville, TX | $136,283,808 | 2024 | Q05 | published | violence: prevention |
| VITAL STRATEGIES INC | New York, NY | $132,394,975 | 2024 | Q30 | published | launch: launch |
| IN-Q-TEL INC | Mc Lean, VA | $132,130,603 | 2024 | Q43 | published | space: outer |
| MANAGEMENT SCIENCES FOR HEALTH INC | Medford, MA | $131,769,559 | 2024 | Q30 | published | women: issues |
| INTERNATIONAL JUSTICE MISSION | Arlington, VA | $129,931,939 | 2024 | Q70 | published | survivor: sexual |
| AGRA | Alexandria, VA | $126,759,117 | 2024 | Q31 | published | women: issues |
| ARAB GULF PROGRAMME FOR DEVELOPMENT | New York, NY | $124,323,993 | 2024 | Q30 | published | women: issues |
| AMERICAN SOCIETY FOR TECHNION- ISRAEL INSTITUTE OF TECHNOLOGY INC | New York, NY | $122,681,563 | 2024 | Q30 | published | survivor: disaster |
| AMERICAN ISRAEL PUBLIC AFFAIRS COMMITTEE | Washington, DC | $122,539,124 | 2024 | Q20 | published | launch: religious |
| TECHNOSERVE INC | Arlington, VA | $122,123,118 | 2024 | Q32 | published | launch: launch |
| UNITED PALESTINIAN APPEAL INC | Washington, DC | $120,665,815 | 2024 | Q33 | published | |
| HELEN KELLER INTERNATIONAL | New York, NY | $120,225,051 | 2024 | Q30 | published | women: issues |
| WINROCK INTERNATIONAL INSTITUTE FOR AGRICULTURAL DEVELOPMENT | Little Rock, AR | $119,231,319 | 2024 | Q31 | published | science: research education |
| INTERNATIONAL INSTITUTE OF TROPICAL AGRICULTURE | Alexandria, VA | $115,116,000 | 2024 | Q31 | published | science: research education |
| PAN AMERICAN DEVELOPMENT FOUNDATION INC | Washington, DC | $113,531,319 | 2024 | Q30 | published | violence: community |
| GLOBAL COMMUNITIES INC | Bethesda, MD | $112,100,528 | 2024 | Q30 | published | |
| AMERICAN COUNCILS FOR INTERNATIONAL EDUCATION ACTR ACCELS INC | Washington, DC | $111,646,743 | 2024 | Q22 | published | |
| JOINT ISRAEL | Israel | $111,513,000 | 2024 | Q30 | published | shelter: disaster |
| MULTIFAITH ALLIANCE INC | New York, NY | $110,316,945 | 2024 | Q05 | published | |
| BROTHERS BROTHER FOUNDATION | Pittsburgh, PA | $108,316,502 | 2025 | Q30 | published | launch: religious |
| HIAS INC | Silver Spring, MD | $107,582,793 | 2024 | Q71 | published | space: for women |
| NATIONAL DEMOCRATIC INSTITUTE FOR INTERNATIONAL AFFAIRS | Washington, DC | $107,205,654 | 2024 | Q30 | published | |
| AGA KHAN FOUNDATION USA | Washington, DC | $106,705,948 | 2025 | Q30 | published | |
| PACT INC | Washington, DC | $106,219,062 | 2024 | Q30 | published | violence: sexual |