Patents
US 8309107 B2: Stable solutions of orlistat for pharmaceutical dosage forms
- Granted
- 2012-11-13
- Filed
- 2009-10-06 application 12574215
- Type
- Utility · 24 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Liquid orlistat-containing fill materials suitable for encapsulating in hard or soft capsules are described herein. The fill material contains orlistat dissolved in one or more medium chain triglycerides or medium chain partial triglycerides, one or more citrate esters, and combinations thereof. The fill material can also contain one or more pharmaceutically acceptable excipients. In one embodiment, the fill material is substantially free of surfactants. The fill material can be encapsulated in hard or soft, gelatin or non-gelatin capsules. The capsules may be coated to modify release of orlistat from the capsule. Alternatively, the fill material can be encapsulated in an enteric capsule, wherein the enteric polymer is a component of the capsule shell, rather than a coating over the capsule shell. The fill materials are stable at elevated temperatures over an extended period of time and allow for high loadings of orlistat (e.g., 20% w/w or higher).
Source: PVGPATDIS, file of 2026-04-10 (ipg121113.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Banner Pharmacaps, Inc. 8 patents | US company or organization | High Point, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Zhi Liu | Jamestown, NC | 8 | PVGPATDIS, file of 2026-04-10 | |
| Dana S. Toops | Coral Springs, FL | 2 | PVGPATDIS, file of 2026-04-10 | |
| Aqeel A. Fatmi | Greensboro, NC | 47 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K9/4858 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-04-18 | Security interest Security interest Security interest | BIONPHARMA HEALTHCARE LLC signed 2022-04-01 | WXM LLC MANASSAS, VA | 59621/844 | ECORSEXC, file of 2026-09-25 |
| 2021-02-01 | Release of security interest Release of security interest | MIDCAP FINANCIAL TRUST signed 2021-01-19 | BIONPHARMA HEALTH INC. PRINCETON, NJ BIONPHARMA HEALTHCARE LLC PRINCETON, NJ BIONPHARMA INC. PRINCETON, NJ | 55100/105 | ECORSEXC, file of 2026-09-25 |
| 2020-12-08 | Release of security interest Release of security interest | ATHYRIUM OPPORTUNITIES II ACQUISITION LP signed 2020-12-01 | BIONPHARMA HEALTHCARE LLC PRINCETON, NJ BIONPHARMA INC. PRINCETON, NJ | 54575/365 | ECORSEXC, file of 2026-09-25 |
| 2020-10-09 | Correction Amended and restated security interest (revolving) | BIONPHARMA HEALTH, INC. signed 2020-09-30 BIONPHARMA HEALTHCARE LLC signed 2020-09-30 BIONPHARMA INC. signed 2020-09-30 | MIDCAP FUNDING IV TRUST, AS AGENT BETHESDA, MD | 54036/93 | ECORSEXC, file of 2026-09-25 |
| 2020-10-09 | Security interest Security interest Security interest (term) | BIONPHARMA HEALTH, INC. signed 2020-09-30 BIONPHARMA HEALTHCARE LLC signed 2020-09-30 BIONPHARMA INC. signed 2020-09-30 | MIDCAP FINANCIAL TRUST, AS AGENT BETHESDA, MD | 54035/836 | ECORSEXC, file of 2026-09-25 |
| 2018-06-07 | Assignment Assignment of assignor's interest | BIONPHARMA HEALTHCARE LLC signed 2018-05-31 | BIONPHARMA INC. PRINCETON, NJ | 46016/1 | ECORSEXC, file of 2026-09-25 |
| 2017-09-28 | Release of security interest Release (reel 032403 / frame 0790) | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH signed 2017-09-21 | BANNER PHARMACAPS INC. HIGH POINT, NC | 44038/28 | ECORSEXC, file of 2026-09-25 |
| 2017-07-12 | Security interest Security interest Notice of succession of agency for patent security interest previously recorded at reel/frame (032403/0790) | UBS AG, STAMFORD BRANCH, AS PRIOR AGENT signed 2017-06-20 | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS SUCCESSOR AGENT NEW YORK, NY | 43173/5 | ECORSEXC, file of 2026-09-25 |
| 2016-01-04 | Security interest Security interest Security interest | BIONPHARMA HEALTHCARE LLC signed 2015-12-01 BIONPHARMA INC. signed 2015-12-01 | ATHYRIUM OPPORTUNITIES II ACQUISITION LP NEW YORK, NY | 37399/659 | ECORSEXC, file of 2026-09-25 |
| 2015-12-15 | Assignment Assignment of assignor's interest | BANNER LIFE SCIENCES LLC signed 2015-12-01 | BIONPHARMA HEALTHCARE LLC PRINCETON, NJ | 37296/992 | ECORSEXC, file of 2026-09-25 |
| 2015-12-15 | Security interest Security interest Security interest (revolver) | BIONPHARMA HEALTHCARE LLC signed 2015-12-01 | MIDCAP FINANCIAL TRUST, AS AGENT BETHESDA, MD | 37292/965 | ECORSEXC, file of 2026-09-25 |
| 2015-12-15 | Security interest Security interest Security interest (term) | BIONPHARMA HEALTHCARE LLC signed 2015-12-01 | MIDCAP FINANCIAL TRUST, AS AGENT BETHESDA, MD | 37292/874 | ECORSEXC, file of 2026-09-25 |
| 2015-11-05 | Correction Corrective assignment to correct the nature of conveyance previously recorded at reel: 034359 frame: 872. assignor(s) hereby confirms the assignment. | BANNER PHARMACAPS INC. signed 2014-11-21 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 37055/101 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Release of security interest Release of security interest | UBS AG, STAMFORD BRANCH signed 2015-07-31 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 36239/188 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Release of security interest Release of security interest | UBS AG, STAMFORD BRANCH signed 2015-07-31 | BANNER LIFE SCIENCES LLC HIGH POINT, NC BANNER PHARMACAPS INC. HIGH POINT, NC | 36224/623 | ECORSEXC, file of 2026-09-25 |
| 2015-03-05 | Security interest Security interest Security interest | BANNER LIFE SCIENCES LLC signed 2015-03-05 | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT STAMFORD, CT | 35133/328 | ECORSEXC, file of 2026-09-25 |
| 2014-12-03 | Name change Change of name | BANNER PHARMACAPS INC. signed 2014-11-01 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 34359/872 | ECORSEXC, file of 2026-09-25 |
| 2014-04-23 | Release of security interest Termination and release of security interest in patent rights | MORGAN STANLEY SENIOR FUNDING, INC. signed 2014-03-11 | BANNER PHARMACAPS INC. HIGH POINT, NC | 32745/454 | ECORSEXC, file of 2026-09-25 |
| 2014-03-11 | Security interest Security interest Security interest | BANNER PHARMACAPS INC. signed 2014-03-11 | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT STAMFORD, CT | 32403/790 | ECORSEXC, file of 2026-09-25 |
| 2012-12-17 | Security interest Security interest Security agreement | BANNER PHARMACAPS INC. signed 2012-12-14 | MORGAN STANLEY SENIOR FUNDING INC., AS COLLATERAL AGENT BALTIMORE, MD | 29481/962 | ECORSEXC, file of 2026-09-25 |
| 2009-12-03 | Assignment Assignment of assignor's interest | FATMI, AQEEL A. signed 2009-10-16 LIU, ZHI signed 2009-10-19 TOOPS, DANA S. signed 2009-10-21 | BANNER PHARMACAPS, INC. HIGH POINT, NC | 23598/238 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.