Patents
US 8877192 B2: Rage fusion proteins and methods of use
- Granted
- 2014-11-04
- Filed
- 2011-01-03 application 12983604
- Type
- Utility · 18 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
Source: PVGPATDIS, file of 2026-04-10 (ipg141104.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| TransTech Pharma, LLC 28 patents | US company or organization | High Point, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Adnan M. M. Mjalli | Oak Ridge, NC | 53 | PVGPATDIS, file of 2026-04-10 | |
| Ye Tian | Jamestown, NC | 108 | PVGPATDIS, file of 2026-04-10 | |
| Jeffrey C. Webster | Jamestown, NC | 4 | PVGPATDIS, file of 2026-04-10 | |
| Robert Rothlein | Greenville, NC | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/705 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/00 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-01-27 | Release of security interest Release of security interest | HORIZON TECHNOLOGY FINANCE CORPORATION, AS COLLATERAL AGENT signed 2021-01-21 | VTV THERAPEUTICS LLC HIGH POINT, NC | 55133/214 | PASDL, file of 2026-10-15 |
| 2018-04-18 | Security interest Security interest Security interest | VTV THERAPEUTICS LLC signed 2018-04-09 | HORIZON TECHNOLOGY FINANCE CORPORATION, AS COLLATERAL AGENT FARMINGTON, CT | 45969/774 | PASDL, file of 2026-10-15 |
| 2015-09-24 | Correction Corrective assignment to correct the receiving party data previously recorded at reel: 036254 frame: 0780. assignor(s) hereby confirms the assignment. | M&F TTP HOLDINGS LLC, AS COLLATERAL AGENT signed 2015-07-29 | VTVX HOLDINGS I LLC HIGH POINT, NC | 36675/407 | ECORSEXC, file of 2026-09-25 |
| 2015-08-03 | Release of security interest Release of security interest | M&F TTP HOLDINGS LLC, AS COLLATERAL AGENT signed 2015-07-29 | VTVX HOLDINGS II LLC HIGH POINT, NC | 36254/780 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Assignment Assignment of assignor's interest | VTVX HOLDINGS I LLC signed 2015-07-29 | VTV THERAPEUTICS LLC HIGH POINT, NC | 36242/354 | ECORSEXC, file of 2026-09-25 |
| 2015-07-30 | Name change Change of name | VTV THERAPEUTICS LLC signed 2015-07-29 | VTVX HOLDINGS I LLC HIGH POINT, NC | 36236/165 | ECORSEXC, file of 2026-09-25 |
| 2015-06-25 | Name change Change of name | TRANSTECH PHARMA, LLC signed 2015-05-18 | VTV THERAPEUTICS LLC HIGH POINT, NC | 36026/219 | ECORSEXC, file of 2026-09-25 |
| 2015-02-26 | Security interest Security interest Security interest | TRANSTECH PHARMA, LLC signed 2015-02-25 | M&F TTP HOLDINGS LLC, AS COLLATERAL AGENT NEW YORK, NY | 35103/356 | ECORSEXC, file of 2026-09-25 |
| 2014-04-07 | Release of security interest Notice of release of security interest in patents for reel/frame 030982/0803 | M&F TTP HOLDINGS LLC signed 2014-03-28 | TRANSTECH PHARMA, LLC HIGH POINT, NC | 32621/860 | ECORSEXC, file of 2026-09-25 |
| 2013-11-26 | Assignment Assignment of assignor's interest | TRANSTECH PHARMA, INC. signed 2013-11-14 | TRANSTECH PHARMA, LLC HIGH POINT, NC | 31678/682 | ECORSEXC, file of 2026-09-25 |
| 2013-08-09 | Security interest Security interest Security agreement | TRANSTECH PHARMA, INC. signed 2013-08-09 | M&F TTP HOLDINGS LLC C/O MACANDREWS & FORBES HOLDINGS INC. NEW YORK, NY | 30982/803 | ECORSEXC, file of 2026-09-25 |
| 2012-03-15 | Assignment Assignment of assignor's interest | TIAN, YE E. signed 2005-09-26 WEBSTER, JEFFREY C. signed 2005-09-27 MJALLI, ADNAN M.M. signed 2005-09-29 ROTHLEIN, ROBERT signed 2005-09-29 | TRANSTECH PHARMA, INC. HIGH POINT, NC | 27868/179 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.