Patents
US 8252727 B2: Antibody diversity generation
- Granted
- 2012-08-28
- Filed
- 2008-02-05 application 12026412
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
Source: PVGPATDIS, file of 2026-04-10 (ipg120828.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Maxygen, Inc. 14 patents | US company or organization | San Mateo, CA | MAXYGEN, INC. State business registration EXACT high confidence: identical full name and state MAXYGEN INC SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Erik Karrer | Fremont, CA | 14 | PVGPATDIS, file of 2026-04-10 | |
| Steven H. Bass | Hillsborough, CA | 17 | PVGPATDIS, file of 2026-04-10 | |
| Robert Whalen | Foster City, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| PHILIP A. PATTEN | Portola Valley, CA | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/1271 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.