Patents
US 9944597 B2: Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof
- Granted
- 2018-04-17
- Filed
- 2014-09-16 application 15021972
- Type
- Utility · 15 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, P-glycoprotein, or cells expressing the β-III isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer.
Source: PVGPATDIS, file of 2026-04-10 (ipg180417.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 3,356 patents | US company or organization | Austin, TX | PVGPATDIS, file of 2026-04-10 | |
| Virginia Commonwealth University 256 patents | US state government | Richmond, VA | Virginia Commonwealth University State business registration EXACT high confidence: identical full name and state Virginia Commonwealth University College or university EXACT high confidence: identical full name and state VIRGINIA COMMONWEALTH UNIVERSITY Federal lobbying client EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| University of Richmond 3 patents | US company or organization | Richmond, VA | University of Richmond State business registration EXACT high confidence: identical full name and state University of Richmond College or university EXACT high confidence: identical full name and state UNIVERSITY OF RICHMOND Federal lobbying client EXACT high confidence: identical full name and state UNIVERSITY OF RICHMOND Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Glen E. Kellogg | Ashland, VA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Chenxiao Da | Chapel Hill, NC | 1 | PVGPATDIS, file of 2026-04-10 | |
| Ashutosh Tripathi | Bryan, TX | 1 | PVGPATDIS, file of 2026-04-10 | |
| John T. Gupton | Midlothian, VA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Nakul Telang | Richmond, VA | 2 | PVGPATDIS, file of 2026-04-10 | |
| James A. Sikorski | Chesterfield, MO | 2 | PVGPATDIS, file of 2026-04-10 | |
| Susan L. Mooberry | San Antonio, TX | 4 | PVGPATDIS, file of 2026-04-10 | |
| Cristina Rohena | San Antonio, TX | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D207/34 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2018-03-07 | Assignment Assignment of assignor's interest | KELLOGG, GLEN E signed 2017-01-18 TRIPATHI, ASHUTOSH signed 2017-01-17 DA, CHENXIAO signed 2017-06-05 | VIRGINIA COMMONWEALTH UNIVERSITY RICHMOND, VA | 45136/860 | PASDL, file of 2026-10-15 |
| 2018-03-07 | Assignment Assignment of assignor's interest | GUPTON, JOHN T signed 2017-10-27 TELANG, NAKUL signed 2017-11-10 SIKORSKI, JAMES A signed 2017-11-25 | UNIVERSITY OF RICHMOND RICHMOND, VA | 45136/661 | PASDL, file of 2026-10-15 |
| 2018-03-07 | Assignment Assignment of assignor's interest | ROHENA, CHRISTINA signed 2018-02-28 MOOBERRY, SUSAN L signed 2018-02-20 | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM AUSTIN, TX | 45136/247 | PASDL, file of 2026-10-15 |
| 2017-12-20 | Assignment Assignment of assignor's interest | GUPTON, JOHN T. signed 2017-10-27 TELANG, NAKUL signed 2017-11-10 SIKORSKI, JAMES A. signed 2017-11-25 | UNIVERSITY OF RICHMOND RICHMOND, VA | 44444/180 | PASDL, file of 2026-10-15 |
| 2017-06-20 | Assignment Assignment of assignor's interest | KELLOGG, GLEN E. signed 2017-01-18 DA, CHENXIAO signed 2017-06-05 TRIPATHI, ASHUTOSH signed 2017-01-17 | VIRGINIA COMMONWEALTH UNIVERSITY RICHMOND, VA | 42760/175 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.