Patents
US 8216571 B2: Fully human anti-VEGF antibodies and methods of using
- Granted
- 2012-07-10
- Filed
- 2008-10-20 application 12739383
- Type
- Utility · 21 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.
Source: PVGPATDIS, file of 2026-04-10 (ipg120710.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| SCHERING CORPORATION 216 patents | US company or organization | Kenilworth, NJ | SCHERING CORPORATION State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Sumant Ramachandra | Northbrook, IL | 8 | PVGPATDIS, file of 2026-04-10 | |
| Walter Robert Bishop | Pequannock, NJ | 1 | PVGPATDIS, file of 2026-04-10 | |
| Linda Masat | Walnut Creek, CA | 20 | PVGPATDIS, file of 2026-04-10 | |
| Chao Bai Huang | San Leandro, CA | 11 | PVGPATDIS, file of 2026-04-10 | |
| Toshihiko Takeuchi | Oakland, CA | 18 | PVGPATDIS, file of 2026-04-10 | |
| Seema Kantak | Pacifica, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Chin-Yi Huang | Fremont, CA | 22 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/22 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P3/10 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K2039/505 | PVGPATDIS, file of 2026-04-10 |
| Y10S | Technical subjects covered by former uspc cross-reference art collections [xracs] and digests | Y10S435/81 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-12-23 | Release of security interest Release of security interest | SILICON VALLEY BANK signed 2025-12-19 | XOMA TECHNOLOGY LTD. EMERYVILLE, CA | 73790/484 | PASDL, file of 2026-10-15 |
| 2018-05-09 | Security interest Security interest Security interest | XOMA TECHNOLOGY LTD. signed 2018-05-07 | SILICON VALLEY BANK SAN FRANCSICO, CA | 46115/459 | PASDL, file of 2026-10-15 |
| 2012-08-30 | Name change Change of name | SCHERING CORPORATION signed 2012-05-02 | MERCK SHARP & DOHME CORP. RAHWAY, NJ | 28884/151 | PASDL, file of 2026-10-15 |
| 2011-06-06 | Assignment Assignment of assignor's interest | RAMACHANDRA, SUMANT signed 2010-09-11 BISHOP, WALTER ROBERT signed 2010-09-21 | SCHERING CORPORATION KENILWORTH, NJ | 26391/726 | ECORSEXC, file of 2026-09-25 |
| 2011-01-10 | Assignment Assignment of assignor's interest | RAMACHANDRA, SUMANT signed 2010-09-11 BISHOP, WALTER ROBERT signed 2010-09-21 | SCHERING CORPORATION KENILWORTH, NJ | 25608/18 | ECORSEXC, file of 2026-09-25 |
| 2010-12-20 | Assignment Assignment of assignor's interest | MASAT, LINDA signed 2010-08-24 HUANG, CHAO BAI signed 2010-08-26 HUANG, CHIN-YI signed 2010-08-26 TAKEUCHI, TOSHIHIKO signed 2010-08-26 KANTAK, SEEMA signed 2010-09-02 | XOMA TECHNOLOGY LTD. BERKELEY, CA | 25530/902 | ECORSEXC, file of 2026-09-25 |
| 2010-12-20 | Assignment Assignment of assignor's interest | RAMACHANDRA, SUMANT signed 2010-09-11 BISHOP, WALTER ROBERT signed 2010-09-21 | SCHERING CORPORATION KENILWORTH, NJ | 25530/838 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.