Patents
US 8258319 B2: Exo- and diastereo- selective synthesis of himbacine analogs
- Granted
- 2012-09-04
- Filed
- 2011-06-24 application 13168029
- Type
- Utility · 11 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
Source: PVGPATDIS, file of 2026-04-10 (ipg120904.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| SCHERING CORPORATION 216 patents | US company or organization | Kenilworth, NJ | SCHERING CORPORATION State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| George G. Wu | Berkeley Heights, NJ | 19 | PVGPATDIS, file of 2026-04-10 | |
| Anantha Sudhakar | Fremont, CA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Tao Wang | Springfield, NJ | 118 | PVGPATDIS, file of 2026-04-10 | |
| Ji Xie | Edison, NJ | 8 | PVGPATDIS, file of 2026-04-10 | |
| Frank Xing Chen | Plainsboro, NJ | 15 | PVGPATDIS, file of 2026-04-10 | |
| Marc Poirier | Stewartsville, NJ | 10 | PVGPATDIS, file of 2026-04-10 | |
| Mingsheng Huang | Plainsboro, NJ | 5 | PVGPATDIS, file of 2026-04-10 | |
| Vijay Sabesan | Millbrae, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Daw-long Kwok | Gillette, NJ | 7 | PVGPATDIS, file of 2026-04-10 | |
| Jian Cui | Edison, NJ | 11 | PVGPATDIS, file of 2026-04-10 | |
| Xiaojing Yang | Waterford, CT | 12 | PVGPATDIS, file of 2026-04-10 | |
| Tiruvettipuram K. Thiruvengadam | Kendall Park, NJ | 10 | PVGPATDIS, file of 2026-04-10 | |
| Jing Liao | Edison, NJ | 12 | PVGPATDIS, file of 2026-04-10 | |
| Ilia Zavialov | Princeton, NJ | 5 | PVGPATDIS, file of 2026-04-10 | |
| Hoa N. Nguyen | Not reported | 4 | PVGPATDIS, file of 2026-04-10 | |
| Ngiap Kie. Lim | Somerville, NJ | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D263/56 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P7/02 | PVGPATDIS, file of 2026-04-10 |
| C07C | Acyclic or carbocyclic compounds | C07C69/606 | PVGPATDIS, file of 2026-04-10 |
| C07F | Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium | C07F7/1804 | PVGPATDIS, file of 2026-04-10 |
| Y02P | Climate change mitigation technologies in the production or processing of goods | Y02P20/55 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2020-10-12 | Assignment Assignment of assignor's interest | ARALEZ PHARMACEUTICALS TRADING DAC signed 2019-05-10 | TOPROL ACQUISITION LLC NEW YORK, NY | 54027/47 | ECORSEXC, file of 2026-09-25 |
| 2020-09-10 | Assignment Assignment of assignor's interest | TOPROL ACQUISITION LLC signed 2020-08-31 | XSPIRE PHARMA, LLC RIDGELAND, MS | 53731/376 | ECORSEXC, file of 2026-09-25 |
| 2018-08-31 | Assignment Receiving party/assignee address change for assignment recorded at reel/frame 039767/0695 | MERCK SHARP & DOHME CORP. signed 2016-09-06 | ARALEZ PHARMACEUTICALS TRADING DAC DUBLIN 2 | 46989/669 | ECORSEXC, file of 2026-09-25 |
| 2018-08-30 | Correction Corrective assignment to correct the conveying party previously recorded at reel: 046696 frame: 0772. assignor(s) hereby confirms the assignment. | ARALEZ PHARMACEUTICALS TRADING DESIGNATED ACTIVITY COMPANY signed 2018-08-10 | DEERFIELD MANAGEMENT COMPANY, L.P., AS ADMINISTRATIVE AGENT NEW YORK, NY | 46988/741 | ECORSEXC, file of 2026-09-25 |
| 2018-08-24 | Security interest Security interest Security interest | ARALEZ PHARMACEUTICAL TRADING DAC signed 2018-08-10 | DEERFIELD MANAGEMENT COMPANY, L.P., AS ADMINISTRATIVE AGENT NEW YORK, NY | 46696/772 | ECORSEXC, file of 2026-09-25 |
| 2016-09-29 | Security interest Security interest Security interest | ARALEZ PHARMACEUTICALS TRADING DAC signed 2016-09-16 | DEERFIELD INTERNATIONAL MASTER FUND, L.P. NEW YORK, NY DEERFIELD PARTNERS, L.P. NEW YORK, NY DEERFIELD PRIVATE DESIGN FUND III, L.P. NEW YORK, NY | 39892/309 | ECORSEXC, file of 2026-09-25 |
| 2016-09-16 | Assignment Assignment of assignor's interest | MERCK SHARP & DOHME CORP. signed 2016-09-06 | ARALEZ PHARMACEUTICALS TRADING DAC DUBLIN 2 | 39767/695 | ECORSEXC, file of 2026-09-25 |
| 2013-03-11 | Name change Change of name | SCHERING CORPORATION signed 2012-05-02 | MERCK SHARP & DOHME CORP. RAHWAY, NJ | 29959/19 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.