Patents
US 9255068 B2: Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
- Granted
- 2016-02-09
- Filed
- 2012-05-14 application 13471275
- Type
- Utility · 72 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
Source: PVGPATDIS, file of 2026-04-10 (ipg160209.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Warner Chilcott Company, LLC 27 patents | US company or organization | Fajardo, PR | WARNER CHILCOTT COMPANY, LLC State business registration EXACT high confidence: identical full name and state WARNER CHILCOTT PLC SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PVGPATDIS, file of 2026-04-10 |
| Paratek Pharmaceuticals, Inc. 41 patents | US company or organization | Boston, MA | PARATEK PHARMACEUTICALS INC Form D issuer EXACT high confidence: identical full name and state PARATEK PHARMACEUTICALS, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Catherine Coulter | Ballymena, GB | 3 | PVGPATDIS, file of 2026-04-10 | |
| Sean M. Johnston | Doylestown, PA | 10 | PVGPATDIS, file of 2026-04-10 | |
| Farzaneh Seyedi | Mansfield, MA | 7 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07C | Acyclic or carbocyclic compounds | C07C237/26 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P17/00 | PVGPATDIS, file of 2026-04-10 |
| C07B | General methods of organic chemistry; apparatus therefor | C07B2200/07 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-03-17 | Release of security interest Release of security interest in patents recorded at reel/frame 71200/0656 | OAKTREE FUND ADMINISTRATION, LLC signed 2026-03-16 | PARATEK PHARMACEUTICALS, INC. CAMBRIDGE, MA | 75101/815 | PASDL, file of 2026-10-15 |
| 2026-03-16 | Security interest Security interest Patent security agreement | PARATEK PHARMACEUTICALS, INC. signed 2026-03-16 | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT MINNEAPOLIS, MN | 75111/244 | PASDL, file of 2026-10-15 |
| 2025-05-22 | Release of security interest Release of security interest in patents recorded at reel/frame 065001/0917 | OAKTREE FUND ADMINISTRATION, LLC signed 2025-05-21 | PARATEK PHARMACEUTICALS, INC. CAMBRIDGE, MA | 71343/407 | PASDL, file of 2026-10-15 |
| 2025-05-22 | Security interest Security interest Security interest | PARATEK PHARMACEUTICALS, INC. signed 2025-05-21 | OAKTREE FUND ADMINISTRATION, LLC LOS ANGELES, CA | 71200/656 | PASDL, file of 2026-10-15 |
| 2023-09-22 | Security interest Security interest Security interest | PARATEK PHARMACEUTICALS, INC. signed 2023-09-21 | OAKTREE FUND ADMINISTRATION, LLC LOS ANGELES, CA | 65001/917 | PASDL, file of 2026-10-15 |
| 2018-02-22 | Correction Corrective assignment to correct the us patent no. 8,050,873 previously recorded on reel 040183 frame 0129. assignor(s) hereby confirms the assignment. | WARNER CHILCOTT COMPANY, LLC signed 2015-12-31 | ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED DUBLIN 17 | 45417/593 | PASDL, file of 2026-10-15 |
| 2016-09-29 | Assignment Assignment of assignor's interest | WARNER CHILCOTT COMPANY, LLC signed 2015-12-31 | ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED DUBLIN 17 | 40183/129 | PASDL, file of 2026-10-15 |
| 2014-12-23 | Release of security interest Termination of lien on patents | MINTZ LEVIN COHN FERRIS GLOVSKY AND POPEO PC signed 2014-12-22 | PARATEK PHARMACEUTICALS, INC. BOSTON, MA | 34700/377 | PASDL, file of 2026-10-15 |
| 2014-10-31 | Release of security interest Release of security interest | HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD., AS COLLATERAL AGENT signed 2014-10-31 | PARATEK PHARMACEUTICALS, INC. BOSTON, MA | 34113/910 | PASDL, file of 2026-10-15 |
| 2014-03-14 | Security interest Security interest Security interest | PARATEK PHARMACEUTICALS, INC. signed 2014-03-07 | HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD., AS COLLATERAL AGENT ZUG | 32448/1 | PASDL, file of 2026-10-15 |
| 2013-03-08 | Missing Notice | PARATEK PHARMACEUTICALS, INC. signed 2013-03-08 | MINTZ LEVIN COHN FERRIS GLOVSKY AND POPEO PC BOSTON, MA | 29940/106 | PASDL, file of 2026-10-15 |
| 2012-09-25 | Assignment Assignment of assignor's interest | COULTER, CATHERINE signed 2012-05-21 JOHNSTON, SEAN M. signed 2012-07-25 SEYEDI, FARZANEH signed 2012-07-25 | PARATEK PHARMACEUTICALS, INC. BOSTON, MA WARNER CHILCOTT COMPANY, LLC FAJARDO, PR | 29018/831 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.