Patents
US 8207170 B2: Heterocyclic substituted piperazines with CXCR3 antagonist activity
- Granted
- 2012-06-26
- Filed
- 2010-11-23 application 12952994
- Type
- Utility · 1 claim
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1:or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
Source: PVGPATDIS, file of 2026-04-10 (ipg120626.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| SCHERING CORPORATION 216 patents | US company or organization | Kenilworth, NJ | SCHERING CORPORATION State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Pharmacopeia Drug Discovery, Inc. 12 patents | US company or organization | Princeton, NJ | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Seong Heon Kim | Livingston, NJ | 15 | PVGPATDIS, file of 2026-04-10 | |
| Gopinadhan N. Anilkumar | Edison, NJ | 7 | PVGPATDIS, file of 2026-04-10 | |
| Michael K. C. Wong | New Brunswick, NJ | 16 | PVGPATDIS, file of 2026-04-10 | |
| Qingbei Zeng | Edison, NJ | 20 | PVGPATDIS, file of 2026-04-10 | |
| Stuart B. Rosenblum | West Orange, NJ | 21 | PVGPATDIS, file of 2026-04-10 | |
| Joseph A. Kozlowski | Princeton, NJ | 67 | PVGPATDIS, file of 2026-04-10 | |
| Yuefei Shao | Princeton, NJ | 5 | PVGPATDIS, file of 2026-04-10 | |
| Brian F. McGuinness | Plainsboro, NJ | 16 | PVGPATDIS, file of 2026-04-10 | |
| Douglas W. Hobbs | Yardley, PA | 9 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D401/12 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/04 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-08-08 | Merger Merger | MERCK SHARP & DOHME CORP. signed 2022-04-07 | MERCK SHARP & DOHME LLC RAHWAY, NJ | 61102/145 | PASDL, file of 2026-10-15 |
| 2012-08-30 | Name change Change of name | SCHERING CORPORATION signed 2012-05-02 | MERCK SHARP & DOHME CORP. RAHWAY, NJ | 28884/151 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.