Patents
US 9730981 B2: Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
- Granted
- 2017-08-15
- Filed
- 2013-05-21 application 13899198
- Type
- Utility · 16 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities.
Source: PVGPATDIS, file of 2026-04-10 (ipg170815.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Salus University 5 patents | US company or organization | Cheltenham, PA | Salus University College or university EXACT high confidence: identical full name and state SALUS UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Wayne State University 333 patents | US company or organization | Detroit, MI | Wayne State University College or university EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Zhuo-Hua Pan | Troy, MI | 12 | PVGPATDIS, file of 2026-04-10 | |
| Alexander M. Dizhoor | Dresher, PA | 3 | Person page FUZZY high confidence | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/177 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P27/02 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K14/705 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/86 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2017-03-17 | Assignment Assignment of assignor's interest | DIZHOOR, ALEXANDER M. signed 2009-07-14 | SALUS UNIVERSITY ELKINS PARK, PA | 41618/308 | PASDL, file of 2026-10-15 |
| 2017-03-17 | Assignment Assignment of assignor's interest | PAN, ZHUO-HUA signed 2009-08-14 | WAYNE STATE UNIVERSITY DETROIT, MI | 41618/306 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.