Patents
US 8604164 B2: High purity lipopeptides
- Granted
- 2013-12-10
- Filed
- 2012-02-16 application 13398219
- Type
- Utility · 41 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
Source: PVGPATDIS, file of 2026-04-10 (ipg131210.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Cubist Pharmaceuticals LLC 29 patents | Foreign company or organization | Lexington, MA | CUBIST PHARMACEUTICALS INC SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Thomas J. Kelleher | Thousand Oaks, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Jan-Ji Lai | Westborough, MA | 11 | PVGPATDIS, file of 2026-04-10 | |
| Joseph P. DeCourcey | Boston, MA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Paul D. Lynch | Arlington, MA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Maurizio Zenoni | Frosinone, IT | 23 | PVGPATDIS, file of 2026-04-10 | |
| Auro R. Tagliani | Pavia, IT | 7 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/12 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P29/00 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K1/145 | PVGPATDIS, file of 2026-04-10 |
| Y10S | Technical subjects covered by former uspc cross-reference art collections [xracs] and digests | Y10S435/886 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2016-09-14 | Name change Change of address | CUBIST PHARMACEUTICALS LLC signed 2016-07-14 | CUBIST PHARMACEUTICALS LLC 6000 LUCERNE 6 | 40026/743 | PASDL, file of 2026-10-15 |
| 2015-08-14 | Correction Corrective assignment to correct the nature of conveyance previously recorded at reel: 036308 frame: 0207. assignor(s) hereby confirms the release of security interest. | ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT signed 2015-07-07 | CUBIST PHARMACEUTICALS, INC. LEXINGTON, MA ADOLOR CORPORATION EXTON, PA CALIXA THERAPEUTICS, INC. LEXINGTON, MA | 36355/184 | PASDL, file of 2026-10-15 |
| 2015-08-12 | Security interest Security interest Security interest | ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT signed 2015-07-07 | CUBIST PHARMACEUTICALS, INC. LEXINGTON, MA ADOLOR CORPORATION EXTON, PA CALIXA THERAPEUTICS, INC. LEXINGTON, MA | 36308/207 | PASDL, file of 2026-10-15 |
| 2015-08-05 | Name change Change of name | CUBIST PHARMACEUTICALS, INC. signed 2015-06-29 | CUBIST PHARMACEUTICALS LLC KENILWORTH, NJ | 36283/189 | PASDL, file of 2026-10-15 |
| 2013-10-22 | Assignment Assignment of assignor's interest | LYNCH, PAUL D. signed 2001-02-13 | PERSEPTIVE BIOSYSTEMS, INCORPORATED FRAMINGHAM, MA | 31452/70 | ECORSEXC, file of 2026-09-25 |
| 2013-10-22 | Assignment Assignment of assignor's interest | PERSEPTIVE BIOSYSTEMS, INCORPORATED signed 2001-02-13 | CUBIST PHARMACEUTICALS, INC. CAMBRIDGE, MA | 31452/43 | ECORSEXC, file of 2026-09-25 |
| 2013-10-22 | Assignment Assignment of assignor's interest | KELLEHER, THOMAS J. signed 2001-01-12 LAI, JAN-JI signed 2001-01-12 DECOURCEY, JOSEPH P. signed 2001-01-19 TAGLIANI, AURO R. signed 2001-01-19 ZENONI, MAURIZIO signed 2001-01-19 | CUBIST PHARMACEUTICALS, INC. LEXINGTON, MA | 31452/14 | ECORSEXC, file of 2026-09-25 |
| 2012-11-20 | Security interest Security interest Security agreement | CUBIST PHARMACEUTICALS, INC. signed 2012-11-20 ADOLOR CORPORATION signed 2012-11-20 CALIXA THERAPEUTICS, INC. signed 2012-11-20 CUBIST PHARMACEUTICALS HOLDINGS, INC. signed 2012-11-20 CUBIST PHARMACEUTICALS U.S. signed 2012-11-20 | ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT TORONTO, ONTARIO | 29339/669 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.