Patents
US 8815818 B2: Phagocytic cell delivery of RNAI
- Granted
- 2014-08-26
- Filed
- 2009-07-17 application 13054696
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides a particulate delivery system for delivering an RNAi construct to phagocytic cells such as macrophages, comprising various configurations of a complex comprising a phagocytic cell-targeting moiety and an RNAi construct. The invention further provides methods of making the delivery system, and their uses, such as treating phagocytic cell-associated disease conditions.
Source: PVGPATDIS, file of 2026-04-10 (ipg140826.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| RXi Pharmaceuticals Corporation 17 patents | US company or organization | Marlborough, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Dmitry Samarsky | Westborough, MA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Tod M. Woolf | Sudbury, MA | 41 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/111 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/549 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2018-12-07 | Name change Change of name | RXI PHARMACEUTICALS CORPORATION signed 2018-11-14 | PHIO PHARMACEUTICALS CORP. MARLBOROUGH, MA | 48380/9 | PASDL, file of 2026-10-15 |
| 2012-05-02 | Release of security interest Release of security interest | TANG CAPITAL PARTNERS, LP signed 2012-05-01 | RXI PHARMACEUTICALS CORPORATION WORCESTER, MA | 28144/110 | PASDL, file of 2026-10-15 |
| 2011-10-26 | Assignment Assignment of assignor's interest | SAMARSKY, DMITRY signed 2011-02-17 WOOLF, TOD M. signed 2011-02-18 | RXI PHARMACEUTICALS CORPORATION WORCESTER, MA | 27124/1 | ECORSEXC, file of 2026-09-25 |
| 2011-09-29 | Name change Change of name | RNCS, INC. signed 2011-09-26 | RXI PHARMACEUTICALS CORPORATION WORCESTER, MA | 26988/874 | PASDL, file of 2026-10-15 |
| 2011-09-26 | Security interest Security interest Security agreement | RNCS, INC. signed 2011-09-24 | TANG CAPITAL PARTNERS, LP SAN DIEGO, CA | 26976/187 | PASDL, file of 2026-10-15 |
| 2011-09-26 | Assignment Assignment of assignor's interest | RXI PHARMACEUTICALS CORPORATION signed 2011-09-24 | RNCS, INC. WORCESTER, MA | 26969/660 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.