Patents
US 9334496 B2: Antisense EGFRAS guanidinium peptide nucleic acid (GPNA) oligonucleotides as antitumor agents
- Granted
- 2016-05-10
- Filed
- 2011-05-13 application 13107344
- Type
- Utility · 2 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A class of antisense agents having a distributed guanidinium peptide nucleic acids (GPNA) backbone which has excellent uptake into mammalian cells, can bind to the target DNA or RNA in a highly sequence specific manner and can resist nucleases and proteases both outside and inside the cell(s) of interest. In one embodiment, either systemic or intratumoral administration of antisense Epidermal Growth Factor Receptor (“EGFR”) GPNA oligonucleotides is believed to downmodulate EGFR levels, thus in turn to reduce head and neck squamous cell carcinoma tumor growth, which has been confirmed to date both in vitro and in vivo.
Source: PVGPATDIS, file of 2026-04-10 (ipg160510.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| EYE & EAR FOUNDATION 1 patents | US company or organization | Pittsburgh, PA | Eye & Ear Foundation State business registration EXACT high confidence: identical full name and state EYE & EAR FOUNDATION INC Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| University of Pittsburgh—Of the Commonwealth System of Higher Education 1,390 patents | US company or organization | Pittsburgh, PA | PVGPATDIS, file of 2026-04-10 | |
| CARNEGIE MELLON UNIVERSITY 794 patents | US company or organization | Pittsburgh, PA | Carnegie Mellon University College or university EXACT high confidence: identical full name and state CARNEGIE MELLON UNIVERSITY Federal lobbying client EXACT high confidence: identical full name and state CARNEGIE MELLON UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jennifer Rubin Grandis | Pittsburgh, PA | 9 | Person page FUZZY medium confidence | PVGPATDIS, file of 2026-04-10 |
| Sufi Mary Thomas | Springdale Township, PA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Danith H. Ly | Pittsburgh, PA | 23 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/111 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2012-09-28 | Assignment Assignment of assignor's interest | LY, DANITH H, PHD signed 2012-08-01 | CARNEGIE MELLON UNIVERSITY PITTSBURGH, PA | 29046/839 | ECORSEXC, file of 2026-09-25 |
| 2011-05-24 | Assignment Assignment of assignor's interest | EYE & EAR FOUNDATION signed 2011-05-03 | UNIVERSITY OF PITTSBURGH--OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION PITTSBURGH, PA EYE & EAR FOUNDATION PITTSBURGH, PA | 26331/353 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.