Patents
US 8957251 B2: Pactamycin analogs and methods of making thereof
- Granted
- 2015-02-17
- Filed
- 2008-04-18 application 12596429
- Type
- Utility · 10 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.
Source: PVGPATDIS, file of 2026-04-10 (ipg150217.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| State of Oregon acting by and through the State Board of Higher Ed. on Behalf of Oregon State Univ. 76 patents | US company or organization | Corvallis, OR | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Taifo Mahmud | Corvallis, OR | 6 | PVGPATDIS, file of 2026-04-10 | |
| Takuya Ito | Tokushima, JP | 2 | PVGPATDIS, file of 2026-04-10 | |
| Patricia M. Flatt | Corvallis, OR | 2 | PVGPATDIS, file of 2026-04-10 | |
| Niran Roongsawang | Corvallis, OR | 2 | PVGPATDIS, file of 2026-04-10 | |
| Norifumi Shirasaka | Corvallis, OR | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07C | Acyclic or carbocyclic compounds | C07C275/26 | PVGPATDIS, file of 2026-04-10 |
| C07D | Heterocyclic compounds | C07D263/52 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/52 | PVGPATDIS, file of 2026-04-10 |
| C12P | Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture | C12P13/02 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.