Patents
US 12767955 B2: CAS9 fusion proteins, RNA-guided gene editing, gene regulation compositions, and methods comprising the same
- Granted
- 2026-10-20
- Filed
- 2020-07-13 application 16927679
- Type
- Utility · 15 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
Source: PTBLXML, file of 2026-10-20 (ipgb20261020.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Duke University 1,375 patents | US company or organization | Durham, NC | Duke University College or university EXACT high confidence: identical full name and state DUKE UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-10-20 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Charles A. Gersbach | Durham, NC | 25 | PTBLXML, file of 2026-10-20 | |
| Isaac B. Hilton | Durham, NC | PTBLXML, file of 2026-10-20 | ||
| Pablo Perez-Pinera | Urbana, IL | 6 | PTBLXML, file of 2026-10-20 | |
| Ami M. Kabadi | Greensboro, NC | 6 | PTBLXML, file of 2026-10-20 | |
| Pratiksha I. Thakore | Durham, IL | 6 | PTBLXML, file of 2026-10-20 | |
| David G. Ousterout | Raleigh, NC | 8 | PTBLXML, file of 2026-10-20 | |
| Joshua B. Black | Durham, NC | 9 | PTBLXML, file of 2026-10-20 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/85 | PTBLXML, file of 2026-10-20 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/465 | PTBLXML, file of 2026-10-20 |
| C07K | Peptides | C07K14/4708 | PTBLXML, file of 2026-10-20 |
| C12Y | Enzymes | C12Y301/00 | PTBLXML, file of 2026-10-20 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.