Patents
US 9108966 B2: Beta-lactamase inhibitors
- Granted
- 2015-08-18
- Filed
- 2014-03-17 application 14216476
- Type
- Utility · 3 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Aryl substituted diazabicyclooctanes (DBO) compounds that inhibit β-lactamases of class A, class C or class D and potentiate β-lactam antibiotics are disclosed. In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains.
Source: PVGPATDIS, file of 2026-04-10 (ipg150818.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Cubist Pharmaceuticals LLC 29 patents | Foreign company or organization | Lexington, MA | CUBIST PHARMACEUTICALS INC SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yu Gui Gu | Acton, MA | 16 | PVGPATDIS, file of 2026-04-10 | |
| Yong He | Bedford, MA | 76 | PVGPATDIS, file of 2026-04-10 | |
| Ning Yin | Lexington, MA | 16 | PVGPATDIS, file of 2026-04-10 | |
| Dylan C. Alexander | Watertown, MA | 9 | PVGPATDIS, file of 2026-04-10 | |
| Jason CROSS | Acton, MA | 36 | PVGPATDIS, file of 2026-04-10 | |
| Robert Busch | Wakefield, MA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Roland E. Dolle | Ashland, MA | 24 | PVGPATDIS, file of 2026-04-10 | |
| Chester A. Metcalf, III | Needham, MA | 23 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D471/08 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/439 | PVGPATDIS, file of 2026-04-10 |
| Y02A | Technologies for adaptation to climate change | Y02A50/30 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2015-08-06 | Assignment Nunc pro tunc assignment | CUBIST PHARMACEUTICALS LLC signed 2015-08-05 | MERCK SHARP & DOHME CORP. RAHWAY, NJ | 36268/626 | ECORSEXC, file of 2026-09-25 |
| 2015-08-05 | Name change Change of name | CUBIST PHARMACEUTICALS, INC. signed 2015-06-29 | CUBIST PHARMACEUTICALS LLC KENILWORTH, NJ | 36283/189 | PASDL, file of 2026-10-15 |
| 2015-02-24 | Assignment Assignment of assignor's interest | ALEXANDER, DYLAN C. signed 2013-04-24 BUSCH, ROBERT signed 2013-04-24 CROSS, JASON B. signed 2013-04-24 DOLLE, ROLAND E. signed 2013-04-24 GU, YU GUI signed 2013-04-24 HE, YONG signed 2013-04-24 YIN, NING signed 2013-04-24 METCALF, CHESTER A., III signed 2013-04-26 | CUBIST PHARMACEUTICALS, INC. LEXINGTON, MA | 35015/831 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.