Patents
US 9505719 B2: Synthesis and use of kinase inhibitors
- Granted
- 2016-11-29
- Filed
- 2013-08-07 application 13961517
- Type
- Utility · 31 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
Source: PVGPATDIS, file of 2026-04-10 (ipg161129.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Verastem, Inc. 13 patents | US company or organization | Needham, MA | Verastem, Inc. Form D issuer EXACT high confidence: identical full name and state VERASTEM, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yixiong Lei | Newark, DE | 1 | PVGPATDIS, file of 2026-04-10 | |
| Carl Henry Behrens | Newark, DE | 2 | PVGPATDIS, file of 2026-04-10 | |
| Hui Li | Hockessin, DE | 203 | PVGPATDIS, file of 2026-04-10 | |
| Connie Sun | Palo Alto, CA | 5 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D213/74 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P19/02 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2016-05-06 | Assignment Assignment of assignor's interest | PONIARD PHARMACEUTICALS, INC. signed 2013-08-29 | ENCARTA, INC. SAN FRANCISCO, CA | 38632/215 | ECORSEXC, file of 2026-09-25 |
| 2016-05-06 | Assignment Assignment of assignor's interest | ENCARTA, INC. signed 2014-02-19 | VERASTEM, INC. CAMBRIDGE, MA | 38488/274 | ECORSEXC, file of 2026-09-25 |
| 2016-05-06 | Assignment Assignment of assignor's interest | BEHRENS, CARL HENRY signed 2010-05-24 LEI, YIXIONG signed 2010-05-24 LI, HUI-YIN (HARRY) signed 2010-05-24 SUN, CONNIE L. signed 2010-05-24 | PONIARD PHARMACEUTICALS, INC SEATTLE, WA | 38484/844 | ECORSEXC, file of 2026-09-25 |
| 2014-02-28 | Assignment Assignment of assignor's interest | BEHRENS, CARL HENRY signed 2010-05-24 LEI, YIXIONG signed 2010-05-24 LI, HUI-YIN signed 2010-05-24 SUN, CONNIE L. signed 2010-05-24 | PONIARD PHARMACEUTICALS, INC SEATTLE, WA | 32320/379 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.