Patents
US 8524280 B2: Methods for enhancing the release and absorption of water insoluble active agents
- Granted
- 2013-09-03
- Filed
- 2009-12-15 application 12638212
- Type
- Utility · 25 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Methods for enhancing the release and/or absorption of poorly water soluble active agents are described herein. The method involves dissolving, melting, or suspending a poorly water soluble active agent in one or more molten fatty acids, conjugated fatty acids, (semi-) solid surfactants of high HLB value, and/or hydrophilic polymers. The molten active agent mixture is then suspended and homogenized in a hydrophilic or lipophilic carrier to form microparticles suspended in the hydrophilic or lipophilic carrier. The particles suspended in the hydrophilic or lipophilic carrier can be encapsulated in a hard or soft gelatin or non-gelatin capsule. It is believed that the microparticles produced by the method described above will exhibit enhanced dissolution profiles. In vitro release studies of formulations containing cilostazol and fenofibrate showed 100% dissolution of cilostazol in 15 minutes and over 90% dissolution of fenofibrate in 35 minutes.
Source: PVGPATDIS, file of 2026-04-10 (ipg130903.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Banner Pharmacaps, Inc. 8 patents | US company or organization | High Point, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Aqeel A. Fatmi | Greensboro, NC | 47 | PVGPATDIS, file of 2026-04-10 | |
| Tae Kyoung Kim | High Point, NC | 47 | PVGPATDIS, file of 2026-04-10 | |
| Karla E. Madrigal | High Point, NC | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/4709 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/18 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2017-09-28 | Release of security interest Release (reel 032403 / frame 0790) | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH signed 2017-09-21 | BANNER PHARMACAPS INC. HIGH POINT, NC | 44038/28 | ECORSEXC, file of 2026-09-25 |
| 2017-07-12 | Security interest Security interest Notice of succession of agency for patent security interest previously recorded at reel/frame (032403/0790) | UBS AG, STAMFORD BRANCH, AS PRIOR AGENT signed 2017-06-20 | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS SUCCESSOR AGENT NEW YORK, NY | 43173/5 | ECORSEXC, file of 2026-09-25 |
| 2017-06-29 | Assignment Nunc pro tunc assignment | BANNER LIFE SCIENCES LLC signed 2017-06-22 | PATHEON SOFTGELS INC HIGH POINT, NC | 43032/619 | ECORSEXC, file of 2026-09-25 |
| 2015-11-05 | Correction Corrective assignment to correct the nature of conveyance previously recorded at reel: 034359 frame: 872. assignor(s) hereby confirms the assignment. | BANNER PHARMACAPS INC. signed 2014-11-21 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 37055/101 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Release of security interest Release of security interest | UBS AG, STAMFORD BRANCH signed 2015-07-31 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 36239/188 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Release of security interest Release of security interest | UBS AG, STAMFORD BRANCH signed 2015-07-31 | BANNER LIFE SCIENCES LLC HIGH POINT, NC BANNER PHARMACAPS INC. HIGH POINT, NC | 36224/623 | ECORSEXC, file of 2026-09-25 |
| 2015-03-05 | Security interest Security interest Security interest | BANNER LIFE SCIENCES LLC signed 2015-03-05 | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT STAMFORD, CT | 35133/328 | ECORSEXC, file of 2026-09-25 |
| 2014-12-03 | Name change Change of name | BANNER PHARMACAPS INC. signed 2014-11-01 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 34359/872 | ECORSEXC, file of 2026-09-25 |
| 2014-04-23 | Release of security interest Termination and release of security interest in patent rights | MORGAN STANLEY SENIOR FUNDING, INC. signed 2014-03-11 | BANNER PHARMACAPS INC. HIGH POINT, NC | 32745/454 | ECORSEXC, file of 2026-09-25 |
| 2014-03-11 | Security interest Security interest Security interest | BANNER PHARMACAPS INC. signed 2014-03-11 | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT STAMFORD, CT | 32403/790 | ECORSEXC, file of 2026-09-25 |
| 2012-12-17 | Security interest Security interest Security agreement | BANNER PHARMACAPS INC. signed 2012-12-14 | MORGAN STANLEY SENIOR FUNDING INC., AS COLLATERAL AGENT BALTIMORE, MD | 29481/962 | ECORSEXC, file of 2026-09-25 |
| 2010-03-08 | Assignment Assignment of assignor's interest | FATMI, AQEEL signed 2010-01-04 | BANNER PHARMACAPS, INC. HIGH POINT, NC | 24042/499 | ECORSEXC, file of 2026-09-25 |
| 2010-03-08 | Assignment Assignment of assignor's interest | KIM, TAE KYOUNG signed 2001-12-03 MADRIGAL, KARLA E. signed 2003-07-07 | BANNER PHARMACAPS, INC. HIGH POINT, NC | 24042/493 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.