Patents
US 8198463 B2: Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.3.0]-hexane compounds and enantiomeric salts thereof
- Granted
- 2012-06-12
- Filed
- 2010-04-09 application 12757322
- Type
- Utility · 3 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid (“D-DTTA”) salt or a (1S,2R,5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt (“L-DTTA”) in a high enantiomeric excess. This invention also provides for a process for preparing a (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid (“D-DBTA”) salt or a (1S,2R,5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid (“L-DBTA”) salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII.
Source: PVGPATDIS, file of 2026-04-10 (ipg120612.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| SCHERING CORPORATION 216 patents | US company or organization | Kenilworth, NJ | SCHERING CORPORATION State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| George G. Wu | Berkeley Heights, NJ | 19 | PVGPATDIS, file of 2026-04-10 | |
| Frank Xing Chen | Plainsboro, NJ | 15 | PVGPATDIS, file of 2026-04-10 | |
| Paitoon Rashatasakhon | Not reported | 3 | PVGPATDIS, file of 2026-04-10 | |
| Jeffrey Eckert | Hazlet, NJ | 10 | PVGPATDIS, file of 2026-04-10 | |
| George S. K. Wong | Summit, NJ | 6 | PVGPATDIS, file of 2026-04-10 | |
| Hong-Chang Lee | Livingston, NJ | 7 | PVGPATDIS, file of 2026-04-10 | |
| Nolan C. Erickson | West Orange, NJ | 2 | PVGPATDIS, file of 2026-04-10 | |
| Jennifer Ann Vance | Scotch Plains, NJ | 3 | PVGPATDIS, file of 2026-04-10 | |
| Peter C. Nirchio | Lebanon, NJ | 2 | PVGPATDIS, file of 2026-04-10 | |
| Juergen Weber | Plainsboro, NJ | 4 | PVGPATDIS, file of 2026-04-10 | |
| David Jieh-Shyh Tsai | Hackettstown, NJ | 5 | PVGPATDIS, file of 2026-04-10 | |
| Nanfei Zou | East Brunswick Township, NJ | 12 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D209/54 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2012-08-30 | Name change Change of name | SCHERING CORPORATION signed 2012-05-02 | MERCK SHARP & DOHME CORP. RAHWAY, NJ | 28884/151 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.