Patents
US 9332750 B2: Cyclic implant perfusion, cleaning and passivation process and implant produced thereby
- Granted
- 2016-05-10
- Filed
- 2014-03-11 application 14203925
- Type
- Utility · 13 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
Source: PVGPATDIS, file of 2026-04-10 (ipg160510.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| RTI Surgical, Inc. 21 patents | US company or organization | Alachua, FL | RTI SURGICAL, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| C. Randal Mills | Alachua, FL | 11 | PVGPATDIS, file of 2026-04-10 | |
| John F. Wironen | Gainesville, FL | 4 | PVGPATDIS, file of 2026-04-10 | |
| Sean Hanstke | Vaughan, CA | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A01N | Preservation of bodies of humans or animals or plants or parts thereof ; biocides, e.g. as disinfectants, as pesticides or as herbicides ; pest repellants or attractants; plant growth regulators | A01N1/165 | PVGPATDIS, file of 2026-04-10 |
| A61L | Methods or apparatus for sterilising materials or objects in general; disinfection, sterilisation or deodorisation of air; chemical aspects of bandages, dressings, absorbent pads or surgical articles; materials for bandages, dressings, absorbent pads or surgical articles | A61L2/025 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2020-07-21 | Release of security interest Release of security interest | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT signed 2020-07-20 | RTI SURGICAL, INC. ALACHUA, FL PIONEER SURGICAL TECHNOLOGY, INC. ALACHUA, FL TUTOGEN MEDICAL, INC. ALACHUA, FL | 53260/398 | PASDL, file of 2026-10-15 |
| 2020-07-20 | Release of security interest Release of security interest | ARES CAPITAL CORPORATION, AS AGENT signed 2020-07-20 | RTI SURGICAL, INC. ALACHUA, FL PIONEER SURGICAL TECHNOLOGY, INC. ALACHUA, FL TUTOGEN MEDICAL, INC. ALACHUA, FL PARADIGM SPINE, LLC NEW YORK, NY FOURTH DIMENSION SPINE, LLC NEW YORK, NY | 53257/652 | PASDL, file of 2026-10-15 |
| 2019-03-08 | Security interest Security interest Security interest | RTI SURGICAL, INC. signed 2019-03-08 PIONEER SURGICAL TECHNOLOGY, INC. signed 2019-03-08 TUTOGEN MEDICAL, INC. signed 2019-03-08 PARADIGM SPINE, LLC signed 2019-03-08 FOURTH DIMENSION SPINE, LLC signed 2019-03-08 | ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT NEW YORK, NY | 48543/505 | PASDL, file of 2026-10-15 |
| 2018-06-07 | Release of security interest Release of security interest | TD BANK, N.A., AS ADMINISTRATIVE AGENT signed 2018-06-05 | RTI SURGICAL, INC. ALACHUA, FL | 46327/864 | PASDL, file of 2026-10-15 |
| 2018-06-06 | Security interest Security interest Security interest | RTI SURGICAL, INC. signed 2018-06-05 PIONEER SURGICAL TECHNOLOGY, INC. signed 2018-06-05 TUTOGEN MEDICAL, INC. signed 2018-06-05 | JPMORGAN CHASE BANK, N.A., AS THE ADMINISTRATIVE AGENT CHICAGO, IL | 46303/926 | PASDL, file of 2026-10-15 |
| 2017-08-20 | Security interest Security interest Security interest | RTI SURGICAL, INC. signed 2017-07-18 | TD BANK, N.A. CHERRY HILL, NJ | 43608/874 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.