Patents
US 12767939 B2: Compositions and methods for gene editing
- Granted
- 2026-10-20
- Filed
- 2022-04-21 application 17726290
- Type
- Utility · 14 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms. Provided herein also are fusion protein compositions that can turn off genes permanently and reversibly in mammalian cells using CRISPR-based epigenome editing. In addition, provided herein are fusion proteins including, from N-terminus to C-terminus, a DNA methyltransferase domain, a nuclease deficient RNA-guided endonuclease enzyme, and a Krüppel associated box domain.
Source: PTBLXML, file of 2026-10-20 (ipgb20261020.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Regents of the University of California 8,781 patents | US company or organization | Oakland, CA | REGENTS OF THE UNIVERSITY OF CALIFORNIA State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-10-20 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jin Chen | San Francisco, CA | PTBLXML, file of 2026-10-20 | ||
| Luke Gilbert | San Francisco, CA | 6 | PTBLXML, file of 2026-10-20 | |
| James Nunez | San Francisco, CA | 3 | PTBLXML, file of 2026-10-20 | |
| Jonathan Weissman | San Francisco, CA | 13 | PTBLXML, file of 2026-10-20 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/62 | PTBLXML, file of 2026-10-20 |
| C07K | Peptides | C07K14/4702 | PTBLXML, file of 2026-10-20 |
| C12Y | Enzymes | C12Y201/01072 | PTBLXML, file of 2026-10-20 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.