Patents
US 8293270 B2: Lipophilic vehicle-based dual controlled release matrix system
- Granted
- 2012-10-23
- Filed
- 2006-10-26 application 11553349
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A lipophilic vehicle-based dual controlled-release matrix, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a suspension, which allows for easier formulation of low dose compounds and/or compounds which are moisture sensitive. The matrix includes two rate controlling barriers for the controlled release of one or more pharmaceutically active agents. The primary rate controlling barrier includes a relatively lipophilic oily vehicle. The primary rate controlling barrier may further comprise or more excipients, dissolved in the lipophilic vehicle, which themselves have rate controlling properties. The secondary rate controlling barrier is a hydrogel-forming polymeric material which is dispersed in the primary rate controlling barrier. As the primary rate controlling barrier breaks down, the pharmaceutically active agent is slowly released and the surrounding aqueous media begins to percolate into the polymer matrix. This results in hydration of the polymer and subsequent formation of a hydrogel, which controls the release of the drug by diffusion through, and/or erosion of, the hydrogel. By dispersing or suspending part of the pharmaceutically active agent in the primary rate controlling vehicle, a dual release profile can be obtained. The combination of release of the drug from the lipophilic oily vehicle and release of the drug from the hydrogel allows for the modulation of drug release for up to 24 hours. This system is particularly useful for moisture sensitive drugs as the oily layer prevents water migration from the shell in to the fill.
Source: PVGPATDIS, file of 2026-04-10 (ipg121023.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Banner Pharmacaps, Inc. 8 patents | US company or organization | High Point, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Karunakar Sukuru | High Point, NC | 10 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K9/4858 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2017-09-28 | Release of security interest Release (reel 032403 / frame 0790) | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH signed 2017-09-21 | BANNER PHARMACAPS INC. HIGH POINT, NC | 44038/28 | ECORSEXC, file of 2026-09-25 |
| 2017-07-12 | Security interest Security interest Notice of succession of agency for patent security interest previously recorded at reel/frame (032403/0790) | UBS AG, STAMFORD BRANCH, AS PRIOR AGENT signed 2017-06-20 | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS SUCCESSOR AGENT NEW YORK, NY | 43173/5 | ECORSEXC, file of 2026-09-25 |
| 2017-06-29 | Assignment Nunc pro tunc assignment | BANNER LIFE SCIENCES LLC signed 2017-06-22 | PATHEON SOFTGELS INC HIGH POINT, NC | 43032/619 | ECORSEXC, file of 2026-09-25 |
| 2015-11-05 | Correction Corrective assignment to correct the nature of conveyance previously recorded at reel: 034359 frame: 872. assignor(s) hereby confirms the assignment. | BANNER PHARMACAPS INC. signed 2014-11-21 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 37055/101 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Release of security interest Release of security interest | UBS AG, STAMFORD BRANCH signed 2015-07-31 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 36239/188 | ECORSEXC, file of 2026-09-25 |
| 2015-07-31 | Release of security interest Release of security interest | UBS AG, STAMFORD BRANCH signed 2015-07-31 | BANNER LIFE SCIENCES LLC HIGH POINT, NC BANNER PHARMACAPS INC. HIGH POINT, NC | 36224/623 | ECORSEXC, file of 2026-09-25 |
| 2015-03-05 | Security interest Security interest Security interest | BANNER LIFE SCIENCES LLC signed 2015-03-05 | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT STAMFORD, CT | 35133/328 | ECORSEXC, file of 2026-09-25 |
| 2014-12-03 | Name change Change of name | BANNER PHARMACAPS INC. signed 2014-11-01 | BANNER LIFE SCIENCES LLC HIGH POINT, NC | 34359/872 | ECORSEXC, file of 2026-09-25 |
| 2014-04-23 | Release of security interest Termination and release of security interest in patent rights | MORGAN STANLEY SENIOR FUNDING, INC. signed 2014-03-11 | BANNER PHARMACAPS INC. HIGH POINT, NC | 32745/454 | ECORSEXC, file of 2026-09-25 |
| 2014-03-11 | Security interest Security interest Security interest | BANNER PHARMACAPS INC. signed 2014-03-11 | UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT STAMFORD, CT | 32403/790 | ECORSEXC, file of 2026-09-25 |
| 2012-12-17 | Security interest Security interest Security agreement | BANNER PHARMACAPS INC. signed 2012-12-14 | MORGAN STANLEY SENIOR FUNDING INC., AS COLLATERAL AGENT BALTIMORE, MD | 29481/962 | ECORSEXC, file of 2026-09-25 |
| 2006-11-29 | Assignment Assignment of assignor's interest | SUKURU, KARUNAKAR signed 2006-11-02 | BANNER PHARMACAPS, INC. HIGH POINT, NC | 18560/977 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.